Cochlear Optogenetics for Auditory Research and Prosthetics

Project Information

OptoHear

Grant agreement ID: 670759

DOI 10.3030/670759

Project closed

EC signature date 4 November 2015

Start date 1 December 2015

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 496 405,00

EU contribution € 2 496 405,00

Coordinated by

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany

Publications

Peer reviewed articles (21)

Understanding and treating paediatric hearing impairment.

Author(s): Christian Wrobel; Maria-Patapia Zafeiriou; Tobias Moser
Published in: EBioMedicine, Issue 63, 2021, Page(s) 103171-, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2020.103171

En route to sound coding strategies for optical cochlear implants

Author(s): Lakshay Khurana; Tamas Harczos; Tobias Moser; Lukasz Jablonski
Published in: iScience, Issue 26(10), 2023, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2023.107725

Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway

Author(s): Burak Bali, David Lopez de la Morena, Artur Mittring, Thomas Mager, Vladan Rankovic, Antoine Tarquin Huet, Tobias Moser
Published in: EMBO Molecular Medicine, Issue 13/6, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013391

Towards optogenetic approaches for hearing restoration

Author(s): Tobias Moser, Alexander Dieter
Published in: Biochemical and Biophysical Research Communications, Issue 527/2, 2020, Page(s) 337-342, ISSN 0006-291X
Publisher: Academic Press
DOI: 10.1016/j.bbrc.2019.12.126

Restoring Hearing with Light

Author(s): Moser, T
Published in: GMS Zeitschrift für Audiologie - Audiological Acoustics; VOL: 5; DOC01 /20230120/, Issue 5, 2023, ISSN 2628-9083
Publisher: Deutsche Gesellschaft für Audiologie

Multiscale photonic imaging of the native and implanted cochlea

Author(s): Daniel Keppeler, Christoph A. Kampshoff, Anupriya Thirumalai, Carlos J. Duque-Afonso, Jannis J. Schaeper, Tabea Quilitz, Mareike Töpperwien, Christian Vogl, Roland Hessler, Alexander Meyer, Tim Salditt, Tobias Moser
Published in: Proceedings of the National Academy of Sciences of the USA, Issue 118(18), 2021, Page(s) e2014472118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2014472118

Towards the optical cochlear implant: optogenetic approaches for hearing restoration

Author(s): Alexander Dieter, Daniel Keppeler, Tobias Moser
Published in: EMBO Molecular Medicine, Issue 12/4, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911618

Fast photoswitchable molecular prosthetics control neuronal activity in the cochlea

Author(s): G. Aida; H. Antoine; C. Matera; T. Anupriya; T. Anupriya; L. Amadeu; M. Tobias; M. Tobias; G. Pau
Published in: ournal of the American Chemical Society, Issue 144, 21, 2022, Page(s) 9229-9239, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1101/2021.05.25.445123

Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice

Author(s): Burak Bali; Eva Gruber-Dujardin; Kathrin Kusch; Vladan Rankovic; Tobias Moser
Published in: Life Science Alliance, Issue 5(8), 2022, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/lsa.202101338

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

Author(s): Hunniford, Victoria; Kühler, Robert; Wolf, Bettina; Keppeler, Daniel; Strenzke, Nicola; Moser, Tobias; Hunniford, Victoria; 1Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany; Kühler, Robert; 3Department of Otolaryngology, University Medical Center Göttingen, Göttingen, Germany; Wolf, Bettina; 1Institute for Auditory Neuroscience and
Published in: Frontiers in Neuroscience, Issue 17, 2023, ISSN 1662-4548
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnins.2023.1105562

Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source

Author(s): Mareike Töpperwien, Regine Gradl, Daniel Keppeler, Malte Vassholz, Alexander Meyer, Roland Hessler, Klaus Achterhold, Bernhard Gleich, Martin Dierolf, Franz Pfeiffer, Tobias Moser, Tim Salditt
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-23144-5

High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics

Author(s): Thomas Mager, David Lopez de la Morena, Verena Senn, Johannes Schlotte, Anna D´Errico, Katrin Feldbauer, Christian Wrobel, Sangyong Jung, Kai Bodensiek, Vladan Rankovic, Lorcan Browne, Antoine Huet, Josephine Jüttner, Phillip G. Wood, Johannes J. Letzkus, Tobias Moser, Ernst Bamberg
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04146-3

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

Author(s): Christian Wrobel, Alexander Dieter, Antoine Huet, Daniel Keppeler, Carlos J. Duque-Afonso, Christian Vogl, Gerhard Hoch, Marcus Jeschke, Tobias Moser
Published in: Science Translational Medicine, Issue 10/449, 2018, Page(s) eaao0540, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aao0540

Near physiological spectral selectivity of cochlear optogenetics

Author(s): Alexander Dieter, Carlos J. Duque-Afonso, Vladan Rankovic, Marcus Jeschke, Tobias Moser
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09980-7

Ultrafast optogenetic stimulation of the auditory pathway by targeting‐optimized Chronos

Author(s): Daniel Keppeler, Ricardo Martins Merino, David Lopez de la Morena, Burak Bali, Antoine Tarquin Huet, Anna Gehrt, Christian Wrobel, Swati Subramanian, Tobias Dombrowski, Fred Wolf, Vladan Rankovic, Andreas Neef, Tobias Moser
Published in: The EMBO Journal, Issue 37/24, 2018, Page(s) e99649, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201899649

μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve

Author(s): Alexander Dieter, Eric Klein, Daniel Keppeler, Lukasz Jablonski, Tamas Harczos, Gerhard Hoch, Vladan Rankovic, Oliver Paul, Marcus Jeschke, Patrick Ruther, Tobias Moser
Published in: EMBO Molecular Medicine, Issue e12387, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012387

Viral rhodopsins 1 are an unique family of light-gated cation channels

Author(s): Dmitrii Zabelskii, Alexey Alekseev, Kirill Kovalev, Vladan Rankovic, Taras Balandin, Dmytro Soloviov, Dmitry Bratanov, Ekaterina Savelyeva, Elizaveta Podolyak, Dmytro Volkov, Svetlana Vaganova, Roman Astashkin, Igor Chizhov, Natalia Yutin, Maksim Rulev, Alexander Popov, Ana-Sofia Eria-Oliveira, Tatiana Rokitskaya, Thomas Mager, Yuri Antonenko, Riccardo Rosselli, Grigoriy Armeev, Konstantin Shaitan
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19457-7

Developing Fast, Red-Light Optogenetic Stimulation of Spiral Ganglion Neurons for Future Optical Cochlear Implants

Author(s): Antoine Tarquin Huet, Tobias Dombrowski, Vladan Rankovic, Anupriya Thirumalai, Tobias Moser
Published in: Frontiers in Molecular Neuroscience, Issue 14, 2021, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.635897

Devising a framework of optogenetic coding in the auditory pathway: Insights from auditory midbrain recordings

Author(s): Maria Michael; Bettina Julia Wolf; Astrid Klinge-Strahl; Marcus Jeschke; Tobias Moser; Alexander Dieter
Published in: Brain Stimulation, Issue 16, 2023, Page(s) 1486-1500, ISSN 1935-861X
Publisher: Elsevier BV
DOI: 10.1016/j.brs.2023.09.018

Graded optogenetic activation of the auditory pathway for hearing restoration

Author(s): Artur Mittring; Tobias Moser; Antoine Huet
Published in: Brain Stimulation, Issue 16(2), 2024, Page(s) 466-483, ISSN 1935-861X
Publisher: Elsevier BV
DOI: 10.1101/2022.09.05.506618

Is there an unmet medical need for improved hearing restoration?

Author(s): Bettina Julia Wolf; Kathrin Kusch; Victoria Hunniford; Barbara Vona; Robert Kühler; Daniel Keppeler; Nicola Strenzke; Tobias Moser
Published in: Embo Molecular Medicine, Issue 14:e15798, 2022, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202215798

Intellectual Property Rights

Patent (1)

MUTANT LIGHT-INDUCIBLE ION CHANNEL OF CHRIMSON

Application/Publication number: 20 17063458
Date: 2017-06-02