Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine

Informations projet

ATLAS

N° de convention de subvention: 669858

DOI 10.3030/669858

Projet clôturé

Date de signature de la CE 19 Novembre 2015

Date de début 1 Decembre 2015

Date de fin 31 Octobre 2021

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total € 2 498 987,50

Contribution de l’UE € 2 498 987,50

Coordonné par

UNIVERSIDADE DE AVEIRO
Portugal

Publications

Peer reviewed articles (34)

Cell Behavior within Nanogrooved Sandwich Culture Systems

Auteurs: Isabel M. Bjørge,Manuel Salmeron-Sanchez,Clara R. Correia,João F. Mano
Publié dans: Small, 2020, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.5281/zenodo.6451257

Advanced Bottom-Up Engineering of Living Architectures

Auteurs: Vítor M. Gaspar,Pedro Lavrador,João Borges,Mariana B. Oliveira,João F. Mano
Publié dans: Advanced Materials, 2019, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6451077

Stimuli-responsive nanocarriers for delivery of bone therapeutics - Barriers and progresses

Auteurs: Pedro Lavrador, Vítor M Gaspar, João F Mano
Publié dans: Journal of Controlled Release, 2018, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.5281/zenodo.6457525

Human Platelet Lysates-Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion Assessment.

Auteurs: Cátia F. Monteiro; Sara Santos; Catarina A. Custódio; João F. Mano
Publié dans: Advanced Science, Vol 7, Iss 7, Pp n/a-n/a (2020), Numéro 2, 2020, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.201902398

Preparation of Well-Dispersed Chitosan/Alginate Hollow Multilayered Microcapsules for Enhanced Cellular Internalization

Auteurs: Carla Ribeiro; João Borges; Ana M. S. Costa; Vítor M. Gaspar; Verónica de Zea Bermudez; João F. Mano
Publié dans: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Numéro 2, 2018, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23030625

Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells

Auteurs: Pankaj Bharmoria; Meena Bisht; Maria C. Gomes; Margarida Martins; Márcia C. Neves; João F. Mano; Igor Bdikin; João A. P. Coutinho; Sónia P. M. Ventura
Publié dans: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021), Numéro 2, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-88482-3

How to design cell-mediated self-assembled colloidal scaffolds

Auteurs: Dias, C. S.; Custodio, C. A.; Antunes, G. C.; da Gama, M. M. Telo; Mano, J. F.; Araujo, N. A. M.
Publié dans: ACS Applied Materials & Interfaces, Numéro 3, 2020, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.48550/arxiv.2006.08270

In-air production of 3D co-culture tumor spheroid hydrogels for expedited drug screening

Auteurs: Jéssica Antunes; Vítor M. Gaspar; Luís Ferreira; Maria Monteiro; Rui Henrique; Carmen Jerónimo; João F. Mano
Publié dans: Acta Biomaterialia, 2019, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.5281/zenodo.6451539

Sequentially Moldable and Bondable Four-Dimensional Hydrogels Compatible with Cell Encapsulation

Auteurs: Oliveira, Mariana B.; Bastos, Henrique X. S.; Mano, João F.
Publié dans: Biomacromolecules, Numéro 6, 2018, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.5281/zenodo.6457303

Fabrication of Artificial Nanobasement Membranes for Cell Compartmentalization in 3D Tissues

Auteurs: Jinfeng Zeng,Naoko Sasaki,Clara R. Correia,João F. Mano,Michiya Matsusaki
Publié dans: Small, 2020, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.5281/zenodo.6413929

Solvent-Free Strategy Yields Size and Shape-Uniform Capsules

Auteurs: Ana M. S. Costa; João F. Mano
Publié dans: Journal of the American Chemical Society, Numéro 1, 2017, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.5281/zenodo.6457856

Control of Cell Alignment and Morphology by Redesigning ECM-Mimetic Nanotopography on Multilayer Membranes.

Auteurs: Maria P. Sousa; Sofia G. Caridade; João F. Mano
Publié dans: Advanced Healthcare MaterialsVolume 6, Numéro 15 1601462, Numéro 2, 2017, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1002/adhm.201601462

Dynamic Electrophoretic Assembly of Metal–Phenolic Films: Accelerated Formation and Cytocompatible Detachment

Auteurs: Gyeongwon Yun, Wongu Youn, Hojae Lee, Sang Yeong Han, Mariana B. Oliveira, Hyeoncheol Cho, Frank Caruso, João F. Mano, and Insung S. Choi
Publié dans: Chemistry of Materials, 2020, ISSN 0897-4756
Éditeur: American Chemical Society
DOI: 10.5281/zenodo.6451365

Liquefied Microcapsules as Dual-Microcarriers for 3D+3D Bottom-Up Tissue Engineering

Auteurs: Clara R. Correia,Isabel M. Bjørge,Jinfeng Zeng,Michiya Matsusaki,João F. Mano
Publié dans: Advanced Healthcare Materials, 2019, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6457479

Cell Encapsulation Systems Toward Modular Tissue Regeneration: From Immunoisolation to Multifunctional Devices

Auteurs: Correia, Clara R.; Nadine, Sara; Mano, João F.
Publié dans: Advanced Functional Materials, Numéro 1, 2020, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.5281/zenodo.6457864

3D-Bioprinted Constructs that Breathe

Auteurs: Clara R. Correia; João F. Mano
Publié dans: Matter Volume 4, Numéro 1, 6 January 2021, Pages 15-17, Numéro 3, 2021, ISSN 2590-2385
Éditeur: Elsevier
DOI: 10.1016/j.matt.2020.12.019

Marine Origin Polysaccharides in Drug Delivery Systems

Auteurs: Matias Cardoso, Rui Costa, João Mano
Publié dans: Marine Drugs, Numéro 14/2, 2016, Page(s) 34, ISSN 1660-3397
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md14020034

Bioactive Hydrogel Marbles

Auteurs: Álvaro J. Leite, Nuno M. Oliveira, Wenlong Song, João F. Mano
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-33192-6

Cell-Adhesive Bioinspired and Catechol-Based Multilayer Freestanding Membranes for Bone Tissue Engineering

Auteurs: Maria Sousa, João Mano
Publié dans: Biomimetics, Numéro 2/4, 2017, Page(s) 19, ISSN 2313-7673
Éditeur: Biomimetics
DOI: 10.3390/biomimetics2040019

Multifunctional laminarin microparticles for cell adhesion and expansion

Auteurs: C.R. Martins, C.A. Custódio, J.F. Mano
Publié dans: Carbohydrate Polymers, Numéro 202, 2018, Page(s) 91-98, ISSN 0144-8617
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2018.08.029

Nanoengineering Hybrid Supramolecular Multilayered Biomaterials Using Polysaccharides and Self-Assembling Peptide Amphiphiles

Auteurs: João Borges, Maria P. Sousa, Goksu Cinar, Sofia G. Caridade, Mustafa O. Guler, João F. Mano
Publié dans: Advanced Functional Materials, Numéro 27/17, 2017, Page(s) 1605122, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201605122

Recent advances on open fluidic systems for biomedical applications: A review

Auteurs: Nuno M. Oliveira, Sara Vilabril, Mariana B. Oliveira, Rui L. Reis, João F. Mano
Publié dans: Materials Science and Engineering: C, Numéro 97, 2019, Page(s) 851-863, ISSN 0928-4931
Éditeur: Elsevier BV
DOI: 10.1016/j.msec.2018.12.040

Semipermeable Capsules Wrapping a Multifunctional and Self-regulated Co-culture Microenvironment for Osteogenic Differentiation

Auteurs: Clara R. Correia, Rogério P. Pirraco, Mariana T. Cerqueira, Alexandra P. Marques, Rui L. Reis, João F. Mano
Publié dans: Scientific Reports, Numéro 6, 2016, Page(s) 21883, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep21883

Strategic Advances in Formation of Cell-in-Shell Structures: From Syntheses to Applications

Auteurs: Beom Jin Kim; Hyeoncheol Cho; João F. Mano; Insung S. Choi
Publié dans: Advanced Materials, 2018, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6406540

Iron Gall Ink Revisited: In Situ Oxidation of Fe(II)–Tannin Complex for Fluidic-Interface Engineering

Auteurs: Hojae Lee,Won Il Kim,Wongu Youn,Taegyun Park,Sangmin Lee,Taek-Soo Kim,João F. Mano,Insung S. Choi
Publié dans: Advanced Materials, 2018, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6407046

Bioinspired bone therapies using naringin: applications and advances

Auteurs: PedroLavradorVitor M.GasparJoão F.Mano
Publié dans: Drug Discovery Today, 2018, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.5281/zenodo.6451108

Mesenchymal Stem Cells Relevance in Multicellular Bioengineered 3D In Vitro Tumor Models

Auteurs: Luís P Ferreira, Vítor M Gaspar, Rui Henrique, Carmen Jerónimo, João F Mano
Publié dans: Biotechnology Journal, 2017, ISSN 1860-6768
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.5281/zenodo.6451569

Cell Surface Engineering to Control Cellular Interactions

Auteurs: Dr. Catarina A. Custódio,Prof. João F. Mano
Publié dans: ChemNanoMat, 2016, ISSN 2199-692X
Éditeur: WILEY
DOI: 10.5281/zenodo.6451304

Mechanochemical Patternable ECM-Mimetic Hydrogels for Programmed Cell Orientation

Auteurs: Pedro Lavrador; Vítor Gaspar; João Mano
Publié dans: Advanced Healthcare Materials, Numéro 1, 2020, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6407048

Geometrically Controlled Liquefied Capsules for Modular Tissue Engineering Strategies

Auteurs: Sara Nadine,Sónia G. Patrício,Cristina C. Barrias,Insung S. Choi,Michiya Matsusaki,Clara R. Correia,João F. Mano
Publié dans: Advanced Biology, 2020, ISSN 2366-7478
Éditeur: WILEY
DOI: 10.5281/zenodo.6406735

Screening of perfused combinatorial 3D microenvironments for cell culture

Auteurs: Diana Lopes , C Fernandes , J Miguel Nóbrega , Sónia G Patrício , Mariana B Oliveira , João F Mano
Publié dans: Acta Biomaterialia, 2019, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.5281/zenodo.6457504

Modeling of Cell-Mediated Self-Assembled Colloidal Scaffolds

Auteurs: C. S. Dias, C. A. Custódio, G. C. Antunes, M. M. Telo da Gama, J. F. Mano, and N. A. M. Araújo
Publié dans: ACS Applied Materials and Interfaces, 2020, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.5281/zenodo.6451600

Cell encapsulation in liquified compartments: Protocol optimization and challenges.

Auteurs: Correia, Clara R.; Ghasemzadeh-Hasankolaei, Maryam; Mano, João F.
Publié dans: PLoS ONE, Numéro 2, 2019, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0218045

Bioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation

Auteurs: Pedro Lavrador 1, Vítor M Gaspar 1, João F Mano 1
Publié dans: Advanced Healthcare Materials, 2018, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6451209

Non-peer reviewed articles (20)

Perinatal tissues and cells in tissue engineering and regenerative medicine

Auteurs: Inês Deus; João F. Mano; Catarina Custódio
Publié dans: Acta Biomaterialia, Numéro 1, 2020, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.5281/zenodo.6411205

Supramolecular dendrimer-containing layer-by-layer nanoassemblies for bioapplications: current status and future prospects

Auteurs: Cristiana F. V. Sousa; Eduardo Fernandez-Megia; João Borges; João F. Mano
Publié dans: Polymer Chemistry, Numéro 4, 2021, ISSN 1759-9954
Éditeur: Royal Society of Chemistry
DOI: 10.5281/zenodo.6414276

Double network laminarin-boronic/alginate dynamic bioink for 3D bioprinting cell-laden constructs

Auteurs: Adérito J. R. Amaral; Gaspar VM; Pedro Lavrador; João F. Mano
Publié dans: BIOFABRICATION, Numéro 1, 2021, ISSN 1758-5082
Éditeur: IOS Press
DOI: 10.5281/zenodo.6405625

An Immunomodulatory Miniaturized 3D Screening Platform Using Liquefied Capsules

Auteurs: Sara Nadine; Clara R Correia; João F Mano
Publié dans: Advanced Healthcare Materials, Numéro 1, 2021, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6407164

Natural Origin Biomaterials for 4D Bioprinting Tissue-Like Constructs

Auteurs: Patrícia D. C. Costa; Dora C. S. Costa; Tiago R. Correia; Vítor M. Gaspar; João F. Mano
Publié dans: Advanced Materials Technologies, Numéro 1, 2021, ISSN 2365-709X
Éditeur: Wiley
DOI: 10.1002/admt.202100168

Design Principles and Multifunctionality in Cell Encapsulation Systems for Tissue Regeneration

Auteurs: Clara R. Correia; Rui L. Reis; João F. Mano
Publié dans: Advanced Healthcare Materials, Numéro 1, 2020, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6411250

GelMA/bioactive silica nanocomposite bioinks for stem cell osteogenic differentiation

Auteurs: Márcia T Tavares, Vítor M Gaspar, Maria V Monteiro, José Paulo S Farinha, Carlos Baleizão, João F Mano
Publié dans: Biofabrication, 2021, ISSN 1758-5082
Éditeur: IOS Press
DOI: 10.5281/zenodo.6407070

Hipster microcarriers: exploring geometrical and topographical cues of non-spherical microcarriers in biomedical applications

Auteurs: Isabel M. Bjørge; Clara R. Correia; João F. Mano
Publié dans: Materials Horizons, Numéro 1, 2022, ISSN 2051-6347
Éditeur: ROYAL SOC CHEMISTRY
DOI: 10.5281/zenodo.6407029

Dynamic microfactories co-encapsulating osteoblastic and adipose-derived stromal cells for the biofabrication of bone units

Auteurs: Sara Nadine; Sónia G Patrício; Clara R Correia; João F Mano
Publié dans: Biofabrication, Numéro 1, 2020, ISSN 1758-5082
Éditeur: IOS Press
DOI: 10.5281/zenodo.6407144

Bioinspired multilayer membranes as potential adhesive patches for skin wound healing†

Auteurs: Maria P. Sousa; Ana I. Neto; Tiago R. Correia; Sónia P. Miguel; Michiya Matsusaki; Ilídio J. Correia; João F. Mano
Publié dans: Biomaterials Science, Numéro 1, 2018, ISSN 2047-4849
Éditeur: ROYAL SOC CHEMISTRY
DOI: 10.5281/zenodo.6416095

Enzymatically degradable, starch-based layer-by-layer films: application to cytocompatible single-cell nanoencapsulation

Auteurs: Hee Chul Moon; Sol Han; João Borges; Tamagno Pesqueira; Hyunwoo Choi; Sang Yeong Han; Hyeoncheol Cho; Ji Hun Park; João F. Mano; Insung S. Choi
Publié dans: Soft Matter, Numéro 1, 2020, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.5281/zenodo.6406864

Tuneable spheroidal hydrogel particles for cell and drug encapsulation

Auteurs: Isabel M. Bjørge; Ana M. S. Costa; A. Sofia Silva; João P. O. Vidal,; J. Miguel Nóbrega; João F. Mano
Publié dans: Soft Matter, Numéro 5, 2018, ISSN 1744-683X
Éditeur: Royal Society of Chemistry
DOI: 10.5281/zenodo.6414816

Design of Protein-Based Liquefied Cell-Laden Capsules with Bioinspired Adhesion for Tissue Engineering

Auteurs: Maria C. Gomes; Dora C.S. Costa; Cláudia S. Oliveira; João F. Mano
Publié dans: Advanced Healthcare Materials, Numéro 1, 2021, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6411543

Fabrication of Quasi-2D Shape-Tailored Microparticles using Wettability Contrast-Based Platforms

Auteurs: Mafalda D. Neto; Aukha Stoppa; Miguel A. Neto; Filipe J. Oliveira; Maria C. Gomes; Aldo R. Boccaccini; Pavel A. Levkin; Mariana B. Oliveira; João F. Mano
Publié dans: Advanced Materials, Numéro 1, 2021, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.5281/zenodo.6411590

Hydrogel 3D in vitro tumor models for screening cell aggregation mediated drug response

Auteurs: Maria Monterio; Vítor Gaspar; Luís Pereira; João Mano
Publié dans: Biomaterials Science, Numéro 1, 2020, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.5281/zenodo.6407058

One-Step All-Aqueous Interfacial Assembly of Robust Membranes for Long-Term Encapsulation and Culture of Adherent Stem/Stromal Cells

Auteurs: Sara Vilabril; Sara Nadine; Catarina M S S Neves; Clara R Correia; Mara G Freire; João A P Coutinho; Mariana B Oliveira; João F Mano
Publié dans: Advanced Healthcare Materials, Numéro 1, 2021, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6407107

Minimalist Tissue Engineering Approaches Using Low Material-Based Bioengineered Systems

Auteurs: Clara R. Correia; Isabel M. Bjørge; Sara Nadine; João F. Mano
Publié dans: Advanced Healthcare Materials, Numéro 1, 2021, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.5281/zenodo.6406910

Thin Silica‐Based Microsheets with Controlled Geometry

Auteurs: Marta M. Maciel; Marta M. Maciel; Sónia G. Patrício; João Borges; Pavel A. Levkin; Tiago Ruivo Correia; João F. Mano
Publié dans: European Journal of Inorganic Chemistry, Numéro 1, 2020, ISSN 1434-1948
Éditeur: John Wiley & Sons Ltd.
DOI: 10.5281/zenodo.6451623

Customizable and Regioselective One-Pot N−H Functionalization of DNA Nucleobases to Create a Library of Nucleobase Derivatives for Biomedical Applications

Auteurs: Dr.Djenisa H.A. Rocha, Carmen M.Machado, VeraSousa, Cristiana F.V.Sousa, Dr.Vera L.M.Silva, Prof. Dr.Artur M.S.Silva, Dr.JoãoBorges, Prof. Dr.João F.Mano
Publié dans: European Journal of Organic Chemistry, 2021, ISSN 1434-193X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.5281/zenodo.6451411

Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

Auteurs: Isabel M. Bjørge; Insung S. Choi; Clara R. Correia; João F. Mano
Publié dans: Nanoscale, Numéro 2, 2019, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.5281/zenodo.6414305

Thesis and dissertations (4)

Bioengineering of nanostructured systems based on nature-inspired surfaces for regeneration of human tissues

Auteurs: Lopes, Flávia Daniela Santos
Publié dans: RIA, Repositório de institucional da Universidade de Aveiro, Numéro 2, 2019
Éditeur: Departamento de Engenharia de Materiais e Cerâmica

Liquified capsules containing nanogrooved microdiscs and co-encapsulated endothelial and mesenchymal stem cells for bone tissue engineering

Auteurs: Carreira, Mariana da Silva
Publié dans: RIA - Repositório Institucional da Universidade de Aveiro, Numéro 2, 2019
Éditeur: Departamento de Química

Liquefied capsules containing microparticles with variable stiffness to control cell differentiation

Auteurs: Pinheiro, Diogo Marques
Publié dans: Repositório Universidade de Aveiro, Numéro 2, 2021
Éditeur: Departamento de Química

Hidrogeis multiestruturais obtidos através de estratégias biomiméticas para aplicações biomédicas

Auteurs: Costa, Ana Margarida Silva
Publié dans: RIA Repositório Institucional da Universidade de Aveiro, Numéro 2, 2020
Éditeur: Departamento de Química - Universidade de Aveiro