Targeting perivascular myofibroblast progenitors to treat cardiac fibrosis and heart failure in chronic kidney disease

Project Information

CureCKDHeart

Grant agreement ID: 677448

DOI 10.3030/677448

Project closed

EC signature date 18 April 2016

Start date 1 May 2016

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 497 888,00

EU contribution € 1 497 888,00

Coordinated by

UNIVERSITAETSKLINIKUM AACHEN
Germany

Publications

Peer reviewed articles (11)

Decoding myofibroblast origins in human kidney fibrosis

Author(s): Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamari JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R.
Published in: Nature, Issue 589, 2021, Page(s) 281-286, ISSN 1476-4687
Publisher: Nature Springer
DOI: 10.1038/s41586-020-2941-1

Chromatin-accesibility estimation from single-cell ATAC-seq data with scOpen.

Author(s): Li Z, Kuppe C, Ziegler S, Cheng M, Kabgani N, Menzel S, Zenke M, Kramann R,* Costa IG
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26530-2

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Author(s): Jitske Jansen; Katharina C. Reimer; James S. Nagai; Finny S. Varghese; Gijs J. Overheul; Marit de Beer; Rona Roverts; Deniz Daviran; Liline A.S. Fermin; Brigith Willemsen; Marcel Beukenboom; Sonja Djudjaj; Saskia von Stillfried; Larissa E. van Eijk; Mirjam Mastik; Marian Bulthuis; Wilfred den Dunnen; Harry van Goor; Jan-Luuk Hillebrands; Sergio H. Triana; Theodore Alexandrov; Marie-Cherelle Timm;
Published in: Cell Stem Cell, Issue 9, 2022, Page(s) 217-231, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.12.010

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

Author(s): Rafael Kramann, Claudia Goettsch, Janewit Wongboonsin, Hiroshi Iwata, Rebekka K. Schneider, Christoph Kuppe, Nadine Kaesler, Monica Chang-Panesso, Flavia G. Machado, Susannah Gratwohl, Kaushal Madhurima, Joshua D. Hutcheson, Sanjay Jain, Elena Aikawa, Benjamin D. Humphreys
Published in: Cell Stem Cell, Issue 19/5, 2016, Page(s) 628-642, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2016.08.001

Gli1 + Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury

Author(s): Rafael Kramann, Janewit Wongboonsin, Monica Chang-Panesso, Flavia G. Machado, Benjamin D. Humphreys
Published in: Journal of the American Society of Nephrology, Issue 28/3, 2017, Page(s) 776-784, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2016030297

Gli1 + Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

Author(s): Rebekka K. Schneider, Ann Mullally, Aurelien Dugourd, Fabian Peisker, Remco Hoogenboezem, Paulina M.H. Van Strien, Eric M. Bindels, Dirk Heckl, Guntram Büsche, David Fleck, Gerhard Müller-Newen, Janewit Wongboonsin, Monica Ventura Ferreira, Victor G. Puelles, Julio Saez-Rodriguez, Benjamin L. Ebert, Benjamin D. Humphreys, Rafael Kramann
Published in: Cell Stem Cell, Issue 20/6, 2017, Page(s) 785-800.e8, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2017.03.008

Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles

Author(s): Leon J. Schurgers, Asim C. Akbulut, Dawid M. Kaczor, Maurice Halder, Rory R. Koenen, Rafael Kramann
Published in: Frontiers in Cardiovascular Medicine, Issue 5, 2018, ISSN 2297-055X
Publisher: Frontiers
DOI: 10.3389/fcvm.2018.00036

Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis

Author(s): Rafael Kramann, Flavia Machado, Haojia Wu, Tetsuro Kusaba, Konrad Hoeft, Rebekka K. Schneider, Benjamin D. Humphreys
Published in: JCI Insight, Issue 3/9, 2018, ISSN 2379-3708
Publisher: American Society of Clinical Investigation
DOI: 10.1172/jci.insight.99561

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis

Author(s): Hélène FE Gleitz, Rafael Kramann, Rebekka K Schneider
Published in: The Journal of Pathology, Issue 245/2, 2018, Page(s) 138-146, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5078

Mapping the cardiac vascular niche in heart failure

Author(s): Peisker F, Halder M, Nagai J Ziegler S, Kaesler N, Hoeft K, Li R, Bindels EMJ, Kuppe C, Moellmann J, Lehrke M, Stoppe C, Schaub MT, Schneider RK, Costa I, Kramann R
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30682-0

Spatial multi-omic map of human myocardial infarction.

Author(s): Kuppe C, Ramirez Flores R, Li Z, Hayat S, Levinson RT, Liao X, Hannani MT, Tanevski J, Wünnemann F, Nagai JS, Halder M, Schumacher D, Menzel S, Schäfer G, Hoeft K, Cheng M, Ziegler S, Zhang X, Peisker F, Kaesler N, Saritas T, Xu Y, Kassner A, Gummert J, Morshuis M, Amrute J, Veltrop RJA, Boor P, KLingel K, van Laake L, Vink A, Hoogenboezem RM, Bindels EMJ, van Laake L, Vink Schneider RK, Lavine
Published in: Nature, 2022, Page(s) 1-12, ISSN 1476-4687
Publisher: Nature Springer
DOI: 10.1038/s41586-022-05060-x