Resultado final
Publication results in Scientific journals and at international conferences and workshops. Easy-to-read information material for the society at large.
Aggregation propensity assessed for all proteinsAggregation propensity - including surface induced aggregation propensity - assessed for all proteins.
Weak and strong protein-protein and protein-excipient interactions are identified.For all proteins in the library the relevant weak and strong protein-protein and protein-excipient interactions are identified.
Structures based on measurements and modelingFor all soluble proteins, there will be at least 1 but preferable 2 or more solution structures based on SAXS measurements and in-silico modeling
Tagg and Tgel are determined for each proteinFor each protein the determination of the temperature of aggregation, Tagg, and gelation, Tgel, using light scattering experiments, differential scanning calorimetry and temperature ramp rheology Measurements.
Protocols for the making of screens 1 and 2 establishedA general protocol for the making of the screens 1 and 2 that are used for all proteins should be ready
International conferenceInternational conferences with contribution from all ESRs as well as external contributions.
Model for the prediction of protein aggregation and stabilityA general model for the prediction of protein aggregation and stability of all proteins
Database with web-based graphical interface will be made public accessible
Project websiteEstablishment of a PIPPI website with a password protected area and a publically accessible area.
For all ESRs a personal carrier Development plan will be ready.
Periodic, financial and final reports to the ECReports will be delivered to the EC periodically. This covers also the Financial reports. A report will be given in when the project finishes.
Evaluation report on training activitiesFor all training activities an evaluation report will be ready
Publicaciones
Autores:
Matja Zalar, Hristo Svilenov, Alexander Golovanov
Publicado en:
European Journal of Pharmaceutics and Biopharmaceutics, 2020, Página(s) 127-136, ISSN 0939-6411
Editor:
Elsevier BV
DOI:
10.1016/j.ejpb.2020.04.002
Autores:
Christin Pohl, Matja Zalar, Inas El Bialy, Sowmya Indrakumar, Günther H. J. Peters, Wolfgang Friess, Alexander P. Golovanov, Werner W. Streicher, Allan Noergaard, and Pernille Harris
Publicado en:
Molecular Pharmaceutics, 2020, ISSN 1543-8384
Editor:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.0c00406
Autores:
Sujata Mahapatra, Marco Polimeni, Lorenzo Gentiluomo , Dierk Roessner , Wolfgang Frieß , Günther H J Peters , Werner W Streicher , Mikael Lund , Pernille Harris
Publicado en:
Molecular Pharmaceutics, 2022, ISSN 1543-8384
Editor:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.1c00627
Autores:
Lorenzo Gentiluomo; Dierk Roessner, Wolfgan Frieß
Publicado en:
International Journal of Pharmaceutics, 2020, ISSN 0378-5173
Editor:
Elsevier BV
DOI:
10.1016/j.ijpharm.2020.119039
Autores:
Roche, A., Gentiluomo, L., Sibanda, N., Roessner, D., Friess, W., Trainoff, S. P., & Curtis, R.
Publicado en:
Journal of Colloid and Interface Science, 2022, ISSN 0021-9797
Editor:
Academic Press
DOI:
10.1016/j.jcis.2021.08.191
Autores:
Hristo Svilenov, Uroš Markoja, Gerhard Winter
Publicado en:
European Journal of Pharmaceutics and Biopharmaceutics, Edición 125, 2018, Página(s) 106-113, ISSN 0939-6411
Editor:
Elsevier BV
DOI:
10.1016/j.ejpb.2018.01.004
Autores:
Hristo Svilenov, Lorenzo Gentiluomo, Wolfgang Friess, Dierk Roessner, Gerhard Winter
Publicado en:
Journal of Pharmaceutical Sciences, Edición 107/12, 2018, Página(s) 3007-3013, ISSN 0022-3549
Editor:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2018.08.004
Autores:
Matja Zalar, Alexander P. Golovanov
Publicado en:
ACS Omega, Edición 4/19, 2019, Página(s) 18248-18256, ISSN 2470-1343
Editor:
Americal Chemical Society
DOI:
10.1021/acsomega.9b02269
Autores:
Roberto Fernandez-Alvarez, Žiga Medoš, Zdeněk Tošner, Alexander Zhigunov, Mariusz Uchman, Stefan Hervø-Hansen, Mikael Lund, Marija Bešter-Rogač, Pavel Matějíček
Publicado en:
Langmuir, Edición 34/47, 2018, Página(s) 14448-14457, ISSN 0743-7463
Editor:
American Chemical Society
DOI:
10.1021/acs.langmuir.8b03462
Autores:
Sowmya Indrakumar, Matja Zalar, Christin Pohl, Allan Nørgaard, Werner Streicher, Pernille Harris, Alexander P. Golovanov, Günther H.J. Peters
Publicado en:
The Journal of Physical Chemistry B, Edición 123/23, 2019, Página(s) 4867-4877, ISSN 1520-6106
Editor:
American Chemical Society
DOI:
10.1021/acs.jpcb.9b02370
Autores:
Matja Zalar, Sowmya Indrakumar, Colin W. Levy, Richard B. Tunnicliffe, Günther H. J. Peters, Alexander P. Golovanov
Publicado en:
Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor:
Nature Publishing Group
DOI:
10.1038/s41598-019-45565-6
Autores:
Dillen Augustijn, Sujata Mahapatra, Werner Streicher, Hristo Svilenov, Alina Kulakova, Christin Pohl, Åsmund Rinnan
Publicado en:
European Journal of Pharmaceutics and Biopharmaceutics, Edición 142, 2019, Página(s) 506-517, ISSN 0939-6411
Editor:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.06.001
Autores:
Marcello Martinez Morales, Matja Zalar, Silvia Sonzini, Alexander P. Golovanov, Christopher F. van der Walle, Jeremy P. Derrick
Publicado en:
Molecular Pharmaceutics, Edición 16/7, 2019, Página(s) 3100-3108, ISSN 1543-8384
Editor:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00338
Autores:
Hristo Svilenov, Gerhard Winter
Publicado en:
European Journal of Pharmaceutics and Biopharmaceutics, Edición 137, 2019, Página(s) 131-139, ISSN 0939-6411
Editor:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.02.018
Autores:
Silvia Sonzini, Maria Laura Greco, Thais Cailleau, Lauren Adams, Luke Masterson, Balakumar Vijayakrishnan, Conor Barry, Phillip Howard, Peter Ravn, Christopher F. van der Walle
Publicado en:
Bioconjugate Chemistry, 2019, ISSN 1043-1802
Editor:
American Chemical Society
DOI:
10.1021/acs.bioconjchem.9b00809
Autores:
Hristo Svilenov, Gerhard Winter
Publicado en:
International Journal of Pharmaceutics, Edición 562, 2019, Página(s) 42-50, ISSN 0378-5173
Editor:
Elsevier BV
DOI:
10.1016/j.ijpharm.2019.03.025
Autores:
Lorenzo Gentiluomo, Vanessa Schneider, Dierk Roessner, Wolfgang Frieß
Publicado en:
Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor:
Nature Publishing Group
DOI:
10.1038/s41598-019-51233-6
Autores:
Andreas Tosstorff, Tim Menzen, Gerhard Winter
Publicado en:
Journal of Pharmaceutical Sciences, Edición 109/1, 2020, Página(s) 301-307, ISSN 0022-3549
Editor:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.10.057
Autores:
Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
Publicado en:
Journal of Structural Biology: X, Edición 4, 2020, Página(s) 100017, ISSN 2590-1524
Editor:
Elsevier
DOI:
10.1016/j.yjsbx.2019.100017
Autores:
Lorenzo Gentiluomo, Hristo L. Svilenov, Dillen Augustijn, Inas El Bialy, Maria Laura Greco, Alina Kulakova, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Aisling Roche, Andreas Tosstorff, Robin Curtis, Jeremy P. Derrick, Allan Nørgaard, Tarik A. Khan, Günther H. J. Peters, Alain Pluen, Åsmund Rinnan, Werner W. Streicher, Christopher F. van der Walle, Shahid Uddi
Publicado en:
Molecular Pharmaceutics, 2020, ISSN 1543-8384
Editor:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00852
Autores:
Max Hebditch, Aisling Roche, Robin A. Curtis, Jim Warwicker
Publicado en:
Journal of Pharmaceutical Sciences, Edición 108/4, 2019, Página(s) 1434-1441, ISSN 0022-3549
Editor:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2018.11.035
Autores:
Lorenzo Gentiluomo, Dierk Roessner, Werner Streicher, Sujata Mahapatra, Pernille Harris, Wolfgang Frieß
Publicado en:
Journal of Pharmaceutical Sciences, Edición 109/1, 2020, Página(s) 443-451, ISSN 0022-3549
Editor:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.09.021
Autores:
Lorenzo Gentiluomo, Dierk Roessner, Dillen Augustijn, Hristo Svilenov, Alina Kulakova, Sujata Mahapatra, Gerhard Winter, Werner Streicher, Åsmund Rinnan, Günther H.J. Peters, Pernille Harris, Wolfgang Frieß
Publicado en:
European Journal of Pharmaceutics and Biopharmaceutics, Edición 141, 2019, Página(s) 81-89, ISSN 0939-6411
Editor:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.05.017
Autores:
Hristo L. Svilenov, Alina Kulakova, Matja Zalar, Alexander P. Golovanov, Pernille Harris, Gerhard Winter
Publicado en:
Journal of Pharmaceutical Sciences, Edición 109/1, 2020, Página(s) 584-594, ISSN 0022-3549
Editor:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.10.065
Autores:
Andreas Tosstorff, Hristo Svilenov, Günther H.J. Peters, Pernille Harris, Gerhard Winter
Publicado en:
European Journal of Pharmaceutics and Biopharmaceutics, Edición 144, 2019, Página(s) 207-216, ISSN 0939-6411
Editor:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.09.010
Autores:
Priyanka Singh, Aisling Roche, Christopher F. van der Walle, Shahid Uddin, Jiali Du, Jim Warwicker, Alain Pluen, Robin Curtis
Publicado en:
Molecular Pharmaceutics, Edición 16/12, 2019, Página(s) 4775-4786, ISSN 1543-8384
Editor:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00430
Autores:
Hristo Svilenov, Tim Menzen, Klaus Richter, Gerhard Winter
Publicado en:
Molecular Pharmaceutics, 2020, Página(s) 2638-2647, ISSN 1543-8392
Editor:
American Chemical Association
DOI:
10.1021/acs.molpharmaceut.0c00330
Autores:
Pernille Harris
Publicado en:
Impact, Edición 2017/8, 2017, Página(s) 75-77, ISSN 2398-7073
Editor:
Science Impact Ltd
DOI:
10.21820/23987073.2017.8.75
Autores:
A. Kulakova, S. Indrakumar, P. Sønderby, L. Gentiluomo, W. Streicher, D. Roessner, W. Frieß, G. H.J.
Peters, P. Harris
Publicado en:
bioRxiv, 2019
Editor:
Cold Spring Harbor Laborator
DOI:
10.1101/742957
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