HIV-1 sensing and signaling in dendritic cells

Informacje na temat projektu

SENTINEL

Identyfikator umowy o grant: 670424

DOI 10.3030/670424

Projekt został zamknięty

Data podpisania przez KE 27 Sierpnia 2015

Data rozpoczęcia 1 Października 2015

Data zakończenia 30 Września 2020

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity € 2 499 156,25

Wkład UE € 2 499 156,00

Koordynowany przez

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

Publikacje

Peer reviewed articles (22)

MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals

Autorzy: Melissa Stunnenberg, Lisa van Pul, Joris K. Sprokholt, Karel A. van Dort, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra
Opublikowane w: Viruses, Numer 12/7, 2020, Strona(/y) 764, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070764

Separate signaling events control TCR downregulation and T cell activation in primary human T cells

Autorzy: Lieve E. H. Donk, Louis S. Ates, Jet Spek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. Heijst
Opublikowane w: Immunity, Inflammation and Disease, Numer 9/1, 2021, Strona(/y) 223-238, ISSN 2050-4527
Wydawca: Wiley
DOI: 10.1002/iid3.383

RIG-I–like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and T H 1 Differentiation

Autorzy: Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Opublikowane w: The Journal of Immunology, Numer 198/12, 2017, Strona(/y) 4764-4771, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1602121

DDX3 in HIV-1 infection and sensing: A paradox

Autorzy: Melissa Stunnenberg, Teunis B.H. Geijtenbeek, Sonja I. Gringhuis
Opublikowane w: Cytokine & Growth Factor Reviews, Numer 40, 2018, Strona(/y) 32-39, ISSN 1359-6101
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.cytogfr.2018.03.001

C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

Autorzy: Marta Bermejo-Jambrina, Julia Eder, Leanne C. Helgers, Nina Hertoghs, Bernadien M. Nijmeijer, Melissa Stunnenberg, Teunis B. H. Geijtenbeek
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2018.00590

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production

Autorzy: Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Opublikowane w: PLOS Pathogens, Numer 13/11, 2017, Strona(/y) e1006738, ISSN 1553-7374
Wydawca: PLOS
DOI: 10.1371/journal.ppat.1006738

DCs facilitate B cell responses against microbial DNA via DC-SIGN

Autorzy: Joris K. Sprokholt, Marieke H. Heineke, Tanja M. Kaptein, John L. van Hamme, Teunis B. H. Geijtenbeek
Opublikowane w: PLOS ONE, Numer 12/10, 2017, Strona(/y) e0185580, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0185580

C-type lectin receptors in the control of T helper cell differentiation

Autorzy: Teunis B. H. Geijtenbeek, Sonja I. Gringhuis
Opublikowane w: Nature Reviews Immunology, Numer 16/7, 2016, Strona(/y) 433-448, ISSN 1474-1733
Wydawca: Nature Publishing Group
DOI: 10.1038/nri.2016.55

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

Autorzy: Carla M. S. Ribeiro, Ramin Sarrami-Forooshani, Laurentia C. Setiawan, Esther M. Zijlstra-Willems, John L. van Hamme, Wikky Tigchelaar, Nicole N. van der Wel, Neeltje A. Kootstra, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Opublikowane w: Nature, Numer 540/7633, 2016, Strona(/y) 448-452, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature20567

Interplay between HIV-1 innate sensing and restriction in mucosal dendritic cells: balancing defense and viral transmission

Autorzy: Nina Hertoghs, Teunis B.H. Geijtenbeek, Carla M.S. Ribeiro
Opublikowane w: Current Opinion in Virology, Numer 22, 2017, Strona(/y) 112-119, ISSN 1879-6257
Wydawca: Elsevier BV
DOI: 10.1016/j.coviro.2017.01.001

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

Autorzy: Sonja I Gringhuis, Nina Hertoghs, Tanja M Kaptein, Esther M Zijlstra-Willems, Ramin Sarrami-Fooroshani, Joris K Sprokholt, Nienke H van Teijlingen, Neeltje A Kootstra, Thijs Booiman, Karel A van Dort, Carla M S Ribeiro, Agata Drewniak, Teunis B H Geijtenbeek
Opublikowane w: Nature Immunology, Numer 18/2, 2016, Strona(/y) 225-235, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/ni.3647

Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission

Autorzy: Bernadien M. Nijmeijer, Julia Eder, Catharina J. M. Langedijk, Tanja M. Kaptein, Sofie Meeussen, Pascale Zimmermann, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2020.00503

Various Tastes of Sugar: The Potential of Glycosylation in Targeting and Modulating Human Immunity via C-Type Lectin Receptors

Autorzy: Stefanie Busold, Noémi A. Nagy, Sander W. Tas, Ronald van Ree, Esther C. de Jong, Teunis B. H. Geijtenbeek
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, ISSN 1664-3224
Wydawca: frontiers
DOI: 10.3389/fimmu.2020.00134

Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity

Autorzy: Melissa Stunnenberg, Joris K. Sprokholt, John L. van Hamme, Tanja M. Kaptein, Esther M. Zijlstra-Willems, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2020.00008

Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells

Autorzy: Nienke H. van Teijlingen, Leanne C. Helgers, Esther M. Zijlstra - Willems, John L. van Hamme, Carla M.S. Ribeiro, Karin Strijbis, Teunis B.H. Geijtenbeek
Opublikowane w: Journal of Reproductive Immunology, Numer 138, 2020, Strona(/y) 103085, ISSN 0165-0378
Wydawca: Elsevier BV
DOI: 10.1016/j.jri.2020.103085

Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction

Autorzy: Nina Hertoghs, Bernadien M. Nijmeijer, Nienke H. van Teijlingen, Angharad E. Fenton-May, Tanja M. Kaptein, John L. van Hamme, John C. Kappes, Neeltje A. Kootstra, Beatrice H. Hahn, Persephone Borrow, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Opublikowane w: PLOS ONE, Numer 14/12, 2019, Strona(/y) e0226651, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0226651

Borrelia miyamotoi Activates Human Dendritic Cells and Elicits T Cell Responses

Autorzy: Lauren M. K. Mason, Joris Koetsveld, Jos J. A. Trentelman, Tanja M. Kaptein, Dieuwertje Hoornstra, Alex Wagemakers, Michelle M. Fikrig, Jasmin I. Ersoz, Anneke Oei, Teunis B. H. Geijtenbeek, Joppe W. R. Hovius
Opublikowane w: The Journal of Immunology, Numer 204/2, 2020, Strona(/y) 386-393, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1801589

Sexually transmitted hepatitis C virus infections: current trends, and recent advances in understanding the spread in men who have sex with men

Autorzy: Bernadien M Nijmeijer, Jelle Koopsen, Janke Schinkel, Maria Prins, Teunis BH Geijtenbeek
Opublikowane w: Journal of the International AIDS Society, Numer 22/S6, 2019, ISSN 1758-2652
Wydawca: International AIDS Society
DOI: 10.1002/jia2.25348

Negative and Positive Selection Pressure During Sexual Transmission of Transmitted Founder HIV-1

Autorzy: Bernadien M. Nijmeijer, Teunis B. H. Geijtenbeek
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2019.01599

HIV ‐1 exposure and immune activation enhance sexual transmission of Hepatitis C virus by primary Langerhans cells

Autorzy: Bernadien M Nijmeijer, Ramin Sarrami‐Forooshani, Gaby S Steba, Renée RCE Schreurs, Sylvie M Koekkoek, Richard Molenkamp, Janke Schinkel, Peter Reiss, Matthijs L Siegenbeek van Heukelom, Marc Valk, Carla MS Ribeiro, Teunis BH Geijtenbeek
Opublikowane w: Journal of the International AIDS Society, Numer 22/3, 2019, Strona(/y) e25268, ISSN 1758-2652
Wydawca: International AIDS Society
DOI: 10.1002/jia2.25268

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Autorzy: Renée R.C.E. Schreurs, Martin E. Baumdick, Adrian F. Sagebiel, Max Kaufmann, Michal Mokry, Paul L. Klarenbeek, Nicola Schaltenberg, Fenja L. Steinert, Jorik M. van Rijn, Agata Drewniak, Sarah-May M.L. The, Roel Bakx, Joep P.M. Derikx, Niek de Vries, Willemijn E. Corpeleijn, Steven T. Pals, Nicola Gagliani, Manuel A. Friese, Sabine Middendorp, Edward E.S. Nieuwenhuis, Konrad Reinshagen, Teunis B.H
Opublikowane w: Immunity, Numer 50/2, 2019, Strona(/y) 462-476.e8, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2018.12.010

Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22–Specific Th Cells

Autorzy: Yohei Otsuka, Eri Watanabe, Eiji Shinya, Sadayuki Okura, Hidehisa Saeki, Teunis B. H. Geijtenbeek, Hidemi Takahashi
Opublikowane w: The Journal of Immunology, Numer 201/10, 2018, Strona(/y) 3006-3016, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1701402