Self-Organising Capacity of Stem Cells during Implantation and Early Post-implantation Development: Implications for Human Development

Project Information

EPIROSE

Grant agreement ID: 669198

DOI

10.3030/669198

Project closed

EC signature date 21 December 2015

Start date 1 January 2016

End date 30 June 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 477 951,00

EU contribution

€ 2 477 951,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Author(s): Christodoulou N, Weberling A, Strathdee D, Anderson KI, Timpson P and Zernicka-Goetz M.
Published in: Nature Communications, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11482-5

Trophectoderm mechanics direct epiblast shape upon embryo implantation

Author(s): Weberling A and Zernicka-Goetz M.
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108655

Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis.

Author(s): Orietti LC, Rosa VS, Antonica F, Kyprianou C, Mansfield W, Marques-Souza H, Shahbazi MN and Zernicka-Goetz M.
Published in: Stem Cell Reports, 2020, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.09.004

Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration

Author(s): Francesco Antonica; Lorenzo Carlo Orietti; Richard L. Mort; Magdalena Zernicka-Goetz
Published in: Developmental Biology, Issue 3, 2019, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2019.03.016

BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo.

Author(s): Sozen B, Demir N and Zernicka-Goetz M
Published in: Developmental Biology, 2021, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2020.11.005

Basement membrane remodelling regulates mouse embryogenesis

Author(s): Kyprianou C, Christodoulou N, Hamilton RS, Nahaboo W, Boomgaard DS, Amadei G, Migeotte I and Zernicka-Goetz M.
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2264-2

Reconstructing aspects of human embryogenesis with pluripotent stem cells.

Author(s): Sozen B, Jorgensen V, Weatherbee BAT, Chen S, Zhu M, Zernicka-Goetz M.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25853-4

Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

Author(s): Singla S, Iwamoto-Stohl LK, Zhu M and Zernicka-Goetz M.
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16796-3

Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro

Author(s): Amadei G, Lau KYC, De Jonghe J, Gantner CW, Sozen B, Chan C, Zhu M, Kyprianou C, Hollfelder F and Zernicka-Goetz M.
Published in: Developmental Cell, 2021, ISSN 1878-1551
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.12.004

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Author(s): Molè MA, Weberling A, Fässler R, Campbell A, Fishel S and Zernicka-Goetz M.
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108834

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.

Author(s): Berna Sozen; Berna Sozen; Andy Cox; Andy Cox; Joachim De Jonghe; Min Bao; Florian Hollfelder; David M. Glover; David M. Glover; Magdalena Zernicka-Goetz; Magdalena Zernicka-Goetz
Published in: Developmental Cell, 2019, ISSN 1878-1551
Publisher: Cell Press
DOI: 10.17863/cam.47244

Deconstructing and reconstructing the mouse and human early embryo

Author(s): Marta N. Shahbazi, Magdalena Zernicka-Goetz
Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 878-887, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0144-x

In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells

Author(s): Sarah Ellys Harrison, Berna Sozen, Magdalena Zernicka-Goetz
Published in: Nature Protocols, Issue 13/7, 2018, Page(s) 1586-1602, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-018-0005-x

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

Author(s): Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M. Glover, Magdalena Zernicka-Goetz
Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 979-989, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0147-7

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

Author(s): Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaelle Recher, Meng Zhu, Agnieszka Jedrusik, Liani G. Devito, Laila Noli, Iain C. Macaulay, Christa Buecker, Yakoub Khalaf, Dusko Ilic, Thierry Voet, John C. Marioni, Magdalena Zernicka-Goetz
Published in: Nature, 2017, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature24675

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

Author(s): Sarah Ellys Harrison, Berna Sozen, Neophytos Christodoulou, Christos Kyprianou, Magdalena Zernicka-Goetz
Published in: Science, Issue 356/6334, 2017, Page(s) eaal1810, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aal1810

Synthetic embryos complete gastrulation to neurulation and organogenesis.

Author(s): Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz M, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M.
Published in: Nature, 2022, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05246-3

An in vitro stem cell model of human epiblast and yolk sac interaction

Author(s): Mackinlay K, Weatherbee BAT, Rosa VS, Handford CE, Hudson G, Coorens T, Pereira LV, Behjati S, Vallier L, Shahbazi M and Zernicka-Goetz M.
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63930

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Author(s): Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N and Zernicka-Goetz M.
Published in: Nature Cell Biology, 2018, ISSN 1476-4679
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0211-3

Intellectual Property Rights

Patent (1)

method and medium composition used to generate stem cell–derived embryos

Application/Publication number: UK 1615343.9
Date: 2017-05-01
Applicant(s): THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE