Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine

Project Information

ATLAS

Grant agreement ID: 669858

DOI

10.3030/669858

Project closed

EC signature date 19 November 2015

Start date 1 December 2015

End date 31 October 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 498 987,50

EU contribution

€ 2 498 987,50

Coordinated by

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (34)

Cell Behavior within Nanogrooved Sandwich Culture Systems

Author(s): Isabel M. Bjørge,Manuel Salmeron-Sanchez,Clara R. Correia,João F. Mano
Published in: Small, 2020, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.5281/zenodo.6451257

Advanced Bottom-Up Engineering of Living Architectures

Author(s): Vítor M. Gaspar,Pedro Lavrador,João Borges,Mariana B. Oliveira,João F. Mano
Published in: Advanced Materials, 2019, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6451077

Stimuli-responsive nanocarriers for delivery of bone therapeutics - Barriers and progresses

Author(s): Pedro Lavrador, Vítor M Gaspar, João F Mano
Published in: Journal of Controlled Release, 2018, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.5281/zenodo.6457525

Human Platelet Lysates-Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion Assessment.

Author(s): Cátia F. Monteiro; Sara Santos; Catarina A. Custódio; João F. Mano
Published in: Advanced Science, Vol 7, Iss 7, Pp n/a-n/a (2020), Issue 2, 2020, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.201902398

Preparation of Well-Dispersed Chitosan/Alginate Hollow Multilayered Microcapsules for Enhanced Cellular Internalization

Author(s): Carla Ribeiro; João Borges; Ana M. S. Costa; Vítor M. Gaspar; Verónica de Zea Bermudez; João F. Mano
Published in: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Issue 2, 2018, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23030625

Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells

Author(s): Pankaj Bharmoria; Meena Bisht; Maria C. Gomes; Margarida Martins; Márcia C. Neves; João F. Mano; Igor Bdikin; João A. P. Coutinho; Sónia P. M. Ventura
Published in: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021), Issue 2, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-88482-3

How to design cell-mediated self-assembled colloidal scaffolds

Author(s): Dias, C. S.; Custodio, C. A.; Antunes, G. C.; da Gama, M. M. Telo; Mano, J. F.; Araujo, N. A. M.
Published in: ACS Applied Materials & Interfaces, Issue 3, 2020, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.48550/arxiv.2006.08270

In-air production of 3D co-culture tumor spheroid hydrogels for expedited drug screening

Author(s): Jéssica Antunes; Vítor M. Gaspar; Luís Ferreira; Maria Monteiro; Rui Henrique; Carmen Jerónimo; João F. Mano
Published in: Acta Biomaterialia, 2019, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.5281/zenodo.6451539

Sequentially Moldable and Bondable Four-Dimensional Hydrogels Compatible with Cell Encapsulation

Author(s): Oliveira, Mariana B.; Bastos, Henrique X. S.; Mano, João F.
Published in: Biomacromolecules, Issue 6, 2018, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.5281/zenodo.6457303

Fabrication of Artificial Nanobasement Membranes for Cell Compartmentalization in 3D Tissues

Author(s): Jinfeng Zeng,Naoko Sasaki,Clara R. Correia,João F. Mano,Michiya Matsusaki
Published in: Small, 2020, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.5281/zenodo.6413929

Solvent-Free Strategy Yields Size and Shape-Uniform Capsules

Author(s): Ana M. S. Costa; João F. Mano
Published in: Journal of the American Chemical Society, Issue 1, 2017, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.5281/zenodo.6457856

Control of Cell Alignment and Morphology by Redesigning ECM-Mimetic Nanotopography on Multilayer Membranes.

Author(s): Maria P. Sousa; Sofia G. Caridade; João F. Mano
Published in: Advanced Healthcare MaterialsVolume 6, Issue 15 1601462, Issue 2, 2017, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.201601462

Dynamic Electrophoretic Assembly of Metal–Phenolic Films: Accelerated Formation and Cytocompatible Detachment

Author(s): Gyeongwon Yun, Wongu Youn, Hojae Lee, Sang Yeong Han, Mariana B. Oliveira, Hyeoncheol Cho, Frank Caruso, João F. Mano, and Insung S. Choi
Published in: Chemistry of Materials, 2020, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.5281/zenodo.6451365

Liquefied Microcapsules as Dual-Microcarriers for 3D+3D Bottom-Up Tissue Engineering

Author(s): Clara R. Correia,Isabel M. Bjørge,Jinfeng Zeng,Michiya Matsusaki,João F. Mano
Published in: Advanced Healthcare Materials, 2019, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6457479

Cell Encapsulation Systems Toward Modular Tissue Regeneration: From Immunoisolation to Multifunctional Devices

Author(s): Correia, Clara R.; Nadine, Sara; Mano, João F.
Published in: Advanced Functional Materials, Issue 1, 2020, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.5281/zenodo.6457864

3D-Bioprinted Constructs that Breathe

Author(s): Clara R. Correia; João F. Mano
Published in: Matter Volume 4, Issue 1, 6 January 2021, Pages 15-17, Issue 3, 2021, ISSN 2590-2385
Publisher: Elsevier
DOI: 10.1016/j.matt.2020.12.019

Marine Origin Polysaccharides in Drug Delivery Systems

Author(s): Matias Cardoso, Rui Costa, João Mano
Published in: Marine Drugs, Issue 14/2, 2016, Page(s) 34, ISSN 1660-3397
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md14020034

Bioactive Hydrogel Marbles

Author(s): Álvaro J. Leite, Nuno M. Oliveira, Wenlong Song, João F. Mano
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-33192-6

Cell-Adhesive Bioinspired and Catechol-Based Multilayer Freestanding Membranes for Bone Tissue Engineering

Author(s): Maria Sousa, João Mano
Published in: Biomimetics, Issue 2/4, 2017, Page(s) 19, ISSN 2313-7673
Publisher: Biomimetics
DOI: 10.3390/biomimetics2040019

Multifunctional laminarin microparticles for cell adhesion and expansion

Author(s): C.R. Martins, C.A. Custódio, J.F. Mano
Published in: Carbohydrate Polymers, Issue 202, 2018, Page(s) 91-98, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2018.08.029

Nanoengineering Hybrid Supramolecular Multilayered Biomaterials Using Polysaccharides and Self-Assembling Peptide Amphiphiles

Author(s): João Borges, Maria P. Sousa, Goksu Cinar, Sofia G. Caridade, Mustafa O. Guler, João F. Mano
Published in: Advanced Functional Materials, Issue 27/17, 2017, Page(s) 1605122, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201605122

Recent advances on open fluidic systems for biomedical applications: A review

Author(s): Nuno M. Oliveira, Sara Vilabril, Mariana B. Oliveira, Rui L. Reis, João F. Mano
Published in: Materials Science and Engineering: C, Issue 97, 2019, Page(s) 851-863, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2018.12.040

Semipermeable Capsules Wrapping a Multifunctional and Self-regulated Co-culture Microenvironment for Osteogenic Differentiation

Author(s): Clara R. Correia, Rogério P. Pirraco, Mariana T. Cerqueira, Alexandra P. Marques, Rui L. Reis, João F. Mano
Published in: Scientific Reports, Issue 6, 2016, Page(s) 21883, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep21883

Strategic Advances in Formation of Cell-in-Shell Structures: From Syntheses to Applications

Author(s): Beom Jin Kim; Hyeoncheol Cho; João F. Mano; Insung S. Choi
Published in: Advanced Materials, 2018, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6406540

Iron Gall Ink Revisited: In Situ Oxidation of Fe(II)–Tannin Complex for Fluidic-Interface Engineering

Author(s): Hojae Lee,Won Il Kim,Wongu Youn,Taegyun Park,Sangmin Lee,Taek-Soo Kim,João F. Mano,Insung S. Choi
Published in: Advanced Materials, 2018, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6407046

Bioinspired bone therapies using naringin: applications and advances

Author(s): PedroLavradorVitor M.GasparJoão F.Mano
Published in: Drug Discovery Today, 2018, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.5281/zenodo.6451108

Mesenchymal Stem Cells Relevance in Multicellular Bioengineered 3D In Vitro Tumor Models

Author(s): Luís P Ferreira, Vítor M Gaspar, Rui Henrique, Carmen Jerónimo, João F Mano
Published in: Biotechnology Journal, 2017, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.5281/zenodo.6451569

Cell Surface Engineering to Control Cellular Interactions

Author(s): Dr. Catarina A. Custódio,Prof. João F. Mano
Published in: ChemNanoMat, 2016, ISSN 2199-692X
Publisher: WILEY
DOI: 10.5281/zenodo.6451304

Mechanochemical Patternable ECM-Mimetic Hydrogels for Programmed Cell Orientation

Author(s): Pedro Lavrador; Vítor Gaspar; João Mano
Published in: Advanced Healthcare Materials, Issue 1, 2020, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6407048

Geometrically Controlled Liquefied Capsules for Modular Tissue Engineering Strategies

Author(s): Sara Nadine,Sónia G. Patrício,Cristina C. Barrias,Insung S. Choi,Michiya Matsusaki,Clara R. Correia,João F. Mano
Published in: Advanced Biology, 2020, ISSN 2366-7478
Publisher: WILEY
DOI: 10.5281/zenodo.6406735

Screening of perfused combinatorial 3D microenvironments for cell culture

Author(s): Diana Lopes , C Fernandes , J Miguel Nóbrega , Sónia G Patrício , Mariana B Oliveira , João F Mano
Published in: Acta Biomaterialia, 2019, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.5281/zenodo.6457504

Modeling of Cell-Mediated Self-Assembled Colloidal Scaffolds

Author(s): C. S. Dias, C. A. Custódio, G. C. Antunes, M. M. Telo da Gama, J. F. Mano, and N. A. M. Araújo
Published in: ACS Applied Materials and Interfaces, 2020, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.5281/zenodo.6451600

Cell encapsulation in liquified compartments: Protocol optimization and challenges.

Author(s): Correia, Clara R.; Ghasemzadeh-Hasankolaei, Maryam; Mano, João F.
Published in: PLoS ONE, Issue 2, 2019, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0218045

Bioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation

Author(s): Pedro Lavrador 1, Vítor M Gaspar 1, João F Mano 1
Published in: Advanced Healthcare Materials, 2018, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6451209

Non-peer reviewed articles (20)

Perinatal tissues and cells in tissue engineering and regenerative medicine

Author(s): Inês Deus; João F. Mano; Catarina Custódio
Published in: Acta Biomaterialia, Issue 1, 2020, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.5281/zenodo.6411205

Supramolecular dendrimer-containing layer-by-layer nanoassemblies for bioapplications: current status and future prospects

Author(s): Cristiana F. V. Sousa; Eduardo Fernandez-Megia; João Borges; João F. Mano
Published in: Polymer Chemistry, Issue 4, 2021, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.5281/zenodo.6414276

Double network laminarin-boronic/alginate dynamic bioink for 3D bioprinting cell-laden constructs

Author(s): Adérito J. R. Amaral; Gaspar VM; Pedro Lavrador; João F. Mano
Published in: BIOFABRICATION, Issue 1, 2021, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.5281/zenodo.6405625

An Immunomodulatory Miniaturized 3D Screening Platform Using Liquefied Capsules

Author(s): Sara Nadine; Clara R Correia; João F Mano
Published in: Advanced Healthcare Materials, Issue 1, 2021, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6407164

Natural Origin Biomaterials for 4D Bioprinting Tissue-Like Constructs

Author(s): Patrícia D. C. Costa; Dora C. S. Costa; Tiago R. Correia; Vítor M. Gaspar; João F. Mano
Published in: Advanced Materials Technologies, Issue 1, 2021, ISSN 2365-709X
Publisher: Wiley
DOI: 10.1002/admt.202100168

Design Principles and Multifunctionality in Cell Encapsulation Systems for Tissue Regeneration

Author(s): Clara R. Correia; Rui L. Reis; João F. Mano
Published in: Advanced Healthcare Materials, Issue 1, 2020, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6411250

GelMA/bioactive silica nanocomposite bioinks for stem cell osteogenic differentiation

Author(s): Márcia T Tavares, Vítor M Gaspar, Maria V Monteiro, José Paulo S Farinha, Carlos Baleizão, João F Mano
Published in: Biofabrication, 2021, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.5281/zenodo.6407070

Hipster microcarriers: exploring geometrical and topographical cues of non-spherical microcarriers in biomedical applications

Author(s): Isabel M. Bjørge; Clara R. Correia; João F. Mano
Published in: Materials Horizons, Issue 1, 2022, ISSN 2051-6347
Publisher: ROYAL SOC CHEMISTRY
DOI: 10.5281/zenodo.6407029

Dynamic microfactories co-encapsulating osteoblastic and adipose-derived stromal cells for the biofabrication of bone units

Author(s): Sara Nadine; Sónia G Patrício; Clara R Correia; João F Mano
Published in: Biofabrication, Issue 1, 2020, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.5281/zenodo.6407144

Bioinspired multilayer membranes as potential adhesive patches for skin wound healing†

Author(s): Maria P. Sousa; Ana I. Neto; Tiago R. Correia; Sónia P. Miguel; Michiya Matsusaki; Ilídio J. Correia; João F. Mano
Published in: Biomaterials Science, Issue 1, 2018, ISSN 2047-4849
Publisher: ROYAL SOC CHEMISTRY
DOI: 10.5281/zenodo.6416095

Enzymatically degradable, starch-based layer-by-layer films: application to cytocompatible single-cell nanoencapsulation

Author(s): Hee Chul Moon; Sol Han; João Borges; Tamagno Pesqueira; Hyunwoo Choi; Sang Yeong Han; Hyeoncheol Cho; Ji Hun Park; João F. Mano; Insung S. Choi
Published in: Soft Matter, Issue 1, 2020, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.5281/zenodo.6406864

Tuneable spheroidal hydrogel particles for cell and drug encapsulation

Author(s): Isabel M. Bjørge; Ana M. S. Costa; A. Sofia Silva; João P. O. Vidal,; J. Miguel Nóbrega; João F. Mano
Published in: Soft Matter, Issue 5, 2018, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.5281/zenodo.6414816

Design of Protein-Based Liquefied Cell-Laden Capsules with Bioinspired Adhesion for Tissue Engineering

Author(s): Maria C. Gomes; Dora C.S. Costa; Cláudia S. Oliveira; João F. Mano
Published in: Advanced Healthcare Materials, Issue 1, 2021, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6411543

Fabrication of Quasi-2D Shape-Tailored Microparticles using Wettability Contrast-Based Platforms

Author(s): Mafalda D. Neto; Aukha Stoppa; Miguel A. Neto; Filipe J. Oliveira; Maria C. Gomes; Aldo R. Boccaccini; Pavel A. Levkin; Mariana B. Oliveira; João F. Mano
Published in: Advanced Materials, Issue 1, 2021, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6411590

Hydrogel 3D in vitro tumor models for screening cell aggregation mediated drug response

Author(s): Maria Monterio; Vítor Gaspar; Luís Pereira; João Mano
Published in: Biomaterials Science, Issue 1, 2020, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.5281/zenodo.6407058

One-Step All-Aqueous Interfacial Assembly of Robust Membranes for Long-Term Encapsulation and Culture of Adherent Stem/Stromal Cells

Author(s): Sara Vilabril; Sara Nadine; Catarina M S S Neves; Clara R Correia; Mara G Freire; João A P Coutinho; Mariana B Oliveira; João F Mano
Published in: Advanced Healthcare Materials, Issue 1, 2021, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6407107

Minimalist Tissue Engineering Approaches Using Low Material-Based Bioengineered Systems

Author(s): Clara R. Correia; Isabel M. Bjørge; Sara Nadine; João F. Mano
Published in: Advanced Healthcare Materials, Issue 1, 2021, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6406910

Thin Silica‐Based Microsheets with Controlled Geometry

Author(s): Marta M. Maciel; Marta M. Maciel; Sónia G. Patrício; João Borges; Pavel A. Levkin; Tiago Ruivo Correia; João F. Mano
Published in: European Journal of Inorganic Chemistry, Issue 1, 2020, ISSN 1434-1948
Publisher: John Wiley & Sons Ltd.
DOI: 10.5281/zenodo.6451623

Customizable and Regioselective One-Pot N−H Functionalization of DNA Nucleobases to Create a Library of Nucleobase Derivatives for Biomedical Applications

Author(s): Dr.Djenisa H.A. Rocha, Carmen M.Machado, VeraSousa, Cristiana F.V.Sousa, Dr.Vera L.M.Silva, Prof. Dr.Artur M.S.Silva, Dr.JoãoBorges, Prof. Dr.João F.Mano
Published in: European Journal of Organic Chemistry, 2021, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.5281/zenodo.6451411

Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

Author(s): Isabel M. Bjørge; Insung S. Choi; Clara R. Correia; João F. Mano
Published in: Nanoscale, Issue 2, 2019, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.5281/zenodo.6414305

Thesis and dissertations (4)

Bioengineering of nanostructured systems based on nature-inspired surfaces for regeneration of human tissues

Author(s): Lopes, Flávia Daniela Santos
Published in: RIA, Repositório de institucional da Universidade de Aveiro, Issue 2, 2019
Publisher: Departamento de Engenharia de Materiais e Cerâmica

Liquified capsules containing nanogrooved microdiscs and co-encapsulated endothelial and mesenchymal stem cells for bone tissue engineering

Author(s): Carreira, Mariana da Silva
Published in: RIA - Repositório Institucional da Universidade de Aveiro, Issue 2, 2019
Publisher: Departamento de Química

Liquefied capsules containing microparticles with variable stiffness to control cell differentiation

Author(s): Pinheiro, Diogo Marques
Published in: Repositório Universidade de Aveiro, Issue 2, 2021
Publisher: Departamento de Química

Hidrogeis multiestruturais obtidos através de estratégias biomiméticas para aplicações biomédicas

Author(s): Costa, Ana Margarida Silva
Published in: RIA Repositório Institucional da Universidade de Aveiro, Issue 2, 2020
Publisher: Departamento de Química - Universidade de Aveiro