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Effects of maternal gestational adiposity on fetal development and perinatal, postnatal and next generation health.

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Publications

Evidence of detrimental effects of prenatal alcohol exposure on offspring birthweight and neurodevelopment from a systematic review of quasi-experimental studies

Author(s): Loubaba Mamluk, Timothy Jones, Sharea Ijaz, Hannah B Edwards, Jelena Savović, Verity Leach, Theresa H M Moore, Stephanie von Hinke, Sarah J Lewis, Jenny L Donovan, Deborah A Lawlor, George Davey Smith, Abigail Fraser, Luisa Zuccolo
Published in: International Journal of Epidemiology, 49/6, 2020, Page(s) 1972-1995, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyz272

Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort

Author(s): Gunn-Helen Moen, Ben Brumpton, Cristen Willer, Bjørn Olav Åsvold, Kåre I. Birkeland, Geng Wang, Michael C. Neale, Rachel M. Freathy, George Davey Smith, Deborah A. Lawlor, Robert M. Kirkpatrick, Nicole M. Warrington, David M. Evans
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19257-z

Metabolomics datasets in the Born in Bradford cohort

Author(s): Kurt Taylor, Nancy McBride, Neil J Goulding, Kimberley Burrows, Dan Mason, Lucy Pembrey, Tiffany Yang, Rafaq Azad, John Wright, Deborah A Lawlor
Published in: Wellcome Open Research, 5, 2020, Page(s) 264, ISSN 2398-502X
Publisher: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.16341.1

Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations

Author(s): Fernando Pires Hartwig, Kate Tilling, George Davey Smith, Deborah A Lawlor, Maria Carolina Borges
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa266

Cardiometabolic health during early adulthood and risk of miscarriage: a prospective study

Author(s): Maria C. Magnus, Diana D. S. Ferreira, Maria Carolina Borges, Kate Tilling, Deborah A. Lawlor, Abigail Fraser
Published in: Wellcome Open Research, 5, 2020, Page(s) 205, ISSN 2398-502X
Publisher: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.16245.1

Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years

Author(s): Jane West, Gillian Santorelli, Paul Collings, Daniel Bingham, Peter Whincup, Naveed Sattar, Tom Norris, John Wright, Debbie A. Lawlor
Published in: Wellcome Open Research, 4, 2019, Page(s) 157, ISSN 2398-502X
Publisher: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.15433.1

Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria

Author(s): Tracy L McGregor, Karen A Hunt, Elaine Yee, Dan Mason, Paul Nioi, Simina Ticau, Marissa Pelosi, Perry R Loken, Sarah Finer, Deborah A Lawlor, Eric B Fauman, Qin Qin Huang, Christopher J Griffiths, Daniel G MacArthur, Richard C Trembath, Devin Oglesbee, John C Lieske, David V Erbe, John Wright, David A van Heel
Published in: eLife, 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.54363

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs

Author(s): Jing Chen, Jonas Bacelis, Pol Sole-Navais, Amit Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M. Freathy, George Davey Smith, Deborah A. Lawlor, Jeffrey C. Murray, Scott M. Williams, Bo Jacobsson, Louis J. Muglia, Ge Zhang
Published in: PLOS Medicine, 17/8, 2020, Page(s) e1003305, ISSN 1549-1676
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1003305

Population reference and healthy standard blood pressure range charts in pregnancy: findings from the Born in Bradford cohort study

Author(s): Gillian Santorelli, Debbie A. Lawlor, Jane West, Derek Tuffnell, Diane Farrar
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-55324-2

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

Author(s): Ralph McGinnis, Valgerdur Steinthorsdottir, Nicholas O Williams, Gudmar Thorleifsson, Scott Shooter, Sigrun Hjartardottir, Suzannah Bumpstead, Lilja Stefansdottir, Lucy Hildyard, Jon K Sigurdsson, John P Kemp, Gabriela B Silva, Liv Cecilie V Thomsen, Tiina Jääskeläinen, Eero Kajantie, Sally Chappell, Noor Kalsheker, Ashley Moffett, Susan Hiby, Wai Kwong Lee, Sandosh Padmanabhan, Nigel A B Simps
Published in: Nature Genetics, 49/8, 2017, Page(s) 1255-1260, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3895

Association of maternal exposures with adiposity at age 4/5 years in white British and Pakistani children: findings from the Born in Bradford study

Author(s): Jane West, Gillian Santorelli, Peter H. Whincup, Lesley Smith, Naveed A. Sattar, Noel Cameron, Diane Farrar, Paul Collings, John Wright, Debbie A. Lawlor
Published in: Diabetologia, 61/1, 2018, Page(s) 242-252, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-017-4457-2

Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study

Author(s): Matias C. Vieira, Sara L. White, Nashita Patel, Paul T. Seed, Annette L. Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M. Nelson, Debbie A. Lawlor, Lucilla Poston, Dharmintra Pasupathy
Published in: BMC Medicine, 15/1, 2017, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-017-0956-8

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Author(s): Robin N Beaumont, Nicole M Warrington, Alana Cavadino, Jessica Tyrrell, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C Richmond, Lavinia Paternoster, Jonathan P Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L Lunetta, Jodie N Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J Barton, Ana Espinosa, Julie A Marsh, Catherine Potter, Ge Zhang
Published in: Human Molecular Genetics, 27/4, 2018, Page(s) 742-756, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddx429

Maternal and fetal genetic contribution to gestational weight gain

Author(s): N M Warrington, R Richmond, B Fenstra, R Myhre, R Gaillard, L Paternoster, C A Wang, R N Beaumont, S Das, M Murcia, S J Barton, A Espinosa, E Thiering, M Atalay, N Pitkänen, I Ntalla, A E Jonsson, R Freathy, V Karhunen, C M T Tiesler, C Allard, A Crawford, S M Ring, M Melbye, P Magnus, F Rivadeneira, L Skotte, T Hansen, J Marsh, M Guxens, J W Holloway, H Grallert, V W V Jaddoe, W L Lowe Jr, T Rou
Published in: International Journal of Obesity, 42/4, 2017, Page(s) 775-784, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/ijo.2017.248

Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts

Author(s): Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor
Published in: PLOS Medicine, 14/8, 2017, Page(s) e1002376, ISSN 1549-1676
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1002376

Gestational diabetes and ultrasound-assessed fetal growth in South Asian and White European women: findings from a prospective pregnancy cohort

Author(s): Judith S. Brand, Jane West, Derek Tuffnell, Philippa K. Bird, John Wright, Kate Tilling, Debbie A. Lawlor
Published in: BMC Medicine, 16/1, 2018, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-018-1191-7

Causal inference—so much more than statistics

Author(s): Neil Pearce, Debbie A Lawlor
Published in: International Journal of Epidemiology, 45/6, 2016, Page(s) 1895-1903, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyw328

Growing up in Bradford: protocol for the age 7–11 follow up of the Born in Bradford birth cohort

Author(s): Philippa K Bird, Rosemary R. C. McEachan, Mark Mon-Williams, Neil Small, Jane West, Peter Whincup, John Wright, Elizabeth Andrews, Sally E Barber, Liam J B Hill, Laura Lennon, Dan Mason, Katy A Shire, Dagmar Waiblinger, Amanda H. Waterman, Deborah A. Lawlor, Kate E. Pickett
Published in: BMC Public Health, 19/1, 2019, ISSN 1471-2458
Publisher: BioMed Central
DOI: 10.1186/s12889-019-7222-2

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Author(s): Christel M. Middeldorp, Janine F. Felix, Anubha Mahajan, Mark I. McCarthy
Published in: European Journal of Epidemiology, 34/3, 2019, Page(s) 279-300, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-019-00502-9

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence

Author(s): Qin Wang, Peter Würtz, Kirsi Auro, Laure Morin-Papunen, Antti J Kangas, Pasi Soininen, Mika Tiainen, Tuulia Tynkkynen, Anni Joensuu, Aki S Havulinna, Kristiina Aalto, Marko Salmi, Stefan Blankenberg, Tanja Zeller, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Veikko Salomaa, Sirpa Jalkanen, Marjo-Riitta Järvelin, Markus Perola, Olli T Raitakari, Debbie A Lawlor, Johannes Kettunen, Mika Ala-Ko
Published in: International Journal of Epidemiology, 45/5, 2016, Page(s) 1445-1457, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyw147

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight

Author(s): Jessica Tyrrell, Rebecca C. Richmond, Tom M. Palmer, Bjarke Feenstra, Janani Rangarajan, Sarah Metrustry, Alana Cavadino, Lavinia Paternoster, Loren L. Armstrong, N. Maneka G. De Silva, Andrew R. Wood, Momoko Horikoshi, Frank Geller, Ronny Myhre, Jonathan P. Bradfield, Eskil Kreiner-Møller, Ville Huikari, Jodie N. Painter, Jouke-Jan Hottenga, Catherine Allard, Diane J. Berry, Luigi Bouchard, Shik
Published in: JAMA, 315/11, 2016, Page(s) 1129, ISSN 0098-7484
Publisher: American Medical Association
DOI: 10.1001/jama.2016.1975

Metabolic signatures of birthweight in 18 288 adolescents and adults

Author(s): Peter Würtz, Qin Wang, Marjo Niironen, Tuulia Tynkkynen, Mika Tiainen, Fotios Drenos, Antti J Kangas, Pasi Soininen, Michael R Skilton, Kauko Heikkilä, Anneli Pouta, Mika Kähönen, Terho Lehtimäki, Richard J Rose, Eero Kajantie, Markus Perola, Jaakko Kaprio, Johan G Eriksson, Olli T Raitakari, Debbie A Lawlor, George Davey Smith, Marjo-Riitta Järvelin, Mika Ala-Korpela, Kirsi Auro
Published in: International Journal of Epidemiology, 45/5, 2016, Page(s) 1539-1550, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyw255

Triangulation in aetiological epidemiology

Author(s): Debbie A. Lawlor, Kate Tilling, George Davey Smith
Published in: International Journal of Epidemiology, 2017, Page(s) dyw314, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyw314

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Author(s): Wang Q, Würtz P, Auro K, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin M-R, Raitakari OT, Kettunen J, Lawlor DA*, Ala-Korpela M* (*equal senior authors)
Published in: BMC Medicine, 2016, 2016, Page(s) 205, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-016-0733-0

Using genetic variation to explore the causal effect of maternal pregnancy adiposity on future offspring adiposity

Author(s): Richmond RC, Timpson NJ, Felix JF, Palmer T, Gaillard R, McMahon G, Davey Smith G, Jaddoe VW, Lawlor DA
Published in: PloS Medicine, 2017, 2017, Page(s) e1002221, ISSN 1549-1277
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1002221

Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis

Author(s): Diane Farrar, Mark Simmonds, Maria Bryant, Trevor A Sheldon, Derek Tuffnell, Su Golder, Fidelma Dunne, Debbie A Lawlor
Published in: BMJ, 2016, Page(s) i4694, ISSN 1756-1833
Publisher: BMA
DOI: 10.1136/bmj.i4694

Infant adiposity following a randomised controlled trial of a behavioural intervention in obese pregnancy

Author(s): N Patel, K M Godfrey, D Pasupathy, J Levin, A C Flynn, L Hayes, A L Briley, R Bell, D A Lawlor, E Oteng-Ntim, S M Nelson, S C Robson, N Sattar, C Singh, J Wardle, S L White, P T Seed, L Poston
Published in: International Journal of Obesity, 2017, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/ijo.2017.44

Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and methods for assessing them

Author(s): Deborah Lawlor, Rebecca Richmond, Nicole Warrington, George McMahon, George Davey Smith, Jack Bowden, David M Evans
Published in: Wellcome Open Research, 2, 2013, Page(s) 11, ISSN 2398-502X
Publisher: Wellcome Trust
DOI: 10.12688/wellcomeopenres.10567.1

Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author(s): Susana Santos, Iris Eekhout, Ellis Voerman, Romy Gaillard, Henrique Barros, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Luigi Gagliardi, Vagelis Georgiu, Keith M. Godfrey, Davide Gori, Veit Grote, Wojciech Hanke, Irva Hertz-Picciotto, Barb
Published in: BMC Medicine, 16/1, 2018, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-018-1189-1

Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study

Author(s): Maria C Magnus, Kozeta Miliku, Anna Bauer, Stephanie M Engel, Janine F Felix, Vincent W V Jaddoe, Debbie A Lawlor, Stephanie J London, Per Magnus, Ralph McGinnis, Wenche Nystad, Christian M Page, Fernando Rivadeneira, Lars C Stene, German Tapia, Nicholas Williams, Carolina Bonilla, Abigail Fraser
Published in: BMJ, Maria C Magnus, Janine F Felix, Vincent W V Jaddoe, Per Magnus, 2018, Page(s) k2167, ISSN 0959-8138
Publisher: British Medical Association
DOI: 10.1136/bmj.k2167

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Author(s): Xueping Liu, Dorte Helenius, Line Skotte, Robin N. Beaumont, Matthias Wielscher, Frank Geller, Julius Juodakis, Anubha Mahajan, Jonathan P. Bradfield, Frederick T. J. Lin, Suzanne Vogelezang, Mariona Bustamante, Tarunveer S. Ahluwalia, Niina Pitkänen, Carol A. Wang, Jonas Bacelis, Maria C. Borges, Ge Zhang, Bruce A. Bedell, Robert M. Rossi, Kristin Skogstrand, Shouneng Peng, Wesley K. Thompson, V
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11881-8

Epigenetics and gestational diabetes: a review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction

Author(s): Hannah R. Elliott, Gemma C. Sharp, Caroline L. Relton, Deborah A. Lawlor
Published in: Diabetologia, 62/12, 2019, Page(s) 2171-2178, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05011-8

Blood pressure change across pregnancy in white British and Pakistani women: analysis of data from the Born in Bradford cohort

Author(s): Diane Farrar, Gillian Santorelli, Debbie A. Lawlor, Derek Tuffnell, Trevor A. Sheldon, Jane West, Corrie Macdonald-Wallis
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-49722-9

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight

Author(s): Liang-Dar Hwang, Deborah A Lawlor, Rachel M Freathy, David M Evans, Nicole M Warrington
Published in: International Journal of Epidemiology, 48/5, 2019, Page(s) 1457-1467, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyz160

A Cross‐Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children

Author(s): Markus Juonala, Susan Ellul, Debbie A. Lawlor, Diana L. Santos Ferreira, John B. Carlin, Michael Cheung, Terence Dwyer, Melissa Wake, Richard Saffery, David P. Burgner
Published in: Journal of the American Heart Association, 8/14, 2019, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.118.011852

Paternal impact on the life course development of obesity and type 2 diabetes in the offspring

Author(s): Gemma C. Sharp, Debbie A. Lawlor
Published in: Diabetologia, 62/10, 2019, Page(s) 1802-1810, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-4919-9

Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis

Author(s): William D. Thompson, Jessica Tyrrell, Maria-Carolina Borges, Robin N. Beaumont, Bridget A. Knight, Andrew R. Wood, Susan M. Ring, Andrew T. Hattersley, Rachel M. Freathy, Debbie A. Lawlor
Published in: PLOS Medicine, 16/6, 2019, Page(s) e1002828, ISSN 1549-1676
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1002828

Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies

Author(s): Judith S. Brand, Romy Gaillard, Jane West, Rosemary R. C. McEachan, John Wright, Ellis Voerman, Janine F. Felix, Kate Tilling, Deborah A. Lawlor
Published in: PLOS Medicine, 16/11, 2019, Page(s) e1002972, ISSN 1549-1676
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1002972

Causal Inference in Environmental Epidemiology

Author(s): Neil Pearce, Jan P. Vandenbroucke, Deborah A. Lawlor
Published in: Epidemiology, 30/3, 2019, Page(s) 311-316, ISSN 1044-3983
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ede.0000000000000987

4-Hydroxyglutamate is a novel predictor of pre-eclampsia

Author(s): Ulla Sovio, Nancy McBride, Angela M Wood, Katya L Masconi, Emma Cook, Francesca Gaccioli, D Stephen Charnock-Jones, Debbie A Lawlor, Gordon C S Smith
Published in: International Journal of Epidemiology, 49/1, 2019, Page(s) 301-311, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyz098

Exploring the role of genetic confounding in the association between maternal and offspring body mass index: evidence from three birth cohorts

Author(s): Tom A Bond, Ville Karhunen, Matthias Wielscher, Juha Auvinen, Minna Männikkö, Sirkka Keinänen-Kiukaanniemi, Marc J Gunter, Janine F Felix, Inga Prokopenko, Jian Yang, Peter M Visscher, David M Evans, Sylvain Sebert, Alex Lewin, Paul F O’Reilly, Debbie A Lawlor, Marjo-Riitta Jarvelin
Published in: International Journal of Epidemiology, 49/1, 2019, Page(s) 233-243, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyz095

Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns

Author(s): Nabila Kazmi, Gemma C. Sharp, Sarah E. Reese, Florianne O. Vehmeijer, Jari Lahti, Christian M. Page, Weiming Zhang, Sheryl L. Rifas-Shiman, Faisal I. Rezwan, Andrew J. Simpkin, Kimberley Burrows, Tom G. Richardson, Diana L. Santos Ferreira, Abigail Fraser, Quaker E. Harmon, Shanshan Zhao, Vincent W.V. Jaddoe, Darina Czamara, Elisabeth B. Binder, Maria C. Magnus, Siri E. Håberg, Wenche Nystad, Ell
Published in: Hypertension, 74/2, 2019, Page(s) 375-383, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.119.12634

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Author(s): Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi, Felix R. Day, Øyvind Helgeland, Charles Laurin, Jonas Bacelis, Shouneng Peng, Ke Hao, Bjarke Feenstra, Andrew R. Wood, Anubha Mahajan, Jessica Tyrrell, Neil R. Robertson, N. William Rayner, Zhen Qiao, Gunn-Helen Moen, Marc Vaudel, Carmen J. Marsit, Jia Chen, Michael Nodzenski, Theresia M. Schnurr, Mohammad H. Zafarmand, Jonathan P. Bradfi
Published in: Nature Genetics, 51/5, 2019, Page(s) 804-814, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0403-1

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author(s): Leanne K. Küpers, Claire Monnereau, Gemma C. Sharp, Paul Yousefi, Lucas A. Salas, Akram Ghantous, Christian M. Page, Sarah E. Reese, Allen J. Wilcox, Darina Czamara, Anne P. Starling, Alexei Novoloaca, Samantha Lent, Ritu Roy, Cathrine Hoyo, Carrie V. Breton, Catherine Allard, Allan C. Just, Kelly M. Bakulski, John W. Holloway, Todd M. Everson, Cheng-Jian Xu, Rae-Chi Huang, Diana A. van der Plaat
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09671-3

Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

Author(s): Ellis Voerman, Susana Santos, Hazel Inskip, Pilar Amiano, Henrique Barros, Marie-Aline Charles, Leda Chatzi, George P. Chrousos, Eva Corpeleijn, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Davide Gori, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie-France Hivert, Daniel Hryhorczuk, Carmen Iñiguez, Anne M. Karvone
Published in: JAMA, 321/17, 2019, Page(s) 1702, ISSN 0098-7484
Publisher: American Medical Association
DOI: 10.1001/jama.2019.3820

The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial

Author(s): Harriet L. Mills, Nashita Patel, Sara L. White, Dharmintra Pasupathy, Annette L. Briley, Diana L. Santos Ferreira, Paul T. Seed, Scott M. Nelson, Naveed Sattar, Kate Tilling, Lucilla Poston, Deborah A. Lawlor
Published in: BMC Medicine, 17/1, 2019, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-018-1248-7

Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization

Author(s): David M Evans, Gunn-Helen Moen, Liang-Dar Hwang, Debbie A Lawlor, Nicole M Warrington
Published in: International Journal of Epidemiology, 48/3, 2019, Page(s) 861-875, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyz019

It's the mother!: How assumptions about the causal primacy of maternal effects influence research on the developmental origins of health and disease

Author(s): Gemma C. Sharp, Deborah A. Lawlor, Sarah S. Richardson
Published in: Social Science & Medicine, 213, 2018, Page(s) 20-27, ISSN 0277-9536
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.socscimed.2018.07.035

Prevalence of Prenatal Depression Symptoms Among 2 Generations of Pregnant Mothers

Author(s): Rebecca M. Pearson, Rebecca E. Carnegie, Callum Cree, Claire Rollings, Louise Rena-Jones, Jonathan Evans, Alan Stein, Kate Tilling, Melanie Lewcock, Debbie A. Lawlor
Published in: JAMA Network Open, 1/3, 2018, Page(s) e180725, ISSN 2574-3805
Publisher: JAMA
DOI: 10.1001/jamanetworkopen.2018.0725

Associations of social and economic and pregnancy exposures with blood pressure in UK White British and Pakistani children age 4/5

Author(s): Jane West, Debbie A. Lawlor, Gillian Santorelli, Paul Collings, Peter H. Whincup, Naveed A. Sattar, Diane Farrar, John Wright
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-27316-1

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Author(s): Simon Kebede Merid, Alexei Novoloaca, Gemma C. Sharp, Leanne K. Küpers, Alvin T. Kho, Ritu Roy, Lu Gao, Isabella Annesi-Maesano, Pooja Jain, Michelle Plusquin, Manolis Kogevinas, Catherine Allard, Florianne O. Vehmeijer, Nabila Kazmi, Lucas A. Salas, Faisal I. Rezwan, Hongmei Zhang, Sylvain Sebert, Darina Czamara, Sheryl L. Rifas-Shiman, Phillip E. Melton, Debbie A. Lawlor, Göran Pershagen, Carr
Published in: Genome Medicine, 12/1, 2020, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-020-0716-9

GLU, a software package for analysing continuously measured glucose levels in epidemiology

Author(s): Louise A C Millard, Nashita Patel, Kate Tilling, Melanie Lewcock, Peter A Flach, Debbie A Lawlor
Published in: International Journal of Epidemiology, 2020, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa004

A maternal serum metabolite ratio predicts fetal growth restriction at term

Author(s): Ulla Sovio, Neil Goulding, Nancy McBride, Emma Cook, Francesca Gaccioli, D. Stephen Charnock-Jones, Debbie A. Lawlor, Gordon C. S. Smith
Published in: Nature Medicine, 26/3, 2020, Page(s) 348-353, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-020-0804-9

Metabolic phenotyping by treatment modality in obese women with gestational diabetes suggests diverse pathophysiology: An exploratory study

Author(s): Sara L. White, Shahina Begum, Matias C. Vieira, Paul Seed, Deborah L. Lawlor, Naveed Sattar, Scott M. Nelson, Paul Welsh, Dharmintra Pasupathy, Lucilla Poston
Published in: PLOS ONE, 15/4, 2020, Page(s) e0230658, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0230658

UK stillbirth trends in over 11 million births provide no evidence to support effectiveness of Growth Assessment Protocol program

Author(s): S. Iliodromiti, G. C. S. Smith, D. A. Lawlor, J. P. Pell, S. M. Nelson
Published in: Ultrasound in Obstetrics & Gynecology, 55/5, 2020, Page(s) 599-604, ISSN 0960-7692
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/uog.21999

Association of the serum metabolomic profile by nuclear magnetic resonance spectroscopy with sperm parameters: a cross-sectional study of 325 men

Author(s): Karema Al Rashid, Amy Taylor, Mary Ann Lumsden, Neil Goulding, Deborah A. Lawlor, Scott M. Nelson
Published in: F&S Science, 1/2, 2020, Page(s) 142-160, ISSN 2666-335X
Publisher: Elsevier
DOI: 10.1016/j.xfss.2020.10.003

Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile

Author(s): William D. Thompson, Robin N. Beaumont, Alan Kuang, Nicole M. Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R. Wood, Denise M. Scholtens, Bridget A. Knight, David M. Evans, William L. Lowe, Gillian Santorelli, Rafaq Azad, Dan Mason, Andrew T. Hattersley, Timothy M. Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A. Lawlor, Rachel M. Freathy
Published in: Diabetologia, 2021, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-021-05570-9

The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

Author(s): Yu, Bing; Zanetti, Krista A; Temprosa, Marinella; Albanes, Demetrius; Appel, Nathan; Barrera, Clara Barrios; Ben-Shlomo, Yoav; Boerwinkle, Eric; Casas, Juan P; Clish, Clary; Dale, Caroline; Dehghan, Abbas; Derkach, Andriy; Eliassen, A Heather; Elliott, Paul; Fahy, Eoin; Gieger, Christian; Gunter, Marc J; Harada, Sei; Harris, Tamara; Herr, Deron R; Herrington, David; Hirschhorn, Joel N; Hoover, Eli
Published in: American Journal of Epidemiology, 1, 2019, Page(s) 991-1012, ISSN 0002-9262
Publisher: Oxford University Press
DOI: 10.1093/aje/kwz028

Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort

Author(s): Kurt Taylor, Diana L Santos Ferreira, Jane West, Tiffany Yang, Massimo Caputo, Deborah A Lawlor
Published in: Metabolites, 2019, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo9090190

The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile

Author(s): Deborah A. Lawlor, Melanie Lewcock, Louise Rena-Jones, Claire Rollings, Vikki Yip, Daniel Smith, Rebecca M. Pearson, Laura Johnson, Louise A. C. Millard, Nashita Patel, Andy Skinner, Kate Tilling
Published in: Wellcome Open Research, 4, 2019, Page(s) 36, ISSN 2398-502X
Publisher: Wellcome Open Research
DOI: 10.12688/wellcomeopenres.15087.1