Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

Project Information

CaSR Biomedicine

Grant agreement ID: 675228

DOI

10.3030/675228

Project closed

EC signature date 17 July 2015

Start date 1 March 2016

End date 29 February 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 657 194,64

EU contribution

€ 3 657 194,64

Coordinated by

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (15)

4th ETN school held

Organise and hold 4th ETN school: Self-presentation & Communication Strategies.

3rd ETN School held

Organise and hold 3rd eTN school: Introduction to Academic Teaching.

First ETN School held

"Organise and hold 1st ETN school: ""CaSR: Molecular and Clinical Aspects""."

First newsletter

Write and circulate the first Newsletter, together with all PIs.

2nd ETN school held

Organise and hold 2nd ETN school: Translational Drug Research.

5th ETN school held

Organise and hold 5th ETN school: Innovation and Entrepreneurship.

Second Newsletter

Write and circulate the 2nd Newsletter, together with all PIs.

International CaSR Symposium

International CaSR Symposium organised.

Presentations at conferences, publications in journals delivered

Presentations at conferences, publications in journals delivered.

Third Newsletter

Write and circulate the 3rd Newsletter, together with all PIs.

Prizes for presentations at AMs awarded

Assessing the presentations of the ESR at the Annual Meetings and awarding prizes to the best ones.

Vacancies advertised

Vacancies advertised.

ECTS certificates awarded

Certificates and ECTS points for the training events awarded.

Outreach activities

Outreach activities organised.

Fourth Newsletter

Write and circulate the 4th Newsletter, together with all PIs.

Websites, patent fillings, videos etc. (2)

Public domain of the webpage on-line

Design of the public website of the CaSR Biomedicine.

Short film on training effectiveness produced

To produce a short film that summarizes the strengths of the offered educational programme from the ESRs’ point of view.

Documents, reports (2)

Training memorandum compiled

Evaluate and compile the strengths of the CaSR Biomedicine training programme into a Memorandum.

Training memorandum sent.

Training memorandum sent to PhD schools & funding agencies.

Publications

Peer reviewed articles (29)

The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell lines

Author(s): K. E. Lines , A. K. Glück, S. Thongjuea, C. Bountra, R. V Thakker, Caroline M Gorvin
Published in: J. Mol Endocrinol, Issue Volume 67: Issue 3, 2021, Page(s) 83–94, ISSN 0952-5041
Publisher: Society for Endocrinology
DOI: 10.1530/jme-21-0030

Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle

Author(s): Romagnoli C, Sharma P, Zonefrati R, Palmini G, Lucattelli E, Ward DT, Ellinger I, Innocenti M, Brandi ML.
Published in: Int J Mol Sci, 2021, Page(s) 22(14):7282, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147282

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

Author(s): Luca Iamartino, Taha Elajnaf, Katharina Gall, Jacquelina David, Teresa Manhardt, Petra Heffeter, Michael Grusch, Sophia Derdak, Sabina Baumgartner-Parzer, Martin Schepelmann, Enikö Kallay
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1867/12, 2020, Page(s) 118836, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2020.118836

PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1.

Author(s): Ana Sastre, Kevin Valentino, Fadil M Hannan, Kate E Lines, Anna K Glück, Mark Stevenson, Michael Ryalls , Rebecca J Gorrigan , Debbie Pullen, Jackie Buck , Sailesh Sankaranarayanan, Jeremy Allgrove, Rajesh V Thakker, Evelien F Gevers.
Published in: New England Journal of Medicine, Issue 8;385(2), 2021, Page(s) 189-191, ISSN 1533-4406
Publisher: NEJM Goup, Owned & Published by the Massachusetts Medical Society.
DOI: 10.1056/nejmc2034981

Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells

Author(s): Martin Schepelmann, Nadja Kupper, Marta Sladczyk, Bethan Mansfield, Teresa Manhardt, Karina Piatek, Luca Iamartino, Daniela Riccardi, Benson M. Kariuki, Marcella Bassetto, Enikö Kallay
Published in: International Journal of Molecular Sciences, Issue 22/18, 2021, Page(s) 10124, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810124

Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives

Author(s): Luca Iamartino, Taha Elajnaf, Enikö Kallay, Martin Schepelmann
Published in: World Journal of Gastroenterology, Issue 24/36, 2018, Page(s) 4119-4131, ISSN 1007-9327
Publisher: W J G Press
DOI: 10.3748/wjg.v24.i36.4119

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Author(s): Anna Ochalek, Balázs Mihalik, Hasan X. Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E. Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés
Published in: Alzheimer's Research & Therapy, Issue 9/1, 2017, Page(s) 1-19, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-017-0317-z

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

Author(s): Valerie N Babinsky, Fadil M Hannan, Reshma D Ramracheya, Quan Zhang, M Andrew Nesbit, Alison Hugill, Liz Bentley, Tertius A Hough, Elizabeth Joynson, Michelle Stewart, Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Caroline M Gorvin, Enikö Kallay, Sara Wells, Roger D Cox, Duncan Richards, Patrik Rorsman, Rajesh V Thakker
Published in: Endocrinology, Issue 158/8, 2017, Page(s) 2486-2502, ISSN 0013-7227
Publisher: The Endocrine Society
DOI: 10.1210/en.2017-00111

The Calcium-Sensing Receptor and the Reproductive System

Author(s): Isabella Ellinger
Published in: Frontiers in Physiology, Issue 7, 2016, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00371

Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer

Author(s): Abhishek Aggarwal, Enikö Kállay
Published in: Frontiers in Physiology, Issue 7, 2016, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00451

Editorial: Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor

Author(s): Enikö Kallay
Published in: Frontiers in Physiology, Issue 9, 2018, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00413

Calcium-sensing receptor internalization is β-arrestin-dependent and modulated by allosteric ligands

Author(s): Iris Mos, Stine E. Jacobsen, Simon Foster, Hans Brauner-Osborne
Published in: Molecular Pharmacology, 2019, Page(s) mol.119.116772, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.116772

The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease

Author(s): Maria Lo Giudice, Balázs Mihalik, András Dinnyés, Julianna Kobolák
Published in: Molecules, Issue 24/14, 2019, Page(s) 2546, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24142546

Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice

Author(s): Taha Elajnaf, Luca Iamartino, Ildiko Mesteri, Christian Müller, Marcella Bassetto, Teresa Manhardt, Sabina Baumgartner-Parzer, Enikö Kallay, Martin Schepelmann
Published in: Nutrients, Issue 11/12, 2019, Page(s) 3072, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11123072

Parathyroid hormone‐like hormone plays a dual role in neuroblastoma depending on PTH 1R expression

Author(s): Marta García, Carlos Javier Rodríguez‐Hernández, Silvia Mateo‐Lozano, Sara Pérez‐Jaume, Eliana Gonçalves‐Alves, Cinzia Lavarino, Jaume Mora, Carmen Torres
Published in: Molecular Oncology, Issue 13/9, 2019, Page(s) 1959-1975, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12542

The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases

Author(s): Souvik Das, Philippe Clézardin, Said Kamel, Michel Brazier, Romuald Mentaverri
Published in: Frontiers in Oncology, Issue 10, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00069

Heterozygous Mutation (Q459R) in the Calcium-Sensing Receptor Gene Causes Familial Hypocalciuric Hypercalcemia 1 (FHH1)

Author(s): Ida Marie Boisen, Iris Mos, Eva Merete Lerche-Black, Anders Juul, Hans Bräuner-Osborne, Martin Blomberg Jensen
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 105/4, 2020, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgz205

Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)

Author(s): Poonam Dharmaraj, Caroline M Gorvin, Astha Soni, Nick D Nelhans, Mie K Olesen, Hannah Boon, Treena Cranston, Rajesh V Thakker, Fadil M Hannan
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 105/5, 2020, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgaa111

Identification of Serine-875 as an Inhibitory Phosphorylation Site in the Calcium-Sensing Receptor

Author(s): Lenah S. Binmahfouz, Patricia P. Centeno, Arthur D. Conigrave, Donald T. Ward
Published in: Molecular Pharmacology, Issue 96/2, 2019, Page(s) 204-211, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.116178

Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

Author(s): Patricia P. Centeno, Amanda Herberger, Hee-Chang Mun, Chialing Tu, Edward F. Nemeth, Wenhan Chang, Arthur D. Conigrave, Donald T. Ward
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12399-9

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons

Author(s): Maria Lo Giudice, Balázs Mihalik, Zsófia Turi, András Dinnyés, Julianna Kobolák
Published in: Journal of Alzheimer's Disease, Issue 72/3, 2019, Page(s) 885-899, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-190602

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Author(s): Julianna Kobolák, Kinga Molnár, Eszter Varga, István Bock, Bálint Jezsó, Annamária Téglási, Shuling Zhou, Maria Lo Giudice, Marianne Hoogeveen-Westerveld, WWM Pim Pijnappel, Phetcharat Phanthong, Norbert Varga, Narisorn Kitiyanant, Kristine Freude, Hideyuki Nakanishi, Lajos László, Poul Hyttel, András Dinnyés
Published in: Experimental Cell Research, Issue 380/2, 2019, Page(s) 216-233, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2019.04.021

Transfer learning using a multi-scale and multi-network ensemble for skin lesion classification

Author(s): Amirreza Mahbod, Gerald Schaefer, Chunliang Wang, Georg Dorffner, Rupert Ecker, Isabella Ellinger
Published in: Computer Methods and Programs in Biomedicine, Issue 193, 2020, Page(s) 105475, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2020.105475

Fusing fine-tuned deep features for skin lesion classification

Author(s): Amirreza Mahbod, Gerald Schaefer, Isabella Ellinger, Rupert Ecker, Alain Pitiot, Chunliang Wang
Published in: Computerized Medical Imaging and Graphics, Issue 71, 2019, Page(s) 19-29, ISSN 0895-6111
Publisher: Elsevier BV
DOI: 10.1016/j.compmedimag.2018.10.007

Physical biology of GPCR signalling dynamics inferred from fluorescence spectroscopy and imaging

Author(s): Sergei Chavez-Abiega, Joachim Goedhart, Frank Johannes Bruggeman
Published in: Current Opinion in Structural Biology, Issue 55, 2019, Page(s) 204-211, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2019.05.007

Activating Mutations of the G-protein Subunit α 11 Interdomain Interface Cause Autosomal Dominant Hypocalcemia Type 2

Author(s): Caroline M Gorvin, Victoria J Stokes, Hannah Boon, Treena Cranston, Anna K Glück, Shailini Bahl, Tessa Homfray, Theingi Aung, Brian Shine, Kate E Lines, Fadil M Hannan, Rajesh V Thakker
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 105/3, 2020, Page(s) 952-963, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgz251

Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis

Author(s): Cecilia Romagnoli, Roberto Zonefrati, Preeti Sharma, Marco Innocenti, Luisella Cianferotti, Maria Luisa Brandi
Published in: Calcified Tissue International, 2020, ISSN 0171-967X
Publisher: Springer Verlag
DOI: 10.1007/s00223-020-00678-3

A Multi-organ Nucleus Segmentation Challenge

Author(s): Neeraj Kumar, Ruchika Verma, Deepak Anand, Yanning Zhou, Omer Fahri Onder, Efstratios Tsougenis, Hao Chen, Pheng Ann Heng, Jiahui Li, Zhiqiang Hu, Yunzhi Wang, Navid Alemi Koohbanani, Mostafa Jahanifar, Neda Zamani Tajeddin, Ali Gooya, Nasir Rajpoot, Xuhua Ren, Sihang Zhou, Qian Wang, Dinggang Shen, Cheng Kun Yang, Chi Hung Weng, Wei Hsiang Yu, Chao Yuan Yeh, Shuang Yang, Shuoyu Xu, Pak Hei Yeung,
Published in: IEEE Transactions on Medical Imaging, 2019, Page(s) 1-1, ISSN 0278-0062
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2947628

Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model.

Author(s): Hannan FM, Gorvin CM, Babinsky VN, Olesen MK, Stewart M, Wells S, Cox RD, Nemeth EF, Thakker RV.
Published in: JBMR Plus., 2020, Page(s) 4(10): e10402., ISSN 2473-4039
Publisher: Wiley
DOI: 10.1002/jbm4.10402

Book chapters (3)

Sensing Extracellular Calcium – An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR)

Author(s): Sergei Chavez-Abiega, Iris Mos, Patricia P. Centeno, Taha Elajnaf, Wolfgang Schlattl, Donald T. Ward, Joachim Goedhart, Enikö Kallay
Published in: Calcium Signaling, Issue 1131, 2020, Page(s) 1031-1063, ISBN 978-3-030-12456-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-12457-1_41

Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion

Author(s): Amirreza Mahbod, Isabella Ellinger, Rupert Ecker, Örjan Smedby, Chunliang Wang
Published in: Image Analysis and Recognition, Issue 10882, 2018, Page(s) 754-762, ISBN 978-3-319-92999-6
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-93000-8_85

A Two-Stage U-Net Algorithm for Segmentation of Nuclei in H&E-Stained Tissues. In: Reyes-Aldasoro C., Janowczyk A., Veta M., Bankhead P., Sirinukunwattana K. (eds) Digital Pathology. ECDP 2019.

Author(s): Mahbod A., Schaefer G., Ellinger I., Ecker R., Smedby Ö., Wang C.
Published in: Digital Pathology. ECDP 2019; Lecture Notes in Computer Science, Issue vol 11435, 2019
Publisher: Springer

Non-peer reviewed articles (1)

“The challenges of researching rare genetic diseases”

Author(s): Anna Gluck
Published in: The Endocrinologist, Issue Issue 132, Summer 2019, 2019, ISSN 0965-1128
Publisher: Society for Endocrinology

Conference proceedings (1)

Skin Lesion Classification Using Hybrid Deep Neural Networks

Author(s): Amirreza Mahbod, Gerald Schaefer, Chunliang Wang, Rupert Ecker, Isabella Ellinge
Published in: ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2019, Page(s) 1229-1233, ISBN 978-1-4799-8131-1
Publisher: IEEE
DOI: 10.1109/icassp.2019.8683352