Mediation of stem cell identity and aging by proteostasis

Project Information

StemProteostasis

Grant agreement ID: 677427

DOI 10.3030/677427

Project closed

EC signature date 28 June 2016

Start date 1 July 2016

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

UNIVERSITAT ZU KOLN
Germany

Publications

Peer reviewed articles (9)

The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress

Author(s): Ernesto Llamas, Salvador Torres‐Montilla, Hyun Ju Lee, María Victoria Barja, Elena Schlimgen, Nick Dunken, Prerana Wagle, Wolfgang Werr, Alga Zuccaro, Manuel Rodríguez‐Concepción, David Vilchez
Published in: Aging Cell, Issue 20/8, 2021, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13446

Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans

Author(s): Giuseppe Calculli, Hyun Ju Lee, Koning Shen, Uyen Pham, Marija Herholz, Aleksandra Trifunovic, Andrew Dillin, David Vilchez
Published in: Science Advances, Issue 7/26, 2021, Page(s) eabg3012, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.abg3012

The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells

Author(s): Azra Fatima, Dilber Irmak, Alireza Noormohammadi, Markus M. Rinschen, Aniruddha Das, Orsolya Leidecker, Christina Schindler, Víctor Sánchez-Gaya, Prerana Wagle, Wojciech Pokrzywa, Thorsten Hoppe, Alvaro Rada-Iglesias, David Vilchez
Published in: Communications Biology, Issue 3/1, 2020, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-020-0984-3

Rewiring of the ubiquitinated proteome determines ageing in C. elegans

Author(s): Seda Koyuncu, Rute Loureiro, Hyun Ju Lee, Prerana Wagle, Marcus Krueger, David Vilchez
Published in: Nature, Issue 596/7871, 2021, Page(s) 285-290, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03781-z

A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells

Author(s): Hyun Ju Lee, Deniz Bartsch, Cally Xiao, Santiago Guerrero, Gaurav Ahuja, Christina Schindler, James J. Moresco, John R. Yates, Fátima Gebauer, Hisham Bazzi, Christoph Dieterich, Leo Kurian, David Vilchez
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01744-5

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Author(s): Alireza Noormohammadi, Amirabbas Khodakarami, Ricardo Gutierrez-Garcia, Hyun Ju Lee, Seda Koyuncu, Tim König, Christina Schindler, Isabel Saez, Azra Fatima, Christoph Dieterich, David Vilchez
Published in: Nature Communications, Issue 7, 2016, Page(s) 13649, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13649

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients

Author(s): Seda Koyuncu, Isabel Saez, Hyun Ju Lee, Ricardo Gutierrez-Garcia, Wojciech Pokrzywa, Azra Fatima, Thorsten Hoppe, David Vilchez
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05320-3

Insights into the ubiquitin-proteasome system of human embryonic stem cells

Author(s): Isabel Saez, Seda Koyuncu, Ricardo Gutierrez-Garcia, Christoph Dieterich, David Vilchez
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-22384-9

Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans

Author(s): Hyun Ju Lee, Alireza Noormohammadi, Seda Koyuncu, Giuseppe Calculli, Milos S. Simic, Marija Herholz, Aleksandra Trifunovic, David Vilchez
Published in: Nature Metabolism, Issue 1/8, 2019, Page(s) 790-810, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-019-0097-9