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HIV-1 sensing and signaling in dendritic cells

Publications

MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals

Auteurs: Melissa Stunnenberg, Lisa van Pul, Joris K. Sprokholt, Karel A. van Dort, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra
Publié dans: Viruses, Issue 12/7, 2020, Page(s) 764, ISSN 1999-4915
DOI: 10.3390/v12070764

Separate signaling events control TCR downregulation and T cell activation in primary human T cells

Auteurs: Lieve E. H. Donk, Louis S. Ates, Jet Spek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. Heijst
Publié dans: Immunity, Inflammation and Disease, Issue 9/1, 2021, Page(s) 223-238, ISSN 2050-4527
DOI: 10.1002/iid3.383

RIG-I–like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and T H 1 Differentiation

Auteurs: Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Publié dans: The Journal of Immunology, Issue 198/12, 2017, Page(s) 4764-4771, ISSN 0022-1767
DOI: 10.4049/jimmunol.1602121

DDX3 in HIV-1 infection and sensing: A paradox

Auteurs: Melissa Stunnenberg, Teunis B.H. Geijtenbeek, Sonja I. Gringhuis
Publié dans: Cytokine & Growth Factor Reviews, Issue 40, 2018, Page(s) 32-39, ISSN 1359-6101
DOI: 10.1016/j.cytogfr.2018.03.001

C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

Auteurs: Marta Bermejo-Jambrina, Julia Eder, Leanne C. Helgers, Nina Hertoghs, Bernadien M. Nijmeijer, Melissa Stunnenberg, Teunis B. H. Geijtenbeek
Publié dans: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.00590

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production

Auteurs: Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Publié dans: PLOS Pathogens, Issue 13/11, 2017, Page(s) e1006738, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1006738

DCs facilitate B cell responses against microbial DNA via DC-SIGN

Auteurs: Joris K. Sprokholt, Marieke H. Heineke, Tanja M. Kaptein, John L. van Hamme, Teunis B. H. Geijtenbeek
Publié dans: PLOS ONE, Issue 12/10, 2017, Page(s) e0185580, ISSN 1932-6203
DOI: 10.1371/journal.pone.0185580

C-type lectin receptors in the control of T helper cell differentiation

Auteurs: Teunis B. H. Geijtenbeek, Sonja I. Gringhuis
Publié dans: Nature Reviews Immunology, Issue 16/7, 2016, Page(s) 433-448, ISSN 1474-1733
DOI: 10.1038/nri.2016.55

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

Auteurs: Carla M. S. Ribeiro, Ramin Sarrami-Forooshani, Laurentia C. Setiawan, Esther M. Zijlstra-Willems, John L. van Hamme, Wikky Tigchelaar, Nicole N. van der Wel, Neeltje A. Kootstra, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Publié dans: Nature, Issue 540/7633, 2016, Page(s) 448-452, ISSN 0028-0836
DOI: 10.1038/nature20567

Interplay between HIV-1 innate sensing and restriction in mucosal dendritic cells: balancing defense and viral transmission

Auteurs: Nina Hertoghs, Teunis B.H. Geijtenbeek, Carla M.S. Ribeiro
Publié dans: Current Opinion in Virology, Issue 22, 2017, Page(s) 112-119, ISSN 1879-6257
DOI: 10.1016/j.coviro.2017.01.001

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

Auteurs: Sonja I Gringhuis, Nina Hertoghs, Tanja M Kaptein, Esther M Zijlstra-Willems, Ramin Sarrami-Fooroshani, Joris K Sprokholt, Nienke H van Teijlingen, Neeltje A Kootstra, Thijs Booiman, Karel A van Dort, Carla M S Ribeiro, Agata Drewniak, Teunis B H Geijtenbeek
Publié dans: Nature Immunology, Issue 18/2, 2016, Page(s) 225-235, ISSN 1529-2908
DOI: 10.1038/ni.3647

Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission

Auteurs: Bernadien M. Nijmeijer, Julia Eder, Catharina J. M. Langedijk, Tanja M. Kaptein, Sofie Meeussen, Pascale Zimmermann, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Publié dans: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.00503

Various Tastes of Sugar: The Potential of Glycosylation in Targeting and Modulating Human Immunity via C-Type Lectin Receptors

Auteurs: Stefanie Busold, Noémi A. Nagy, Sander W. Tas, Ronald van Ree, Esther C. de Jong, Teunis B. H. Geijtenbeek
Publié dans: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.00134

Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity

Auteurs: Melissa Stunnenberg, Joris K. Sprokholt, John L. van Hamme, Tanja M. Kaptein, Esther M. Zijlstra-Willems, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Publié dans: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.00008

Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells

Auteurs: Nienke H. van Teijlingen, Leanne C. Helgers, Esther M. Zijlstra - Willems, John L. van Hamme, Carla M.S. Ribeiro, Karin Strijbis, Teunis B.H. Geijtenbeek
Publié dans: Journal of Reproductive Immunology, Issue 138, 2020, Page(s) 103085, ISSN 0165-0378
DOI: 10.1016/j.jri.2020.103085

Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction

Auteurs: Nina Hertoghs, Bernadien M. Nijmeijer, Nienke H. van Teijlingen, Angharad E. Fenton-May, Tanja M. Kaptein, John L. van Hamme, John C. Kappes, Neeltje A. Kootstra, Beatrice H. Hahn, Persephone Borrow, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Publié dans: PLOS ONE, Issue 14/12, 2019, Page(s) e0226651, ISSN 1932-6203
DOI: 10.1371/journal.pone.0226651

Borrelia miyamotoi Activates Human Dendritic Cells and Elicits T Cell Responses

Auteurs: Lauren M. K. Mason, Joris Koetsveld, Jos J. A. Trentelman, Tanja M. Kaptein, Dieuwertje Hoornstra, Alex Wagemakers, Michelle M. Fikrig, Jasmin I. Ersoz, Anneke Oei, Teunis B. H. Geijtenbeek, Joppe W. R. Hovius
Publié dans: The Journal of Immunology, Issue 204/2, 2020, Page(s) 386-393, ISSN 0022-1767
DOI: 10.4049/jimmunol.1801589

Sexually transmitted hepatitis C virus infections: current trends, and recent advances in understanding the spread in men who have sex with men

Auteurs: Bernadien M Nijmeijer, Jelle Koopsen, Janke Schinkel, Maria Prins, Teunis BH Geijtenbeek
Publié dans: Journal of the International AIDS Society, Issue 22/S6, 2019, ISSN 1758-2652
DOI: 10.1002/jia2.25348

Negative and Positive Selection Pressure During Sexual Transmission of Transmitted Founder HIV-1

Auteurs: Bernadien M. Nijmeijer, Teunis B. H. Geijtenbeek
Publié dans: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.01599

HIV ‐1 exposure and immune activation enhance sexual transmission of Hepatitis C virus by primary Langerhans cells

Auteurs: Bernadien M Nijmeijer, Ramin Sarrami‐Forooshani, Gaby S Steba, Renée RCE Schreurs, Sylvie M Koekkoek, Richard Molenkamp, Janke Schinkel, Peter Reiss, Matthijs L Siegenbeek van Heukelom, Marc Valk, Carla MS Ribeiro, Teunis BH Geijtenbeek
Publié dans: Journal of the International AIDS Society, Issue 22/3, 2019, Page(s) e25268, ISSN 1758-2652
DOI: 10.1002/jia2.25268

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Auteurs: Renée R.C.E. Schreurs, Martin E. Baumdick, Adrian F. Sagebiel, Max Kaufmann, Michal Mokry, Paul L. Klarenbeek, Nicola Schaltenberg, Fenja L. Steinert, Jorik M. van Rijn, Agata Drewniak, Sarah-May M.L. The, Roel Bakx, Joep P.M. Derikx, Niek de Vries, Willemijn E. Corpeleijn, Steven T. Pals, Nicola Gagliani, Manuel A. Friese, Sabine Middendorp, Edward E.S. Nieuwenhuis, Konrad Reinshagen, Teunis B.H
Publié dans: Immunity, Issue 50/2, 2019, Page(s) 462-476.e8, ISSN 1074-7613
DOI: 10.1016/j.immuni.2018.12.010

Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22–Specific Th Cells

Auteurs: Yohei Otsuka, Eri Watanabe, Eiji Shinya, Sadayuki Okura, Hidehisa Saeki, Teunis B. H. Geijtenbeek, Hidemi Takahashi
Publié dans: The Journal of Immunology, Issue 201/10, 2018, Page(s) 3006-3016, ISSN 0022-1767
DOI: 10.4049/jimmunol.1701402