Unravelling respiratory microflows in silico and in vitro: novel paths for targeted pulmonary delivery in infants and young children

Project Information

RespMicroFlows

Grant agreement ID: 677772

DOI 10.3030/677772

Project closed

EC signature date 2 March 2016

Start date 1 June 2016

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 937 500,00

EU contribution € 1 937 500,00

Coordinated by

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

Publications

Peer reviewed articles (12)

Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways

Author(s): Lihi Shachar-Berman, Yan Ostrovski, Alessandro De Rosis, Stavros Kassinos, Josué Sznitman
Published in: European Journal of Pharmaceutical Sciences, Issue 113, 2017, Page(s) 145-151, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2017.09.023

One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures

Author(s): Philipp Hofemeier, Kenishiro Koshiyama, Shigeo Wada, Josué Sznitman
Published in: European Journal of Pharmaceutical Sciences, Issue 113, 2017, Page(s) 53-63, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2017.09.033

Revisiting high-frequency oscillatory ventilation in vitro and in silico in neonatal conductive airway

Author(s): Katrin Bauer, Eliram Nof, Josué Sznitman
Published in: Clinical Biomechanics, 2017, ISSN 0268-0033
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.clinbiomech.2017.11.009

Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles

Author(s): Josué Sznitman, Ostrovski, Philipp Hofemeier
Published in: International Journal of Nanomedicine, Issue Volume 11, 2016, Page(s) 3385-3395, ISSN 1178-2013
Publisher: Dove Press
DOI: 10.2147/IJN.S102138

The role of anisotropic expansion for pulmonary acinar aerosol deposition

Author(s): Philipp Hofemeier, Josué Sznitman
Published in: Journal of Biomechanics, Issue 49/14, 2016, Page(s) 3543-3548, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2016.08.025

Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method

Author(s): Yan Ostrovski, Simon Dorfman, Maksim Mezhericher, Stavros Kassinos, Josué Sznitman
Published in: Flow, Turbulence and Combustion, 2018, ISSN 1386-6184
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10494-018-9927-1

Biomimetics of the pulmonary environment in vitro : A microfluidics perspective

Author(s): Janna Tenenbaum-Katan, Arbel Artzy-Schnirman, Rami Fishler, Netanel Korin, Josué Sznitman
Published in: Biomicrofluidics, Issue 12/4, 2018, Page(s) 042209, ISSN 1932-1058
Publisher: American Institute of Physics
DOI: 10.1063/1.5023034

Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)

Author(s): Prashant Das, Eliram Nof, Israel Amirav, Stavros C. Kassinos, Josué Sznitman
Published in: PLOS ONE, Issue 13/11, 2018, Page(s) e0207711, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0207711

Red blood cell dynamics in biomimetic microfluidic networks of pulmonary alveolar capillaries

Author(s): Hagit Stauber, Dan Waisman, Netanel Korin, Josué Sznitman
Published in: Biomicrofluidics, Issue 11/1, 2017, Page(s) 014103, ISSN 1932-1058
Publisher: American Institute of Physics
DOI: 10.1063/1.4973930

Streamline crossing: An essential mechanism for aerosol dispersion in the pulmonary acinus

Author(s): Rami Fishler, Yan Ostrovski, Chao-Yi Lu, Josué Sznitman
Published in: Journal of Biomechanics, Issue 50, 2017, Page(s) 222-227, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2016.11.043

Particle sizing of pharmaceutical aerosols via direct imaging of particle settling velocities

Author(s): Rami Fishler, Frank Verhoeven, Wilbur de Kruijf, Josué Sznitman
Published in: European Journal of Pharmaceutical Sciences, Issue 113, 2017, Page(s) 152-158, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2017.08.016

Red blood cell (RBC) suspensions in confined microflows: Pressure-flow relationship

Author(s): Hagit Stauber, Dan Waisman, Netanel Korin, Josué Sznitman
Published in: Medical Engineering & Physics, Issue 48, 2017, Page(s) 49-54, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2017.08.006

Other (1)

Novel aerodynamic sizing method using image-based analysis of settling velocities

Author(s): Rami Fishler and Josue Sznitman
Published in: Inhalation, Issue 11, 2017, Page(s) 21-25
Publisher: Inhalation

Intellectual Property Rights

Patent (10)

Device, system and method for measuring particle size

Application/Publication number: WO 2017037724A1
Date: 2017-09-03

FOAM FOR PULMONARY DRUG DELIVERY

Application/Publication number: TECH- P-91-PC
Date: 2017-11-06

FOAM FOR PULMONARY DRUG DELIVERY

Application/Publication number: TECH- P-91-PC
Date: 2017-11-06

TARGETED DELIVERY OF AEROSOLS OF MAGNETIZED ACTIVE AGENTS

Application/Publication number: PCT /IL2017/050472
Date: 2017-04-25

TARGETED DELIVERY OF AEROSOLS OF MAGNETIZED ACTIVE AGENTS

Application/Publication number: PCT /IL2017/050472
Date: 2017-04-25

FOAM FOR PULMONARY DRUG DELIVERY

Application/Publication number: TECH- P-91-PC
Date: 2017-11-06

FOAM FOR PULMONARY DRUG DELIVERY

Application/Publication number: TECH- P-91-PC
Date: 2017-11-06

TARGETED DELIVERY OF AEROSOLS OF MAGNETIZED ACTIVE AGENTS

Application/Publication number: PCT /IL2017/050472
Date: 2017-04-25

Device, system and method for measuring particle size

Application/Publication number: WO 2017037724A1
Date: 2017-09-03

Device, system and method for measuring particle size

Application/Publication number: WO 2017037724A1
Date: 2017-09-03