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Reconstitution of Chromosome Replication and Epigenetic Inheritance

Publications

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Auteurs: Allison W McClure; John FX Diffley
Publié dans: eLife, Issue 2, 2022, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.1101/2021.04.09.439171

The mechanism of eukaryotic CMG helicase activation

Auteurs: Max E. Douglas, Ferdos Abid Ali, Alessandro Costa, John F. X. Diffley
Publié dans: Nature, Issue 555/7695, 2018, Page(s) 265-268, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature25787

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

Auteurs: Gideon Coster, John F. X. Diffley
Publié dans: Science, Issue 357/6348, 2017, Page(s) 314-318, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aan0063

Cryo-EM structure of a licensed DNA replication origin

Auteurs: Ferdos Abid Ali, Max E. Douglas, Julia Locke, Valerie E. Pye, Andrea Nans, John F. X. Diffley, Alessandro Costa
Publié dans: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-02389-0

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

Auteurs: Joseph T.P. Yeeles, Agnieska Janska, Anne Early, John F.X. Diffley
Publié dans: Molecular Cell, Issue 65/1, 2017, Page(s) 105-116, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2016.11.017

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

Auteurs: Christoph F. Kurat, Joseph T.P. Yeeles, Harshil Patel, Anne Early, John F.X. Diffley
Publié dans: Molecular Cell, Issue 65/1, 2017, Page(s) 117-130, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2016.11.016

Cdt1 stabilizes an open MCM ring for helicase loading

Auteurs: Jordi Frigola, Jun He, Kerstin Kinkelin, Valerie E. Pye, Ludovic Renault, Max E. Douglas, Dirk Remus, Peter Cherepanov, Alessandro Costa, John F. X. Diffley
Publié dans: Nature Communications, Issue 8, 2017, Page(s) 15720, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms15720

CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

Auteurs: Jin Chuan Zhou, Agnieszka Janska, Panchali Goswami, Ludovic Renault, Ferdos Abid Ali, Abhay Kotecha, John F. X. Diffley, Alessandro Costa
Publié dans: Proceedings of the National Academy of Sciences, Issue 114/16, 2017, Page(s) 4141-4146, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1700530114

Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants

Auteurs: Belén Gómez-González, Harshil Patel, Anne Early, John F. X. Diffley
Publié dans: Genetics, Issue 211/2, 2019, Page(s) 503-513, ISSN 0016-6731
Éditeur: Genetics Society of America
DOI: 10.1534/genetics.118.301817

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Auteurs: Thomas C. R. Miller, Julia Locke, Julia F. Greiwe, John F. X. Diffley, Alessandro Costa
Publié dans: Nature, Issue 575/7784, 2019, Page(s) 704-710, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-019-1768-0

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Auteurs: Panchali Goswami, Ferdos Abid Ali, Max E. Douglas, Julia Locke, Andrew Purkiss, Agnieszka Janska, Patrik Eickhoff, Anne Early, Andrea Nans, Alan M. C. Cheung, John F. X. Diffley, Alessandro Costa
Publié dans: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-07417-1

A DNA replication fork-centric view of the budding yeast DNA damage response

Auteurs: Allison W. McClure; Berta Canal; John F.X. Diffley
Publié dans: eLife, Issue 2, 2022, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.25418/crick.21164149

Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro.

Auteurs: Max E. Douglas; John F.X. Diffley
Publié dans: Nucleic Acids Research, Issue 1, 2021, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkab416

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