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Synaptic Dysfunction in Alzheimer Disease

Deliverables

ESRs recruited

Report on the recruitment of ESRs

Detailed plans for third years training and meetings

A plan and schedule of the third year's courses and meetings.

Detailed plans for second years training and meetings

A plan and schedule of the second year's courses and meetings

Detailed plans for first years training and meetings

A plan and schedule of the first year's courses and meetings

Doctoral degrees

The ESRs will write their doctoral theses and hold their dissertation defence according to their customs at their local university. The defence will be evaluated by local committees. For Swedish ESRs the disserattion might be delayed up to 12 mo due to high requirements.

Half-time control reports and seminars by the ESRs

Each ESR will write a half-time report and hold a seminar at their corresponding university. The report will be evaluated by local comittees.

Public dissemination, including workshop with People living with dementia

A report will be written on the public dissemniation acheived so far including an evaluation of the workshop with People living with dementia mo 19.

Publications

Publications will be provided with open access throughout the project. A report on all publications will be included in the mid-term report and in the final report.

Established website

The external website will be established. It will later be developed together with the ESRs.

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Publications

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers

Author(s): Una Smailovic, Thomas Koenig, Ingemar Kåreholt, Thomas Andersson, Milica Gregoric Kramberger, Bengt Winblad, Vesna Jelic
Published in: Neurobiology of Aging, Issue 63, 2018, Page(s) 88-95, ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2017.11.005

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Author(s): Antonia Piazzesi, Dražen Papić, Fabio Bertan, Paolo Salomoni, Pierluigi Nicotera, Daniele Bano
Published in: Cell Reports, Issue 17/4, 2016, Page(s) 987-996, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.09.074

The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux

Author(s): Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, Anaïs Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-40887-x

Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena

Author(s): Elena Marcello, Stefano Musardo, Lina Vandermeulen, Silvia Pelucchi, Fabrizio Gardoni, Nadia Santo, Flavia Antonucci, Monica Di Luca
Published in: Molecular Neurobiology, Issue 56/10, 2019, Page(s) 7136-7143, ISSN 0893-7648
DOI: 10.1007/s12035-019-1583-5

Propagation of tau pathology: integrating insights from post mortem and in vivo studies

Author(s): Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll
Published in: Biological Psychiatry, Issue Oct 3, 19, 2019, Page(s) 31744-5, ISSN 0006-3223
DOI: 10.1016/j.biopsych.2019.09.019

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Author(s): Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak, Norbert Zilka
Published in: Journal of Alzheimer’s Disease & Parkinsonism, Issue 07/06, 2017, ISSN 2161-0460
DOI: 10.4172/2161-0460.1000400

Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction

Author(s): Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano
Published in: The EMBO Journal, Issue 38/6, 2019, Page(s) e99558, ISSN 0261-4189
DOI: 10.15252/embj.201899558

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer

Author(s): Riccardo Filadi, Nuno Santos Leal, Bernadette Schreiner, Alice Rossi, Giacomo Dentoni, Catarina Moreira Pinho, Birgitta Wiehager, Domenico Cieri, Tito Calì, Paola Pizzo, Maria Ankarcrona
Published in: Current Biology, Issue 28/3, 2018, Page(s) 369-382.e6, ISSN 0960-9822
DOI: 10.1016/j.cub.2017.12.047

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

Author(s): Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona
Published in: Acta Neuropathologica Communications, Issue 6/1, 2018, ISSN 2051-5960
DOI: 10.1186/s40478-018-0605-2

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

Author(s): Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-06813-x

Inhibitory interneurons in Alzheimer’s disease

Author(s): G .Vargova, T. Vogels, Z. Kostecka, T. Hromadka
Published in: Bratislava Medical Journal, Issue 119/04, 2018, Page(s) 205-209, ISSN 1336-0345
DOI: 10.4149/bll_2018_038

WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans

Author(s): Kostoula Troulinaki, Sven Büttner, Anaïs Marsal Cots, Simona Maida, Katharina Meyer, Fabio Bertan, Anna Gioran, Antonia Piazzesi, Alessandra Fornarelli, Pierluigi Nicotera, Daniele Bano
Published in: Cell Death Discovery, Issue 4/1, 2018, ISSN 2058-7716
DOI: 10.1038/s41420-017-0005-6

Intersection of pathological tau and microglia at the synapse

Author(s): Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádka
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
DOI: 10.1186/s40478-019-0754-y

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

Author(s): Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernandez, Muhammad A Ismail, Silvia Maioli, Eduardo Matute, Eva Maria Jimenez-Mateos, Ingemar Björkhem, Javier DeFelipe, Angel Cedazo-Minguez
Published in: Cerebral Cortex, Issue 29/1, 2018, Page(s) 429-446, ISSN 1047-3211
DOI: 10.1093/cercor/bhy274

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies

Author(s): Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman
Published in: Frontiers in Aging Neuroscience, Issue 11, 2019, ISSN 1663-4365
DOI: 10.3389/fnagi.2019.00273

Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration

Author(s): Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Published in: Neurobiology of Disease, Issue 134, 2020, Page(s) 104645, ISSN 0969-9961
DOI: 10.1016/j.nbd.2019.104645

Neurophysiological Markers of Alzheimer’s Disease: Quantitative EEG Approach

Author(s): Una Smailovic, Vesna Jelic
Published in: Neurology and Therapy, Issue 8/S2, 2019, Page(s) 37-55, ISSN 2193-8253
DOI: 10.1007/s40120-019-00169-0

The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease

Author(s): Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket M Nigam, Steven L Carroll, Bengt Winblad, Nenad Bogdanovic, Gaël Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O Tjernberg, Susanne Frykman
Published in: Molecular & Cellular Proteomics, 2019, Page(s) mcp.RA119.001737, ISSN 1535-9476
DOI: 10.1074/mcp.ra119.001737

EEG time signature in Alzheimer´s disease: Functional brain networks falling apart

Author(s): Una Smailovic, Thomas Koenig, Erika J Laukka, Grégoria Kalpouzos, Thomas Andersson, Bengt Winblad, Vesna Jelic
Published in: NeuroImage: Clinical, Issue 24, 2019, Page(s) 102046, ISSN 2213-1582
DOI: 10.1016/j.nicl.2019.102046