Innovative training network: Immunoprofile-directed stratification of patients with the autoimmune disorder thrombotic thrombocytopenic purpura

Project Information

PROFILE

Grant agreement ID: 675746

DOI 10.3030/675746

Project closed

EC signature date 3 August 2015

Start date 1 October 2015

End date 30 September 2019

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 1 464 397,92

EU contribution € 1 464 397,92

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Deliverables

Websites, patent fillings, videos etc. (1)

Communication 6.1

Website established

Other (5)

Scientific WP(1-4).6

PhD awarded to all 6 ESRs. Three PhDs at Sanguine and 3 PhDs at KULeuven

Scientific WP(1-4).5

Second paper for all ESRs. Each beneficiary is responsible for its respective ESRs. (Not only Icosagen)

Scientific WP(1-4).4

First paper for all ESRs All responsible beneficiaries take the lead for their respective ESR (not only Icosagen).

Training 5.4

PROFILE Conference

Training 5.3

8 workshops including summerschool at M 6, 12, 18, 24, 30, 36 , 42 and 48

Documents, reports (2)

Scientific WP(1-4).3

Final report PROFILE project

Scientific WP(1-4).2

Report WPs at M 6, 12, 18, 24, 30, 36 , 42 and 48 Benefeciaries responsible for the respective WPs take the lead (not only Protobios)

Publications

Peer reviewed articles (16)

Understanding therapeutic targets in thrombotic thrombocytopenic purpura

Author(s): Bérangère S. Joly, Karen Vanhoorelbeke, Agnès Veyradier
Published in: Intensive Care Medicine, Issue 43/9, 2017, Page(s) 1398-1400, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-016-4662-3

Mechanisms of Autoantibody-Induced Pathology

Author(s): Ralf J. Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M. McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M. Hammers, Jon M. Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A. Manz, Fal
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00603

Thrombotic thrombocytopenic purpura

Author(s): Johanna A. Kremer Hovinga, Paul Coppo, Bernhard Lämmle, Joel L. Moake, Toshiyuki Miyata, Karen Vanhoorelbeke
Published in: Nature Reviews Disease Primers, Issue 3, 2017, Page(s) 17020, ISSN 2056-676X
Publisher: Nature Publishing Group
DOI: 10.1038/nrdp.2017.20

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ

Author(s): Johana Hrdinová, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron
Published in: Haematologica, Issue 103/6, 2018, Page(s) 1083-1092, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.179119

Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13

Author(s): An-Sofie Schelpe, Christelle Orlando, Bogac Ercig, Chloë Geeroms, Inge Pareyn, Nele Vandeputte, Leydi Carolina Velásquez Pereira, Elien Roose, Karel Fostier, Gerry A.F. Nicolaes, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke, Kristin Jochmans
Published in: European Journal of Haematology, Issue 101/2, 2018, Page(s) 191-199, ISSN 0902-4441
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejh.13094

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers

Author(s): Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo
Published in: Haematologica, Issue 103/7, 2018, Page(s) 1099-1109, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.151407

ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw–Schulman Syndrome

Author(s): Bérangère Joly, Pierre Boisseau, Elien Roose, Alain Stepanian, Nathalie Biebuyck, Julien Hogan, François Provot, Yahsou Delmas, Céline Garrec, Karen Vanhoorelbeke, Paul Coppo, Agnès Veyradier
Published in: Thrombosis and Haemostasis, Issue 118/11, 2018, Page(s) 1902-1917, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1055/s-0038-1673686

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura

Author(s): Bogac Ercig, Kanin Wichapong, Chris Reutelingsperger, Karen Vanhoorelbeke, Jan Voorberg, Gerry Nicolaes
Published in: Thrombosis and Haemostasis, Issue 118/01, 2018, Page(s) 028-041, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1160/th17-06-0404

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura

Author(s): Elien Roose, Gestur Vidarsson, Kadri Kangro, Onno Verhagen, Ilaria Mancini, Linda Desender, Inge Pareyn, Nele Vandeputte, Aline Vandenbulcke, Chiara Vendramin, An-Sofie Schelpe, Jan Voorberg, Marie-Agnès Azerad, Laurent Gilardin, Marie Scully, Daan Dierickx, Hans Deckmyn, Simon De Meyer, Flora Peyvandi, Karen Vanhoorelbeke
Published in: Thrombosis and Haemostasis, Issue 118/10, 2018, Page(s) 1729-1742, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1055/s-0038-1669459

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura

Author(s): Matthieu Jestin, Ygal Benhamou, An-Sofie Schelpe, Elien Roose, François Provôt, Lionel Galicier, Miguel Hié, Claire Presne, Pascale Poullin, Alain Wynckel, Samir Saheb, Christophe Deligny, Aude Servais, Stéphane Girault, Yahsou Delmas, Tarik Kanouni, Alexandre Lautrette, Dominique Chauveau, Christiane Mousson, Pierre Perez, Jean-Michel Halimi, Anne Charvet-Rumpler, Mohamed Hamidou, Pascal Cath
Published in: Blood, Issue 132/20, 2018, Page(s) 2143-2153, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2018-04-840090

An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura

Author(s): E. Roose, A. S. Schelpe, B. S. Joly, M. Peetermans, P. Verhamme, J. Voorberg, A. Greinacher, H. Deckmyn, S. F. De Meyer, P. Coppo, A. Veyradier, K. Vanhoorelbeke
Published in: Journal of Thrombosis and Haemostasis, Issue 16/2, 2018, Page(s) 378-388, ISSN 1538-7933
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jth.13922

Crystal structure and substrate-induced activation of ADAMTS13

Author(s): Anastasis Petri, Hyo Jung Kim, Yaoxian Xu, Rens de Groot, Chan Li, Aline Vandenbulcke, Karen Vanhoorelbeke, Jonas Emsley, James T. B. Crawley
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11474-5

Understanding thrombotic microangiopathies in children

Author(s): Bérangère S. Joly, X. Long Zheng, Agnès Veyradier
Published in: Intensive Care Medicine, Issue 44/9, 2018, Page(s) 1536-1538, ISSN 0342-4642
Publisher: Springer Verlag
DOI: 10.1007/s00134-018-5059-2

Transfer of ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura via kidney transplantation

Author(s): Lara Zafrani, Charlotte Dekimpe, Bérangère. S. Joly, Elien Roose, Fabienne Fieux, Elie Azoulay, Marie-Noëlle Peraldi, Antoine Durrbach, Paul Coppo, Karen Vanhoorelbeke, Agnès Veyradier
Published in: Haematologica, Issue 104/6, 2019, Page(s) e277-e280, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.219063

Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients

Author(s): An-Sofie Schelpe, Elien Roose, Bérangère S. Joly, Inge Pareyn, Ilaria Mancini, Marina Biganzoli, Hans Deckmyn, Jan Voorberg, Rob Fijnheer, Flora Peyvandi, Simon F. De Meyer, Paul Coppo, Agnès Veyradier, Karen Vanhoorelbeke
Published in: Haematologica, Issue 104/6, 2019, Page(s) 1268-1276, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.205666

The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages

Author(s): Fabian C. Verbij, Nicoletta Sorvillo, Paul H. P. Kaijen, Johana Hrdinova, Ivan Peyron, Rob Fijnheer, Anja ten Brinke, Alexander B. Meijer, Floris P. J. van Alphen, Timo K. van den Berg, Jonas J. H. Graversen, Soren K. Moestrup, Jan Voorberg
Published in: Blood Advances, Issue 1/5, 2017, Page(s) 293-305, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2016001321