Objective
The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease. Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for the involved partners as it will advance the Euopean capacity to bring innovative approaches to the untapped potential of the CNS therapeutic market.
Fields of science
Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
3012 Bern
Switzerland
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Participants (11)
60323 Frankfurt Am Main
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20139 Milano
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1050 Bruxelles / Brussel
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6726 Szeged
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62000 Arras
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69117 Heidelberg
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1015 Lausanne
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Participation ended
1081 HV Amsterdam
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MK7 6AA Milton Keynes
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60438 Frankfurt
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1081 HV Amsterdam
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Partners (8)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
4070 Basel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
33617 Bielefeld
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
2333 BD Leiden
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
80539 Munchen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
35128 Padova
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
92110 San Diego
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Winterthur
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
10117 BERLIN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.