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Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

Rezultaty

4th ETN school held

Organise and hold 4th ETN school: Self-presentation & Communication Strategies.

3rd ETN School held

Organise and hold 3rd eTN school: Introduction to Academic Teaching.

First ETN School held

"Organise and hold 1st ETN school: ""CaSR: Molecular and Clinical Aspects""."

First newsletter

Write and circulate the first Newsletter, together with all PIs.

2nd ETN school held

Organise and hold 2nd ETN school: Translational Drug Research.

5th ETN school held

Organise and hold 5th ETN school: Innovation and Entrepreneurship.

Second Newsletter

Write and circulate the 2nd Newsletter, together with all PIs.

International CaSR Symposium

International CaSR Symposium organised.

Presentations at conferences, publications in journals delivered

Presentations at conferences, publications in journals delivered.

Third Newsletter

Write and circulate the 3rd Newsletter, together with all PIs.

Prizes for presentations at AMs awarded

Assessing the presentations of the ESR at the Annual Meetings and awarding prizes to the best ones.

Vacancies advertised

Vacancies advertised.

ECTS certificates awarded

Certificates and ECTS points for the training events awarded.

Outreach activities

Outreach activities organised.

Fourth Newsletter

Write and circulate the 4th Newsletter, together with all PIs.

Public domain of the webpage on-line

Design of the public website of the CaSR Biomedicine.

Short film on training effectiveness produced

To produce a short film that summarizes the strengths of the offered educational programme from the ESRs’ point of view.

Training memorandum compiled

Evaluate and compile the strengths of the CaSR Biomedicine training programme into a Memorandum.

Training memorandum sent.

Training memorandum sent to PhD schools & funding agencies.

Publikacje

The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell lines

Autorzy: K. E. Lines , A. K. Glück, S. Thongjuea, C. Bountra, R. V Thakker, Caroline M Gorvin
Opublikowane w: J. Mol Endocrinol, Numer Volume 67: Numer 3, 2021, Strona(/y) 83–94, ISSN 0952-5041
Wydawca: Society for Endocrinology
DOI: 10.1530/jme-21-0030

Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle

Autorzy: Romagnoli C, Sharma P, Zonefrati R, Palmini G, Lucattelli E, Ward DT, Ellinger I, Innocenti M, Brandi ML.
Opublikowane w: Int J Mol Sci, 2021, Strona(/y) 22(14):7282, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147282

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

Autorzy: Luca Iamartino, Taha Elajnaf, Katharina Gall, Jacquelina David, Teresa Manhardt, Petra Heffeter, Michael Grusch, Sophia Derdak, Sabina Baumgartner-Parzer, Martin Schepelmann, Enikö Kallay
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Numer 1867/12, 2020, Strona(/y) 118836, ISSN 0167-4889
Wydawca: Elsevier BV
DOI: 10.1016/j.bbamcr.2020.118836

PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1.

Autorzy: Ana Sastre, Kevin Valentino, Fadil M Hannan, Kate E Lines, Anna K Glück, Mark Stevenson, Michael Ryalls , Rebecca J Gorrigan , Debbie Pullen, Jackie Buck , Sailesh Sankaranarayanan, Jeremy Allgrove, Rajesh V Thakker, Evelien F Gevers.
Opublikowane w: New England Journal of Medicine, Numer 8;385(2), 2021, Strona(/y) 189-191, ISSN 1533-4406
Wydawca: NEJM Goup, Owned & Published by the Massachusetts Medical Society.
DOI: 10.1056/nejmc2034981

Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells

Autorzy: Martin Schepelmann, Nadja Kupper, Marta Sladczyk, Bethan Mansfield, Teresa Manhardt, Karina Piatek, Luca Iamartino, Daniela Riccardi, Benson M. Kariuki, Marcella Bassetto, Enikö Kallay
Opublikowane w: International Journal of Molecular Sciences, Numer 22/18, 2021, Strona(/y) 10124, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810124

Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives

Autorzy: Luca Iamartino, Taha Elajnaf, Enikö Kallay, Martin Schepelmann
Opublikowane w: World Journal of Gastroenterology, Numer 24/36, 2018, Strona(/y) 4119-4131, ISSN 1007-9327
Wydawca: W J G Press
DOI: 10.3748/wjg.v24.i36.4119

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Autorzy: Anna Ochalek, Balázs Mihalik, Hasan X. Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E. Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés
Opublikowane w: Alzheimer's Research & Therapy, Numer 9/1, 2017, Strona(/y) 1-19, ISSN 1758-9193
Wydawca: BioMed Central
DOI: 10.1186/s13195-017-0317-z

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

Autorzy: Valerie N Babinsky, Fadil M Hannan, Reshma D Ramracheya, Quan Zhang, M Andrew Nesbit, Alison Hugill, Liz Bentley, Tertius A Hough, Elizabeth Joynson, Michelle Stewart, Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Caroline M Gorvin, Enikö Kallay, Sara Wells, Roger D Cox, Duncan Richards, Patrik Rorsman, Rajesh V Thakker
Opublikowane w: Endocrinology, Numer 158/8, 2017, Strona(/y) 2486-2502, ISSN 0013-7227
Wydawca: The Endocrine Society
DOI: 10.1210/en.2017-00111

The Calcium-Sensing Receptor and the Reproductive System

Autorzy: Isabella Ellinger
Opublikowane w: Frontiers in Physiology, Numer 7, 2016, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00371

Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer

Autorzy: Abhishek Aggarwal, Enikö Kállay
Opublikowane w: Frontiers in Physiology, Numer 7, 2016, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2016.00451

Editorial: Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor

Autorzy: Enikö Kallay
Opublikowane w: Frontiers in Physiology, Numer 9, 2018, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00413

Calcium-sensing receptor internalization is β-arrestin-dependent and modulated by allosteric ligands

Autorzy: Iris Mos, Stine E. Jacobsen, Simon Foster, Hans Brauner-Osborne
Opublikowane w: Molecular Pharmacology, 2019, Strona(/y) mol.119.116772, ISSN 0026-895X
Wydawca: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.116772

The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease

Autorzy: Maria Lo Giudice, Balázs Mihalik, András Dinnyés, Julianna Kobolák
Opublikowane w: Molecules, Numer 24/14, 2019, Strona(/y) 2546, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24142546

Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice

Autorzy: Taha Elajnaf, Luca Iamartino, Ildiko Mesteri, Christian Müller, Marcella Bassetto, Teresa Manhardt, Sabina Baumgartner-Parzer, Enikö Kallay, Martin Schepelmann
Opublikowane w: Nutrients, Numer 11/12, 2019, Strona(/y) 3072, ISSN 2072-6643
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu11123072

Parathyroid hormone‐like hormone plays a dual role in neuroblastoma depending on PTH 1R expression

Autorzy: Marta García, Carlos Javier Rodríguez‐Hernández, Silvia Mateo‐Lozano, Sara Pérez‐Jaume, Eliana Gonçalves‐Alves, Cinzia Lavarino, Jaume Mora, Carmen Torres
Opublikowane w: Molecular Oncology, Numer 13/9, 2019, Strona(/y) 1959-1975, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.1002/1878-0261.12542

The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases

Autorzy: Souvik Das, Philippe Clézardin, Said Kamel, Michel Brazier, Romuald Mentaverri
Opublikowane w: Frontiers in Oncology, Numer 10, 2020, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00069

Heterozygous Mutation (Q459R) in the Calcium-Sensing Receptor Gene Causes Familial Hypocalciuric Hypercalcemia 1 (FHH1)

Autorzy: Ida Marie Boisen, Iris Mos, Eva Merete Lerche-Black, Anders Juul, Hans Bräuner-Osborne, Martin Blomberg Jensen
Opublikowane w: The Journal of Clinical Endocrinology & Metabolism, Numer 105/4, 2020, ISSN 0021-972X
Wydawca: The Endocrine Society
DOI: 10.1210/clinem/dgz205

Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)

Autorzy: Poonam Dharmaraj, Caroline M Gorvin, Astha Soni, Nick D Nelhans, Mie K Olesen, Hannah Boon, Treena Cranston, Rajesh V Thakker, Fadil M Hannan
Opublikowane w: The Journal of Clinical Endocrinology & Metabolism, Numer 105/5, 2020, ISSN 0021-972X
Wydawca: The Endocrine Society
DOI: 10.1210/clinem/dgaa111

Identification of Serine-875 as an Inhibitory Phosphorylation Site in the Calcium-Sensing Receptor

Autorzy: Lenah S. Binmahfouz, Patricia P. Centeno, Arthur D. Conigrave, Donald T. Ward
Opublikowane w: Molecular Pharmacology, Numer 96/2, 2019, Strona(/y) 204-211, ISSN 0026-895X
Wydawca: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.116178

Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

Autorzy: Patricia P. Centeno, Amanda Herberger, Hee-Chang Mun, Chialing Tu, Edward F. Nemeth, Wenhan Chang, Arthur D. Conigrave, Donald T. Ward
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-12399-9

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons

Autorzy: Maria Lo Giudice, Balázs Mihalik, Zsófia Turi, András Dinnyés, Julianna Kobolák
Opublikowane w: Journal of Alzheimer's Disease, Numer 72/3, 2019, Strona(/y) 885-899, ISSN 1387-2877
Wydawca: IOS Press
DOI: 10.3233/jad-190602

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Autorzy: Julianna Kobolák, Kinga Molnár, Eszter Varga, István Bock, Bálint Jezsó, Annamária Téglási, Shuling Zhou, Maria Lo Giudice, Marianne Hoogeveen-Westerveld, WWM Pim Pijnappel, Phetcharat Phanthong, Norbert Varga, Narisorn Kitiyanant, Kristine Freude, Hideyuki Nakanishi, Lajos László, Poul Hyttel, András Dinnyés
Opublikowane w: Experimental Cell Research, Numer 380/2, 2019, Strona(/y) 216-233, ISSN 0014-4827
Wydawca: Academic Press
DOI: 10.1016/j.yexcr.2019.04.021

Transfer learning using a multi-scale and multi-network ensemble for skin lesion classification

Autorzy: Amirreza Mahbod, Gerald Schaefer, Chunliang Wang, Georg Dorffner, Rupert Ecker, Isabella Ellinger
Opublikowane w: Computer Methods and Programs in Biomedicine, Numer 193, 2020, Strona(/y) 105475, ISSN 0169-2607
Wydawca: Elsevier BV
DOI: 10.1016/j.cmpb.2020.105475

Fusing fine-tuned deep features for skin lesion classification

Autorzy: Amirreza Mahbod, Gerald Schaefer, Isabella Ellinger, Rupert Ecker, Alain Pitiot, Chunliang Wang
Opublikowane w: Computerized Medical Imaging and Graphics, Numer 71, 2019, Strona(/y) 19-29, ISSN 0895-6111
Wydawca: Elsevier BV
DOI: 10.1016/j.compmedimag.2018.10.007

Physical biology of GPCR signalling dynamics inferred from fluorescence spectroscopy and imaging

Autorzy: Sergei Chavez-Abiega, Joachim Goedhart, Frank Johannes Bruggeman
Opublikowane w: Current Opinion in Structural Biology, Numer 55, 2019, Strona(/y) 204-211, ISSN 0959-440X
Wydawca: Elsevier BV
DOI: 10.1016/j.sbi.2019.05.007

Activating Mutations of the G-protein Subunit α 11 Interdomain Interface Cause Autosomal Dominant Hypocalcemia Type 2

Autorzy: Caroline M Gorvin, Victoria J Stokes, Hannah Boon, Treena Cranston, Anna K Glück, Shailini Bahl, Tessa Homfray, Theingi Aung, Brian Shine, Kate E Lines, Fadil M Hannan, Rajesh V Thakker
Opublikowane w: The Journal of Clinical Endocrinology & Metabolism, Numer 105/3, 2020, Strona(/y) 952-963, ISSN 0021-972X
Wydawca: The Endocrine Society
DOI: 10.1210/clinem/dgz251

Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis

Autorzy: Cecilia Romagnoli, Roberto Zonefrati, Preeti Sharma, Marco Innocenti, Luisella Cianferotti, Maria Luisa Brandi
Opublikowane w: Calcified Tissue International, 2020, ISSN 0171-967X
Wydawca: Springer Verlag
DOI: 10.1007/s00223-020-00678-3

A Multi-organ Nucleus Segmentation Challenge

Autorzy: Neeraj Kumar, Ruchika Verma, Deepak Anand, Yanning Zhou, Omer Fahri Onder, Efstratios Tsougenis, Hao Chen, Pheng Ann Heng, Jiahui Li, Zhiqiang Hu, Yunzhi Wang, Navid Alemi Koohbanani, Mostafa Jahanifar, Neda Zamani Tajeddin, Ali Gooya, Nasir Rajpoot, Xuhua Ren, Sihang Zhou, Qian Wang, Dinggang Shen, Cheng Kun Yang, Chi Hung Weng, Wei Hsiang Yu, Chao Yuan Yeh, Shuang Yang, Shuoyu Xu, Pak Hei Yeung,
Opublikowane w: IEEE Transactions on Medical Imaging, 2019, Strona(/y) 1-1, ISSN 0278-0062
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tmi.2019.2947628

Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model.

Autorzy: Hannan FM, Gorvin CM, Babinsky VN, Olesen MK, Stewart M, Wells S, Cox RD, Nemeth EF, Thakker RV.
Opublikowane w: JBMR Plus., 2020, Strona(/y) 4(10): e10402., ISSN 2473-4039
Wydawca: Wiley
DOI: 10.1002/jbm4.10402

Sensing Extracellular Calcium – An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR)

Autorzy: Sergei Chavez-Abiega, Iris Mos, Patricia P. Centeno, Taha Elajnaf, Wolfgang Schlattl, Donald T. Ward, Joachim Goedhart, Enikö Kallay
Opublikowane w: Calcium Signaling, Numer 1131, 2020, Strona(/y) 1031-1063, ISBN 978-3-030-12456-4
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-12457-1_41

Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion

Autorzy: Amirreza Mahbod, Isabella Ellinger, Rupert Ecker, Örjan Smedby, Chunliang Wang
Opublikowane w: Image Analysis and Recognition, Numer 10882, 2018, Strona(/y) 754-762, ISBN 978-3-319-92999-6
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-319-93000-8_85

A Two-Stage U-Net Algorithm for Segmentation of Nuclei in H&E-Stained Tissues. In: Reyes-Aldasoro C., Janowczyk A., Veta M., Bankhead P., Sirinukunwattana K. (eds) Digital Pathology. ECDP 2019.

Autorzy: Mahbod A., Schaefer G., Ellinger I., Ecker R., Smedby Ö., Wang C.
Opublikowane w: Digital Pathology. ECDP 2019; Lecture Notes in Computer Science, Numer vol 11435, 2019
Wydawca: Springer

“The challenges of researching rare genetic diseases”

Autorzy: Anna Gluck
Opublikowane w: The Endocrinologist, Numer Numer 132, Summer 2019, 2019, ISSN 0965-1128
Wydawca: Society for Endocrinology

Skin Lesion Classification Using Hybrid Deep Neural Networks

Autorzy: Amirreza Mahbod, Gerald Schaefer, Chunliang Wang, Rupert Ecker, Isabella Ellinge
Opublikowane w: ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2019, Strona(/y) 1229-1233, ISBN 978-1-4799-8131-1
Wydawca: IEEE
DOI: 10.1109/icassp.2019.8683352

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