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Brain barriers training

Objective

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease. Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for the involved partners as it will advance the Euopean capacity to bring innovative approaches to the untapped potential of the CNS therapeutic market.

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Coordinator

UNIVERSITAET BERN
Address
Hochschulstrasse 6
3012 Bern
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 530 453,52

Participants (11)

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 249 216,48
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
EU contribution
€ 258 061,32
Address
Via Adamello 16
20139 Milano
Activity type
Research Organisations
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 250 560
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Hungary
EU contribution
€ 223 913,52
Address
Temesvari Korut 62
6726 Szeged
Activity type
Research Organisations
UNIVERSITE D'ARTOIS
France
EU contribution
€ 262 875,60
Address
Rue Du Temple 9
62000 Arras
Activity type
Higher or Secondary Education Establishments
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 249 216,48
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 265 226,76
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
STICHTING VU

Participation ended

Netherlands
EU contribution
€ 0
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
THE OPEN UNIVERSITY
United Kingdom
EU contribution
€ 273 287,88
Address
Walton Hall
MK7 6AA Milton Keynes
Activity type
Higher or Secondary Education Establishments
GENXPRO GMBH
Germany
EU contribution
€ 249 216,48
Address
Altenhofter Allee 3
60438 Frankfurt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING VUMC
Netherlands
EU contribution
€ 255 374,28
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations

Partners (8)

F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LAVISION BIOTEC GMBH
Germany
Address
Astastrasse 14
33617 Bielefeld
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NCARDIA BV
Netherlands
Address
Gallileiweg 8
2333 BD Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
BRAINS FOR BRAIN FOUNDATION ONLUS
Italy
Address
Via Giustiniani 3
35128 Padova
Activity type
Research Organisations
UNIVERSITY OF SAN DIEGO
United States
Address
5998 Alcala Park Hughes Administration Center
92110 San Diego
Activity type
Higher or Secondary Education Establishments
Scitec-media GmbH
Switzerland
Address

Winterthur
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TP21 GMBH
Germany
Address
Luisenstrasse 14
10117 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)