Rezultaty
Publication results in Scientific journals and at international conferences and workshops. Easy-to-read information material for the society at large.
Aggregation propensity assessed for all proteinsAggregation propensity - including surface induced aggregation propensity - assessed for all proteins.
Weak and strong protein-protein and protein-excipient interactions are identified.For all proteins in the library the relevant weak and strong protein-protein and protein-excipient interactions are identified.
Structures based on measurements and modelingFor all soluble proteins, there will be at least 1 but preferable 2 or more solution structures based on SAXS measurements and in-silico modeling
Tagg and Tgel are determined for each proteinFor each protein the determination of the temperature of aggregation, Tagg, and gelation, Tgel, using light scattering experiments, differential scanning calorimetry and temperature ramp rheology Measurements.
Protocols for the making of screens 1 and 2 establishedA general protocol for the making of the screens 1 and 2 that are used for all proteins should be ready
International conferenceInternational conferences with contribution from all ESRs as well as external contributions.
Model for the prediction of protein aggregation and stabilityA general model for the prediction of protein aggregation and stability of all proteins
Database with web-based graphical interface will be made public accessible
Project websiteEstablishment of a PIPPI website with a password protected area and a publically accessible area.
For all ESRs a personal carrier Development plan will be ready.
Periodic, financial and final reports to the ECReports will be delivered to the EC periodically. This covers also the Financial reports. A report will be given in when the project finishes.
Evaluation report on training activitiesFor all training activities an evaluation report will be ready
Publikacje
Autorzy:
Matja Zalar, Hristo Svilenov, Alexander Golovanov
Opublikowane w:
European Journal of Pharmaceutics and Biopharmaceutics, 2020, Strona(/y) 127-136, ISSN 0939-6411
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejpb.2020.04.002
Autorzy:
Christin Pohl, Matja Zalar, Inas El Bialy, Sowmya Indrakumar, Günther H. J. Peters, Wolfgang Friess, Alexander P. Golovanov, Werner W. Streicher, Allan Noergaard, and Pernille Harris
Opublikowane w:
Molecular Pharmaceutics, 2020, ISSN 1543-8384
Wydawca:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.0c00406
Autorzy:
Sujata Mahapatra, Marco Polimeni, Lorenzo Gentiluomo , Dierk Roessner , Wolfgang Frieß , Günther H J Peters , Werner W Streicher , Mikael Lund , Pernille Harris
Opublikowane w:
Molecular Pharmaceutics, 2022, ISSN 1543-8384
Wydawca:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.1c00627
Autorzy:
Lorenzo Gentiluomo; Dierk Roessner, Wolfgan Frieß
Opublikowane w:
International Journal of Pharmaceutics, 2020, ISSN 0378-5173
Wydawca:
Elsevier BV
DOI:
10.1016/j.ijpharm.2020.119039
Autorzy:
Roche, A., Gentiluomo, L., Sibanda, N., Roessner, D., Friess, W., Trainoff, S. P., & Curtis, R.
Opublikowane w:
Journal of Colloid and Interface Science, 2022, ISSN 0021-9797
Wydawca:
Academic Press
DOI:
10.1016/j.jcis.2021.08.191
Autorzy:
Hristo Svilenov, Uroš Markoja, Gerhard Winter
Opublikowane w:
European Journal of Pharmaceutics and Biopharmaceutics, Numer 125, 2018, Strona(/y) 106-113, ISSN 0939-6411
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejpb.2018.01.004
Autorzy:
Hristo Svilenov, Lorenzo Gentiluomo, Wolfgang Friess, Dierk Roessner, Gerhard Winter
Opublikowane w:
Journal of Pharmaceutical Sciences, Numer 107/12, 2018, Strona(/y) 3007-3013, ISSN 0022-3549
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2018.08.004
Autorzy:
Matja Zalar, Alexander P. Golovanov
Opublikowane w:
ACS Omega, Numer 4/19, 2019, Strona(/y) 18248-18256, ISSN 2470-1343
Wydawca:
Americal Chemical Society
DOI:
10.1021/acsomega.9b02269
Autorzy:
Roberto Fernandez-Alvarez, Žiga Medoš, Zdeněk Tošner, Alexander Zhigunov, Mariusz Uchman, Stefan Hervø-Hansen, Mikael Lund, Marija Bešter-Rogač, Pavel Matějíček
Opublikowane w:
Langmuir, Numer 34/47, 2018, Strona(/y) 14448-14457, ISSN 0743-7463
Wydawca:
American Chemical Society
DOI:
10.1021/acs.langmuir.8b03462
Autorzy:
Sowmya Indrakumar, Matja Zalar, Christin Pohl, Allan Nørgaard, Werner Streicher, Pernille Harris, Alexander P. Golovanov, Günther H.J. Peters
Opublikowane w:
The Journal of Physical Chemistry B, Numer 123/23, 2019, Strona(/y) 4867-4877, ISSN 1520-6106
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jpcb.9b02370
Autorzy:
Matja Zalar, Sowmya Indrakumar, Colin W. Levy, Richard B. Tunnicliffe, Günther H. J. Peters, Alexander P. Golovanov
Opublikowane w:
Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-019-45565-6
Autorzy:
Dillen Augustijn, Sujata Mahapatra, Werner Streicher, Hristo Svilenov, Alina Kulakova, Christin Pohl, Åsmund Rinnan
Opublikowane w:
European Journal of Pharmaceutics and Biopharmaceutics, Numer 142, 2019, Strona(/y) 506-517, ISSN 0939-6411
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.06.001
Autorzy:
Marcello Martinez Morales, Matja Zalar, Silvia Sonzini, Alexander P. Golovanov, Christopher F. van der Walle, Jeremy P. Derrick
Opublikowane w:
Molecular Pharmaceutics, Numer 16/7, 2019, Strona(/y) 3100-3108, ISSN 1543-8384
Wydawca:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00338
Autorzy:
Hristo Svilenov, Gerhard Winter
Opublikowane w:
European Journal of Pharmaceutics and Biopharmaceutics, Numer 137, 2019, Strona(/y) 131-139, ISSN 0939-6411
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.02.018
Autorzy:
Silvia Sonzini, Maria Laura Greco, Thais Cailleau, Lauren Adams, Luke Masterson, Balakumar Vijayakrishnan, Conor Barry, Phillip Howard, Peter Ravn, Christopher F. van der Walle
Opublikowane w:
Bioconjugate Chemistry, 2019, ISSN 1043-1802
Wydawca:
American Chemical Society
DOI:
10.1021/acs.bioconjchem.9b00809
Autorzy:
Hristo Svilenov, Gerhard Winter
Opublikowane w:
International Journal of Pharmaceutics, Numer 562, 2019, Strona(/y) 42-50, ISSN 0378-5173
Wydawca:
Elsevier BV
DOI:
10.1016/j.ijpharm.2019.03.025
Autorzy:
Lorenzo Gentiluomo, Vanessa Schneider, Dierk Roessner, Wolfgang Frieß
Opublikowane w:
Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-019-51233-6
Autorzy:
Andreas Tosstorff, Tim Menzen, Gerhard Winter
Opublikowane w:
Journal of Pharmaceutical Sciences, Numer 109/1, 2020, Strona(/y) 301-307, ISSN 0022-3549
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.10.057
Autorzy:
Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
Opublikowane w:
Journal of Structural Biology: X, Numer 4, 2020, Strona(/y) 100017, ISSN 2590-1524
Wydawca:
Elsevier
DOI:
10.1016/j.yjsbx.2019.100017
Autorzy:
Lorenzo Gentiluomo, Hristo L. Svilenov, Dillen Augustijn, Inas El Bialy, Maria Laura Greco, Alina Kulakova, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Aisling Roche, Andreas Tosstorff, Robin Curtis, Jeremy P. Derrick, Allan Nørgaard, Tarik A. Khan, Günther H. J. Peters, Alain Pluen, Åsmund Rinnan, Werner W. Streicher, Christopher F. van der Walle, Shahid Uddi
Opublikowane w:
Molecular Pharmaceutics, 2020, ISSN 1543-8384
Wydawca:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00852
Autorzy:
Max Hebditch, Aisling Roche, Robin A. Curtis, Jim Warwicker
Opublikowane w:
Journal of Pharmaceutical Sciences, Numer 108/4, 2019, Strona(/y) 1434-1441, ISSN 0022-3549
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2018.11.035
Autorzy:
Lorenzo Gentiluomo, Dierk Roessner, Werner Streicher, Sujata Mahapatra, Pernille Harris, Wolfgang Frieß
Opublikowane w:
Journal of Pharmaceutical Sciences, Numer 109/1, 2020, Strona(/y) 443-451, ISSN 0022-3549
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.09.021
Autorzy:
Lorenzo Gentiluomo, Dierk Roessner, Dillen Augustijn, Hristo Svilenov, Alina Kulakova, Sujata Mahapatra, Gerhard Winter, Werner Streicher, Åsmund Rinnan, Günther H.J. Peters, Pernille Harris, Wolfgang Frieß
Opublikowane w:
European Journal of Pharmaceutics and Biopharmaceutics, Numer 141, 2019, Strona(/y) 81-89, ISSN 0939-6411
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.05.017
Autorzy:
Hristo L. Svilenov, Alina Kulakova, Matja Zalar, Alexander P. Golovanov, Pernille Harris, Gerhard Winter
Opublikowane w:
Journal of Pharmaceutical Sciences, Numer 109/1, 2020, Strona(/y) 584-594, ISSN 0022-3549
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.10.065
Autorzy:
Andreas Tosstorff, Hristo Svilenov, Günther H.J. Peters, Pernille Harris, Gerhard Winter
Opublikowane w:
European Journal of Pharmaceutics and Biopharmaceutics, Numer 144, 2019, Strona(/y) 207-216, ISSN 0939-6411
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.09.010
Autorzy:
Priyanka Singh, Aisling Roche, Christopher F. van der Walle, Shahid Uddin, Jiali Du, Jim Warwicker, Alain Pluen, Robin Curtis
Opublikowane w:
Molecular Pharmaceutics, Numer 16/12, 2019, Strona(/y) 4775-4786, ISSN 1543-8384
Wydawca:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00430
Autorzy:
Hristo Svilenov, Tim Menzen, Klaus Richter, Gerhard Winter
Opublikowane w:
Molecular Pharmaceutics, 2020, Strona(/y) 2638-2647, ISSN 1543-8392
Wydawca:
American Chemical Association
DOI:
10.1021/acs.molpharmaceut.0c00330
Autorzy:
Pernille Harris
Opublikowane w:
Impact, Numer 2017/8, 2017, Strona(/y) 75-77, ISSN 2398-7073
Wydawca:
Science Impact Ltd
DOI:
10.21820/23987073.2017.8.75
Autorzy:
A. Kulakova, S. Indrakumar, P. Sønderby, L. Gentiluomo, W. Streicher, D. Roessner, W. Frieß, G. H.J.
Peters, P. Harris
Opublikowane w:
bioRxiv, 2019
Wydawca:
Cold Spring Harbor Laborator
DOI:
10.1101/742957
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