Innovative training network: Immunoprofile-directed stratification of patients with the autoimmune disorder thrombotic thrombocytopenic purpura

Informazioni relative al progetto

PROFILE

ID dell’accordo di sovvenzione: 675746

DOI

10.3030/675746

Progetto chiuso

Data della firma CE 3 Agosto 2015

Data di avvio 1 Ottobre 2015

Data di completamento 30 Settembre 2019

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 1 464 397,92

Contributo UE

€ 1 464 397,92

Coordinato da

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Communication 6.1

Website established

Other (5)

Scientific WP(1-4).6

PhD awarded to all 6 ESRs. Three PhDs at Sanguine and 3 PhDs at KULeuven

Scientific WP(1-4).5

Second paper for all ESRs. Each beneficiary is responsible for its respective ESRs. (Not only Icosagen)

Scientific WP(1-4).4

First paper for all ESRs All responsible beneficiaries take the lead for their respective ESR (not only Icosagen).

Training 5.4

PROFILE Conference

Training 5.3

8 workshops including summerschool at M 6, 12, 18, 24, 30, 36 , 42 and 48

Documents, reports (2)

Scientific WP(1-4).3

Final report PROFILE project

Scientific WP(1-4).2

Report WPs at M 6, 12, 18, 24, 30, 36 , 42 and 48 Benefeciaries responsible for the respective WPs take the lead (not only Protobios)

Pubblicazioni

Peer reviewed articles (16)

Understanding therapeutic targets in thrombotic thrombocytopenic purpura

Autori: Bérangère S. Joly, Karen Vanhoorelbeke, Agnès Veyradier
Pubblicato in: Intensive Care Medicine, Numero 43/9, 2017, Pagina/e 1398-1400, ISSN 0342-4642
Editore: Springer Verlag
DOI: 10.1007/s00134-016-4662-3

Mechanisms of Autoantibody-Induced Pathology

Autori: Ralf J. Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M. McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M. Hammers, Jon M. Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A. Manz, Fal
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00603

Thrombotic thrombocytopenic purpura

Autori: Johanna A. Kremer Hovinga, Paul Coppo, Bernhard Lämmle, Joel L. Moake, Toshiyuki Miyata, Karen Vanhoorelbeke
Pubblicato in: Nature Reviews Disease Primers, Numero 3, 2017, Pagina/e 17020, ISSN 2056-676X
Editore: Nature Publishing Group
DOI: 10.1038/nrdp.2017.20

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ

Autori: Johana Hrdinová, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron
Pubblicato in: Haematologica, Numero 103/6, 2018, Pagina/e 1083-1092, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.179119

Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13

Autori: An-Sofie Schelpe, Christelle Orlando, Bogac Ercig, Chloë Geeroms, Inge Pareyn, Nele Vandeputte, Leydi Carolina Velásquez Pereira, Elien Roose, Karel Fostier, Gerry A.F. Nicolaes, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke, Kristin Jochmans
Pubblicato in: European Journal of Haematology, Numero 101/2, 2018, Pagina/e 191-199, ISSN 0902-4441
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ejh.13094

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers

Autori: Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo
Pubblicato in: Haematologica, Numero 103/7, 2018, Pagina/e 1099-1109, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.151407

ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw–Schulman Syndrome

Autori: Bérangère Joly, Pierre Boisseau, Elien Roose, Alain Stepanian, Nathalie Biebuyck, Julien Hogan, François Provot, Yahsou Delmas, Céline Garrec, Karen Vanhoorelbeke, Paul Coppo, Agnès Veyradier
Pubblicato in: Thrombosis and Haemostasis, Numero 118/11, 2018, Pagina/e 1902-1917, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1055/s-0038-1673686

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura

Autori: Bogac Ercig, Kanin Wichapong, Chris Reutelingsperger, Karen Vanhoorelbeke, Jan Voorberg, Gerry Nicolaes
Pubblicato in: Thrombosis and Haemostasis, Numero 118/01, 2018, Pagina/e 028-041, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1160/th17-06-0404

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura

Autori: Elien Roose, Gestur Vidarsson, Kadri Kangro, Onno Verhagen, Ilaria Mancini, Linda Desender, Inge Pareyn, Nele Vandeputte, Aline Vandenbulcke, Chiara Vendramin, An-Sofie Schelpe, Jan Voorberg, Marie-Agnès Azerad, Laurent Gilardin, Marie Scully, Daan Dierickx, Hans Deckmyn, Simon De Meyer, Flora Peyvandi, Karen Vanhoorelbeke
Pubblicato in: Thrombosis and Haemostasis, Numero 118/10, 2018, Pagina/e 1729-1742, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1055/s-0038-1669459

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura

Autori: Matthieu Jestin, Ygal Benhamou, An-Sofie Schelpe, Elien Roose, François Provôt, Lionel Galicier, Miguel Hié, Claire Presne, Pascale Poullin, Alain Wynckel, Samir Saheb, Christophe Deligny, Aude Servais, Stéphane Girault, Yahsou Delmas, Tarik Kanouni, Alexandre Lautrette, Dominique Chauveau, Christiane Mousson, Pierre Perez, Jean-Michel Halimi, Anne Charvet-Rumpler, Mohamed Hamidou, Pascal Cath
Pubblicato in: Blood, Numero 132/20, 2018, Pagina/e 2143-2153, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2018-04-840090

An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura

Autori: E. Roose, A. S. Schelpe, B. S. Joly, M. Peetermans, P. Verhamme, J. Voorberg, A. Greinacher, H. Deckmyn, S. F. De Meyer, P. Coppo, A. Veyradier, K. Vanhoorelbeke
Pubblicato in: Journal of Thrombosis and Haemostasis, Numero 16/2, 2018, Pagina/e 378-388, ISSN 1538-7933
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jth.13922

Crystal structure and substrate-induced activation of ADAMTS13

Autori: Anastasis Petri, Hyo Jung Kim, Yaoxian Xu, Rens de Groot, Chan Li, Aline Vandenbulcke, Karen Vanhoorelbeke, Jonas Emsley, James T. B. Crawley
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11474-5

Understanding thrombotic microangiopathies in children

Autori: Bérangère S. Joly, X. Long Zheng, Agnès Veyradier
Pubblicato in: Intensive Care Medicine, Numero 44/9, 2018, Pagina/e 1536-1538, ISSN 0342-4642
Editore: Springer Verlag
DOI: 10.1007/s00134-018-5059-2

Transfer of ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura via kidney transplantation

Autori: Lara Zafrani, Charlotte Dekimpe, Bérangère. S. Joly, Elien Roose, Fabienne Fieux, Elie Azoulay, Marie-Noëlle Peraldi, Antoine Durrbach, Paul Coppo, Karen Vanhoorelbeke, Agnès Veyradier
Pubblicato in: Haematologica, Numero 104/6, 2019, Pagina/e e277-e280, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.219063

Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients

Autori: An-Sofie Schelpe, Elien Roose, Bérangère S. Joly, Inge Pareyn, Ilaria Mancini, Marina Biganzoli, Hans Deckmyn, Jan Voorberg, Rob Fijnheer, Flora Peyvandi, Simon F. De Meyer, Paul Coppo, Agnès Veyradier, Karen Vanhoorelbeke
Pubblicato in: Haematologica, Numero 104/6, 2019, Pagina/e 1268-1276, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.205666

The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages

Autori: Fabian C. Verbij, Nicoletta Sorvillo, Paul H. P. Kaijen, Johana Hrdinova, Ivan Peyron, Rob Fijnheer, Anja ten Brinke, Alexander B. Meijer, Floris P. J. van Alphen, Timo K. van den Berg, Jonas J. H. Graversen, Soren K. Moestrup, Jan Voorberg
Pubblicato in: Blood Advances, Numero 1/5, 2017, Pagina/e 293-305, ISSN 2473-9529
Editore: American Society of Hematology
DOI: 10.1182/bloodadvances.2016001321