Skip to main content

Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy

Objective

Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill this gap. We will provide a novel discovery strategy based on systems biology concepts that uses mathematical and network theoretical models to identify brain sites and functional networks that can be targeted specifically by therapeutic interventions. To build predictive models of the ‘relapse-prone’ state of brain networks we will use magnetic resonance imaging and neurochemical data from patients and laboratory animals. The mathematical models will be rigorously tested through experimental procedures aimed to guide network dynamics towards increased resilience. We expect to identify hubs that promote ‘relapse-proneness’ and to predict how aberrant network states could be normalized. Proof of concept experiments in animal will need to demonstrate this possibility by showing directed remodeling of functional brain networks by targeted interventions prescribed by the theoretical framework. Thus, our translational goal will be achieved by a theoretical and experimental framework for making predictions based on fMRI and mathematical modeling, which is verified in animals, and which can be transferred to humans. To achieve this goal we have assembled an interdisciplinary consortium (eight European countries) of world-class expertise in all complementary skills required for the project. If successful this project will positively impact on the development of new therapies for a disorder with largely unmet clinical needs, and thus help to address a serious and widespread health problem in our societies.

Field of science

  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Address
Square J 5
68159 Mannheim
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 861 352,50

Participants (14)

THE UNIVERSITY OF SUSSEX
United Kingdom
EU contribution
€ 449 943,75
Address
Sussex House Falmer
BN1 9RH Brighton
Activity type
Higher or Secondary Education Establishments
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 416 625
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 259 252,50
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG

Participation ended

Germany
EU contribution
€ 0
Address
Universitaetsplatz 2
39106 Magdeburg
Activity type
Higher or Secondary Education Establishments
INSTITUTUL ROMAN DE STIINTA SI TEHNOLOGIE

Participation ended

Romania
EU contribution
€ 227 826,25
Address
Str. Saturn Nr. 24-26
400504 Cluj-napoca
Activity type
Research Organisations
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 161 140
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 389 791,25
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 448 258,75
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 408 687,50
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
METANOMICS HEALTH GMBH

Participation ended

Germany
EU contribution
€ 0
Address
Tegeler Weg 33
10589 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BRAIN RESEARCH AND DEVELOPMENT SERVICES LTD
Israel
EU contribution
€ 150 747,50
Address
19 Hartom Street Bynet Building 3Rd Floor Har Hotz
9777518 Jerusalem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 550 000
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 250 000
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE
Romania
EU contribution
€ 186 298,75
Address
Piata Timotei Cipariu Nr. 9 Bl. Ia Sca.2 Ap.20
400191 Cluj Napoca
Activity type
Research Organisations