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INtestinal Tissue ENgineering Solution

Deliverables

Obtaining tissue

We will set up a standard Operating Procedure for obtaining the tissue sample that is required for the in vitro procedure up to the transplantation. The protocol will describe the regulatory approval, the logistics and the technical description of the isolation up to taking it into culture.

Tool for engaging the public

A new tool for engaging publics, including school students and patients, around short bowel syndrome, and potential clinical uses of intestinal stem cells.

Website

Creation and launch of INTENS project-specific website at www.intens.info as well as linking from EuroStemCell, PINNT, Short Gut Foundation and other relevant websites.

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Publications

The hope and the hype of organoid research

Author(s): Meritxell Huch, Juergen A. Knoblich, Matthias P. Lutolf, Alfonso Martinez-Arias
Published in: Development, Issue 144/6, 2017, Page(s) 938-941, ISSN 0950-1991
DOI: 10.1242/dev.150201

Multiscale microenvironmental perturbation of pluripotent stem cell fate and self-organization

Author(s): Yoji Tabata, Matthias P. Lutolf
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/srep44711

Progress and potential in organoid research

Author(s): Giuliana Rossi, Andrea Manfrin, Matthias P. Lutolf
Published in: Nature Reviews Genetics, Issue 19/11, 2018, Page(s) 671-687, ISSN 1471-0056
DOI: 10.1038/s41576-018-0051-9

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

Author(s): Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen
Published in: Cell Stem Cell, Issue 22/1, 2018, Page(s) 35-49.e7, ISSN 1934-5909
DOI: 10.1016/j.stem.2017.11.001

Mammalian body plan engineering: Lessons and challenges

Author(s): Alfonso Martinez Arias, Matthias P. Lutolf
Published in: Current Opinion in Systems Biology, Issue 11, 2018, Page(s) 50-56, ISSN 2452-3100
DOI: 10.1016/j.coisb.2018.07.007

Transplantation of enteric nervous system stem cells rescues nitric oxide synthase deficient mouse colon

Author(s): Conor J. McCann, Julie E. Cooper, Dipa Natarajan, Benjamin Jevans, Laura E. Burnett, Alan J. Burns, Nikhil Thapar
Published in: Nature Communications, Issue 8, 2017, Page(s) 15937, ISSN 2041-1723
DOI: 10.1038/ncomms15937

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Author(s): Claudia Y. Janda, Luke T. Dang, Changjiang You, Junlei Chang, Wim de Lau, Zhendong A. Zhong, Kelley S. Yan, Owen Marecic, Dirk Siepe, Xingnan Li, James D. Moody, Bart O. Williams, Hans Clevers, Jacob Piehler, David Baker, Calvin J. Kuo, K. Christopher Garcia
Published in: Nature, Issue 545/7653, 2017, Page(s) 234-237, ISSN 0028-0836
DOI: 10.1038/nature22306

Establishing Proximal and Distal Regional Identities in Murine and Human Tissue-Engineered Lung and Trachea

Author(s): Andrew Trecartin, Soula Danopoulos, Ryan Spurrier, Hanaa Knaneh-Monem, Michael Hiatt, Barbara Driscoll, Christian Hochstim, Denise Al-Alam, Tracy C. Grikscheit
Published in: Tissue Engineering Part C: Methods, Issue 22/11, 2016, Page(s) 1049-1057, ISSN 1937-3384
DOI: 10.1089/ten.TEC.2016.0261

Functional Human and Murine Tissue-Engineered Liver Is Generated from Adult Stem/Progenitor Cells

Author(s): Nirmala Mavila, Andrew Trecartin, Ryan Spurrier, Yi Xiao, Xiaogang Hou, David James, Xiaowei Fu, Brian Truong, Clara Wang, Gerald S. Lipshutz, Kasper S. Wang, Tracy C. Grikscheit
Published in: STEM CELLS Translational Medicine, Issue 6/1, 2017, Page(s) 238-248, ISSN 2157-6564
DOI: 10.5966/sctm.2016-0205