Structural, genetic and functional analyses of broadly neutralizing antibodies against human pathogens

Publications

Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation

Auteurs: Crystal Sao-Fong Cheung, Alexander Fruehwirth, Philipp Carl Georg Paparoditis, Chen-Hsiang Shen, Mathilde Foglierini, M. Gordon Joyce, Kwanyee Leung, Luca Piccoli, Reda Rawi, Chiara Silacci-Fregni, Yaroslav Tsybovsky, Raffaello Verardi, Lingshu Wang, Shuishu Wang, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Gwo-Yu Chuang, Davide Corti, John R. Mascola, Lawrence Shapiro, Peter D. Kwong, Antonio Lanzave
Publié dans: Cell Reports, Numéro 32/9, 2020, Page(s) 108088, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.108088

The Antibody Response to Plasmodium falciparum: Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies.

Auteurs: Tan, J., L. Piccoli and A. Lanzavecchia
Publié dans: Ann Rev Immunol, 2019, Page(s) 225-246, ISSN 0732-0582
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-042617-053301

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

Auteurs: Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli, Sonia Barbieri, Mathilde Foglierini, Chiara Silacci Fregni, Jessica Marcandalli, Said Jongo, Salim Abdulla, Laurent Perez, Giampietro Corradin, Luca Varani, Federica Sallusto, Betty Kim Lee Sim, Stephen L Hoffman, Stefan H I Kappe, Claudia Daubenberger, Ian A Wilson, Antonio Lanzavecchia
Publié dans: Nature Medicine, Numéro 24/4, 2018, Page(s) 401-407, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/nm.4513

Dissecting human antibody responses: useful, basic and surprising findings

Auteurs: Antonio Lanzavecchia
Publié dans: EMBO Molecular Medicine, Numéro 10/3, 2018, Page(s) e8879, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201808879

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

Auteurs: Kathrin Pieper, Joshua Tan, Luca Piccoli, Mathilde Foglierini, Sonia Barbieri, Yiwei Chen, Chiara Silacci-Fregni, Tobias Wolf, David Jarrossay, Marica Anderle, Abdirahman Abdi, Francis M. Ndungu, Ogobara K. Doumbo, Boubacar Traore, Tuan M. Tran, Said Jongo, Isabelle Zenklusen, Peter D. Crompton, Claudia Daubenberger, Peter C. Bull, Federica Sallusto, Antonio Lanzavecchia
Publié dans: Nature, Numéro 548/7669, 2017, Page(s) 597-601, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature23670

Antibody-guided vaccine design: identification of protective epitopes

Auteurs: Antonio Lanzavecchia, Alexander Frühwirth, Laurent Perez, Davide Corti
Publié dans: Current Opinion in Immunology, Numéro 41, 2016, Page(s) 62-67, ISSN 0952-7915
Éditeur: Elsevier BV
DOI: 10.1016/j.coi.2016.06.001

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

Auteurs: Nicole L. Kallewaard, Davide Corti, Patrick J. Collins, Ursula Neu, Josephine M. McAuliffe, Ebony Benjamin, Leslie Wachter-Rosati, Frances J. Palmer-Hill, Andy Q. Yuan, Philip A. Walker, Matthias K. Vorlaender, Siro Bianchi, Barbara Guarino, Anna De Marco, Fabrizia Vanzetta, Gloria Agatic, Mathilde Foglierini, Debora Pinna, Blanca Fernandez-Rodriguez, Alexander Fruehwirth, Chiara Silacci, Roksana
Publié dans: Cell, Numéro 166/3, 2016, Page(s) 596-608, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2016.05.073

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

Auteurs: Joshua Tan, Kathrin Pieper, Luca Piccoli, Abdirahman Abdi, Mathilde Foglierini, Roger Geiger, Claire Maria Tully, David Jarrossay, Francis Maina Ndungu, Juliana Wambua, Philip Bejon, Chiara Silacci Fregni, Blanca Fernandez-Rodriguez, Sonia Barbieri, Siro Bianchi, Kevin Marsh, Vandana Thathy, Davide Corti, Federica Sallusto, Peter Bull, Antonio Lanzavecchia
Publié dans: Nature, Numéro 529/7584, 2015, Page(s) 105-109, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature16450

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4

Auteurs: Guillaume B. E. Stewart-Jones, Gwo-Yu Chuang, Kai Xu, Tongqing Zhou, Priyamvada Acharya, Yaroslav Tsybovsky, Li Ou, Baoshan Zhang, Blanca Fernandez-Rodriguez, Valentina Gilardi, Chiara Silacci-Fregni, Martina Beltramello, Ulrich Baxa, Aliaksandr Druz, Wing-Pui Kong, Paul V. Thomas, Yongping Yang, Kathryn E. Foulds, John-Paul Todd, Hui Wei, Andres M. Salazar, Diana G. Scorpio, Bridget Carragher, Cl
Publié dans: Proceedings of the National Academy of Sciences, Numéro 115/48, 2018, Page(s) 12265-12270, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1811980115

Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations

Auteurs: Jiwon Lee, Philipp Paparoditis, Andrew P. Horton, Alexander Frühwirth, Jonathan R. McDaniel, Jiwon Jung, Daniel R. Boutz, Dania A. Hussein, Yuri Tanno, Leontios Pappas, Gregory C. Ippolito, Davide Corti, Antonio Lanzavecchia, George Georgiou
Publié dans: Cell Host & Microbe, Numéro 25/3, 2019, Page(s) 367-376.e5, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2019.01.010

Droits de propriété intellectuelle

“Novel malaria vaccines and antibodies binding to plasmodium sporozoites”

Numéro de demande/publication: PCT PCT/EP2018/060113
Date: 2017-04-19
Demandeur(s): FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA

“Novel malaria vaccines and antibodies binding to plasmodium sporozoites”

Numéro de demande/publication: PCT PCT/EP2018/060113
Date: 2017-04-19
Demandeur(s): FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA

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