Structural, genetic and functional analyses of broadly neutralizing antibodies against human pathogens

Project Information

BROADimmune

Grant agreement ID: 670955

DOI 10.3030/670955

Project closed

EC signature date 30 September 2015

Start date 1 October 2015

End date 30 September 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 867 500,00

EU contribution € 1 867 500,00

Coordinated by

FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland

Publications

Peer reviewed articles (10)

Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation

Author(s): Crystal Sao-Fong Cheung, Alexander Fruehwirth, Philipp Carl Georg Paparoditis, Chen-Hsiang Shen, Mathilde Foglierini, M. Gordon Joyce, Kwanyee Leung, Luca Piccoli, Reda Rawi, Chiara Silacci-Fregni, Yaroslav Tsybovsky, Raffaello Verardi, Lingshu Wang, Shuishu Wang, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Gwo-Yu Chuang, Davide Corti, John R. Mascola, Lawrence Shapiro, Peter D. Kwong, Antonio Lanzave
Published in: Cell Reports, Issue 32/9, 2020, Page(s) 108088, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108088

The Antibody Response to Plasmodium falciparum: Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies.

Author(s): Tan, J., L. Piccoli and A. Lanzavecchia
Published in: Ann Rev Immunol, 2019, Page(s) 225-246, ISSN 0732-0582
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-042617-053301

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

Author(s): Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli, Sonia Barbieri, Mathilde Foglierini, Chiara Silacci Fregni, Jessica Marcandalli, Said Jongo, Salim Abdulla, Laurent Perez, Giampietro Corradin, Luca Varani, Federica Sallusto, Betty Kim Lee Sim, Stephen L Hoffman, Stefan H I Kappe, Claudia Daubenberger, Ian A Wilson, Antonio Lanzavecchia
Published in: Nature Medicine, Issue 24/4, 2018, Page(s) 401-407, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4513

Dissecting human antibody responses: useful, basic and surprising findings

Author(s): Antonio Lanzavecchia
Published in: EMBO Molecular Medicine, Issue 10/3, 2018, Page(s) e8879, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201808879

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

Author(s): Kathrin Pieper, Joshua Tan, Luca Piccoli, Mathilde Foglierini, Sonia Barbieri, Yiwei Chen, Chiara Silacci-Fregni, Tobias Wolf, David Jarrossay, Marica Anderle, Abdirahman Abdi, Francis M. Ndungu, Ogobara K. Doumbo, Boubacar Traore, Tuan M. Tran, Said Jongo, Isabelle Zenklusen, Peter D. Crompton, Claudia Daubenberger, Peter C. Bull, Federica Sallusto, Antonio Lanzavecchia
Published in: Nature, Issue 548/7669, 2017, Page(s) 597-601, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature23670

Antibody-guided vaccine design: identification of protective epitopes

Author(s): Antonio Lanzavecchia, Alexander Frühwirth, Laurent Perez, Davide Corti
Published in: Current Opinion in Immunology, Issue 41, 2016, Page(s) 62-67, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2016.06.001

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

Author(s): Nicole L. Kallewaard, Davide Corti, Patrick J. Collins, Ursula Neu, Josephine M. McAuliffe, Ebony Benjamin, Leslie Wachter-Rosati, Frances J. Palmer-Hill, Andy Q. Yuan, Philip A. Walker, Matthias K. Vorlaender, Siro Bianchi, Barbara Guarino, Anna De Marco, Fabrizia Vanzetta, Gloria Agatic, Mathilde Foglierini, Debora Pinna, Blanca Fernandez-Rodriguez, Alexander Fruehwirth, Chiara Silacci, Roksana
Published in: Cell, Issue 166/3, 2016, Page(s) 596-608, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2016.05.073

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

Author(s): Joshua Tan, Kathrin Pieper, Luca Piccoli, Abdirahman Abdi, Mathilde Foglierini, Roger Geiger, Claire Maria Tully, David Jarrossay, Francis Maina Ndungu, Juliana Wambua, Philip Bejon, Chiara Silacci Fregni, Blanca Fernandez-Rodriguez, Sonia Barbieri, Siro Bianchi, Kevin Marsh, Vandana Thathy, Davide Corti, Federica Sallusto, Peter Bull, Antonio Lanzavecchia
Published in: Nature, Issue 529/7584, 2015, Page(s) 105-109, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature16450

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4

Author(s): Guillaume B. E. Stewart-Jones, Gwo-Yu Chuang, Kai Xu, Tongqing Zhou, Priyamvada Acharya, Yaroslav Tsybovsky, Li Ou, Baoshan Zhang, Blanca Fernandez-Rodriguez, Valentina Gilardi, Chiara Silacci-Fregni, Martina Beltramello, Ulrich Baxa, Aliaksandr Druz, Wing-Pui Kong, Paul V. Thomas, Yongping Yang, Kathryn E. Foulds, John-Paul Todd, Hui Wei, Andres M. Salazar, Diana G. Scorpio, Bridget Carragher, Cl
Published in: Proceedings of the National Academy of Sciences, Issue 115/48, 2018, Page(s) 12265-12270, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1811980115

Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations

Author(s): Jiwon Lee, Philipp Paparoditis, Andrew P. Horton, Alexander Frühwirth, Jonathan R. McDaniel, Jiwon Jung, Daniel R. Boutz, Dania A. Hussein, Yuri Tanno, Leontios Pappas, Gregory C. Ippolito, Davide Corti, Antonio Lanzavecchia, George Georgiou
Published in: Cell Host & Microbe, Issue 25/3, 2019, Page(s) 367-376.e5, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.01.010

Intellectual Property Rights

Patent (2)

“Novel malaria vaccines and antibodies binding to plasmodium sporozoites”

Application/Publication number: PCT PCT/EP2018/060113
Date: 2017-04-19
Applicant(s): FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA

“Novel malaria vaccines and antibodies binding to plasmodium sporozoites”

Application/Publication number: PCT PCT/EP2018/060113
Date: 2017-04-19
Applicant(s): FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA