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Forefront Research in 3D Disease Cancer Models as in vitro Screening Technologies

Deliverables

Implementation of specific standard operating procedures (SOPs)

Implementation of specific standard operating procedures (SOPs)

Report on internal meetings/evaluations on project progress and achievements, steering committee meetings and on coordination activities and risk management (M12)

Report on internal meetings/evaluations on project progress and achievements, steering committee meetings and on coordination activities and risk management (M12)

Report on the selection process of the ERA Chair holder

Report on the selection process of the ERA Chair holder, including the text of the vacancy notice, places of publication, composition of the selection panel, CVs of applicants, minutes of selection panel meeting(s) as well as any other document allowing for a full assessment of the openness of the selection procedure.

Implementation of the Consortium Non Disclosure Agreement

Implementation of the Consortium Non Disclosure Agreement

Report on the first year secondements from and to UMINHO

Report on the first year secondements from and to UMINHO

Report on the publications upload task

Report on the publications upload task

Report on the selection process of the experienced researchers

Report on the selection process of the experienced researchers

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Publications

Peptide-modified dendrimer nanoparticles for targeted therapy of colorectal cancer

Author(s): Carvalho, M. R.; Carvalho, C. R.; Maia, F. Raquel; Caballero, David; Kundu, S. C.; Reis, R. L.; Oliveira, Joaquim M.
Published in: Advanced Therapeutics, 7, 2019, Page(s) 1900132, ISSN 2366-3987
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adtp.201900132

Long-term preservation effects on biological properties of acellular placental sponge patches.

Author(s): Fatemeh Asgari; Sadjad Khosravimelal; Morteza Koruji; Zahra Aliakbar Ahovan; Ali Shirani; Ali Hashemi; Hatef Ghasemi Hamidabadi; Narendra Pal Singh Chauhan; Lorenzo Moroni; Rui L. Reis; Subhas C. Kundu; Mazaher Gholipourmalekabadi
Published in: Materials Science & Engineering C-Materials for Biological Applications, 7, 2021, Page(s) 111814, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2020.111814

Mechanical Property of Hydrogels and the Presence of Adipose Stem Cells in Tumor Stroma Affect Spheroid Formation in the 3D Osteosarcoma Model.

Author(s): Kundu, B.; Bastos, A. R. F.; Brancato, V.; Cerqueira, M. T.; Oliveira, J. M.; Correlo, V. M.; Reis, R. L.; Kundu, S. C.
Published in: ACS Applied Materials & Interfaces, 4, 2019, Page(s) 14548–14559, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b22724

3D protein-based bilayer artificial skin for guided scarless healing of full-thickness burn wounds in vivo

Author(s): Gholipourmalekabadi, M.; Seifalian, A.; Urbanska, A.; Omrani, M. D.; Hardy, J.; Madjd, Z.; Hashemi, S. M.; Ghanbarian, H.; Brouki, M. P.; Mozafari, M.; Reis, R. L.; Kundu, S. C.; Samadikuchaksaraei, A.
Published in: Biomacromolecules, 4, 2018, Page(s) 2409–2422, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.7b01807

Fabricated porous silk fibroin particles for pH-responsive drug delivery and targeting of tumor cells

Author(s): Sun, Ning Lei, Rong Xu, Jianghui Kundu, Subhas C. Cai, Yurong Yao, Juming Ni, Qingqing
Published in: Journal of Materials Science, 2018, Page(s) 3319-3330, ISSN 1573-4803
Publisher: Springer Nature
DOI: 10.1007/s10853-018-3022-9

Micropatterned gellan gum-based hydrogels tailored with laminin-derived peptides for skeletal muscle tissue engineering

Author(s): Alheib, Omar da Silva, Lucilia P. Caballero, David Pires, Ricardo A. Kundu, Subhas C. Correlo, Vitor M. Reis, Rui L.
Published in: Biomaterials, 2021, Page(s) 121217, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.121217

Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin

Author(s): De Trizio, Antonella; Srisuk, Pathomthat; Costa, Rui R.; Fraga, Alexandra G.; Modena, Tiziana; Genta, Ida; Dorati, Rossella; Pedrosa, Jorge; Conti, Bice; Correlo, V. M.; Reis, R. L.
Published in: Reactive and Functional Polymers, 5, 2017, Page(s) 38-48, ISSN 1381-5148
Publisher: Elsevier BV
DOI: 10.1016/j.reactfunctpolym.2017.03.004

Anti-Cancer Drug Validation: the Contribution of Tissue Engineered Models

Author(s): Carvalho, Mariana R.; Lima, Daniela; Reis, R. L.; Oliveira, J. M.; Correlo, V. M.
Published in: Stem Cell Reviews and Reports, 8, 2017, Page(s) 347-363, ISSN 1558-6804
Publisher: Springer Nature
DOI: 10.1007/s12015-017-9720-x

A silk fibroin hydrogel with reversible sol–gel transition

Author(s): Yin, Zhuping; Wu, Feng; Xing, Tieling; Yadavalli, Vamsi K.; Kundu, Subhas C.; Lu, Shenzhou
Published in: RSC Advances, 2, 2017, Page(s) 24085-24096, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7ra02682j

Emerging tumor spheroids technologies for 3D in vitro cancer modeling.

Author(s): Rodrigues, Tânia; Kundu, Banani; Silva-Correia, Joana; Kundu, S.C.; Oliveira, Joaquim M.; Reis, Rui L.; Correlo, Vitor M.
Published in: Pharmacology & Therapeutics, 8, 2018, Page(s) 201-211, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2017.10.018

Organ-on-chip models of cancer metastasis for future personalized medicine: from chip to the patient

Author(s): D Caballero, S Kaushik, VM Correlo, JM Oliveira, RL Reis, SC Kundu
Published in: Biomaterials, 2017, Page(s) 98-115, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.10.005

Multilayer platform to model the bioactivity of hyaluronic acid in gastric cancer.

Author(s): Sara Amorim; Diana Soares da Costa; Stefan Mereiter; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Published in: Materials Science and Engineering: C, 9, 2021, Page(s) 111616, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2020.111616

Chinese oak tasar silkworm antheraea pernyi silk Proteins: Current strategies and future perspectives for biomedical applications

Author(s): Silva, S. S.; Kundu, B.; Lu, S.; Reis, R. L.; Kundu, Subhas C
Published in: Macromolecular Bioscience, 8, 2019, Page(s) 1800252, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.201800252

Biomimetic synthesis of sericin and silica hybrid colloidosomes for stimuli-responsive anti-cancer drug delivery systems

Author(s): Yang, Ying Cai, Yurong Sun, Ning Li, Ruijing Li, Wenhua Kundu, Subhas C. Kong, Xiangdong Yao, Juming
Published in: Colloids and Surfaces B: Biointerfaces, 2017, Page(s) 102-111, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2016.12.013

Influence of hyaluronan density on the behavior of breast cancer cells with different CD44 expression

Author(s): Ana M. Carvalho; Diana Pereira Soares Costa; Rui L. Reis; Iva Pashkuleva
Published in: Advanced Healthcare Materials, 8, 2022, Page(s) 2101309, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202101309

Hyaluronic Acid of Low Molecular Weight Triggers the Invasive “Hummingbird” Phenotype on Gastric Cancer Cells

Author(s): Sara Amorim; Diana Soares da Costa; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Published in: Advanced Biosystems, 12, 2020, Page(s) 2000122, ISSN 2366-7478
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/adbi.202000122

Targeting of EGFR, VEGFR2, and Akt by Engineered Dual Drug Encapsulated Mesoporous Silica–Gold Nanoclusters Sensitizes Tamoxifen-Resistant Breast Cancer

Author(s): Kumar, B. N. Prashanth Puvvada, Nagaprasad Rajput, Shashi Sarkar, Siddik Mahto, Madhusudan Kr Yallapu, Murali M. Pathak, Amita Emdad, Luni Das, Swadesh K. Reis, Rui L. Kundu, S. C. Fisher, Paul B. Mandal, Mahitosh
Published in: Molecular Pharmaceutics, 2018, Page(s) 2698-2713, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00218

Tumor-Associated Protrusion Fluctuations as a Signature of Cancer Invasiveness

Author(s): Caballero, David Brancato, Virginia Lima, Ana C. Abreu, Catarina M. Neves, Nuno M. Correlo, Vitor M. Oliveira, Joaquim M. Reis, Rui L. Kundu, Subhas C.
Published in: Advanced Biology, 2021, Page(s) 2101019, ISSN 2701-0198
Publisher: John Wiley & Sons
DOI: 10.1002/adbi.202101019

3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells.

Author(s): Sara Amorim; Diana Soares da Costa; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Published in: Biomaterials Science, 5, 2021, Page(s) 252-260, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0bm00843e

Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells.

Author(s): Amorim, Sara; da Costa, Diana Soares; Freitas, Daniela; Reis, Celso A.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo A.
Published in: Scientific Reports, 12, 2018, Page(s) 16058, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34445-0

Functionalized silk fibroin nanofiber as drug carriers: Advantages and challenges

Author(s): Farokhi, Mehdi Mottaghitalab, Fatemeh Reis, Rui L. Ramakrishna, Seeram Kundu, Subhas C.
Published in: Journal of Controlled Release, 2020, Page(s) 324-347, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2020.02.022

Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse

Author(s): Alexandra Brito; Patrícia M. R. Pereira; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva
Published in: Nanoscale, 11, 2020, Page(s) 19088-19092, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr05008c

In Vivo Characterizations of the Immune Properties of Sericin: An Ancient Material with Emerging Value in Biomedical Applications.

Author(s): Zhanying Jiao; Song Yu; Yang Jin; Cheng Zhang; Dong Peng; Zhenzhen Chen; Panpan Chang; Subhas C. Kundu; Guobin Wang; Zheng Wang; Lin Wang
Published in: Macromolecular Bioscience, 8, 2017, Page(s) 1700229, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.201700229

Tumor - stroma interactions alter the sensitivity of drug in breast cancer

Author(s): Brancato, V.; Kundu, Banani; Oliveira, Joaquim M.; Correlo, V. M.; Reis, R. L.; Kundu, Subhas C
Published in: Frontiers in Materials, 1, 2020, ISSN 2296-8016
Publisher: Frontiers
DOI: 10.3389/fmats.2020.00116

Extracellular matrix mimics using hyaluronan-based biomaterials

Author(s): Amorim, S.; Reis, C. A.; Reis, R. L.; Pires, R. A.
Published in: Trends in Biotechnology, 6, 2021, Page(s) 90-104, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2020.06.003

Expanding the Conformational Landscape of Minimalistic Tripeptides by Their O-Glycosylation.

Author(s): Alexandra Manuela Fernandes Brito; Alexandra Manuela Fernandes Brito; Dhwanit Dave; Ayala Lampel; Vânia I. B. Castro; Daniela Kroiss; Rui L. Reis; Tell Tuttle; Rein V. Ulijn; Ricardo A. Pires; Iva Pashkuleva
Published in: Journal of the American Chemical Society, 3, 2021, Page(s) 19703-19710, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c07592

Silk Fibroin/Polyvinyl Pyrrolidone Interpenetrating Polymer Network Hydrogels

Author(s): Kuang, Dajiang Wu, Feng Yin, Zhuping Zhu, Tian Xing, Tieling Kundu, Subhas C. Lu, Shenzhou
Published in: Polymers, 2018, Page(s) 153, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym10020153

Layer-by-layer films based on catechol-modified polysaccharides produced by dip- and spin-coating onto different substrates

Author(s): Almeida, Ana C.; Vale, A. Catarina; Pires, R. A.; Reis, R. L.; Alves, N. M.
Published in: Journal of Biomedical Materials Research Part B: Applied Biomaterials, 13, 2020, Page(s) 1412-1427, ISSN 1552-4973
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jbm.b.34489

Green solvents combined with bioactive compounds as delivery systems: present status and future trends

Author(s): Simone S. Silva; Joana Gomes; Rui L. Reis; Subhas C. Kundu
Published in: ACS Applied Bio Materials, 4, 2021, Page(s) 4000-4013, ISSN 2576-6422
Publisher: American Chemical Society
DOI: 10.1021/acsabm.1c00013

Template mediated protein self-assembly as a valuable tool in regenerative therapy.

Author(s): Kundu, B; Eltohamy, M; Yadavalli, VK; Reis, RL; Kim, HW
Published in: Biomedical Materials, 8, 2018, Page(s) 044101, ISSN 1748-605X
Publisher: IOP Publishing
DOI: 10.1088/1748-605x/aab2fe

Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles† †Electronic supplementary information (ESI) available: Synthetic procedures and characterization data. See DOI: 10.1039/c8sc04361b

Author(s): Brito, Alexandra; Abul-Haija, Yousef M.; da Costa, Diana Soares; Novoa-Carballal, Ramon; Reis, Rui L.; Ulijn, Rein V.; Pires, Ricardo A.; Pashkuleva, Iva
Published in: Chemical Science, 12, 2019, Page(s) 2385-2390, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc04361b

Protocols for decellularization of human amniotic membrane

Author(s): Sadjad Khosravimelal; Maryam Momeni; Mahdieh Gholipur; Subhas C. Kundu; Mazaher Gholipourmalekabadi
Published in: Methods in Cell Biology, 9, 2020, Page(s) 37-47, ISSN 0091-679X
Publisher: Academic Press
DOI: 10.1016/bs.mcb.2019.11.004

The Biophysics of Cell Migration: Biasing Cell Motion with Feynman Ratchets

Author(s): David Caballero; Subhas C. Kundu; Rui L. Reis
Published in: The Biophysicist, 2, 2020, Page(s) 7, ISSN 2578-6970
Publisher: Biophysical Society
DOI: 10.35459/tbp.2020.000150

Bioengineering of fibroblast-conditioned polycaprolactone/gelatin electrospun scaffold for skin tissue engineering

Author(s): Ayna Yazdanpanah, Zahra Madjd,Mohamad Pezeshki-Modaress, Zahra Khosrowpour, Paniz Farshi,Leila Eini, Jafar Kiani,Morteza Seifi, Subhas C. Kundu,Roya Ghods, Mazaher Gholipourmalekabadi
Published in: Artificial Organs, 2022, ISSN 0160-564X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/aor.14169

Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer

Author(s): Abreu, Catarina M. Costa-Silva, Bruno Reis, Rui L. Kundu, Subhas C. Caballero, David
Published in: Lab on a Chip, 2022, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2lc00006g

Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery

Author(s): Carvalho, Ana M.; Teixeira, Raquel; Novoa-Carballal, Ramón; Pires, Ricardo A.; Reis, Rui L.; Pashkuleva, Iva
Published in: Biomacromolecules, 10, 2018, Page(s) 2991–2999, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00561

Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

Author(s): Sara Amorim; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Published in: Journal of Materials Chemistry B, 5, 2020, Page(s) 3880-3885, ISSN 2050-750X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tb00407c

Combined Silk Fibroin Microneedles for Insulin Delivery.

Author(s): Mingmei Zhu; Yang Liu; Jiang Fujian; Jiaxin Cao; Subhas C. Kundu; Shenzhou Lu
Published in: ACS Biomaterials Science & Engineering, 1, 2020, Page(s) 3422-3429, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.0c00273

Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1

Author(s): Alexandra Brito; Patrícia M. R. Pereira; Diana Soares da Costa; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva
Published in: Chemical Science, 11, 2020, Page(s) 3737-3744, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc00954g

A peptide-modified solid lipid nanoparticle formulation of paclitaxel modulates immunity and outperforms dacarbazine in a murine melanoma model

Author(s): Banerjee, Indranil; De, Manjarika; Dey, Goutam; Bharti, Rashmi; Chattopadhyay, Sankha; Ali, Nahid; Chakrabarti, Partha; Reis, Rui L.; Kundu, Subhas C.; Mandal, Mahitosh
Published in: Biomaterials Science, 1, 2019, Page(s) 1161-1178, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8bm01403e

Modulation of Hypertrophic Scar Formation Using Amniotic Membrane/Electrospun Silk Fibroin Bilayer Membrane in a Rabbit Ear Model.

Author(s): Gholipourmalekabadi, Mazaher; Khosravimelal, Sadjad; Nokhbedehghan, Zeinab; Sameni, Marzieh; Jajarmi, Vahid; Urbanska, Aleksandra M.; Mirzaei, Hadi; Salimi, Maryam; Chauhan, Narendra Pal Singh; Mobaraki, Mohammadmahdi; Reis, Rui L; Samadikuchaksaraei, Ali; Kundu, Subhas C
Published in: ACS Biomaterials Science & Engineering, 1, 2019, Page(s) 1487-1496, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.8b01521

Protein Nanoparticles: Promising Platforms for Drug Delivery Applications.

Author(s): Jain, Annish; Singh, Sumit K.; Arya, Shailendra K.; Kundu, Subhas C.; Kapoor, Sonia
Published in: ACS Biomaterials Science & Engineering, 1, 2018, Page(s) 3939-3961, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.8b01098

Highly elastomeric photocurable silk hydrogels.

Author(s): Dajiang Kuang; Jiang Fujian; Feng Wu; Kulwinder Kaur; Sourabh Ghosh; Subhas C. Kundu; Shenzhou Lu
Published in: International Journal of Biological Macromolecules, 4, 2019, Page(s) 838-845, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2019.05.068

Horseradish Peroxidase-Crosslinked Calcium-Containing Silk Fibroin Hydrogels as Artificial Matrices for Bone Cancer Research

Author(s): Lara Pierantoni; Viviana P. Ribeiro; Lígia Costa; Sandra Pina; Alain da Silva Morais; Joana Silva-Correia; Subhas C. Kundu; Antonella Motta; Antonella Motta; Rui L. Reis; J. M. Oliveira
Published in: Macromolecular Bioscience, 10, 2021, Page(s) 2000425, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202000425

Nonmulberry silk proteins: multipurpose ingredient in bio-functional assembly

Author(s): Naskar, Deboki Sapru, Sunaina Ghosh, Ananta K. Reis, Rui L. Dey, Tuli Kundu, Subhas C.
Published in: Biomedical Materials, 2021, Page(s) 062002, ISSN 1748-6041
Publisher: Institute of Physics Publishing
DOI: 10.1088/1748-605x/ac20a0

Green pathway for processing non-mulberry antheraea pernyi silk fibroin/chitin-based sponges: biophysical and biochemical characterization

Author(s): Simone S. Silva; Simone S. Silva; Joana M. Gomes; Joana M. Gomes; Ana Catarina Vale; Ana Catarina Vale; Shenzhou Lu; Rui L. Reis; Rui L. Reis; Rui L. Reis; Subhas C. Kundu; Subhas C. Kundu
Published in: Frontiers in Materials, 1, 2020, ISSN 2296-8016
Publisher: Frontiers
DOI: 10.3389/fmats.2020.00135

Electric Phenomenon: A Disregarded Tool in Tissue Engineering and Regenerative Medicine

Author(s): da Silva, Lucília P.; Kundu, Subhas C.; Reis, Rui L.; Correlo, Vitor M.
Published in: Trends in Biotechnology, 1, 2020, Page(s) 24-49, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2019.07.002

Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—A review

Author(s): Joaquim Miguel Oliveira, António José Salgado, Nuno Sousa, João Filipe Mano, Rui Luís Reis
Published in: Progress in Polymer Science, 35/9, 2010, Page(s) 1163-1194, ISSN 0079-6700
Publisher: Elsevier BV
DOI: 10.1016/j.progpolymsci.2010.04.006

Controlling Cancer Cell Fate Using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile

Author(s): Ricardo A. Pires, Yousef M. Abul-Haija, Diana S. Costa, Ramon Novoa-Carballal, Rui L. Reis, Rein V. Ulijn, Iva Pashkuleva
Published in: Journal of the American Chemical Society, 00027863, 2015, Page(s) 576-579, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/ja5111893

Gellan gum-coated gold nanorods: an intracellular nanosystem for bone tissue engineering

Author(s): Sílvia Vieira, Stephanie Vial, F. Raquel Maia, Mariana Carvalho, Rui L. Reis, Pedro L. Granja, J. Miguel Oliveira
Published in: RSC Adv., 20462069, 2015, Page(s) 77996-78005, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/C5RA13556G

Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models

Author(s): Mariana R. Carvalho, Daniela Lima, Rui L. Reis, Vitor M. Correlo, Joaquim M. Oliveira
Published in: Trends in Biotechnology, 33/11, 2015, Page(s) 667-678, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2015.09.009

In vitro evaluation of the cytotoxicity and cellular uptake of CMCht/PAMAM dendrimer nanoparticles by glioblastoma cell models

Author(s): M. Pojo, S. R. Cerqueira, T. Mota, A. Xavier-Magalhães, S. Ribeiro-Samy, J. F. Mano, J. M. Oliveira, R. L. Reis, N. Sousa, B. M. Costa, A. J. Salgado
Published in: Journal of Nanoparticle Research, 13880764, 2013, ISSN 1388-0764
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11051-013-1621-6

Fabrication of Flexible, Fully Organic, Degradable Energy Storage Devices Using Silk Proteins.

Author(s): Pal, Ramendra K.; Kundu, Subhas C.; Yadavalli, Vamsi K.
Published in: ACS Applied Materials & Interfaces, 1, 2018, Page(s) 9620-9628, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.7b19309

Chitosan-intercalated montmorillonite/Poly (Vinyl alcohol) nanofibers as a platform to guide neuron-like differentiation of human dental pulp stem cells

Author(s): Hamidabadi, H. G.; Rezvani, Z.; Nazm Bojnordi, M.; Shirinzadeh, H.; Seifalian, A. M.; Joghataei, M. T.; Razaghpour, M.; Alibakhshi, A.; Yazdanpanah, A.; Salimi, M.; Mozafari, M.; Urbanska, A. M.; Reis, R. L.; Kundu, Subhas C; Gholipourmalekabadi, M.
Published in: ACS Applied Materials & Interfaces, 2, 2017, Page(s) 11392-11404, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.6b14283

Modulation of inflammation by anti-TNFα mAb-dendrimer nanoparticles loaded in tyramine-modified gellan gum hydrogels in a cartilage-on-a-chip model

Author(s): Oliveira, I.M., Carvalho M.R., Fernandes, D.C., Abreu, C.M., Maia, F. R., Pereira, H. Caballero, D., Kundu, S.C., Reis, R.L., and Oliveira, J.M
Published in: Journal of Materials Chemistry B, 2021, Page(s) 4211-4218, ISSN 2050-750X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tb00802a

Tropoelastin-Coated Tendon Biomimetic Scaffolds Promote Stem Cell Tenogenic Commitment and Deposition of Elastin-Rich Matrix

Author(s): Almeida, Helena; Domingues, Rui M. A.; Mithieux, Suzanne M.; Pires, Ricardo A.; Gonçalves, Ana I.; Gómez-Florit, Manuel; Reis, Rui L.; Weiss, Anthony S.; Gomes, Manuela E.
Published in: ACS Applied Materials & Interfaces, 14, 2019, Page(s) 19830-19840, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b04616

Orientational behaviors of silk fibroin hydrogels

Author(s): Chen, Daqi Yin, Zhuping Wu, Feng Fu, Hua Kundu, Subhas C. Lu, Shenzhou
Published in: Journal of Applied Polymer Science, 2017, Page(s) 45050, ISSN 0021-8995
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/app.45050

Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms

Author(s): Ana R. Araújo; Juan Correa; Vicente Dominguez-Arca; Rui L. Reis; Eduardo Fernandez-Megia; Ricardo A. Pires
Published in: ACS Applied Materials & Interfaces, 8, 2021, Page(s) 59673-59682, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c17823

Silk fibroin/amniotic membrane 3D bi-layered artificial skin

Author(s): Mazaher Gholipourmalekabadi; Ali Samadikuchaksaraei; Alexander M. Seifalian; Aleksandra M. Urbanska; Hossein Ghanbarian; John G. Hardy; Mir Davood Omrani; Masoud Mozafari; Rui L. Reis; Subhas C. Kundu
Published in: Biomedical Materials, 1, 2018, Page(s) 035003, ISSN 1748-605X
Publisher: IOP Publishing
DOI: 10.1088/1748-605x/aa999b

Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria

Author(s): Araújo, Ana R. Araújo, Ana C. Reis, Rui L. Pires, Ricardo A.
Published in: ACS Biomaterials Science & Engineering, 2021, Page(s) 1022-1030, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.0c01698

Silk fibroin for skin injury repair: Where do things stand?

Author(s): Mazaher Gholipourmalekabadi; Sunaina Sapru; Ali Samadikuchaksaraei; Rui L. Reis; David L. Kaplan; Subhas C. Kundu; Subhas C. Kundu
Published in: Advanced Drug Delivery Reviews, 1, 2020, Page(s) 28-53, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2019.09.003

adipoSIGHT in Therapeutic Response: Consequences in Osteosarcoma Treatment

Author(s): Kundu, Banani Brancato, Virginia Oliveira, Joaquim Correlo, Vitor M. Reis, Rui L. Kundu, Subhas C.
Published in: Bioengineering, 2021, Page(s) 83, ISSN 2306-5354
Publisher: MDPI
DOI: 10.3390/bioengineering8060083

Curcumin ameliorates the targeted delivery of methotrexate intercalated montmorillonite clay to cancer cells

Author(s): Kar, Subrata; Kundu, Banani; Reis, R.L.; Sarkar, Ruma; Nandy, Papiya; Basu, Ruma; Das, Sukhen
Published in: European Journal of Pharmaceutical Sciences, 1, 2019, Page(s) 91-102, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2019.05.006

Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue

Author(s): Fernandes, João S. Gentile, Piergiorgio Pires, Ricardo A. Reis, Rui L. Hatton, Paul V.
Published in: Acta Biomaterialia, 2017, Page(s) 2-11, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2017.06.046

Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development.

Author(s): Diana Soares da Costa; João Carlos Sousa; Sandro Da Mesquita; Nevena I. Petkova-Yankova; Fernanda Marques; Rui L. Reis; Nuno Sousa; Iva Pashkuleva
Published in: Molecules, 2, 2020, Page(s) 795, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25040795

3D biosensors in advanced medical diagnostics of high mortality diseases

Author(s): Rita Rebelo; Ana I. Barbosa; David Caballero; Il Keun Kwon; J. M. Oliveira; Subhas C. Kundu; Rui L. Reis; Vitor M. Correlo
Published in: Biosensors and Bioelectronics, 10, 2019, Page(s) 20-39, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2018.12.057

Breast tumor-on-chip models: From disease modeling to personalized drug screening

Author(s): Bano Subia; Ujjwal Ranjan Dahiya; Sarita Mishra; Jessica Ayache; Guilhem Velve Casquillas; David Caballero; Rui L. Reis; Subhas C. Kundu
Published in: Journal of Controlled Release, 7, 2021, Page(s) 103-120, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2020.12.057

Human microcirculation-on-chip models in cancer research: key integration of lymphatic and blood vasculatures

Author(s): Luque-González, Maria Angélica; Reis, R. L.; Kundu, Subhas C; Caballero, David
Published in: Advanced Biosystems, 2, 2020, Page(s) 2000045, ISSN 2366-7478
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adbi.202000045

Highly Absorbent Silk Fibroin Protein Xerogel

Author(s): Cheng, Kang Tao, Xiaosheng Qi, Zhenzhen Yin, Zuqiang Kundu, Subhas C. Lu, Shenzhou
Published in: ACS Biomaterials Science & Engineering, 2021, Page(s) 3594-3607, ISSN 2373-9878
Publisher: American ChemicalSociety
DOI: 10.1021/acsbiomaterials.1c00467

Substituted Borosilicate Glasses with Improved Osteogenic Capacity for Bone Tissue Engineering.

Author(s): João S. Fernandes; Piergiorgio Gentile; Aileen Crawford; Ricardo A. Pires; Paul V. Hatton; Rui L. Reis
Published in: Tissue Engineering Part A, 10, 2017, Page(s) 1331-1342, ISSN 2152-4947
Publisher: Mary Ann Liebert, Inc. publishers
DOI: 10.1089/ten.tea.2016.0386

Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications

Author(s): Brito, Alexandra Kassem, Salma Reis, Rui L. Ulijn, Rein V. Pires, Ricardo A. Pashkuleva, Iva
Published in: Chem, 2021, Page(s) 2943-2964, ISSN 2451-9294
Publisher: Elsevier
DOI: 10.1016/j.chempr.2021.04.011

Silk fibroin promotes mineralization of gellan gum hydrogels.

Author(s): Banani Kundu; Virginia Brancato; Joaquim M. Oliveira; Vitor M. Correlo; Rui L. Reis; Subhas C. Kundu
Published in: International Journal of Biological Macromolecules, 1, 2020, Page(s) 1328-1334, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2019.10.269

Silk Fibroin Microneedle Patches for the Treatment of Insomnia

Author(s): Qi, Zhenzhen Cao, Jiaxin Tao, Xiaosheng Wu, Xinyi Kundu, Subhas C. Lu, Shenzhou
Published in: Pharmaceutics, 2021, Page(s) 2198, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122198

Precision biomaterials in cancer theranostics and modelling

Author(s): Caballero, David Abreu, Catarina M. Lima, Ana C. Neves, Nuno N. Reis, Rui L. Kundu, Subhas C.
Published in: Biomaterials, 2022, Page(s) 121299, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.121299

Could 3D models of cancer enhance drug screening?

Author(s): Brancato, Virginia Oliveira, Joaquim Miguel Correlo, Vitor Manuel Reis, Rui Luis Kundu, Subhas C.
Published in: Biomaterials, 2020, Page(s) 119744, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119744

Micropatterned Silk-Fibroin/Eumelanin Composite Films for Bioelectronic Applications

Author(s): Yun Hee Youn; Yun Hee Youn; Sayantan Pradhan; Lucília P. da Silva; Il Keun Kwon; Subhas C. Kundu; Rui L. Reis; Rui L. Reis; Vamsi K. Yadavalli; Vitor M. Correlo
Published in: ACS Biomaterials Science & Engineering, 11, 2021, Page(s) 2466-2474, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.1c00216

Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence

Author(s): Costa, Rui R.; González-Pérez, Miguel; Herrero-Gutiérrez, Marcos; Pires, Ricardo A.; Alonso, Matilde; Rodriguez-Cabello, J. Carlos; Reis, Rui L.; Pashkuleva, Iva
Published in: Biomacromolecules, 6, 2018, Page(s) 3401–3411, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00723

Convection patterns gradients of non-living and living micro-entities in hydrogels

Author(s): Raphaël F. Canadas, Pedro Patrício, Ricardo A. Pires, Virginia Brancato, Luca Gasperini, João B. Costa, David Caballero, Helder Pereira, Ping Yong, Lucilia da Silva, Jie Chen, Subhas C. Kundu, Nuno A. M. Araújo, Rui L. Reis, Alexandra P. Marques, Joaquim M. Oliveira
Published in: Applied Materials Today, 2020, Page(s) 100859, ISSN 2352-9407
Publisher: Elsevier
DOI: 10.1016/j.apmt.2020.100859

Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior

Author(s): Mendes, Bárbara B.; Gómez-Florit, Manuel; Pires, Ricardo A.; Domingues, Rui M. A.; Reis, Rui L.; Gomes, Manuela E.
Published in: Nanoscale, 10, 2018, Page(s) 17388-17401, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nr04273j

Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

Author(s): Ana R. Araújo; Sérgio Camero; Pablo Taboada; Rui L. Reis; Ricardo A. Pires
Published in: Chemical Communications, 11, 2020, Page(s) 3187-3190, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc00192a

Chapter 4 - Biomatrices that mimic the cancer extracellular environment

Author(s): Amorim, Sara Reis, Rui L. Pires, Ricardo A.
Published in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Publisher: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00004-6

Chapter 1 - Trends in biomaterials for three-dimensional cancer modeling

Author(s): Caballero, David Reis, Rui L. Kundu, Subhas C.
Published in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Publisher: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00001-0

Polysaccharides in Cancer Therapy

Author(s): Kundu, Banani Reis, Rui L. Kundu, S. C.
Published in: Polysaccharides of Microbial Origin: Biomedical Applications, 2020, ISBN 978-3-030-35734-4
Publisher: Springer Nature
DOI: 10.1007/978-3-030-35734-4_42-1

Chitosan-Based Gels for Regenerative Medicine Applications

Author(s): Bharti, Deepti Pradhan, Bikash Verma, Sarika Kundu, Subhas C. Correia de Oliveira, Joaquim Miguel Antunes Banerjee, Indranil Pal, Kunal
Published in: Polysaccharides of Microbial Origin: Biomedical Applications, 2020, Page(s) 1-25, ISBN 978-3-030-35734-4
Publisher: Springer Nature
DOI: 10.1007/978-3-030-35734-4_65-1

Chapter 15 - Microfluidic systems in cancer research

Author(s): Caballero, David Luque-González, Maria Angélica Reis, Rui L. Kundu, Subhas C.
Published in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Publisher: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00015-0

Tissue engineering and regenerative medicine research - how can it contribute to fight future pandemics?

Author(s): David Caballero; Mariana Carvalho; Subhas C. Kundu; Joaquim M. Oliveira; Natália M. Alves; Rui L. Reis
Published in: A Universidade do Minho em tempos de pandemia: Tomo II: (Re)Ações, 1, 2020, Page(s) 391-416, ISBN 978-989-8974-28-0
Publisher: UMinho Editora
DOI: 10.21814/uminho.ed.24.18

Chapter 10 - 3D cancer spheroids and microtissues

Author(s): Brancato, Virginia Reis, Rui L. Kundu, Subhas C.
Published in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Publisher: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00010-1

Chapter 26 - Biodetection and sensing for cancer diagnostics

Author(s): Rebelo, Rita Barbosa, Ana I. Kundu, Subhas C. Reis, Rui L. Correlo, Vitor M.
Published in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Publisher: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00026-5

Engineering Patient-on-a-Chip Models for Personalized Cancer Medicine

Author(s): David Caballero; Rui L. Reis; Subhas C. Kundu
Published in: Advances in Experimental Medicine and Biology ISBN: 9783030365875, 5, 2020, Page(s) 43-64, ISBN 978-3-030-36588-2
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-36588-2_4

Chapter 9 - Metastasis in three-dimensional biomaterials

Author(s): Kundu, Banani Reis, Rui L. Kundu, Subhas C.
Published in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Publisher: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00009-5

Natural Polymers for Biophotonic Use

Author(s): Rebelo, Rita Caldas, Mariana Neves, Miguel A. D. Kundu, Subhas C. Reis, Rui L. Correlo, Vitor
Published in: Polysaccharides of Microbial Origin: Biomedical Applications, 2020, Page(s) 1-20, ISBN 978-3-030-35734-4
Publisher: Springer Nature
DOI: 10.1007/978-3-030-35734-4_50-1

Natural Polyphenols as Modulators of the Fibrillization of Islet Amyloid Polypeptide.

Author(s): Ana R. Araújo; Rui L. Reis; Ricardo A. Pires
Published in: Biomimicked Biomaterials, 10, 2020, Page(s) 159-176, ISBN 978-981-15-3262-7
Publisher: Springer
DOI: 10.1007/978-981-15-3262-7_11

Cell-derived Matrices - Part A

Author(s): David Caballero, Subhas C. Kundu, Rui Luís Reis
Published in: Cell-derived Matrices - Part A, 2020, ISBN 978-0-12-820172-5
Publisher: Elsevier

Cell-derived Matrices - Part B

Author(s): David Caballero, Subhas C. Kundu, Rui L. Reis
Published in: Cell-derived Matrices - Part B, 2020, ISBN 978-0-12-820174-9
Publisher: Elsevier

Biomaterials for 3D tumor modelling

Author(s): Subhas C. Kundu and Rui L. Reis
Published in: Biomaterials for 3D tumor modelling, 2020, ISBN 978-0-12-818128-7
Publisher: Elsevier
DOI: 10.1016/c2018-0-03075-3

Engineering silk biomaterials for cancer therapy

Author(s): Sapru, Sunaina; Naskar, Deboki; Kundu, Banani; Ghosh, Ananta K.; Mandal, Mahitosh; Reis, R. L.; Kundu, Subhas C
Published in: 2017 TERMIS - Americas Conference & Exhibition, 1, 2017, Page(s) S-1-S-159
Publisher: Mary Ann Liebert, Inc publishers
DOI: 10.1089/ten.tea.2017.29003.abstracts

Sponge-derived silica for tissue regeneration - Bioceramics of deep-sea sponge

Author(s): Dudik, Olesia; Leonor, I. B.; Xavier, Joana R.; Rapp, Hans Tore; Pires, R. A.; Silva, Tiago José Quinteiros Lopes Henriques; Reis, R. L.
Published in: Materials Today 21(5) 577-578, 13, 2018, Page(s) 577-578., ISSN 1369-7021
Publisher: Elsevier
DOI: 10.1016/j.mattod.2018.03.025

Preface

Author(s): Caballero, David Kundu, Subhas C. Reis, Rui Luís
Published in: Methods in Cell Biology, 2020, ISSN 0091-679X
Publisher: Academic Press
DOI: 10.1016/s0091-679x(20)30054-6