Exploring mechanisms of gene repression and escape during X-chromosome inactivation

Project Information

XPRESS

Grant agreement ID: 671027

DOI

10.3030/671027

Project closed

EC signature date 23 September 2015

Start date 1 November 2015

End date 30 April 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 312 500,00

EU contribution

€ 2 312 500,00

Coordinated by

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

The Molecular and Nuclear Dynamics of X-Chromosome Inactivation

Author(s): François Dossin, Edith Heard
Published in: Cold Spring Harbor Perspectives in Biology, 2021, Page(s) a040196, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a040196

Parental-to-embryo switch of chromosome organization in early embryogenesis

Author(s): Samuel Collombet, Noémie Ranisavljevic, Takashi Nagano, Csilla Varnai, Tarak Shisode, Wing Leung, Tristan Piolot, Rafael Galupa, Maud Borensztein, Nicolas Servant, Peter Fraser, Katia Ancelin, Edith Heard
Published in: Nature, Issue 580/7801, 2020, Page(s) 142-146, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2125-z

The Implication of Early Chromatin Changes in X Chromosome Inactivation

Author(s): Jan Jakub Żylicz, Aurélie Bousard, Kristina Žumer, Francois Dossin, Eusra Mohammad, Simão Teixeira da Rocha, Björn Schwalb, Laurène Syx, Florent Dingli, Damarys Loew, Patrick Cramer, Edith Heard
Published in: Cell, Issue 176/1-2, 2019, Page(s) 182-197.e23, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.11.041

H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing

Author(s): Sjoerd J D Tjalsma, Mayako Hori, Yuko Sato, Aurelie Bousard, Akito Ohi, Ana Cláudia Raposo, Julia Roensch, Agnes Le Saux, Jumpei Nogami, Kazumitsu Maehara, Tomoya Kujirai, Tetsuya Handa, Sandra Bagés‐Arnal, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Simão Teixeira da Rocha, Jan J Żylicz, Hiroshi Kimura, Edith Heard
Published in: EMBO reports, Issue 22/3, 2021, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202051989

Locus specific epigenetic modalities of random allelic expression imbalance

Author(s): Lucile Marion-Poll, Benjamin Forêt, Dina Zielinski, Florian Massip, Mikael Attia, Ava C. Carter, Laurène Syx, Howard Y. Chang, Anne-Valerie Gendrel, Edith Heard
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25630-3

X chromosome inactivation: new players in the initiation of gene silencing

Author(s): Ines Pinheiro, Edith Heard
Published in: F1000Research, Issue 6, 2017, Page(s) 344, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.10707.1

Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease, and Evolution

Author(s): Rafael Galupa, Edith Heard
Published in: Cold Spring Harbor Symposia on Quantitative Biology, Issue 82, 2017, Page(s) 267-278, ISSN 0091-7451
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/sqb.2017.82.035030

Closing the loop: 3C versus DNA FISH

Author(s): Luca Giorgetti, Edith Heard
Published in: Genome Biology, Issue 17/1, 2016, ISSN 1474-760X
Publisher: biomedcentral
DOI: 10.1186/s13059-016-1081-2

Structural organization of the inactive X chromosome in the mouse

Author(s): Luca Giorgetti, Bryan R. Lajoie, Ava C. Carter, Mikael Attia, Ye Zhan, Jin Xu, Chong Jian Chen, Noam Kaplan, Howard Y. Chang, Edith Heard, Job Dekker
Published in: Nature, Issue 535/7613, 2016, Page(s) 575-579, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature18589

Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation

Author(s): Simão T da Rocha, Edith Heard
Published in: Nature Structural & Molecular Biology, Issue 24/3, 2017, Page(s) 197-204, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3370

SPEN integrates transcriptional and epigenetic control of X-inactivation

Author(s): François Dossin, Inês Pinheiro, Jan J. Żylicz, Julia Roensch, Samuel Collombet, Agnès Le Saux, Tomasz Chelmicki, Mikaël Attia, Varun Kapoor, Ye Zhan, Florent Dingli, Damarys Loew, Thomas Mercher, Job Dekker, Edith Heard
Published in: Nature, Issue 578/7795, 2020, Page(s) 455-460, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-1974-9

The role of Xist ‐mediated Polycomb recruitment in the initiation of X‐chromosome inactivation

Author(s): Aurélie Bousard, Ana Cláudia Raposo, Jan Jakub Żylicz, Christel Picard, Vanessa Borges Pires, Yanyan Qi, Cláudia Gil, Laurène Syx, Howard Y Chang, Edith Heard, Simão Teixeira da Rocha
Published in: EMBO reports, Issue 20/10, 2019, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201948019

Kinetics of Xist -induced gene silencing can be predicted from combinations of epigenetic and genomic features

Author(s): Lisa Barros de Andrade e Sousa, Iris Jonkers, Laurène Syx, Ilona Dunkel, Julie Chaumeil, Christel Picard, Benjamin Foret, Chong-Jian Chen, John T. Lis, Edith Heard, Edda G. Schulz, Annalisa Marsico
Published in: Genome Research, Issue 29/7, 2019, Page(s) 1087-1099, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.245027.118

In-cell identification and measurement of RNA-protein interactions

Author(s): Antoine Graindorge, Inês Pinheiro, Anna Nawrocka, Allison C. Mallory, Peter Tsvetkov, Noa Gil, Carlo Carolis, Frank Buchholz, Igor Ulitsky, Edith Heard, Mikko Taipale, Alena Shkumatava
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13235-w

Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective

Author(s): Jan J. Żylicz, Edith Heard
Published in: Annual Review of Biochemistry, Issue 89/1, 2020, Page(s) 255-282, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-062917-012655

A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

Author(s): Rafael Galupa, Elphège Pierre Nora, Rebecca Worsley-Hunt, Christel Picard, Chris Gard, Joke Gerarda van Bemmel, Nicolas Servant, Yinxiu Zhan, Fatima El Marjou, Colin Johanneau, Patricia Diabangouaya, Agnès Le Saux, Sonia Lameiras, Juliana Pipoli da Fonseca, Friedemann Loos, Joost Gribnau, Sylvain Baulande, Uwe Ohler, Luca Giorgetti, Edith Heard
Published in: Molecular Cell, Issue 77/2, 2020, Page(s) 352-367.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.10.030