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Deciphering PI3K biology in health and disease

Objective

The Phosphoinositide 3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration. This inevitably leads to the involvement of the PI3K signalling pathway in a number of different diseases, ranging from inflammation and diabetes to cancer, with PI3K pathway alterations present in almost 80% of human cancers. Therefore, PI3Ks have emerged as important targets for drug discovery and, during 2014, the first PI3K inhibitor was approved by FDA in the US for the treatment of a lymphocytic leukaemia. Nonetheless, our understanding of PI3K-mediated signalling is still poor and only a fraction of the potential therapeutic applications have been addressed so far, leaving a large amount of translational work unexplored. Europe features a set of top quality research institutions and pharmaceutical companies focused on PI3K studies but their activities have been so far scattered. This proposal fills this gap by providing a multidisciplinary network (biochemistry, mouse studies, disease models, drug development, software development) and an unprecedented training opportunity from the bench to the bedside (from pre-clinical discoveries to clinical trials), through cutting edge molecular biology, drug discovery and clinical trial organization. The proposal is aimed at training young investigators in deep understanding of the different PI3K isoforms in distinct tissues and to translate this knowledge into a new generation of PI3K inhibitors, treatment modalities and into identify new uses for existing PI3K inhibitors.

Coordinator

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Net EU contribution
€ 530 172,72
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (10)

UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 546 575,76
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FORSCHUNGSVERBUND BERLIN EV
Germany
Net EU contribution
€ 498 432,96
Address
Rudower Chaussee 17
12489 Berlin

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Region
Berlin Berlin Berlin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE BABRAHAM INSTITUTE
United Kingdom
Net EU contribution
€ 440 297,14
Address
Babraham Hall
CB22 3AT Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 525 751,20
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
Net EU contribution
€ 262 875,60
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden

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Region
Grand Est Alsace Bas-Rhin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
Spain
Net EU contribution
€ 247 872,96
Address
Calle Nazaret 115-117
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI TORINO
Italy
Net EU contribution
€ 258 061,32
Address
Via Giuseppe Verdi 8
10124 Torino

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Region
Nord-Ovest Piemonte Torino
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 265 226,76
Address
Petersplatz 1
4051 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ARIVIS AG
Germany
Net EU contribution
€ 214 603,08
Address
Einsteinstrasse 10
85716 Unterschleissheim

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Landkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 106 278,62
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (2)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UbiK media S.L.
Spain
Net EU contribution
€ 0,00
Address

Barcelona

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Institut Clinique de la Souris
France
Net EU contribution
€ 0,00
Address

Illkirch-graffenstaden

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00