Forefront Research in 3D Disease Cancer Models as in vitro Screening Technologies

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Implementation of specific standard operating procedures (SOPs)
Report on internal meetings/evaluations on project progress and achievements, steering committee meetings and on coordination activities and risk management (M12)
Report on the selection process of the ERA Chair holder

Report on the selection process of the ERA Chair holder, including the text of the vacancy notice, places of publication, composition of the selection panel, CVs of applicants, minutes of selection panel meeting(s) as well as any other document allowing for a full assessment of the openness of the selection procedure.

Implementation of the Consortium Non Disclosure Agreement
Report on the first year secondements from and to UMINHO
Report on the publications upload task
Report on the selection process of the experienced researchers

Pubblicazioni

Peptide-modified dendrimer nanoparticles for targeted therapy of colorectal cancer

Autori: Carvalho, M. R.; Carvalho, C. R.; Maia, F. Raquel; Caballero, David; Kundu, S. C.; Reis, R. L.; Oliveira, Joaquim M.
Pubblicato in: Advanced Therapeutics, Numero 7, 2019, Pagina/e 1900132, ISSN 2366-3987
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adtp.201900132

Long-term preservation effects on biological properties of acellular placental sponge patches.

Autori: Fatemeh Asgari; Sadjad Khosravimelal; Morteza Koruji; Zahra Aliakbar Ahovan; Ali Shirani; Ali Hashemi; Hatef Ghasemi Hamidabadi; Narendra Pal Singh Chauhan; Lorenzo Moroni; Rui L. Reis; Subhas C. Kundu; Mazaher Gholipourmalekabadi
Pubblicato in: Materials Science & Engineering C-Materials for Biological Applications, Numero 7, 2021, Pagina/e 111814, ISSN 0928-4931
Editore: Elsevier BV
DOI: 10.1016/j.msec.2020.111814

Mechanical Property of Hydrogels and the Presence of Adipose Stem Cells in Tumor Stroma Affect Spheroid Formation in the 3D Osteosarcoma Model.

Autori: Kundu, B.; Bastos, A. R. F.; Brancato, V.; Cerqueira, M. T.; Oliveira, J. M.; Correlo, V. M.; Reis, R. L.; Kundu, S. C.
Pubblicato in: ACS Applied Materials & Interfaces, Numero 4, 2019, Pagina/e 14548–14559, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.8b22724

3D protein-based bilayer artificial skin for guided scarless healing of full-thickness burn wounds in vivo

Autori: Gholipourmalekabadi, M.; Seifalian, A.; Urbanska, A.; Omrani, M. D.; Hardy, J.; Madjd, Z.; Hashemi, S. M.; Ghanbarian, H.; Brouki, M. P.; Mozafari, M.; Reis, R. L.; Kundu, S. C.; Samadikuchaksaraei, A.
Pubblicato in: Biomacromolecules, Numero 4, 2018, Pagina/e 2409–2422, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.7b01807

Fabricated porous silk fibroin particles for pH-responsive drug delivery and targeting of tumor cells

Autori: Sun, Ning Lei, Rong Xu, Jianghui Kundu, Subhas C. Cai, Yurong Yao, Juming Ni, Qingqing
Pubblicato in: Journal of Materials Science, 2018, Pagina/e 3319-3330, ISSN 1573-4803
Editore: Springer Nature
DOI: 10.1007/s10853-018-3022-9

Micropatterned gellan gum-based hydrogels tailored with laminin-derived peptides for skeletal muscle tissue engineering

Autori: Alheib, Omar da Silva, Lucilia P. Caballero, David Pires, Ricardo A. Kundu, Subhas C. Correlo, Vitor M. Reis, Rui L.
Pubblicato in: Biomaterials, 2021, Pagina/e 121217, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.121217

Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin

Autori: De Trizio, Antonella; Srisuk, Pathomthat; Costa, Rui R.; Fraga, Alexandra G.; Modena, Tiziana; Genta, Ida; Dorati, Rossella; Pedrosa, Jorge; Conti, Bice; Correlo, V. M.; Reis, R. L.
Pubblicato in: Reactive and Functional Polymers, Numero 5, 2017, Pagina/e 38-48, ISSN 1381-5148
Editore: Elsevier BV
DOI: 10.1016/j.reactfunctpolym.2017.03.004

Anti-Cancer Drug Validation: the Contribution of Tissue Engineered Models

Autori: Carvalho, Mariana R.; Lima, Daniela; Reis, R. L.; Oliveira, J. M.; Correlo, V. M.
Pubblicato in: Stem Cell Reviews and Reports, Numero 8, 2017, Pagina/e 347-363, ISSN 1558-6804
Editore: Springer Nature
DOI: 10.1007/s12015-017-9720-x

A silk fibroin hydrogel with reversible sol–gel transition

Autori: Yin, Zhuping; Wu, Feng; Xing, Tieling; Yadavalli, Vamsi K.; Kundu, Subhas C.; Lu, Shenzhou
Pubblicato in: RSC Advances, Numero 2, 2017, Pagina/e 24085-24096, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/c7ra02682j

Emerging tumor spheroids technologies for 3D in vitro cancer modeling.

Autori: Rodrigues, Tânia; Kundu, Banani; Silva-Correia, Joana; Kundu, S.C.; Oliveira, Joaquim M.; Reis, Rui L.; Correlo, Vitor M.
Pubblicato in: Pharmacology & Therapeutics, Numero 8, 2018, Pagina/e 201-211, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2017.10.018

Organ-on-chip models of cancer metastasis for future personalized medicine: from chip to the patient

Autori: D Caballero, S Kaushik, VM Correlo, JM Oliveira, RL Reis, SC Kundu
Pubblicato in: Biomaterials, 2017, Pagina/e 98-115, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.10.005

Multilayer platform to model the bioactivity of hyaluronic acid in gastric cancer.

Autori: Sara Amorim; Diana Soares da Costa; Stefan Mereiter; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Pubblicato in: Materials Science and Engineering: C, Numero 9, 2021, Pagina/e 111616, ISSN 0928-4931
Editore: Elsevier BV
DOI: 10.1016/j.msec.2020.111616

Chinese oak tasar silkworm antheraea pernyi silk Proteins: Current strategies and future perspectives for biomedical applications

Autori: Silva, S. S.; Kundu, B.; Lu, S.; Reis, R. L.; Kundu, Subhas C
Pubblicato in: Macromolecular Bioscience, Numero 8, 2019, Pagina/e 1800252, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.201800252

Biomimetic synthesis of sericin and silica hybrid colloidosomes for stimuli-responsive anti-cancer drug delivery systems

Autori: Yang, Ying Cai, Yurong Sun, Ning Li, Ruijing Li, Wenhua Kundu, Subhas C. Kong, Xiangdong Yao, Juming
Pubblicato in: Colloids and Surfaces B: Biointerfaces, 2017, Pagina/e 102-111, ISSN 0927-7765
Editore: Elsevier BV
DOI: 10.1016/j.colsurfb.2016.12.013

Influence of hyaluronan density on the behavior of breast cancer cells with different CD44 expression

Autori: Ana M. Carvalho; Diana Pereira Soares Costa; Rui L. Reis; Iva Pashkuleva
Pubblicato in: Advanced Healthcare Materials, Numero 8, 2022, Pagina/e 2101309, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202101309

Hyaluronic Acid of Low Molecular Weight Triggers the Invasive “Hummingbird” Phenotype on Gastric Cancer Cells

Autori: Sara Amorim; Diana Soares da Costa; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Pubblicato in: Advanced Biosystems, Numero 12, 2020, Pagina/e 2000122, ISSN 2366-7478
Editore: John Wiley & Sons Ltd
DOI: 10.1002/adbi.202000122

Targeting of EGFR, VEGFR2, and Akt by Engineered Dual Drug Encapsulated Mesoporous Silica–Gold Nanoclusters Sensitizes Tamoxifen-Resistant Breast Cancer

Autori: Kumar, B. N. Prashanth Puvvada, Nagaprasad Rajput, Shashi Sarkar, Siddik Mahto, Madhusudan Kr Yallapu, Murali M. Pathak, Amita Emdad, Luni Das, Swadesh K. Reis, Rui L. Kundu, S. C. Fisher, Paul B. Mandal, Mahitosh
Pubblicato in: Molecular Pharmaceutics, 2018, Pagina/e 2698-2713, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00218

Tumor-Associated Protrusion Fluctuations as a Signature of Cancer Invasiveness

Autori: Caballero, David Brancato, Virginia Lima, Ana C. Abreu, Catarina M. Neves, Nuno M. Correlo, Vitor M. Oliveira, Joaquim M. Reis, Rui L. Kundu, Subhas C.
Pubblicato in: Advanced Biology, 2021, Pagina/e 2101019, ISSN 2701-0198
Editore: John Wiley & Sons
DOI: 10.1002/adbi.202101019

In vitro evaluation of the cytotoxicity and cellular uptake of CMCht/PAMAM dendrimer nanoparticles by glioblastoma cell models

Autori: M. Pojo, S. R. Cerqueira, T. Mota, A. Xavier-Magalhães, S. Ribeiro-Samy, J. F. Mano, J. M. Oliveira, R. L. Reis, N. Sousa, B. M. Costa, A. J. Salgado
Pubblicato in: Journal of Nanoparticle Research, Numero 15/5, 2013, ISSN 1388-0764
Editore: Kluwer Academic Publishers
DOI: 10.1007/s11051-013-1621-6

3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells.

Autori: Sara Amorim; Diana Soares da Costa; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Pubblicato in: Biomaterials Science, Numero 5, 2021, Pagina/e 252-260, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d0bm00843e

Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells.

Autori: Amorim, Sara; da Costa, Diana Soares; Freitas, Daniela; Reis, Celso A.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo A.
Pubblicato in: Scientific Reports, Numero 12, 2018, Pagina/e 16058, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-34445-0

Functionalized silk fibroin nanofiber as drug carriers: Advantages and challenges

Autori: Farokhi, Mehdi Mottaghitalab, Fatemeh Reis, Rui L. Ramakrishna, Seeram Kundu, Subhas C.
Pubblicato in: Journal of Controlled Release, 2020, Pagina/e 324-347, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2020.02.022

Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse

Autori: Alexandra Brito; Patrícia M. R. Pereira; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva
Pubblicato in: Nanoscale, Numero 11, 2020, Pagina/e 19088-19092, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/d0nr05008c

In Vivo Characterizations of the Immune Properties of Sericin: An Ancient Material with Emerging Value in Biomedical Applications.

Autori: Zhanying Jiao; Song Yu; Yang Jin; Cheng Zhang; Dong Peng; Zhenzhen Chen; Panpan Chang; Subhas C. Kundu; Guobin Wang; Zheng Wang; Lin Wang
Pubblicato in: Macromolecular Bioscience, Numero 8, 2017, Pagina/e 1700229, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.201700229

Tumor - stroma interactions alter the sensitivity of drug in breast cancer

Autori: Brancato, V.; Kundu, Banani; Oliveira, Joaquim M.; Correlo, V. M.; Reis, R. L.; Kundu, Subhas C
Pubblicato in: Frontiers in Materials, Numero 1, 2020, ISSN 2296-8016
Editore: Frontiers
DOI: 10.3389/fmats.2020.00116

Extracellular matrix mimics using hyaluronan-based biomaterials

Autori: Amorim, S.; Reis, C. A.; Reis, R. L.; Pires, R. A.
Pubblicato in: Trends in Biotechnology, Numero 6, 2021, Pagina/e 90-104, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2020.06.003

Expanding the Conformational Landscape of Minimalistic Tripeptides by Their O-Glycosylation.

Autori: Alexandra Manuela Fernandes Brito; Alexandra Manuela Fernandes Brito; Dhwanit Dave; Ayala Lampel; Vânia I. B. Castro; Daniela Kroiss; Rui L. Reis; Tell Tuttle; Rein V. Ulijn; Ricardo A. Pires; Iva Pashkuleva
Pubblicato in: Journal of the American Chemical Society, Numero 3, 2021, Pagina/e 19703-19710, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c07592

Silk Fibroin/Polyvinyl Pyrrolidone Interpenetrating Polymer Network Hydrogels

Autori: Kuang, Dajiang Wu, Feng Yin, Zhuping Zhu, Tian Xing, Tieling Kundu, Subhas C. Lu, Shenzhou
Pubblicato in: Polymers, 2018, Pagina/e 153, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym10020153

Layer-by-layer films based on catechol-modified polysaccharides produced by dip- and spin-coating onto different substrates

Autori: Almeida, Ana C.; Vale, A. Catarina; Pires, R. A.; Reis, R. L.; Alves, N. M.
Pubblicato in: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Numero 13, 2020, Pagina/e 1412-1427, ISSN 1552-4973
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jbm.b.34489

Green solvents combined with bioactive compounds as delivery systems: present status and future trends

Autori: Simone S. Silva; Joana Gomes; Rui L. Reis; Subhas C. Kundu
Pubblicato in: ACS Applied Bio Materials, Numero 4, 2021, Pagina/e 4000-4013, ISSN 2576-6422
Editore: American Chemical Society
DOI: 10.1021/acsabm.1c00013

Template mediated protein self-assembly as a valuable tool in regenerative therapy.

Autori: Kundu, B; Eltohamy, M; Yadavalli, VK; Reis, RL; Kim, HW
Pubblicato in: Biomedical Materials, Numero 8, 2018, Pagina/e 044101, ISSN 1748-605X
Editore: IOP Publishing
DOI: 10.1088/1748-605x/aab2fe

Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles† †Electronic supplementary information (ESI) available: Synthetic procedures and characterization data. See DOI: 10.1039/c8sc04361b

Autori: Brito, Alexandra; Abul-Haija, Yousef M.; da Costa, Diana Soares; Novoa-Carballal, Ramon; Reis, Rui L.; Ulijn, Rein V.; Pires, Ricardo A.; Pashkuleva, Iva
Pubblicato in: Chemical Science, Numero 12, 2019, Pagina/e 2385-2390, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c8sc04361b

Protocols for decellularization of human amniotic membrane

Autori: Sadjad Khosravimelal; Maryam Momeni; Mahdieh Gholipur; Subhas C. Kundu; Mazaher Gholipourmalekabadi
Pubblicato in: Methods in Cell Biology, Numero 9, 2020, Pagina/e 37-47, ISSN 0091-679X
Editore: Academic Press
DOI: 10.1016/bs.mcb.2019.11.004

The Biophysics of Cell Migration: Biasing Cell Motion with Feynman Ratchets

Autori: David Caballero; Subhas C. Kundu; Rui L. Reis
Pubblicato in: The Biophysicist, Numero 2, 2020, Pagina/e 7, ISSN 2578-6970
Editore: Biophysical Society
DOI: 10.35459/tbp.2020.000150

Bioengineering of fibroblast-conditioned polycaprolactone/gelatin electrospun scaffold for skin tissue engineering

Autori: Ayna Yazdanpanah, Zahra Madjd,Mohamad Pezeshki-Modaress, Zahra Khosrowpour, Paniz Farshi,Leila Eini, Jafar Kiani,Morteza Seifi, Subhas C. Kundu,Roya Ghods, Mazaher Gholipourmalekabadi
Pubblicato in: Artificial Organs, 2022, ISSN 0160-564X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/aor.14169

Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer

Autori: Abreu, Catarina M. Costa-Silva, Bruno Reis, Rui L. Kundu, Subhas C. Caballero, David
Pubblicato in: Lab on a Chip, 2022, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/d2lc00006g

Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery

Autori: Carvalho, Ana M.; Teixeira, Raquel; Novoa-Carballal, Ramón; Pires, Ricardo A.; Reis, Rui L.; Pashkuleva, Iva
Pubblicato in: Biomacromolecules, Numero 10, 2018, Pagina/e 2991–2999, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b00561

Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

Autori: Sara Amorim; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires
Pubblicato in: Journal of Materials Chemistry B, Numero 5, 2020, Pagina/e 3880-3885, ISSN 2050-750X
Editore: Royal Society of Chemistry
DOI: 10.1039/d0tb00407c

Combined Silk Fibroin Microneedles for Insulin Delivery.

Autori: Mingmei Zhu; Yang Liu; Jiang Fujian; Jiaxin Cao; Subhas C. Kundu; Shenzhou Lu
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 1, 2020, Pagina/e 3422-3429, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.0c00273

Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1

Autori: Alexandra Brito; Patrícia M. R. Pereira; Diana Soares da Costa; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva
Pubblicato in: Chemical Science, Numero 11, 2020, Pagina/e 3737-3744, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc00954g

A peptide-modified solid lipid nanoparticle formulation of paclitaxel modulates immunity and outperforms dacarbazine in a murine melanoma model

Autori: Banerjee, Indranil; De, Manjarika; Dey, Goutam; Bharti, Rashmi; Chattopadhyay, Sankha; Ali, Nahid; Chakrabarti, Partha; Reis, Rui L.; Kundu, Subhas C.; Mandal, Mahitosh
Pubblicato in: Biomaterials Science, Numero 1, 2019, Pagina/e 1161-1178, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/c8bm01403e

Modulation of Hypertrophic Scar Formation Using Amniotic Membrane/Electrospun Silk Fibroin Bilayer Membrane in a Rabbit Ear Model.

Autori: Gholipourmalekabadi, Mazaher; Khosravimelal, Sadjad; Nokhbedehghan, Zeinab; Sameni, Marzieh; Jajarmi, Vahid; Urbanska, Aleksandra M.; Mirzaei, Hadi; Salimi, Maryam; Chauhan, Narendra Pal Singh; Mobaraki, Mohammadmahdi; Reis, Rui L; Samadikuchaksaraei, Ali; Kundu, Subhas C
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 1, 2019, Pagina/e 1487-1496, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.8b01521

Protein Nanoparticles: Promising Platforms for Drug Delivery Applications.

Autori: Jain, Annish; Singh, Sumit K.; Arya, Shailendra K.; Kundu, Subhas C.; Kapoor, Sonia
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 1, 2018, Pagina/e 3939-3961, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.8b01098

Highly elastomeric photocurable silk hydrogels.

Autori: Dajiang Kuang; Jiang Fujian; Feng Wu; Kulwinder Kaur; Sourabh Ghosh; Subhas C. Kundu; Shenzhou Lu
Pubblicato in: International Journal of Biological Macromolecules, Numero 4, 2019, Pagina/e 838-845, ISSN 0141-8130
Editore: Elsevier BV
DOI: 10.1016/j.ijbiomac.2019.05.068

Horseradish Peroxidase-Crosslinked Calcium-Containing Silk Fibroin Hydrogels as Artificial Matrices for Bone Cancer Research

Autori: Lara Pierantoni; Viviana P. Ribeiro; Lígia Costa; Sandra Pina; Alain da Silva Morais; Joana Silva-Correia; Subhas C. Kundu; Antonella Motta; Antonella Motta; Rui L. Reis; J. M. Oliveira
Pubblicato in: Macromolecular Bioscience, Numero 10, 2021, Pagina/e 2000425, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202000425

Nonmulberry silk proteins: multipurpose ingredient in bio-functional assembly

Autori: Naskar, Deboki Sapru, Sunaina Ghosh, Ananta K. Reis, Rui L. Dey, Tuli Kundu, Subhas C.
Pubblicato in: Biomedical Materials, 2021, Pagina/e 062002, ISSN 1748-6041
Editore: Institute of Physics Publishing
DOI: 10.1088/1748-605x/ac20a0

Green pathway for processing non-mulberry antheraea pernyi silk fibroin/chitin-based sponges: biophysical and biochemical characterization

Autori: Simone S. Silva; Simone S. Silva; Joana M. Gomes; Joana M. Gomes; Ana Catarina Vale; Ana Catarina Vale; Shenzhou Lu; Rui L. Reis; Rui L. Reis; Rui L. Reis; Subhas C. Kundu; Subhas C. Kundu
Pubblicato in: Frontiers in Materials, Numero 1, 2020, ISSN 2296-8016
Editore: Frontiers
DOI: 10.3389/fmats.2020.00135

Electric Phenomenon: A Disregarded Tool in Tissue Engineering and Regenerative Medicine

Autori: da Silva, Lucília P.; Kundu, Subhas C.; Reis, Rui L.; Correlo, Vitor M.
Pubblicato in: Trends in Biotechnology, Numero 1, 2020, Pagina/e 24-49, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2019.07.002

Controlling Cancer Cell Fate Using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile

Autori: Ricardo A. Pires, Yousef M. Abul-Haija, Diana S. Costa, Ramon Novoa-Carballal, Rui L. Reis, Rein V. Ulijn, Iva Pashkuleva
Pubblicato in: Journal of the American Chemical Society, Numero 00027863, 2015, Pagina/e 576-579, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/ja5111893

Gellan gum-coated gold nanorods: an intracellular nanosystem for bone tissue engineering

Autori: Sílvia Vieira, Stephanie Vial, F. Raquel Maia, Mariana Carvalho, Rui L. Reis, Pedro L. Granja, J. Miguel Oliveira
Pubblicato in: RSC Adv., Numero 20462069, 2015, Pagina/e 77996-78005, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/C5RA13556G

In vitro evaluation of the cytotoxicity and cellular uptake of CMCht/PAMAM dendrimer nanoparticles by glioblastoma cell models

Autori: M. Pojo, S. R. Cerqueira, T. Mota, A. Xavier-Magalhães, S. Ribeiro-Samy, J. F. Mano, J. M. Oliveira, R. L. Reis, N. Sousa, B. M. Costa, A. J. Salgado
Pubblicato in: Journal of Nanoparticle Research, Numero 13880764, 2013, ISSN 1388-0764
Editore: Kluwer Academic Publishers
DOI: 10.1007/s11051-013-1621-6

Fabrication of Flexible, Fully Organic, Degradable Energy Storage Devices Using Silk Proteins.

Autori: Pal, Ramendra K.; Kundu, Subhas C.; Yadavalli, Vamsi K.
Pubblicato in: ACS Applied Materials & Interfaces, Numero 1, 2018, Pagina/e 9620-9628, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.7b19309

Chitosan-intercalated montmorillonite/Poly (Vinyl alcohol) nanofibers as a platform to guide neuron-like differentiation of human dental pulp stem cells

Autori: Hamidabadi, H. G.; Rezvani, Z.; Nazm Bojnordi, M.; Shirinzadeh, H.; Seifalian, A. M.; Joghataei, M. T.; Razaghpour, M.; Alibakhshi, A.; Yazdanpanah, A.; Salimi, M.; Mozafari, M.; Urbanska, A. M.; Reis, R. L.; Kundu, Subhas C; Gholipourmalekabadi, M.
Pubblicato in: ACS Applied Materials & Interfaces, Numero 2, 2017, Pagina/e 11392-11404, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.6b14283

Modulation of inflammation by anti-TNFα mAb-dendrimer nanoparticles loaded in tyramine-modified gellan gum hydrogels in a cartilage-on-a-chip model

Autori: Oliveira, I.M., Carvalho M.R., Fernandes, D.C., Abreu, C.M., Maia, F. R., Pereira, H. Caballero, D., Kundu, S.C., Reis, R.L., and Oliveira, J.M
Pubblicato in: Journal of Materials Chemistry B, 2021, Pagina/e 4211-4218, ISSN 2050-750X
Editore: Royal Society of Chemistry
DOI: 10.1039/d1tb00802a

Tropoelastin-Coated Tendon Biomimetic Scaffolds Promote Stem Cell Tenogenic Commitment and Deposition of Elastin-Rich Matrix

Autori: Almeida, Helena; Domingues, Rui M. A.; Mithieux, Suzanne M.; Pires, Ricardo A.; Gonçalves, Ana I.; Gómez-Florit, Manuel; Reis, Rui L.; Weiss, Anthony S.; Gomes, Manuela E.
Pubblicato in: ACS Applied Materials & Interfaces, Numero 14, 2019, Pagina/e 19830-19840, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.9b04616

Orientational behaviors of silk fibroin hydrogels

Autori: Chen, Daqi Yin, Zhuping Wu, Feng Fu, Hua Kundu, Subhas C. Lu, Shenzhou
Pubblicato in: Journal of Applied Polymer Science, 2017, Pagina/e 45050, ISSN 0021-8995
Editore: John Wiley & Sons Inc.
DOI: 10.1002/app.45050

Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms

Autori: Ana R. Araújo; Juan Correa; Vicente Dominguez-Arca; Rui L. Reis; Eduardo Fernandez-Megia; Ricardo A. Pires
Pubblicato in: ACS Applied Materials & Interfaces, Numero 8, 2021, Pagina/e 59673-59682, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.1c17823

Silk fibroin/amniotic membrane 3D bi-layered artificial skin

Autori: Mazaher Gholipourmalekabadi; Ali Samadikuchaksaraei; Alexander M. Seifalian; Aleksandra M. Urbanska; Hossein Ghanbarian; John G. Hardy; Mir Davood Omrani; Masoud Mozafari; Rui L. Reis; Subhas C. Kundu
Pubblicato in: Biomedical Materials, Numero 1, 2018, Pagina/e 035003, ISSN 1748-605X
Editore: IOP Publishing
DOI: 10.1088/1748-605x/aa999b

Vescalagin and castalagin present bactericidal activity toward methicillin-resistant bacteria

Autori: Araújo, Ana R. Araújo, Ana C. Reis, Rui L. Pires, Ricardo A.
Pubblicato in: ACS Biomaterials Science & Engineering, 2021, Pagina/e 1022-1030, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.0c01698

Silk fibroin for skin injury repair: Where do things stand?

Autori: Mazaher Gholipourmalekabadi; Sunaina Sapru; Ali Samadikuchaksaraei; Rui L. Reis; David L. Kaplan; Subhas C. Kundu; Subhas C. Kundu
Pubblicato in: Advanced Drug Delivery Reviews, Numero 1, 2020, Pagina/e 28-53, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2019.09.003

Gellan gum-coated gold nanorods: an intracellular nanosystem for bone tissue engineering

Autori: Sílvia Vieira, Stephanie Vial, F. Raquel Maia, Mariana Carvalho, Rui L. Reis, Pedro L. Granja, J. Miguel Oliveira
Pubblicato in: RSC Adv., Numero 5/95, 2015, Pagina/e 77996-78005, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/C5RA13556G

adipoSIGHT in Therapeutic Response: Consequences in Osteosarcoma Treatment

Autori: Kundu, Banani Brancato, Virginia Oliveira, Joaquim Correlo, Vitor M. Reis, Rui L. Kundu, Subhas C.
Pubblicato in: Bioengineering, 2021, Pagina/e 83, ISSN 2306-5354
Editore: MDPI
DOI: 10.3390/bioengineering8060083

Curcumin ameliorates the targeted delivery of methotrexate intercalated montmorillonite clay to cancer cells

Autori: Kar, Subrata; Kundu, Banani; Reis, R.L.; Sarkar, Ruma; Nandy, Papiya; Basu, Ruma; Das, Sukhen
Pubblicato in: European Journal of Pharmaceutical Sciences, Numero 1, 2019, Pagina/e 91-102, ISSN 0928-0987
Editore: Elsevier BV
DOI: 10.1016/j.ejps.2019.05.006

Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue

Autori: Fernandes, João S. Gentile, Piergiorgio Pires, Ricardo A. Reis, Rui L. Hatton, Paul V.
Pubblicato in: Acta Biomaterialia, 2017, Pagina/e 2-11, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2017.06.046

Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development.

Autori: Diana Soares da Costa; João Carlos Sousa; Sandro Da Mesquita; Nevena I. Petkova-Yankova; Fernanda Marques; Rui L. Reis; Nuno Sousa; Iva Pashkuleva
Pubblicato in: Molecules, Numero 2, 2020, Pagina/e 795, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25040795

3D biosensors in advanced medical diagnostics of high mortality diseases

Autori: Rita Rebelo; Ana I. Barbosa; David Caballero; Il Keun Kwon; J. M. Oliveira; Subhas C. Kundu; Rui L. Reis; Vitor M. Correlo
Pubblicato in: Biosensors and Bioelectronics, Numero 10, 2019, Pagina/e 20-39, ISSN 0956-5663
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2018.12.057

Breast tumor-on-chip models: From disease modeling to personalized drug screening

Autori: Bano Subia; Ujjwal Ranjan Dahiya; Sarita Mishra; Jessica Ayache; Guilhem Velve Casquillas; David Caballero; Rui L. Reis; Subhas C. Kundu
Pubblicato in: Journal of Controlled Release, Numero 7, 2021, Pagina/e 103-120, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2020.12.057

Human microcirculation-on-chip models in cancer research: key integration of lymphatic and blood vasculatures

Autori: Luque-González, Maria Angélica; Reis, R. L.; Kundu, Subhas C; Caballero, David
Pubblicato in: Advanced Biosystems, Numero 2, 2020, Pagina/e 2000045, ISSN 2366-7478
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adbi.202000045

Highly Absorbent Silk Fibroin Protein Xerogel

Autori: Cheng, Kang Tao, Xiaosheng Qi, Zhenzhen Yin, Zuqiang Kundu, Subhas C. Lu, Shenzhou
Pubblicato in: ACS Biomaterials Science & Engineering, 2021, Pagina/e 3594-3607, ISSN 2373-9878
Editore: American ChemicalSociety
DOI: 10.1021/acsbiomaterials.1c00467

Substituted Borosilicate Glasses with Improved Osteogenic Capacity for Bone Tissue Engineering.

Autori: João S. Fernandes; Piergiorgio Gentile; Aileen Crawford; Ricardo A. Pires; Paul V. Hatton; Rui L. Reis
Pubblicato in: Tissue Engineering Part A, Numero 10, 2017, Pagina/e 1331-1342, ISSN 2152-4947
Editore: Mary Ann Liebert, Inc. publishers
DOI: 10.1089/ten.tea.2016.0386

Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications

Autori: Brito, Alexandra Kassem, Salma Reis, Rui L. Ulijn, Rein V. Pires, Ricardo A. Pashkuleva, Iva
Pubblicato in: Chem, 2021, Pagina/e 2943-2964, ISSN 2451-9294
Editore: Elsevier
DOI: 10.1016/j.chempr.2021.04.011

Silk fibroin promotes mineralization of gellan gum hydrogels.

Autori: Banani Kundu; Virginia Brancato; Joaquim M. Oliveira; Vitor M. Correlo; Rui L. Reis; Subhas C. Kundu
Pubblicato in: International Journal of Biological Macromolecules, Numero 1, 2020, Pagina/e 1328-1334, ISSN 0141-8130
Editore: Elsevier BV
DOI: 10.1016/j.ijbiomac.2019.10.269

Controlling Cancer Cell Fate Using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile

Autori: Ricardo A. Pires, Yousef M. Abul-Haija, Diana S. Costa, Ramon Novoa-Carballal, Rui L. Reis, Rein V. Ulijn, Iva Pashkuleva
Pubblicato in: Journal of the American Chemical Society, Numero 137/2, 2015, Pagina/e 576-579, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/ja5111893

Silk Fibroin Microneedle Patches for the Treatment of Insomnia

Autori: Qi, Zhenzhen Cao, Jiaxin Tao, Xiaosheng Wu, Xinyi Kundu, Subhas C. Lu, Shenzhou
Pubblicato in: Pharmaceutics, 2021, Pagina/e 2198, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122198

Precision biomaterials in cancer theranostics and modelling

Autori: Caballero, David Abreu, Catarina M. Lima, Ana C. Neves, Nuno N. Reis, Rui L. Kundu, Subhas C.
Pubblicato in: Biomaterials, 2022, Pagina/e 121299, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.121299

Could 3D models of cancer enhance drug screening?

Autori: Brancato, Virginia Oliveira, Joaquim Miguel Correlo, Vitor Manuel Reis, Rui Luis Kundu, Subhas C.
Pubblicato in: Biomaterials, 2020, Pagina/e 119744, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119744

Micropatterned Silk-Fibroin/Eumelanin Composite Films for Bioelectronic Applications

Autori: Yun Hee Youn; Yun Hee Youn; Sayantan Pradhan; Lucília P. da Silva; Il Keun Kwon; Subhas C. Kundu; Rui L. Reis; Rui L. Reis; Vamsi K. Yadavalli; Vitor M. Correlo
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 11, 2021, Pagina/e 2466-2474, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.1c00216

Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence

Autori: Costa, Rui R.; González-Pérez, Miguel; Herrero-Gutiérrez, Marcos; Pires, Ricardo A.; Alonso, Matilde; Rodriguez-Cabello, J. Carlos; Reis, Rui L.; Pashkuleva, Iva
Pubblicato in: Biomacromolecules, Numero 6, 2018, Pagina/e 3401–3411, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b00723

Convection patterns gradients of non-living and living micro-entities in hydrogels

Autori: Raphaël F. Canadas, Pedro Patrício, Ricardo A. Pires, Virginia Brancato, Luca Gasperini, João B. Costa, David Caballero, Helder Pereira, Ping Yong, Lucilia da Silva, Jie Chen, Subhas C. Kundu, Nuno A. M. Araújo, Rui L. Reis, Alexandra P. Marques, Joaquim M. Oliveira
Pubblicato in: Applied Materials Today, 2020, Pagina/e 100859, ISSN 2352-9407
Editore: Elsevier
DOI: 10.1016/j.apmt.2020.100859

Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior

Autori: Mendes, Bárbara B.; Gómez-Florit, Manuel; Pires, Ricardo A.; Domingues, Rui M. A.; Reis, Rui L.; Gomes, Manuela E.
Pubblicato in: Nanoscale, Numero 10, 2018, Pagina/e 17388-17401, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c8nr04273j

Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

Autori: Ana R. Araújo; Sérgio Camero; Pablo Taboada; Rui L. Reis; Ricardo A. Pires
Pubblicato in: Chemical Communications, Numero 11, 2020, Pagina/e 3187-3190, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc00192a

Chapter 4 - Biomatrices that mimic the cancer extracellular environment

Autori: Amorim, Sara Reis, Rui L. Pires, Ricardo A.
Pubblicato in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Editore: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00004-6

Chapter 1 - Trends in biomaterials for three-dimensional cancer modeling

Autori: Caballero, David Reis, Rui L. Kundu, Subhas C.
Pubblicato in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Editore: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00001-0

Polysaccharides in Cancer Therapy

Autori: Kundu, Banani Reis, Rui L. Kundu, S. C.
Pubblicato in: Polysaccharides of Microbial Origin: Biomedical Applications, 2020, ISBN 978-3-030-35734-4
Editore: Springer Nature
DOI: 10.1007/978-3-030-35734-4_42-1

Chitosan-Based Gels for Regenerative Medicine Applications

Autori: Bharti, Deepti Pradhan, Bikash Verma, Sarika Kundu, Subhas C. Correia de Oliveira, Joaquim Miguel Antunes Banerjee, Indranil Pal, Kunal
Pubblicato in: Polysaccharides of Microbial Origin: Biomedical Applications, 2020, Pagina/e 1-25, ISBN 978-3-030-35734-4
Editore: Springer Nature
DOI: 10.1007/978-3-030-35734-4_65-1

Chapter 15 - Microfluidic systems in cancer research

Autori: Caballero, David Luque-González, Maria Angélica Reis, Rui L. Kundu, Subhas C.
Pubblicato in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Editore: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00015-0

Tissue engineering and regenerative medicine research - how can it contribute to fight future pandemics?

Autori: David Caballero; Mariana Carvalho; Subhas C. Kundu; Joaquim M. Oliveira; Natália M. Alves; Rui L. Reis
Pubblicato in: A Universidade do Minho em tempos de pandemia: Tomo II: (Re)Ações, Numero 1, 2020, Pagina/e 391-416, ISBN 978-989-8974-28-0
Editore: UMinho Editora
DOI: 10.21814/uminho.ed.24.18

Chapter 10 - 3D cancer spheroids and microtissues

Autori: Brancato, Virginia Reis, Rui L. Kundu, Subhas C.
Pubblicato in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Editore: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00010-1

Chapter 26 - Biodetection and sensing for cancer diagnostics

Autori: Rebelo, Rita Barbosa, Ana I. Kundu, Subhas C. Reis, Rui L. Correlo, Vitor M.
Pubblicato in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Editore: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00026-5

Engineering Patient-on-a-Chip Models for Personalized Cancer Medicine

Autori: David Caballero; Rui L. Reis; Subhas C. Kundu
Pubblicato in: Advances in Experimental Medicine and Biology ISBN: 9783030365875, Numero 5, 2020, Pagina/e 43-64, ISBN 978-3-030-36588-2
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-36588-2_4

Chapter 9 - Metastasis in three-dimensional biomaterials

Autori: Kundu, Banani Reis, Rui L. Kundu, Subhas C.
Pubblicato in: Biomaterials for 3D Tumor Modeling, 2020, ISBN 978-0-12-818128-7
Editore: Elsevier
DOI: 10.1016/b978-0-12-818128-7.00009-5

Natural Polymers for Biophotonic Use

Autori: Rebelo, Rita Caldas, Mariana Neves, Miguel A. D. Kundu, Subhas C. Reis, Rui L. Correlo, Vitor
Pubblicato in: Polysaccharides of Microbial Origin: Biomedical Applications, 2020, Pagina/e 1-20, ISBN 978-3-030-35734-4
Editore: Springer Nature
DOI: 10.1007/978-3-030-35734-4_50-1

Natural Polyphenols as Modulators of the Fibrillization of Islet Amyloid Polypeptide.

Autori: Ana R. Araújo; Rui L. Reis; Ricardo A. Pires
Pubblicato in: Biomimicked Biomaterials, Numero 10, 2020, Pagina/e 159-176, ISBN 978-981-15-3262-7
Editore: Springer
DOI: 10.1007/978-981-15-3262-7_11

Cell-derived Matrices - Part A

Autori: David Caballero, Subhas C. Kundu, Rui Luís Reis
Pubblicato in: Cell-derived Matrices - Part A, 2020, ISBN 978-0-12-820172-5
Editore: Elsevier

Cell-derived Matrices - Part B

Autori: David Caballero, Subhas C. Kundu, Rui L. Reis
Pubblicato in: Cell-derived Matrices - Part B, 2020, ISBN 978-0-12-820174-9
Editore: Elsevier

Biomaterials for 3D tumor modelling

Autori: Subhas C. Kundu and Rui L. Reis
Pubblicato in: Biomaterials for 3D tumor modelling, 2020, ISBN 978-0-12-818128-7
Editore: Elsevier
DOI: 10.1016/c2018-0-03075-3

Engineering silk biomaterials for cancer therapy

Autori: Sapru, Sunaina; Naskar, Deboki; Kundu, Banani; Ghosh, Ananta K.; Mandal, Mahitosh; Reis, R. L.; Kundu, Subhas C
Pubblicato in: 2017 TERMIS - Americas Conference & Exhibition, Numero 1, 2017, Pagina/e S-1-S-159
Editore: Mary Ann Liebert, Inc publishers
DOI: 10.1089/ten.tea.2017.29003.abstracts

Sponge-derived silica for tissue regeneration - Bioceramics of deep-sea sponge

Autori: Dudik, Olesia; Leonor, I. B.; Xavier, Joana R.; Rapp, Hans Tore; Pires, R. A.; Silva, Tiago José Quinteiros Lopes Henriques; Reis, R. L.
Pubblicato in: Materials Today 21(5) 577-578, Numero 13, 2018, Pagina/e 577-578., ISSN 1369-7021
Editore: Elsevier
DOI: 10.1016/j.mattod.2018.03.025

Preface

Autori: Caballero, David Kundu, Subhas C. Reis, Rui Luís
Pubblicato in: Methods in Cell Biology, 2020, ISSN 0091-679X
Editore: Academic Press
DOI: 10.1016/s0091-679x(20)30054-6

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