Targeting perivascular myofibroblast progenitors to treat cardiac fibrosis and heart failure in chronic kidney disease

Pubblicazioni

Decoding myofibroblast origins in human kidney fibrosis

Autori: Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamari JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R.
Pubblicato in: Nature, Numero 589, 2021, Pagina/e 281-286, ISSN 1476-4687
Editore: Nature Springer
DOI: 10.1038/s41586-020-2941-1

Chromatin-accesibility estimation from single-cell ATAC-seq data with scOpen.

Autori: Li Z, Kuppe C, Ziegler S, Cheng M, Kabgani N, Menzel S, Zenke M, Kramann R,* Costa IG
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-26530-2

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Autori: Jitske Jansen; Katharina C. Reimer; James S. Nagai; Finny S. Varghese; Gijs J. Overheul; Marit de Beer; Rona Roverts; Deniz Daviran; Liline A.S. Fermin; Brigith Willemsen; Marcel Beukenboom; Sonja Djudjaj; Saskia von Stillfried; Larissa E. van Eijk; Mirjam Mastik; Marian Bulthuis; Wilfred den Dunnen; Harry van Goor; Jan-Luuk Hillebrands; Sergio H. Triana; Theodore Alexandrov; Marie-Cherelle Timm;
Pubblicato in: Cell Stem Cell, Numero 9, 2022, Pagina/e 217-231, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2021.12.010

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

Autori: Rafael Kramann, Claudia Goettsch, Janewit Wongboonsin, Hiroshi Iwata, Rebekka K. Schneider, Christoph Kuppe, Nadine Kaesler, Monica Chang-Panesso, Flavia G. Machado, Susannah Gratwohl, Kaushal Madhurima, Joshua D. Hutcheson, Sanjay Jain, Elena Aikawa, Benjamin D. Humphreys
Pubblicato in: Cell Stem Cell, Numero 19/5, 2016, Pagina/e 628-642, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2016.08.001

Gli1 + Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury

Autori: Rafael Kramann, Janewit Wongboonsin, Monica Chang-Panesso, Flavia G. Machado, Benjamin D. Humphreys
Pubblicato in: Journal of the American Society of Nephrology, Numero 28/3, 2017, Pagina/e 776-784, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/ASN.2016030297

Gli1 + Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

Autori: Rebekka K. Schneider, Ann Mullally, Aurelien Dugourd, Fabian Peisker, Remco Hoogenboezem, Paulina M.H. Van Strien, Eric M. Bindels, Dirk Heckl, Guntram Büsche, David Fleck, Gerhard Müller-Newen, Janewit Wongboonsin, Monica Ventura Ferreira, Victor G. Puelles, Julio Saez-Rodriguez, Benjamin L. Ebert, Benjamin D. Humphreys, Rafael Kramann
Pubblicato in: Cell Stem Cell, Numero 20/6, 2017, Pagina/e 785-800.e8, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2017.03.008

Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles

Autori: Leon J. Schurgers, Asim C. Akbulut, Dawid M. Kaczor, Maurice Halder, Rory R. Koenen, Rafael Kramann
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 5, 2018, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2018.00036

Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis

Autori: Rafael Kramann, Flavia Machado, Haojia Wu, Tetsuro Kusaba, Konrad Hoeft, Rebekka K. Schneider, Benjamin D. Humphreys
Pubblicato in: JCI Insight, Numero 3/9, 2018, ISSN 2379-3708
Editore: American Society of Clinical Investigation
DOI: 10.1172/jci.insight.99561

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis

Autori: Hélène FE Gleitz, Rafael Kramann, Rebekka K Schneider
Pubblicato in: The Journal of Pathology, Numero 245/2, 2018, Pagina/e 138-146, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.5078

Mapping the cardiac vascular niche in heart failure

Autori: Peisker F, Halder M, Nagai J Ziegler S, Kaesler N, Hoeft K, Li R, Bindels EMJ, Kuppe C, Moellmann J, Lehrke M, Stoppe C, Schaub MT, Schneider RK, Costa I, Kramann R
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30682-0

Spatial multi-omic map of human myocardial infarction.

Autori: Kuppe C, Ramirez Flores R, Li Z, Hayat S, Levinson RT, Liao X, Hannani MT, Tanevski J, Wünnemann F, Nagai JS, Halder M, Schumacher D, Menzel S, Schäfer G, Hoeft K, Cheng M, Ziegler S, Zhang X, Peisker F, Kaesler N, Saritas T, Xu Y, Kassner A, Gummert J, Morshuis M, Amrute J, Veltrop RJA, Boor P, KLingel K, van Laake L, Vink A, Hoogenboezem RM, Bindels EMJ, van Laake L, Vink Schneider RK, Lavine
Pubblicato in: Nature, 2022, Pagina/e 1-12, ISSN 1476-4687
Editore: Nature Springer
DOI: 10.1038/s41586-022-05060-x

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