Synaptic Dysfunction in Alzheimer Disease

Informations projet

SyDAD

N° de convention de subvention: 676144

DOI

10.3030/676144

Projet clôturé

Date de signature de la CE 6 Août 2015

Date de début 1 Novembre 2015

Date de fin 31 Octobre 2019

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 846 736,44

Contribution de l’UE

€ 3 846 736,44

Coordonné par

KAROLINSKA INSTITUTET
Sweden

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

ESRs recruited

Report on the recruitment of ESRs

Detailed plans for third years training and meetings

A plan and schedule of the third year's courses and meetings.

Detailed plans for second years training and meetings

A plan and schedule of the second year's courses and meetings

Detailed plans for first years training and meetings

A plan and schedule of the first year's courses and meetings

Doctoral degrees

The ESRs will write their doctoral theses and hold their dissertation defence according to their customs at their local university. The defence will be evaluated by local committees. For Swedish ESRs the disserattion might be delayed up to 12 mo due to high requirements.

Half-time control reports and seminars by the ESRs

Each ESR will write a half-time report and hold a seminar at their corresponding university. The report will be evaluated by local comittees.

Public dissemination, including workshop with People living with dementia

A report will be written on the public dissemniation acheived so far including an evaluation of the workshop with People living with dementia mo 19.

Websites, patent fillings, videos etc. (2)

Publications

Publications will be provided with open access throughout the project. A report on all publications will be included in the mid-term report and in the final report.

Established website

The external website will be established. It will later be developed together with the ESRs.

Publications

Peer reviewed articles (19)

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers

Auteurs: Una Smailovic, Thomas Koenig, Ingemar Kåreholt, Thomas Andersson, Milica Gregoric Kramberger, Bengt Winblad, Vesna Jelic
Publié dans: Neurobiology of Aging, Numéro 63, 2018, Page(s) 88-95, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.11.005

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Auteurs: Antonia Piazzesi, Dražen Papić, Fabio Bertan, Paolo Salomoni, Pierluigi Nicotera, Daniele Bano
Publié dans: Cell Reports, Numéro 17/4, 2016, Page(s) 987-996, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2016.09.074

The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux

Auteurs: Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, Anaïs Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-40887-x

Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena

Auteurs: Elena Marcello, Stefano Musardo, Lina Vandermeulen, Silvia Pelucchi, Fabrizio Gardoni, Nadia Santo, Flavia Antonucci, Monica Di Luca
Publié dans: Molecular Neurobiology, Numéro 56/10, 2019, Page(s) 7136-7143, ISSN 0893-7648
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12035-019-1583-5

Propagation of tau pathology: integrating insights from post mortem and in vivo studies

Auteurs: Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll
Publié dans: Biological Psychiatry, Numéro Oct 3, 19, 2019, Page(s) 31744-5, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2019.09.019

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Auteurs: Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak, Norbert Zilka
Publié dans: Journal of Alzheimer’s Disease & Parkinsonism, Numéro 07/06, 2017, ISSN 2161-0460
Éditeur: Omics International
DOI: 10.4172/2161-0460.1000400

Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction

Auteurs: Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano
Publié dans: The EMBO Journal, Numéro 38/6, 2019, Page(s) e99558, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.201899558

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer

Auteurs: Riccardo Filadi, Nuno Santos Leal, Bernadette Schreiner, Alice Rossi, Giacomo Dentoni, Catarina Moreira Pinho, Birgitta Wiehager, Domenico Cieri, Tito Calì, Paola Pizzo, Maria Ankarcrona
Publié dans: Current Biology, Numéro 28/3, 2018, Page(s) 369-382.e6, ISSN 0960-9822
Éditeur: Cell Press
DOI: 10.1016/j.cub.2017.12.047

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

Auteurs: Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona
Publié dans: Acta Neuropathologica Communications, Numéro 6/1, 2018, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-018-0605-2

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

Auteurs: Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-06813-x

Inhibitory interneurons in Alzheimer’s disease

Auteurs: G .Vargova, T. Vogels, Z. Kostecka, T. Hromadka
Publié dans: Bratislava Medical Journal, Numéro 119/04, 2018, Page(s) 205-209, ISSN 1336-0345
Éditeur: AEPress
DOI: 10.4149/bll_2018_038

WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans

Auteurs: Kostoula Troulinaki, Sven Büttner, Anaïs Marsal Cots, Simona Maida, Katharina Meyer, Fabio Bertan, Anna Gioran, Antonia Piazzesi, Alessandra Fornarelli, Pierluigi Nicotera, Daniele Bano
Publié dans: Cell Death Discovery, Numéro 4/1, 2018, ISSN 2058-7716
Éditeur: Springer Nature
DOI: 10.1038/s41420-017-0005-6

Intersection of pathological tau and microglia at the synapse

Auteurs: Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádka
Publié dans: Acta Neuropathologica Communications, Numéro 7/1, 2019, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-019-0754-y

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

Auteurs: Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernandez, Muhammad A Ismail, Silvia Maioli, Eduardo Matute, Eva Maria Jimenez-Mateos, Ingemar Björkhem, Javier DeFelipe, Angel Cedazo-Minguez
Publié dans: Cerebral Cortex, Numéro 29/1, 2018, Page(s) 429-446, ISSN 1047-3211
Éditeur: Oxford University Press
DOI: 10.1093/cercor/bhy274

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies

Auteurs: Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman
Publié dans: Frontiers in Aging Neuroscience, Numéro 11, 2019, ISSN 1663-4365
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnagi.2019.00273

Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration

Auteurs: Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Publié dans: Neurobiology of Disease, Numéro 134, 2020, Page(s) 104645, ISSN 0969-9961
Éditeur: Academic Press
DOI: 10.1016/j.nbd.2019.104645

Neurophysiological Markers of Alzheimer’s Disease: Quantitative EEG Approach

Auteurs: Una Smailovic, Vesna Jelic
Publié dans: Neurology and Therapy, Numéro 8/S2, 2019, Page(s) 37-55, ISSN 2193-8253
Éditeur: Springer
DOI: 10.1007/s40120-019-00169-0

The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease

Auteurs: Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket M Nigam, Steven L Carroll, Bengt Winblad, Nenad Bogdanovic, Gaël Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O Tjernberg, Susanne Frykman
Publié dans: Molecular & Cellular Proteomics, 2019, Page(s) mcp.RA119.001737, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra119.001737

EEG time signature in Alzheimer´s disease: Functional brain networks falling apart

Auteurs: Una Smailovic, Thomas Koenig, Erika J Laukka, Grégoria Kalpouzos, Thomas Andersson, Bengt Winblad, Vesna Jelic
Publié dans: NeuroImage: Clinical, Numéro 24, 2019, Page(s) 102046, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1016/j.nicl.2019.102046

Droits de propriété intellectuelle

Patent (1)

ACTIVATOR PEPTIDES OF THE ENZYME ADAM 10 AND RELATED USES IN THE TREATMENT OF ALZHEIMER'S DISEASE

Numéro de demande/publication: 20 18060511
Date: 2018-12-21
Demandeur(s): UNIVERSITA DEGLI STUDI DI MILANO