Next-generation Detection of Antigen Responsive T-cells

Project Information

nextDART

Grant agreement ID: 677268

DOI 10.3030/677268

Project closed

EC signature date 10 May 2016

Start date 1 June 2016

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 070,00

EU contribution € 1 499 070,00

Coordinated by

DANMARKS TEKNISKE UNIVERSITET
Denmark

Publications

Peer reviewed articles (8)

Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Author(s): Sunil Kumar Saini, Andreas Due Ørskov, Anne-Mette Bjerregaard, Ashwin Unnikrishnan, Staffan Holmberg-Thydén, Annie Borch, Kathrine Valentini Jensen, Govardhan Anande, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Marianne Bach Treppendahl, Anne Ortved Gang, Inge Høgh Dufva, Zoltan Szallasi, Nicola Ternette, Anders Gorm Pedersen, Aron Charles Eklund, John Pimanda, Kirsten Grønbæk
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19464-8

The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Author(s): Ehsan Ghorani, James L. Reading, Jake Y. Henry, Marc Robert de Massy, Rachel Rosenthal, Virginia Turati, Kroopa Joshi, Andrew J. S. Furness, Assma Ben Aissa, Sunil Kumar Saini, Sofie Ramskov, Andrew Georgiou, Mariana Werner Sunderland, Yien Ning Sophia Wong, Maria Vila De Mucha, William Day, Felipe Galvez-Cancino, Pablo D. Becker, Imran Uddin, Theres Oakes, Mazlina Ismail, Tahel Ronel, Annemarie W
Published in: Nature Cancer, Issue 1/5, 2020, Page(s) 546-561, ISSN 2662-1347
Publisher: Nature publishing group
DOI: 10.1038/s43018-020-0066-y

Human endogenous retroviruses and their implication for immunotherapeutics of cancer

Author(s): A S Attermann, A -M Bjerregaard, S K Saini, K Grønbæk, S R Hadrup
Published in: Annals of Oncology, Issue 29/11, 2018, Page(s) 2183-2191, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdy413

T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide–MHC complexes

Author(s): Amalie K Bentzen, Lina Such, Kamilla K Jensen, Andrea M Marquard, Leon E Jessen, Natalie J Miller, Candice D Church, Rikke Lyngaa, David M Koelle, Jürgen C Becker, Carsten Linnemann, Ton N M Schumacher, Paolo Marcatili, Paul Nghiem, Morten Nielsen, Sine R Hadrup
Published in: Nature Biotechnology, Issue 36/12, 2018, Page(s) 1191-1196, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.4303

Determining T-cell specificity to understand and treat disease

Author(s): Sine Reker Hadrup, Evan W. Newell
Published in: Nature Biomedical Engineering, Issue 1/10, 2017, Page(s) 784-795, ISSN 2157-846X
Publisher: Nature Publishing group
DOI: 10.1038/s41551-017-0143-4

T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation

Author(s): Amalie Kai Bentzen, Sine Reker Hadrup
Published in: Immuno-Oncology Technology, Issue 2, 2019, Page(s) 1-10, ISSN 2590-0188
Publisher: Elsevier Inc
DOI: 10.1016/j.iotech.2019.06.003

Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

Author(s): Sunil Kumar Saini, Tripti Tamhane, Raghavendra Anjanappa, Ankur Saikia, Sofie Ramskov, Marco Donia, Inge Marie Svane, Søren Nyboe Jakobsen, Maria Garcia-Alai, Martin Zacharias, Rob Meijers, Sebastian Springer, Sine Reker Hadrup
Published in: Science Immunology, Issue 4/37, 2019, Page(s) eaau9039, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aau9039

Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations

Author(s): Ulla Kring Hansen, Sofie Ramskov, Anne-Mette Bjerregaard, Annie Borch, Rikke Andersen, Arianna Draghi, Marco Donia, Amalie Kai Bentzen, Andrea Marion Marquard, Zoltan Szallasi, Aron Charles Eklund, Inge Marie Svane, Sine Reker Hadrup
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Immunology
DOI: 10.3389/fimmu.2020.00373