“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics

Deliverables

Publications

Trans -Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

Author(s): E. Johanna L. Stéen, Jesper T. Jørgensen, Kerstin Johann, Kamilla Nørregaard, Barbara Sohr, Dennis Svatunek, Alexander Birke, Vladimir Shalgunov, Patricia E. Edem, Raffaella Rossin, Christine Seidl, Friederike Schmid, Marc S. Robillard, Jesper L. Kristensen, Hannes Mikula, Matthias Barz, Andreas Kjær, Matthias M. Herth
Published in: ACS Nano, Issue 14/1, 2020, Page(s) 568-584, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b06905

Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging

Author(s): Patricia E. Edem, Jesper T. Jørgensen, Kamilla Nørregaard, Rafaella Rossin, Abdolreza Yazdani, John F. Valliant, Marc Robillard, Matthias M. Herth, Andreas Kjaer
Published in: Molecules, Issue 25/3, 2020, Page(s) 463, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25030463

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

Author(s): Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch, Matthias M. Herth
Published in: EJNMMI Research, Issue 9/1, 2019, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-019-0520-y

HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation

Author(s): Stefan Kramer, Dennis Svatunek, Irina Alberg, Barbara Gräfen, Sascha Schmitt, Lydia Braun, Arthur H. A. M. van Onzen, Raffaella Rossin, Kaloian Koynov, Hannes Mikula, Rudolf Zentel
Published in: Biomacromolecules, Issue 20/10, 2019, Page(s) 3786-3797, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.9b00868

Tetrazine- and trans -cyclooctene-functionalised polypept(o)ides for fast bioorthogonal tetrazine ligation

Author(s): Kerstin Johann, Dennis Svatunek, Christine Seidl, Silvia Rizzelli, Tobias A. Bauer, Lydia Braun, Kaloian Koynov, Hannes Mikula, Matthias Barz
Published in: Polymer Chemistry, Issue 11/27, 2020, Page(s) 4396-4407, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0py00375a

Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry

Author(s): E. Johanna L. Stéen, Jesper T. Jørgensen, Christoph Denk, Umberto M. Battisti, Kamilla Nørregaard, Patricia E. Edem, Klas Bratteby, Vladimir Shalgunov, Martin Wilkovitsch, Dennis Svatunek, Christian B. M. Poulie, Lars Hvass, Marina Simón, Thomas Wanek, Raffaella Rossin, Marc Robillard, Jesper L. Kristensen, Hannes Mikula, Andreas Kjaer, Matthias M. Herth
Published in: ACS Pharmacology & Translational Science, Issue 4/2, 2021, Page(s) 824-833, ISSN 2575-9108
Publisher: ACS Publications
DOI: 10.1021/acsptsci.1c00007

Direct Cu-mediated aromatic 18 F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging

Author(s): Rocío García-Vázquez, Umberto M. Battisti, Jesper T. Jørgensen, Vladimir Shalgunov, Lars Hvass, Daniel L. Stares, Ida N. Petersen, François Crestey, Andreas Löffler, Dennis Svatunek, Jesper L. Kristensen, Hannes Mikula, Andreas Kjaer, Matthias M. Herth
Published in: Chemical Science, 2021, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc02789a

A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines

Author(s): Dennis Svatunek, Christoph Denk, Hannes Mikula
Published in: Monatshefte für Chemie - Chemical Monthly, Issue 149/4, 2018, Page(s) 833-837, ISSN 0026-9247
Publisher: Springer Verlag
DOI: 10.1007/s00706-017-2110-x

Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines

Author(s): E. Johanna L. Stéen, Patricia E. Edem, Kamilla Nørregaard, Jesper T. Jørgensen, Vladimir Shalgunov, Andreas Kjaer, Matthias M. Herth
Published in: Biomaterials, Issue 179, 2018, Page(s) 209-245, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2018.06.021

Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction

Author(s): E. Johanna L. Stéen, Vladimir Shalgunov, Christoph Denk, Hannes Mikula, Andreas Kjaer, Jesper L. Kristensen, Matthias M. Herth
Published in: European Journal of Organic Chemistry, 2018, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201801457

Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications

Author(s): Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula
Published in: ChemBioChem, 2019, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900042

Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking

Author(s): Christoph Denk, Martin Wilkovitsch, Emma Aneheim, Matthias Herth, Holger Jensen, Sture Lindegren, Hannes Mikula
Published in: ChemPlusChem, 2019, ISSN 2192-6506
Publisher: Wiley-VCH Verlag
DOI: 10.1002/cplu.201900114

Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18 F-Radiolabeling of Base-Sensitive Tracers

Author(s): Klas Bratteby, Vladimir Shalgunov, Umberto Maria Battisti, Ida Nyman Petersen, Sara Lopes van den Broek, Tomas Ohlsson, Nic Gillings, Maria Erlandsson, Matthias M. Herth
Published in: ACS Pharmacology & Translational Science, 2021, ISSN 2575-9108
Publisher: ACS Publications
DOI: 10.1021/acsptsci.1c00133

Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging

Author(s): E. Johanna L. Stéen, Jesper T. Jørgensen, Ida N. Petersen, Kamilla Nørregaard, Szabolcs Lehel, Vladimir Shalgunov, Alexander Birke, Patricia E. Edem, Elina T. L'Estrade, Hanne D. Hansen, Jonas Villadsen, Maria Erlandsson, Tomas Ohlsson, Abdolreza Yazdani, John F. Valliant, Jesper L. Kristensen, Matthias Barz, Gitte M. Knudsen, Andreas Kjær, Matthias M. Herth
Published in: Bioorganic & Medicinal Chemistry Letters, Issue 29/8, 2019, Page(s) 986-990, ISSN 0960-894X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2019.02.014

Uncovering the key role of distortion in tetrazine ligations guides the design of bioorthogonal tools with high reactivity and superior stability

Author(s): Svatunek D, Wilkovitsch M, Hartmann L, Houk KN, Mikula H
Published in: ChemRxiv, 2021, ISSN 2573-2293
Publisher: Cambridge University Press
DOI: 10.33774/chemrxiv-2021-vnwzk

Intellectual Property Rights

NOVEL TETRAZINE COMPOUNDS FOR IN VIVO IMAGING

Application/Publication number: 20 19050374
Date: 2019-11-29

18F-LABELED NOVEL TETRAZINES IMAGING PROBES FOR PRETARGETING IN PET IMAGING

Application/Publication number: 20 20064432
Date: 2020-05-25

AGENTS FOR CLEAVING LABELS FROM BIOMOLECULES IN VIVO

Application/Publication number: 20 20050387
Date: 2020-06-17
Applicant(s): TAGWORKS PHARMACEUTICALS BV

COMPOUNDS FOR FAST AND EFFICIENT CLICK RELEASE

Application/Publication number: 20 20050388
Date: 2020-06-17
Applicant(s): TAGWORKS PHARMACEUTICALS BV

POLYPEPT(O)ID-BASED GRAFT COPOLYMERS FOR IN VIVO IMAGING BY TETRAZINE TRANSCYCLOOCTENE CLICK CHEMISTRY

Application/Publication number: 20 19067060
Date: 2019-06-26