Unravelling respiratory microflows in silico and in vitro: novel paths for targeted pulmonary delivery in infants and young children

Project Information

RespMicroFlows

Grant agreement ID: 677772

DOI

10.3030/677772

Project closed

EC signature date 2 March 2016

Start date 1 June 2016

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 937 500,00

EU contribution

€ 1 937 500,00

Coordinated by

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways

Author(s): Lihi Shachar-Berman, Yan Ostrovski, Alessandro De Rosis, Stavros Kassinos, Josué Sznitman
Published in: European Journal of Pharmaceutical Sciences, Issue 113, 2017, Page(s) 145-151, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2017.09.023

One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures

Author(s): Philipp Hofemeier, Kenishiro Koshiyama, Shigeo Wada, Josué Sznitman
Published in: European Journal of Pharmaceutical Sciences, Issue 113, 2017, Page(s) 53-63, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2017.09.033

Revisiting high-frequency oscillatory ventilation in vitro and in silico in neonatal conductive airway

Author(s): Katrin Bauer, Eliram Nof, Josué Sznitman
Published in: Clinical Biomechanics, 2017, ISSN 0268-0033
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.clinbiomech.2017.11.009

Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles

Author(s): Josué Sznitman, Ostrovski, Philipp Hofemeier
Published in: International Journal of Nanomedicine, Issue Volume 11, 2016, Page(s) 3385-3395, ISSN 1178-2013
Publisher: Dove Press
DOI: 10.2147/IJN.S102138

The role of anisotropic expansion for pulmonary acinar aerosol deposition

Author(s): Philipp Hofemeier, Josué Sznitman
Published in: Journal of Biomechanics, Issue 49/14, 2016, Page(s) 3543-3548, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2016.08.025

Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method

Author(s): Yan Ostrovski, Simon Dorfman, Maksim Mezhericher, Stavros Kassinos, Josué Sznitman
Published in: Flow, Turbulence and Combustion, 2018, ISSN 1386-6184
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10494-018-9927-1

Biomimetics of the pulmonary environment in vitro : A microfluidics perspective

Author(s): Janna Tenenbaum-Katan, Arbel Artzy-Schnirman, Rami Fishler, Netanel Korin, Josué Sznitman
Published in: Biomicrofluidics, Issue 12/4, 2018, Page(s) 042209, ISSN 1932-1058
Publisher: American Institute of Physics
DOI: 10.1063/1.5023034

Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)

Author(s): Prashant Das, Eliram Nof, Israel Amirav, Stavros C. Kassinos, Josué Sznitman
Published in: PLOS ONE, Issue 13/11, 2018, Page(s) e0207711, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0207711

Red blood cell dynamics in biomimetic microfluidic networks of pulmonary alveolar capillaries

Author(s): Hagit Stauber, Dan Waisman, Netanel Korin, Josué Sznitman
Published in: Biomicrofluidics, Issue 11/1, 2017, Page(s) 014103, ISSN 1932-1058
Publisher: American Institute of Physics
DOI: 10.1063/1.4973930

Streamline crossing: An essential mechanism for aerosol dispersion in the pulmonary acinus

Author(s): Rami Fishler, Yan Ostrovski, Chao-Yi Lu, Josué Sznitman
Published in: Journal of Biomechanics, Issue 50, 2017, Page(s) 222-227, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2016.11.043

Particle sizing of pharmaceutical aerosols via direct imaging of particle settling velocities

Author(s): Rami Fishler, Frank Verhoeven, Wilbur de Kruijf, Josué Sznitman
Published in: European Journal of Pharmaceutical Sciences, Issue 113, 2017, Page(s) 152-158, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2017.08.016

Red blood cell (RBC) suspensions in confined microflows: Pressure-flow relationship

Author(s): Hagit Stauber, Dan Waisman, Netanel Korin, Josué Sznitman
Published in: Medical Engineering & Physics, Issue 48, 2017, Page(s) 49-54, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2017.08.006

Other (1)

Novel aerodynamic sizing method using image-based analysis of settling velocities

Author(s): Rami Fishler and Josue Sznitman
Published in: Inhalation, Issue 11, 2017, Page(s) 21-25
Publisher: Inhalation

Intellectual Property Rights

Patent (3)

FOAM FOR PULMONARY DRUG DELIVERY

Application/Publication number: TECH- P-91-PC
Date: 2017-11-06
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Device, system and method for measuring particle size

Application/Publication number: WO 2017037724A1
Date: 2017-09-03
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

TARGETED DELIVERY OF AEROSOLS OF MAGNETIZED ACTIVE AGENTS

Application/Publication number: PCT /IL2017/050472
Date: 2017-04-25
Applicant(s): TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY