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Brain barriers training

Objective

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease. Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for the involved partners as it will advance the Euopean capacity to bring innovative approaches to the untapped potential of the CNS therapeutic market.

Coordinator

UNIVERSITAET BERN
Net EU contribution
€ 530 453,52
Address
Hochschulstrasse 6
3012 Bern
Switzerland

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (11)

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
Net EU contribution
€ 249 216,48
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Italy
Net EU contribution
€ 258 061,32
Address
Via Adamello 16
20139 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Net EU contribution
€ 250 560,00
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Hungary
Net EU contribution
€ 223 913,52
Address
Temesvari Korut 62
6726 Szeged

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Region
Alföld és Észak Dél-Alföld Csongrád
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITE D'ARTOIS
France
Net EU contribution
€ 262 875,60
Address
Rue Du Temple 9
62000 Arras

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Region
Hauts-de-France Nord-Pas de Calais Pas-de-Calais
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
Net EU contribution
€ 249 216,48
Address
Seminarstrasse 2
69117 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 265 226,76
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STICHTING VU

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
De Boelelaan 1105
1081 HV Amsterdam
Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
THE OPEN UNIVERSITY
United Kingdom
Net EU contribution
€ 273 287,88
Address
Walton Hall
MK7 6AA Milton Keynes

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Milton Keynes
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
GENXPRO GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Altenhofter Allee 3
60438 Frankfurt

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Darmstadt Frankfurt am Main, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
STICHTING VUMC
Netherlands
Net EU contribution
€ 255 374,28
Address
De Boelelaan 1117
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Other funding
€ 0,00

Partners (8)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

F. HOFFMANN-LA ROCHE AG
Switzerland
Net EU contribution
€ 0,00
Address
Grenzacherstrasse 124
4070 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

LAVISION BIOTEC GMBH
Germany
Net EU contribution
€ 0,00
Address
Astastrasse 14
33617 Bielefeld

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Detmold Bielefeld, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NCARDIA BV
Netherlands
Net EU contribution
€ 0,00
Address
Gallileiweg 8
2333 BD Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 0,00
Address
Hofgartenstrasse 8
80539 Munchen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BRAINS FOR BRAIN FOUNDATION ONLUS
Italy
Net EU contribution
€ 0,00
Address
Via Giustiniani 3
35128 Padova

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Region
Nord-Est Veneto Padova
Activity type
Research Organisations
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITY OF SAN DIEGO
United States
Net EU contribution
€ 0,00
Address
5998 Alcala Park Hughes Administration Center
92110 San Diego

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Scitec-media GmbH
Switzerland
Net EU contribution
€ 0,00
Address

Winterthur

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

TP21 GMBH
Germany
Net EU contribution
€ 0,00
Address
Luisenstrasse 14
10117 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00