“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics

Risultati finali

Pubblicazioni

Trans -Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

Autori: E. Johanna L. Stéen, Jesper T. Jørgensen, Kerstin Johann, Kamilla Nørregaard, Barbara Sohr, Dennis Svatunek, Alexander Birke, Vladimir Shalgunov, Patricia E. Edem, Raffaella Rossin, Christine Seidl, Friederike Schmid, Marc S. Robillard, Jesper L. Kristensen, Hannes Mikula, Matthias Barz, Andreas Kjær, Matthias M. Herth
Pubblicato in: ACS Nano, Numero 14/1, 2020, Pagina/e 568-584, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.9b06905

Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging

Autori: Patricia E. Edem, Jesper T. Jørgensen, Kamilla Nørregaard, Rafaella Rossin, Abdolreza Yazdani, John F. Valliant, Marc Robillard, Matthias M. Herth, Andreas Kjaer
Pubblicato in: Molecules, Numero 25/3, 2020, Pagina/e 463, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25030463

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

Autori: Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch, Matthias M. Herth
Pubblicato in: EJNMMI Research, Numero 9/1, 2019, ISSN 2191-219X
Editore: Springer Berlin
DOI: 10.1186/s13550-019-0520-y

HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation

Autori: Stefan Kramer, Dennis Svatunek, Irina Alberg, Barbara Gräfen, Sascha Schmitt, Lydia Braun, Arthur H. A. M. van Onzen, Raffaella Rossin, Kaloian Koynov, Hannes Mikula, Rudolf Zentel
Pubblicato in: Biomacromolecules, Numero 20/10, 2019, Pagina/e 3786-3797, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b00868

Tetrazine- and trans -cyclooctene-functionalised polypept(o)ides for fast bioorthogonal tetrazine ligation

Autori: Kerstin Johann, Dennis Svatunek, Christine Seidl, Silvia Rizzelli, Tobias A. Bauer, Lydia Braun, Kaloian Koynov, Hannes Mikula, Matthias Barz
Pubblicato in: Polymer Chemistry, Numero 11/27, 2020, Pagina/e 4396-4407, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/d0py00375a

Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry

Autori: E. Johanna L. Stéen, Jesper T. Jørgensen, Christoph Denk, Umberto M. Battisti, Kamilla Nørregaard, Patricia E. Edem, Klas Bratteby, Vladimir Shalgunov, Martin Wilkovitsch, Dennis Svatunek, Christian B. M. Poulie, Lars Hvass, Marina Simón, Thomas Wanek, Raffaella Rossin, Marc Robillard, Jesper L. Kristensen, Hannes Mikula, Andreas Kjaer, Matthias M. Herth
Pubblicato in: ACS Pharmacology & Translational Science, Numero 4/2, 2021, Pagina/e 824-833, ISSN 2575-9108
Editore: ACS Publications
DOI: 10.1021/acsptsci.1c00007

Direct Cu-mediated aromatic 18 F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging

Autori: Rocío García-Vázquez, Umberto M. Battisti, Jesper T. Jørgensen, Vladimir Shalgunov, Lars Hvass, Daniel L. Stares, Ida N. Petersen, François Crestey, Andreas Löffler, Dennis Svatunek, Jesper L. Kristensen, Hannes Mikula, Andreas Kjaer, Matthias M. Herth
Pubblicato in: Chemical Science, 2021, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sc02789a

A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines

Autori: Dennis Svatunek, Christoph Denk, Hannes Mikula
Pubblicato in: Monatshefte für Chemie - Chemical Monthly, Numero 149/4, 2018, Pagina/e 833-837, ISSN 0026-9247
Editore: Springer Verlag
DOI: 10.1007/s00706-017-2110-x

Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines

Autori: E. Johanna L. Stéen, Patricia E. Edem, Kamilla Nørregaard, Jesper T. Jørgensen, Vladimir Shalgunov, Andreas Kjaer, Matthias M. Herth
Pubblicato in: Biomaterials, Numero 179, 2018, Pagina/e 209-245, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2018.06.021

Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction

Autori: E. Johanna L. Stéen, Vladimir Shalgunov, Christoph Denk, Hannes Mikula, Andreas Kjaer, Jesper L. Kristensen, Matthias M. Herth
Pubblicato in: European Journal of Organic Chemistry, 2018, ISSN 1434-193X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201801457

Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications

Autori: Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula
Pubblicato in: ChemBioChem, 2019, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900042

Multifunctional clickable reagents for rapid bioorthogonal astatination and radio-crosslinking

Autori: Christoph Denk, Martin Wilkovitsch, Emma Aneheim, Matthias Herth, Holger Jensen, Sture Lindegren, Hannes Mikula
Pubblicato in: ChemPlusChem, 2019, ISSN 2192-6506
Editore: Wiley-VCH Verlag
DOI: 10.1002/cplu.201900114

Insights into Elution of Anion Exchange Cartridges: Opening the Path toward Aliphatic 18 F-Radiolabeling of Base-Sensitive Tracers

Autori: Klas Bratteby, Vladimir Shalgunov, Umberto Maria Battisti, Ida Nyman Petersen, Sara Lopes van den Broek, Tomas Ohlsson, Nic Gillings, Maria Erlandsson, Matthias M. Herth
Pubblicato in: ACS Pharmacology & Translational Science, 2021, ISSN 2575-9108
Editore: ACS Publications
DOI: 10.1021/acsptsci.1c00133

Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging

Autori: E. Johanna L. Stéen, Jesper T. Jørgensen, Ida N. Petersen, Kamilla Nørregaard, Szabolcs Lehel, Vladimir Shalgunov, Alexander Birke, Patricia E. Edem, Elina T. L'Estrade, Hanne D. Hansen, Jonas Villadsen, Maria Erlandsson, Tomas Ohlsson, Abdolreza Yazdani, John F. Valliant, Jesper L. Kristensen, Matthias Barz, Gitte M. Knudsen, Andreas Kjær, Matthias M. Herth
Pubblicato in: Bioorganic & Medicinal Chemistry Letters, Numero 29/8, 2019, Pagina/e 986-990, ISSN 0960-894X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2019.02.014

Uncovering the key role of distortion in tetrazine ligations guides the design of bioorthogonal tools with high reactivity and superior stability

Autori: Svatunek D, Wilkovitsch M, Hartmann L, Houk KN, Mikula H
Pubblicato in: ChemRxiv, 2021, ISSN 2573-2293
Editore: Cambridge University Press
DOI: 10.33774/chemrxiv-2021-vnwzk

Diritti di proprietà intellettuale

NOVEL TETRAZINE COMPOUNDS FOR IN VIVO IMAGING

Numero candidatura/pubblicazione: 20 19050374
Data: 2019-11-29

18F-LABELED NOVEL TETRAZINES IMAGING PROBES FOR PRETARGETING IN PET IMAGING

Numero candidatura/pubblicazione: 20 20064432
Data: 2020-05-25

AGENTS FOR CLEAVING LABELS FROM BIOMOLECULES IN VIVO

Numero candidatura/pubblicazione: 20 20050387
Data: 2020-06-17
Candidato/i: TAGWORKS PHARMACEUTICALS BV

COMPOUNDS FOR FAST AND EFFICIENT CLICK RELEASE

Numero candidatura/pubblicazione: 20 20050388
Data: 2020-06-17
Candidato/i: TAGWORKS PHARMACEUTICALS BV

POLYPEPT(O)ID-BASED GRAFT COPOLYMERS FOR IN VIVO IMAGING BY TETRAZINE TRANSCYCLOOCTENE CLICK CHEMISTRY

Numero candidatura/pubblicazione: 20 19067060
Data: 2019-06-26