Hybrid immune-eluding nanocrystals as smart and active theranostic weapons against cancer

Información del proyecto

TROJANANOHORSE

Identificador del acuerdo de subvención: 678151

DOI

10.3030/678151

Proyecto cerrado

Fecha de la firma de la CE 22 Febrero 2016

Fecha de inicio 1 Marzo 2016

Fecha de finalización 31 Agosto 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 489 219,00

Aportación de la UE

€ 1 489 219,00

Coordinado por

POLITECNICO DI TORINO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Thesis and dissertations (21)

Establishing the rationale for the design of an enhanced mRNA vaccine based on hybrid nanosystems: use of lipid-coated nanoparticles

Autores: Gae Azzara
Publicado en: 2021
Editor: Politecnico di Torino

Sviluppo di nanoparticelle ibride di Ossido di Zinco per la terapia antitumorale aventi proprietà biocompatibili e biodegradabili

Autores: Bianca Dumontel
Publicado en: 2016
Editor: POLITECNICO DI TORINO

Biocompatibility and cytotoxicity evaluation of hybrid nanocrystals for cancer therapy

Autores: Marta Canta
Publicado en: 2019
Editor: Politecnico di Torino

Sonophotocatalytic degradation of Rhodamine B via radicals generation by micro/nano zinc oxide particles

Autores: Carmine Lops
Publicado en: 2017
Editor: Politecnico di Torino

The role of ERC Funds schemes and their effects in the technology transfer process: a case study on team dynamics and collaborations between startups and industries

Autores: Greta Gasperoni, Giorgia Di Trapani
Publicado en: 2021
Editor: Politecnico di Torino

ZnO nanostructures for photo- and sonocatalysis employment

Autores: Federico Bresso
Publicado en: 2019
Editor: Politecnico di Torino

Study of micro- and nano-metric zinc oxide powders for the sono- and photo-catalytic degradation of Rhodamine B

Autores: Katia Di Casare
Publicado en: 2017
Editor: POLITECNICO DI TORINO

Study of a new ultrasound-based device in combination with smart nanoparticles for the treatment of cancer

Autores: Luisa Racca
Publicado en: 2019
Editor: Politecnico di Torino

The role of zinc oxide nanostructures as antimicrobial and biocompatible agents

Autores: Pasquale Sanvitale
Publicado en: 2018
Editor: POLITECNICO DI TORINO

Development and biostability evaluation of hybrid nanoconstructs for cancer therapy based onzinc oxide nanocrystals

Autores: Bianca Dumontel
Publicado en: 2021
Editor: Politecnico di Torino

Extracellular vesicles and their current role in cancer immunotherapy

Autores: Carla Giacobino
Publicado en: 2020
Editor: Politecnico di Torino

Hybrid biomimetic nanoconstructs against cancer: preparation and properties

Autores: Francesca Susa
Publicado en: 2018
Editor: Politecnico di Torino

Behaviour of biocompatible nanoparticles in biological fluids and in living cancer cells

Autores: Walter Fazzini
Publicado en: 2018
Editor: Politecnico di Torino

Cavitation analysis of ultrasound experiments with silica nanoparticles

Autores: Federico Zagallo
Publicado en: 2019
Editor: Politecnico di Torino

Nanostructured microfluidic devices to collect exosomes for biomedical applications

Autores: Federica Barbaresco
Publicado en: 2016
Editor: POLITECNICO DI TORINO

Evaluation of high intensity focused ultrasound assisted by metal oxide nanoparticles for their promising use in anticancer therapy

Autores: Giuseppe Leonetti
Publicado en: 2019
Editor: Politecnico di Torino

Ultrasound-induced Reactive Oxygen Species generation by Zinc Oxide Nanostructures: Mechanisms and Applications

Autores: Andrea Ancona
Publicado en: 2019
Editor: Politecnico di Torino

DEVELOPMENT OF HYBRID NANOPARTICLES FOR CANCER THERAPY BASED ON EXOSOMES AND ZINC OXIDE NANOCRYSTALS

Autores: Beatriz Bujeda
Publicado en: 2017
Editor: Politecnico di Torino

Ultrasound stimulation of piezoelectric ZnO lms for cell growth

Autores: Marco Carofiglio
Publicado en: 2019
Editor: Politecnico di Torino

ZnO nano-structures for photo- and sonocatalysis applications

Autores: Federico Bresso
Publicado en: 2019
Editor: Politecnico di Torino

Mesoporous Silica Nanoparticle as advanced drug delivery system: the effect of biomimetic lipid shielding

Autores: Simona Villata
Publicado en: 2020
Editor: Politecnico di Torino

Peer reviewed articles (23)

Iron-Doped ZnO Nanoparticles as Multifunctional Nanoplatforms for Theranostics

Autores: Marco Carofiglio, Marco Laurenti, Veronica Vighetto, Luisa Racca, Sugata Barui, Nadia Garino, Roberto Gerbaldo, Francesco Laviano, Valentina Cauda
Publicado en: Nanomaterials, Edición 11/10, 2021, Página(s) 2628, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano11102628

Remotely Activated Nanoparticles for Anticancer Therapy

Autores: Luisa Racca, Valentina Cauda
Publicado en: Nano-Micro Letters, Edición 13/1, 2021, ISSN 2150-5551
Editor: Open Access Science Online
DOI: 10.1007/s40820-020-00537-8

Biomimetic Amorphous Titania Nanoparticles as Ultrasound Responding Agents to Improve Cavitation and ROS Production for Sonodynamic Therapy

Autores: Joana C. Matos, Marco Laurenti, Veronica Vighetto, Laura C. J. Pereira, João Carlos Waerenborgh, M. Clara Gonçalves, Valentina Cauda
Publicado en: Applied Sciences, Edición 10/23, 2020, Página(s) 8479, ISSN 2076-3417
Editor: MDPI
DOI: 10.3390/app10238479

Smart Shockwave Responsive Titania-Based Nanoparticles for Cancer Treatment

Autores: Veronica Vighetto, Luisa Racca, Marta Canta, Joana C. Matos, Bianca Dumontel, Maria Clara Gonçalves, Valentina Cauda
Publicado en: Pharmaceutics, Edición 13/9, 2021, Página(s) 1423, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091423

Ultrasound Triggered ZnO‐Based Devices for Tunable and Multifaceted Biomedical Applications

Autores: Marco Carofiglio, Marco Laurenti, Giada Graziana Genchi, Gianni Ciofani, Marta Grochowicz, Valentina Cauda
Publicado en: Advanced Materials Interfaces, 2021, Página(s) 2101021, ISSN 2196-7350
Editor: Wiley Online Library
DOI: 10.1002/admi.202101021

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Autores: Luisa Racca, Tania Limongi, Veronica Vighetto, Bianca Dumontel, Andrea Ancona, Marta Canta, Giancarlo Canavese, Nadia Garino, Valentina Cauda
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2020.00577

Lipid-Coated Zinc Oxide Nanoparticles as Innovative ROS-Generators for Photodynamic Therapy in Cancer Cells

Autores: Andrea Ancona, Bianca Dumontel, Nadia Garino, Benjamin Demarco, Dimitra Chatzitheodoridou, Walter Fazzini, Hanna Engelke, Valentina Cauda
Publicado en: Nanomaterials, Edición 8/3, 2018, Página(s) 143, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano8030143

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Autores: Giancarlo Canavese, Andrea Ancona, Luisa Racca, Marta Canta, Bianca Dumontel, Federica Barbaresco, Tania Limongi, Valentina Cauda
Publicado en: Chemical Engineering Journal, Edición 340, 2018, Página(s) 155-172, ISSN 1385-8947
Editor: Elsevier BV
DOI: 10.1016/j.cej.2018.01.060

Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer

Autores: B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese, V. Cauda
Publicado en: Journal of Materials Chemistry B, Edición 5/44, 2017, Página(s) 8799-8813, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/c7tb02229h

A Microwave-Assisted Synthesis of Zinc Oxide Nanocrystals Finely Tuned for Biological Applications

Autores: Nadia Garino, Tania Limongi, Bianca Dumontel, Marta Canta, Luisa Racca, Marco Laurenti, Micaela Castellino, Alberto Casu, Andrea Falqui, Valentina Cauda
Publicado en: Nanomaterials, Edición 9/2, 2019, Página(s) 212, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano9020212

Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent

Autores: Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-Regì
Publicado en: RSC Advances, Edición 9/20, 2019, Página(s) 11312-11321, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/c8ra10236h

Sonophotocatalytic degradation mechanisms of Rhodamine B dye via radicals generation by micro- and nano-particles of ZnO

Autores: Carmine Lops, Andrea Ancona, Katia Di Cesare, Bianca Dumontel, Nadia Garino, Giancarlo Canavese, Simelys Hérnandez, Valentina Cauda
Publicado en: Applied Catalysis B: Environmental, Edición 243, 2019, Página(s) 629-640, ISSN 0926-3373
Editor: Elsevier BV
DOI: 10.1016/j.apcatb.2018.10.078

Improving dispersal of therapeutic nanoparticles in the human body

Autores: Tania Limongi, Marta Canta, Luisa Racca, Andrea Ancona, Stefania Tritta, Veronica Vighetto, Valentina Cauda
Publicado en: Nanomedicine, Edición 14/7, 2019, Página(s) 797-801, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm-2019-0070

ZnO nanocrystals shuttled by extracellular vesicles as effective Trojan nano-horses against cancer cells

Autores: Bianca Dumontel, Francesca Susa, Tania Limongi, Marta Canta, Luisa Racca, Angelica Chiodoni, Nadia Garino, Giulia Chiabotto, Maria L. Centomo, Ymera Pignochino, Valentina Cauda
Publicado en: Nanomedicine, Edición 14/21, 2019, Página(s) 2815-2833, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm-2019-0231

Nanoparticles for hematologic diseases detection and treatment

Autores: Tania Limongi, Francesca Susa, Valentina Cauda
Publicado en: Hematology and Medical Oncology, Edición 4/2, 2019, Página(s) 1-12, ISSN 2398-8495
Editor: OAT
DOI: 10.15761/hmo.1000183

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Autores: Francesca Susa, Tania Limongi, Bianca Dumontel, Veronica Vighetto, Valentina Cauda
Publicado en: Cancers, Edición 11/12, 2019, Página(s) 1979, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11121979

The Synergistic Effect of Nanocrystals Combined With Ultrasound in the Generation of Reactive Oxygen Species for Biomedical Applications

Autores: Veronica Vighetto, Andrea Ancona, Luisa Racca, Tania Limongi, Adriano Troia, Giancarlo Canavese, Valentina Cauda
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 7, 2019, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2019.00374

The investigation of the parameters affecting the ZnO nanoparticles cytotoxicity behaviour: a tutorial review.

Autores: Marta Canta, Valentina Cauda
Publicado en: Biomaterials Science, 2020, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d0bm01086c

Extracellular Vesicles and Their Current Role in Cancer Immunotherapy

Autores: Carla Giacobino; Marta Canta; Cristina Fornaguera; Salvador Borrós; Valentina Cauda
Publicado en: Cancers, Edición vol 13, 2021, Página(s) 2280, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092280

Leveraging re-chargeable nanobubbles on amine-functionalized ZnO nanocrystals for sustained ultrasound cavitation towards echographic imaging

Autores: Andrea Ancona, Adriano Troia, Nadia Garino, Bianca Dumontel, Valentina Cauda, Giancarlo Canavese
Publicado en: Ultrasonics Sonochemistry, Edición 67, 2020, Página(s) 105132, ISSN 1350-4177
Editor: Elsevier BV
DOI: 10.1016/j.ultsonch.2020.105132

EVs and Bioengineering: From Cellular Products to Engineered Nanomachines

Autores: Simona Villata, Marta Canta, Valentina Cauda
Publicado en: International Journal of Molecular Sciences, Edición 21/17, 2020, Página(s) 6048, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21176048

Correction to: Remotely Activated Nanoparticles for Anticancer Therapy

Autores: Luisa Racca, Valentina Cauda
Publicado en: Nano-Micro Letters, Edición 13/1, 2021, ISSN 2150-5551
Editor: Open Access Science Online
DOI: 10.1007/s40820-020-00553-8

Enhancing the preservation of liposomes: The role of cryoprotectants, lipid formulations and freezing approaches

Autores: Francesca Susa, Giulia Bucca, Tania Limongi, Valentina Cauda, Roberto Pisano
Publicado en: Cryobiology, Edición 98, 2021, Página(s) 46-56, ISSN 0011-2240
Editor: Academic Press
DOI: 10.1016/j.cryobiol.2020.12.009

Other (1)

Multimodal hybrid and theranostic nanoparticles as smart Trojan horses to fight cancer

Autores: Cauda, Valentina Alice
Publicado en: PROJECT REPOSITORY JOURNAL, Edición 6, 2020, Página(s) 108–110
Editor: EDMA

Conference proceedings (6)

The shielding effect of phospholipidic bilayers on zinc oxide nanocrystals for biomedical applications

Autores: Cauda V., Dumontel B., Canta M., Garino N., Limongi T.
Publicado en: Proceeding of the Merck Young Chemists Symposium, 2017, Página(s) 30, ISBN 978-88-86208-89-5
Editor: F. Bella, L. Botta, A. Bauchicchio, R. Cucciniello, A. D’Urso, A. Erba, P. Franco, E. Lenci, G. Mazzone, A. Soldà, S. Staderini, L. Triggiani, and D. Spinelli

CancerTO - Nanoscience in Cancer Immunotherapy

Autores: Racca Luisa, Limongi Tania, Vighetto Veronica, Dumontel Bianca, Ancona Andrea, Canta Marta, Canavese Giancarlo, Garino Nadia, Cauda Valentina Alice
Publicado en: CancerTO - Nanoscience in Cancer Immunotherapy, 2021, Página(s) 102-103, ISBN 9782889665433
Editor: Frontiers Media SA
DOI: 10.3389/978-2-88966-543-3

Investigation of cytotoxic effects of different ZnO nanostructures on living cancer cells

Autores: Luisa Racca, Bianca Dumontel, Beatrice Miccoli, Marta Canta, Loredana Serpe, Roberto Canaparo, Cristiano Di Benedetto, Andrea Falqui, and Valentina Cauda
Publicado en: Proceedings of the Merck Young Chemists Symposium, Edición Once a year, 2016, Página(s) 158, ISBN 978-88-86208-92-5
Editor: F. Bella, L. Botta, A. Bauchicchio, R. Cucciniello, A. D’Urso, A. Erba, P. Franco, E. Lenci, G. Mazzone, M. Pavone, A. Soldà, S. Staderini, L. Triggiani, and D. Spinelli

“Enhanced biostability and biocompatibility of zinc oxide nanocrystals shielded by a phospholipid bilayer”

Autores: B. Dumontel, M. Canta, F. Susa, L. Racca, A. Ancona, N. Garino, T. Limongi, A. Chiodoni, V. Cauda
Publicado en: Proceeding of the Merck and Elsevier Young Chemists Symposium (MEYCS 2018), Edición once a year, 2018, Página(s) 169, ISBN 978-88-94952-03-2
Editor: F. Bella, L. Botta, R. Cucciniello, A. D’Urso, P. Franco, E. Lenci, G. Mazzone, M. Schlich, A. Soldà, R. Spezzano, S. Staderini, and L. Triggiani

“Biomimetic hybrid nanoconstructs for cancer therapy”

Autores: F. Susa, B. Dumontel, M. Canta, L. Racca, N. Garino, T. Limongi, A. Chiodoni, V. Cauda
Publicado en: Proceeding of the Merck and Elsevier Young Chemists Symposium (MEYCS 2018), Edición once a year, 2018, Página(s) 191, ISBN 978-88-94952-03-2
Editor: F. Bella, L. Botta, R. Cucciniello, A. D’Urso, P. Franco, E. Lenci, G. Mazzone, M. Schlich, A. Soldà, R. Spezzano, S. Staderini, and L. Triggiani

Lipid-coated zinc oxide nanocrystals as innovative ROS-generators for photodynamic therapy

Autores: Ancona A, Engelke H, Garino N, Racca L, Dumontel B, Fazzini W, Cauda V
Publicado en: Proceeding of the Merck Young Chemists Symposium, 2017, ISBN 978-88-86208-89-5
Editor: F. Bella, L. Botta, A. Bauchicchio, R. Cucciniello, A. D’Urso, A. Erba, P. Franco, E. Lenci, G. Mazzone, A. Soldà, S. Staderini, L. Triggiani, and D. Spinelli

Derechos de propiedad intelectual

Patent (2)

BIOMIMETIC NON-IMMUNOGENIC NANOASSEMBLY FOR THE ANTITUMOR THERAPY

Número de solicitud/publicación: 18 807126
Fecha: 2018-10-30
Solicitante(s): POLITECNICO DI TORINO

METHOD OF ACTIVATION OF A SONOSENSITIZING AGENT

Número de solicitud/publicación: 20 20052014
Fecha: 2020-03-09
Solicitante(s): POLITECNICO DI TORINO