Nanomedicine: an integrative approach

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Prizes

ESR-ITN prizes (best presentation, best publication, best expose for lay public.

Certificates

ESR Certificates of research-specific/complementary training granted to ESRs.

Website

First online version of network public website.

Publications

Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles

Auteurs: Michèle Dai; Evangelos Georgilis; Guillaume Goudounet; Bertrand Garbay; Jan Pille; Jan C. M. van Hest; Xavier Schultze; Elisabeth Garanger; Sébastien Lecommandoux
Publié dans: Polymers, 2021, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym13091470

Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics

Auteurs: Bresseleers, J, Bagheri, M, Lebleu, C, Lecommandoux, S, Sandre, O, Pijpers, IAB, Mason, AF, Meeuwissen, S., van Nostrum, C., Hennink, WE, van Hest, JCM
Publié dans: Polymers, 2020, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym12112572

Wormlike Nanovector with Enhanced Drug Loading Using Blends of Biodegradable Block Copolymers

Auteurs: Ridolfo, R, Arends, JJ, van Hest, JCM , Williams, DS
Publié dans: Biomacromolecules, 2020, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.0c00169

Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface

Auteurs: Shirin Tavakoli, Karen Peynshaert, Tatu Lajunen, Joke Devoldere, Eva M del Amo, Marika Ruponen, Stefaan de Smedt, Katrien Remaut, Arto Urtti
Publié dans: Journal of controlled release, 2020, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2020.10.028

Size-tunable nanoneedle arrays for influencing stem cell morphology, gene expression and nuclear membrane curvature

Auteurs: Seong, H, Higgins, SG, Penders, J, Armstrong, JPK, Crowder, SW, Moore, AC, Sero, JE, Becce, M, Stevens, MM
Publié dans: ACS Nano, 2020, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.9b08689

Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner

Auteurs: Thijs Van de Vyver, Bram Bogaert, Lynn De Backer, Freya Joris, Roberta Guagliardo, Jelter Van Hoeck, Pieterjan Merckx, Serge Van Calenbergh, Srinivas Ramishetti, Dan Peer, Katrien Remaut, Stefaan C De Smedt, Koen Raemdonck
Publié dans: ACS Nano, 2020, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.0c00666

Photoactivated Polymersome Nanomotors: Traversing Biological Barriers

Auteurs: Jingxin Shao, Shoupeng Cao, D.S. Williams, LKEA Abdelmohsen, Jan C.M. van Hest
Publié dans: Angewandte Chemie Int Ed, 2021, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202003748

Assessing the impact of silicon nanowires on bacterial transformation and viability of Escherichia coli

Auteurs: Becce, M,Kloeckner, A, Higgins, S, Penders, J, Hachim Diaz, DJ, Bashor, CJ, Edwards, A, Stevens, M
Publié dans: Journal of Materials Chemistry B, 2021, ISSN 2050-750X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0tb02762f

Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System

Auteurs: Otto K Kari; Shirin Tavakoli; Petteri Parkkila;Simone Baan; Roosa Savolainen; Teemu Ruoslahti; Niklas G Johansson; Joseph Ndika; Harri Alenius; Tapani Viitala; Arto Urtti; Tatu Lajunen
Publié dans: Pharmaceutics, 2020, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12080763

Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling

Auteurs: Conor C Horgan, Anika Nagelkerke, Thomas E Whittaker, Valeria Nele, Lucia Massi, Ulrike Kauscher, Jelle Penders, Mads S Bergholt, Steve R Hood, Molly M Stevens
Publié dans: JOURNAL OF MATERIALS CHEMISTRY B, 2020, ISSN 2050-750X
Éditeur: ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00620c

Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo-Dynamic Therapy

Auteurs: S. Cao, Y. Xia, J. Shao, B. Guo,Y. Dong, IAB Pijpers, Z. Zhong, F. Meng, LKEA Abdelmohsen, D.S. Williams, Jan C.M. van Hest
Publié dans: Angewandte Chemie int ed, 2021, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202105103

High pressure nebulization (PIPAC) versus injection for the intraperitoneal administration of mRNA complexes

Auteurs: Shariati, Molood; Zhang, Heyang; Van de Sande, Leen; Descamps, Benedicte; Vanhove, Chris; Willaert, Wouter; Ceelen, Wim; De Smedt, Stefaan C.; Remaut, Katrien
Publié dans: PHARMACEUTICAL RESEARCH, 2019, ISSN 0724-8741
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-019-2646-z

Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery

Auteurs: Shao, JX, Cao, SP, Wu, HL, Abdelmohsen, LKEA, van Hest, JCM
Publié dans: PHARMACEUTICS, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13111833

Influence of surface charge on the formulation of elongated PEG-b-PDLLA nanoparticles

Auteurs: Roxane Ridolfo; David S. Williams; Jan C. M. van Hest
Publié dans: Polymer Chemistry, Numéro 14, 2020, ISSN 1759-9954
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0py00280a

In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy

Auteurs: Håkon Høgset, Conor C Horgan, James P K Armstrong, Mads S Bergholt, Vincenzo Torraca, Qu Chen, Timothy J Keane, Laurence Bugeon, Margaret J Dallman, Serge Mostowy, Molly M Stevens
Publié dans: Nature Communications, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-19827-1

Compartmentalized cross-linked enzymatic nano-aggregates (c-CLEnA) for efficient in-flow biocatalysis

Auteurs: M. Teresa De Martino; Fabio Tonin; N. Amy Yewdall; Mona Abdelghani; David S. Williams; Ulf Hanefeld; Floris P. J. T. Rutjes; Loai K. E. A. Abdelmohsen; Jan C. M. van Hest
Publié dans: Chemical Science, 11, 2765 - 2769, Numéro 18, 2020, ISSN 2041-6520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9sc05420k

Self-Assembly or Coassembly of Multiresponsive Histidine-Containing Elastin-Like Polypeptide Block Copolymers

Auteurs: Abdelghani, M, Shao, JX, Le, DHT, Wu, HL, van Hest, JCM
Publié dans: Macromolecular Bioscience, 2021, ISSN 1616-5187
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202100081

Porous silicon nanoneedles modulate endocytosis to deliver biological payloads

Auteurs: Gopal, S, Chiappini, C, Penders, J, Leonardo, V, Seong, H, Rothery, S, Korchev, Y, Shevchuk, A, Stevens, MM
Publié dans: Advanced Materials, 2019, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201806788

Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region

Auteurs: Junnuthula, V, Boroujeni, AS, Cao, SP, Tavakoli, S, Ridolfo, R, Toropainen, E, Ruponen, M ,van Hest, JCM , Urtti, A
Publié dans: Pharmaceutics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040445

Gold nanocluster extracellular vesicle supraparticles: Self-assembled nanostructures for 3D uptake visualization

Auteurs: Kauscher, U; Pender,s J; Nagelkerke, A; Holme, M; Nele, V; Massi, L; Gopal, S; Whittaker, T; Stevens, M
Publié dans: Langmuir, 2020, ISSN 0743-7463
Éditeur: American Chemical Society
DOI: 10.1021/acs.langmuir.9b03479

Programming supramolecular peptide materials by modulating the intermediate steps in the complex assembly pathway: Implications for biomedical applications

Auteurs: Chun Yin Jerry Lau; Enrico Mastrobattista
Publié dans: CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2021, ISSN 1359-0294
Éditeur: Pergamon Press
DOI: 10.1016/j.cocis.2020.101396

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

Auteurs: George R. Dakwar, Molood Shariati, Wouter Willaert, Wim Ceelen, Stefaan C. De Smedt, Katrien Remaut
Publié dans: Advanced Drug Delivery Reviews, Numéro 108, 2017, Page(s) 13-24, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2016.07.001

Feedback-Induced Temporal Control of “Breathing” Polymersomes To Create Self-Adaptive Nanoreactors

Auteurs: Hailong Che, Shoupeng Cao, Jan C. M. van Hest
Publié dans: Journal of the American Chemical Society, Numéro 140/16, 2018, Page(s) 5356-5359, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.8b02387

Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy

Auteurs: Jingxin Shao, Mona Abdelghani, Guizhi Shen, Shoupeng Cao, David S. Williams, Jan C. M. van Hest
Publié dans: ACS Nano, Numéro 12/5, 2018, Page(s) 4877-4885, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.8b01772

Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies

Auteurs: Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, Yifeng Xia, Shoupeng Cao, David S. Williams, Fenghua Meng, Jan C. M. Hest, Zhiyuan Zhong
Publié dans: ADVANCED THERAPEUTICS, Numéro 1/8, 2018, Page(s) 1800068, ISSN 2366-3987
Éditeur: Wiley
DOI: 10.1002/adtp.201800068

Effect of Formulation and Processing Parameters on the Size of mPEG- b -p(HPMA-Bz) Polymeric Micelles

Auteurs: Mahsa Bagheri, Jaleesa Bresseleers, Aida Varela-Moreira, Olivier Sandre, Silvie A. Meeuwissen, Raymond M. Schiffelers, Josbert M. Metselaar, Cornelus F. van Nostrum, Jan C. M. van Hest, Wim E. Hennink
Publié dans: Langmuir, Numéro 34/50, 2018, Page(s) 15495-15506, ISSN 0743-7463
Éditeur: American Chemical Society
DOI: 10.1021/acs.langmuir.8b03576

Biodegradable, Drug-Loaded Nanovectors via Direct Hydration as a New Platform for Cancer Therapeutics

Auteurs: Roxane Ridolfo, Benjamin C. Ede, Paraskevi Diamanti, Paul B. White, Adam W. Perriman, Jan C. M. van Hest, Allison Blair, David S. Williams
Publié dans: Small, Numéro 14/32, 2018, Page(s) 1703774, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201703774

pH-Induced Transformation of Biodegradable Multilamellar Nanovectors for Enhanced Tumor Penetration

Auteurs: Shoupeng Cao, Loai K. E. A. Abdelmohsen, Jingxin Shao, Joep van den Dikkenberg, Enrico Mastrobattista, David S. Williams, Jan C. M. van Hest
Publié dans: ACS Macro Letters, Numéro 7/11, 2018, Page(s) 1394-1399, ISSN 2161-1653
Éditeur: American Chemical Society
DOI: 10.1021/acsmacrolett.8b00807

Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells

Auteurs: Jingxin Shao, Imke A. B. Pijpers, Shoupeng Cao, David S. Williams, Xuehai Yan, Junbai Li, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Publié dans: Advanced Science, Numéro 6/5, 2019, Page(s) 1801678, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.201801678

Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy

Auteurs: Jianzhi Zhu, Zhicong Li, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi, Han Wang, Jan C. M. van Hest
Publié dans: Theranostics, Numéro 9/26, 2019, Page(s) 8048-8060, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.37054

Molecular Programming of Biodegradable Nanoworms via Ionically Induced Morphology Switch toward Asymmetric Therapeutic Carriers

Auteurs: Shoupeng Cao, Jingxin Shao, Yifeng Xia, Hailong Che, Zhiyuan Zhong, Fenghua Meng, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen, David S. Williams
Publié dans: Small, Numéro 15/38, 2019, Page(s) 1901849, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201901849

ATP-Mediated Transient Behavior of Stomatocyte Nanosystems

Auteurs: Hailong Che, Jianzhi Zhu, Shidong Song, Alexander F. Mason, Shoupeng Cao, Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Publié dans: Angewandte Chemie International Edition, Numéro 58/37, 2019, Page(s) 13113-13118, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201906331

Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine

Auteurs: Yigit Altay, Shoupeng Cao, Hailong Che, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Publié dans: Biomacromolecules, Numéro 20/11, 2019, Page(s) 4053-4064, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.9b01341

Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier

Auteurs: Bano Subia, Mika Reinisalo, Namit Dey, Shirin Tavakoli, Astrid Subrizi, Munia Ganguli, Marika Ruponen
Publié dans: European Journal of Pharmaceutics and Biopharmaceutics, Numéro 140, 2019, Page(s) 91-99, ISSN 0939-6411
Éditeur: Elsevier BV
DOI: 10.1016/j.ejpb.2019.05.003

Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA

Auteurs: Roberta Guagliardo, Pieterjan Merckx, Agata Zamborlin, Lynn De Backer, Mercedes Echaide, Jesus Pérez-Gil, Stefaan C. De Smedt, Koen Raemdonck
Publié dans: Pharmaceutics, Numéro 11/9, 2019, Page(s) 431, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11090431

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

Auteurs: Pieterjan Merckx, Lynn De Backer, Lien Van Hoecke, Roberta Guagliardo, Mercedes Echaide, Pieter Baatsen, Bárbara Olmeda, Xavier Saelens, Jésus Pérez-Gil, Stefaan C. De Smedt, Koen Raemdonck
Publié dans: Acta Biomaterialia, Numéro 78, 2018, Page(s) 236-246, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2018.08.012

mRNA Polyplexes with Post-Conjugated GALA Peptides Efficiently Target, Transfect, and Activate Antigen Presenting Cells

Auteurs: Bo Lou, Stefaan De Koker, Chun Yin Jerry Lau, Wim E. Hennink, Enrico Mastrobattista
Publié dans: Bioconjugate Chemistry, Numéro 30/2, 2018, Page(s) 461-475, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.8b00524

In vivo biocompatibility and immunogenicity of metal–phenolic gelation

Auteurs: Mattias Björnmalm, Lok Man Wong, Jonathan P. Wojciechowski, Jelle Penders, Conor C. Horgan, Marsilea A. Booth, Nicholas G. Martin, Susanne Sattler, Molly M. Stevens
Publié dans: Chemical Science, Numéro 10/43, 2019, Page(s) 10179-10194, ISSN 2041-6520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9sc03325d

Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses

Auteurs: Neda Kordalivand, Elena Tondini, Chun Yin Jerry Lau, Tina Vermonden, Enrico Mastrobattista, Wim E. Hennink, Ferry Ossendorp, Cornelus F. van Nostrum
Publié dans: Journal of Controlled Release, Numéro 315, 2019, Page(s) 114-125, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2019.10.048

Aerosolization of Nanotherapeutics as a Newly Emerging Treatment Regimen for Peritoneal Carcinomatosis

Auteurs: Molood Shariati, Wouter Willaert, Wim Ceelen, Stefaan C. De Smedt, Katrien Remaut
Publié dans: Cancers, Numéro 11/7, 2019, Page(s) 906, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11070906

Single Particle Automated Raman Trapping Analysis

Auteurs: Jelle Penders, Isaac J. Pence, Conor C. Horgan, Mads S. Bergholt, Christopher S. Wood, Adrian Najer, Ulrike Kauscher, Anika Nagelkerke, Molly M. Stevens
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-06397-6

Scale-Up of the Manufacturing Process To Produce Docetaxel-Loaded mPEG- b -p(HPMA-Bz) Block Copolymer Micelles for Pharmaceutical Applications

Auteurs: Jaleesa Bresseleers, Mahsa Bagheri, Gert Storm, Josbert M. Metselaar, Wim E. Hennink, Silvie A. Meeuwissen, Jan C. M. van Hest
Publié dans: Organic Process Research & Development, Numéro 23/12, 2019, Page(s) 2707-2715, ISSN 1083-6160
Éditeur: American Chemical Society
DOI: 10.1021/acs.oprd.9b00387

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

Auteurs: Roberta Guagliardo, Jesús Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
Publié dans: Journal of Controlled Release, Numéro 291, 2018, Page(s) 116-126, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2018.10.012

Controlling the morphology of copolymeric vectors for next generation nanomedicine

Auteurs: David S. Williams, Imke A.B. Pijpers, Roxane Ridolfo, Jan C.M. van Hest
Publié dans: Journal of Controlled Release, Numéro 259, 2017, Page(s) 29-39, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2017.02.030

High-Throughput Molecular Imaging via Deep-Learning-Enabled Raman Spectroscopy

Auteurs: Conor C. Horgan, Magnus Jensen, Anika Nagelkerke, Jean-Philippe St-Pierre, Tom Vercauteren, Molly M. Stevens, Mads S. Bergholt
Publié dans: Analytical Chemistry, 2021, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.1c02178

Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy

Auteurs: Cao, SP, Shao, JX, Wu, HL, Song, S, De Martino, MT, Pijpers, IAB, Friedrich, H, Abdelmohsen, LKEA , Williams, DS2, van Hest, JCM
Publié dans: Nature Communications, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-22279-w

Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring

Auteurs: Conor Horgan, Mads Bergholt, Anika Nagelkerke, May Zaw Thin, Isaac Pence, Ulrike Kauscher, Tammy Kalber, Daniel Stuckey, Molly Stevens
Publié dans: Theranostics, 2021, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.53031

Amphiphilic AIEgen-polymer aggregates: Design, self-assembly and biomedical applications

Auteurs: Cao, SP, Shao, JX, Abdelmohsen, LKEA, van Hest, JCM
Publié dans: Aggregate, 2021, ISSN 2692-4560
Éditeur: Wiley & Sons
DOI: 10.1002/agt2.128

Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications

Auteurs: Georgilis, E , Abdelghani, M , Pille, J , Aydinlioglu, E, van Hest, JCM , Lecommandoux, S, Garanger, E
Publié dans: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2020.119537

Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility.

Auteurs: Cao, Shoupeng, Wu, Hanglong, Pijpers, Imke A B, Shao, Jingxin, Abdelmohsen, Loai, K E A, Williams, David S, van Hest, Jan C M
Publié dans: ACS Nano, 2021, ISSN 1936-086X
Éditeur: ACS
DOI: 10.1021/acsnano.1c07343

Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides

Auteurs: Chun Yin Jerry Lau; Federico Fontana; Laurens D. B. Mandemaker; Dennie Wezendonk; Benjamin Vermeer; Alexandre M. J. J. Bonvin; Renko de Vries; Heyang Zhang; Katrien Remaut; Joep van den Dikkenberg; João Medeiros-Silva; Alia Hassan; Barbara Perrone; Rainer Kuemmerle; Fabrizio Gelain; Wim E. Hennink; Markus Weingarth; Enrico Mastrobattista
Publié dans: Communications Chemistry, 2020, ISSN 2399-3669
Éditeur: Nature Research
DOI: 10.1038/s42004-020-00417-7

Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations

Auteurs: Shirin Tavakoli, Otto Kalevi Kari, Tiina Turunen, Tatu Lajunen, Mechthild Schmitt, Julia Lehtinen, Fumitaka Tasaka, Petteri Parkkila, Joseph Ndika, Tapani Viitala, Harri Alenius, Arto Urtti, Astrid Subrizi
Publié dans: MOLECULAR PHARMACEUTICS, 2021, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00411

Surfactant protein B promotes cytosolic SiRNA delivery by adopting a virus-like mechanism of action

Auteurs: Guagliardo, R, Herman, L, Penders, J, Zamborlin, A, De Keersmaecker, H, Van de Vyver, T, Verstraeten, S, Merckx, P, Mingeot-Leclercq, M-P, Echaide, M, Pérez-Gil, J, Stevens, MM, De Smedt, SC, Raemdonck, K
Publié dans: ACS Nano, 2021, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.0c04489

Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium

Auteurs: Ridolfo, R, Tavakoli, S, Junnuthula, V, Williams, DS, Urtti, A ,van Hest, JCM
Publié dans: Biomacromolecules, 2021, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.0c00726

Image-guided Raman spectroscopy probe-tracking for tumor margin delineation

Auteurs: Horgan, CC; Bergholt, MS; Thin, MZ; Nagelkerke, A; Kennedy, R; Kalber, TL; Stuckey, DJ; Stevens, MM
Publié dans: journal of biomedical optics, 2021, ISSN 1083-3668
Éditeur: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.26.3.036002

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