Hybrid immune-eluding nanocrystals as smart and active theranostic weapons against cancer

Project Information

TROJANANOHORSE

Grant agreement ID: 678151

DOI 10.3030/678151

Project closed

EC signature date 22 February 2016

Start date 1 March 2016

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 489 219,00

EU contribution € 1 489 219,00

Coordinated by

POLITECNICO DI TORINO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Thesis and dissertations (21)

Establishing the rationale for the design of an enhanced mRNA vaccine based on hybrid nanosystems: use of lipid-coated nanoparticles

Author(s): Gae Azzara
Published in: 2021
Publisher: Politecnico di Torino

Sviluppo di nanoparticelle ibride di Ossido di Zinco per la terapia antitumorale aventi proprietà biocompatibili e biodegradabili

Author(s): Bianca Dumontel
Published in: 2016
Publisher: POLITECNICO DI TORINO

Biocompatibility and cytotoxicity evaluation of hybrid nanocrystals for cancer therapy

Author(s): Marta Canta
Published in: 2019
Publisher: Politecnico di Torino

Sonophotocatalytic degradation of Rhodamine B via radicals generation by micro/nano zinc oxide particles

Author(s): Carmine Lops
Published in: 2017
Publisher: Politecnico di Torino

The role of ERC Funds schemes and their effects in the technology transfer process: a case study on team dynamics and collaborations between startups and industries

Author(s): Greta Gasperoni, Giorgia Di Trapani
Published in: 2021
Publisher: Politecnico di Torino

ZnO nanostructures for photo- and sonocatalysis employment

Author(s): Federico Bresso
Published in: 2019
Publisher: Politecnico di Torino

Study of micro- and nano-metric zinc oxide powders for the sono- and photo-catalytic degradation of Rhodamine B

Author(s): Katia Di Casare
Published in: 2017
Publisher: POLITECNICO DI TORINO

Study of a new ultrasound-based device in combination with smart nanoparticles for the treatment of cancer

Author(s): Luisa Racca
Published in: 2019
Publisher: Politecnico di Torino

The role of zinc oxide nanostructures as antimicrobial and biocompatible agents

Author(s): Pasquale Sanvitale
Published in: 2018
Publisher: POLITECNICO DI TORINO

Development and biostability evaluation of hybrid nanoconstructs for cancer therapy based onzinc oxide nanocrystals

Author(s): Bianca Dumontel
Published in: 2021
Publisher: Politecnico di Torino

Extracellular vesicles and their current role in cancer immunotherapy

Author(s): Carla Giacobino
Published in: 2020
Publisher: Politecnico di Torino

Hybrid biomimetic nanoconstructs against cancer: preparation and properties

Author(s): Francesca Susa
Published in: 2018
Publisher: Politecnico di Torino

Behaviour of biocompatible nanoparticles in biological fluids and in living cancer cells

Author(s): Walter Fazzini
Published in: 2018
Publisher: Politecnico di Torino

Cavitation analysis of ultrasound experiments with silica nanoparticles

Author(s): Federico Zagallo
Published in: 2019
Publisher: Politecnico di Torino

Nanostructured microfluidic devices to collect exosomes for biomedical applications

Author(s): Federica Barbaresco
Published in: 2016
Publisher: POLITECNICO DI TORINO

Evaluation of high intensity focused ultrasound assisted by metal oxide nanoparticles for their promising use in anticancer therapy

Author(s): Giuseppe Leonetti
Published in: 2019
Publisher: Politecnico di Torino

Ultrasound-induced Reactive Oxygen Species generation by Zinc Oxide Nanostructures: Mechanisms and Applications

Author(s): Andrea Ancona
Published in: 2019
Publisher: Politecnico di Torino

DEVELOPMENT OF HYBRID NANOPARTICLES FOR CANCER THERAPY BASED ON EXOSOMES AND ZINC OXIDE NANOCRYSTALS

Author(s): Beatriz Bujeda
Published in: 2017
Publisher: Politecnico di Torino

Ultrasound stimulation of piezoelectric ZnO lms for cell growth

Author(s): Marco Carofiglio
Published in: 2019
Publisher: Politecnico di Torino

ZnO nano-structures for photo- and sonocatalysis applications

Author(s): Federico Bresso
Published in: 2019
Publisher: Politecnico di Torino

Mesoporous Silica Nanoparticle as advanced drug delivery system: the effect of biomimetic lipid shielding

Author(s): Simona Villata
Published in: 2020
Publisher: Politecnico di Torino

Peer reviewed articles (23)

Iron-Doped ZnO Nanoparticles as Multifunctional Nanoplatforms for Theranostics

Author(s): Marco Carofiglio, Marco Laurenti, Veronica Vighetto, Luisa Racca, Sugata Barui, Nadia Garino, Roberto Gerbaldo, Francesco Laviano, Valentina Cauda
Published in: Nanomaterials, Issue 11/10, 2021, Page(s) 2628, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11102628

Remotely Activated Nanoparticles for Anticancer Therapy

Author(s): Luisa Racca, Valentina Cauda
Published in: Nano-Micro Letters, Issue 13/1, 2021, ISSN 2150-5551
Publisher: Open Access Science Online
DOI: 10.1007/s40820-020-00537-8

Biomimetic Amorphous Titania Nanoparticles as Ultrasound Responding Agents to Improve Cavitation and ROS Production for Sonodynamic Therapy

Author(s): Joana C. Matos, Marco Laurenti, Veronica Vighetto, Laura C. J. Pereira, João Carlos Waerenborgh, M. Clara Gonçalves, Valentina Cauda
Published in: Applied Sciences, Issue 10/23, 2020, Page(s) 8479, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app10238479

Smart Shockwave Responsive Titania-Based Nanoparticles for Cancer Treatment

Author(s): Veronica Vighetto, Luisa Racca, Marta Canta, Joana C. Matos, Bianca Dumontel, Maria Clara Gonçalves, Valentina Cauda
Published in: Pharmaceutics, Issue 13/9, 2021, Page(s) 1423, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091423

Ultrasound Triggered ZnO‐Based Devices for Tunable and Multifaceted Biomedical Applications

Author(s): Marco Carofiglio, Marco Laurenti, Giada Graziana Genchi, Gianni Ciofani, Marta Grochowicz, Valentina Cauda
Published in: Advanced Materials Interfaces, 2021, Page(s) 2101021, ISSN 2196-7350
Publisher: Wiley Online Library
DOI: 10.1002/admi.202101021

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Author(s): Luisa Racca, Tania Limongi, Veronica Vighetto, Bianca Dumontel, Andrea Ancona, Marta Canta, Giancarlo Canavese, Nadia Garino, Valentina Cauda
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00577

Lipid-Coated Zinc Oxide Nanoparticles as Innovative ROS-Generators for Photodynamic Therapy in Cancer Cells

Author(s): Andrea Ancona, Bianca Dumontel, Nadia Garino, Benjamin Demarco, Dimitra Chatzitheodoridou, Walter Fazzini, Hanna Engelke, Valentina Cauda
Published in: Nanomaterials, Issue 8/3, 2018, Page(s) 143, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano8030143

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Author(s): Giancarlo Canavese, Andrea Ancona, Luisa Racca, Marta Canta, Bianca Dumontel, Federica Barbaresco, Tania Limongi, Valentina Cauda
Published in: Chemical Engineering Journal, Issue 340, 2018, Page(s) 155-172, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2018.01.060

Enhanced biostability and cellular uptake of zinc oxide nanocrystals shielded with a phospholipid bilayer

Author(s): B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese, V. Cauda
Published in: Journal of Materials Chemistry B, Issue 5/44, 2017, Page(s) 8799-8813, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7tb02229h

A Microwave-Assisted Synthesis of Zinc Oxide Nanocrystals Finely Tuned for Biological Applications

Author(s): Nadia Garino, Tania Limongi, Bianca Dumontel, Marta Canta, Luisa Racca, Marco Laurenti, Micaela Castellino, Alberto Casu, Andrea Falqui, Valentina Cauda
Published in: Nanomaterials, Issue 9/2, 2019, Page(s) 212, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano9020212

Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent

Author(s): Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-Regì
Published in: RSC Advances, Issue 9/20, 2019, Page(s) 11312-11321, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ra10236h

Sonophotocatalytic degradation mechanisms of Rhodamine B dye via radicals generation by micro- and nano-particles of ZnO

Author(s): Carmine Lops, Andrea Ancona, Katia Di Cesare, Bianca Dumontel, Nadia Garino, Giancarlo Canavese, Simelys Hérnandez, Valentina Cauda
Published in: Applied Catalysis B: Environmental, Issue 243, 2019, Page(s) 629-640, ISSN 0926-3373
Publisher: Elsevier BV
DOI: 10.1016/j.apcatb.2018.10.078

Improving dispersal of therapeutic nanoparticles in the human body

Author(s): Tania Limongi, Marta Canta, Luisa Racca, Andrea Ancona, Stefania Tritta, Veronica Vighetto, Valentina Cauda
Published in: Nanomedicine, Issue 14/7, 2019, Page(s) 797-801, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2019-0070

ZnO nanocrystals shuttled by extracellular vesicles as effective Trojan nano-horses against cancer cells

Author(s): Bianca Dumontel, Francesca Susa, Tania Limongi, Marta Canta, Luisa Racca, Angelica Chiodoni, Nadia Garino, Giulia Chiabotto, Maria L. Centomo, Ymera Pignochino, Valentina Cauda
Published in: Nanomedicine, Issue 14/21, 2019, Page(s) 2815-2833, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2019-0231

Nanoparticles for hematologic diseases detection and treatment

Author(s): Tania Limongi, Francesca Susa, Valentina Cauda
Published in: Hematology and Medical Oncology, Issue 4/2, 2019, Page(s) 1-12, ISSN 2398-8495
Publisher: OAT
DOI: 10.15761/hmo.1000183

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Author(s): Francesca Susa, Tania Limongi, Bianca Dumontel, Veronica Vighetto, Valentina Cauda
Published in: Cancers, Issue 11/12, 2019, Page(s) 1979, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11121979

The Synergistic Effect of Nanocrystals Combined With Ultrasound in the Generation of Reactive Oxygen Species for Biomedical Applications

Author(s): Veronica Vighetto, Andrea Ancona, Luisa Racca, Tania Limongi, Adriano Troia, Giancarlo Canavese, Valentina Cauda
Published in: Frontiers in Bioengineering and Biotechnology, Issue 7, 2019, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2019.00374

The investigation of the parameters affecting the ZnO nanoparticles cytotoxicity behaviour: a tutorial review.

Author(s): Marta Canta, Valentina Cauda
Published in: Biomaterials Science, 2020, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0bm01086c

Extracellular Vesicles and Their Current Role in Cancer Immunotherapy

Author(s): Carla Giacobino; Marta Canta; Cristina Fornaguera; Salvador Borrós; Valentina Cauda
Published in: Cancers, Issue vol 13, 2021, Page(s) 2280, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092280

Leveraging re-chargeable nanobubbles on amine-functionalized ZnO nanocrystals for sustained ultrasound cavitation towards echographic imaging

Author(s): Andrea Ancona, Adriano Troia, Nadia Garino, Bianca Dumontel, Valentina Cauda, Giancarlo Canavese
Published in: Ultrasonics Sonochemistry, Issue 67, 2020, Page(s) 105132, ISSN 1350-4177
Publisher: Elsevier BV
DOI: 10.1016/j.ultsonch.2020.105132

EVs and Bioengineering: From Cellular Products to Engineered Nanomachines

Author(s): Simona Villata, Marta Canta, Valentina Cauda
Published in: International Journal of Molecular Sciences, Issue 21/17, 2020, Page(s) 6048, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21176048

Correction to: Remotely Activated Nanoparticles for Anticancer Therapy

Author(s): Luisa Racca, Valentina Cauda
Published in: Nano-Micro Letters, Issue 13/1, 2021, ISSN 2150-5551
Publisher: Open Access Science Online
DOI: 10.1007/s40820-020-00553-8

Enhancing the preservation of liposomes: The role of cryoprotectants, lipid formulations and freezing approaches

Author(s): Francesca Susa, Giulia Bucca, Tania Limongi, Valentina Cauda, Roberto Pisano
Published in: Cryobiology, Issue 98, 2021, Page(s) 46-56, ISSN 0011-2240
Publisher: Academic Press
DOI: 10.1016/j.cryobiol.2020.12.009

Other (1)

Multimodal hybrid and theranostic nanoparticles as smart Trojan horses to fight cancer

Author(s): Cauda, Valentina Alice
Published in: PROJECT REPOSITORY JOURNAL, Issue 6, 2020, Page(s) 108–110
Publisher: EDMA

Conference proceedings (6)

The shielding effect of phospholipidic bilayers on zinc oxide nanocrystals for biomedical applications

Author(s): Cauda V., Dumontel B., Canta M., Garino N., Limongi T.
Published in: Proceeding of the Merck Young Chemists Symposium, 2017, Page(s) 30, ISBN 978-88-86208-89-5
Publisher: F. Bella, L. Botta, A. Bauchicchio, R. Cucciniello, A. D’Urso, A. Erba, P. Franco, E. Lenci, G. Mazzone, A. Soldà, S. Staderini, L. Triggiani, and D. Spinelli

CancerTO - Nanoscience in Cancer Immunotherapy

Author(s): Racca Luisa, Limongi Tania, Vighetto Veronica, Dumontel Bianca, Ancona Andrea, Canta Marta, Canavese Giancarlo, Garino Nadia, Cauda Valentina Alice
Published in: CancerTO - Nanoscience in Cancer Immunotherapy, 2021, Page(s) 102-103, ISBN 9782889665433
Publisher: Frontiers Media SA
DOI: 10.3389/978-2-88966-543-3

Investigation of cytotoxic effects of different ZnO nanostructures on living cancer cells

Author(s): Luisa Racca, Bianca Dumontel, Beatrice Miccoli, Marta Canta, Loredana Serpe, Roberto Canaparo, Cristiano Di Benedetto, Andrea Falqui, and Valentina Cauda
Published in: Proceedings of the Merck Young Chemists Symposium, Issue Once a year, 2016, Page(s) 158, ISBN 978-88-86208-92-5
Publisher: F. Bella, L. Botta, A. Bauchicchio, R. Cucciniello, A. D’Urso, A. Erba, P. Franco, E. Lenci, G. Mazzone, M. Pavone, A. Soldà, S. Staderini, L. Triggiani, and D. Spinelli

“Enhanced biostability and biocompatibility of zinc oxide nanocrystals shielded by a phospholipid bilayer”

Author(s): B. Dumontel, M. Canta, F. Susa, L. Racca, A. Ancona, N. Garino, T. Limongi, A. Chiodoni, V. Cauda
Published in: Proceeding of the Merck and Elsevier Young Chemists Symposium (MEYCS 2018), Issue once a year, 2018, Page(s) 169, ISBN 978-88-94952-03-2
Publisher: F. Bella, L. Botta, R. Cucciniello, A. D’Urso, P. Franco, E. Lenci, G. Mazzone, M. Schlich, A. Soldà, R. Spezzano, S. Staderini, and L. Triggiani

“Biomimetic hybrid nanoconstructs for cancer therapy”

Author(s): F. Susa, B. Dumontel, M. Canta, L. Racca, N. Garino, T. Limongi, A. Chiodoni, V. Cauda
Published in: Proceeding of the Merck and Elsevier Young Chemists Symposium (MEYCS 2018), Issue once a year, 2018, Page(s) 191, ISBN 978-88-94952-03-2
Publisher: F. Bella, L. Botta, R. Cucciniello, A. D’Urso, P. Franco, E. Lenci, G. Mazzone, M. Schlich, A. Soldà, R. Spezzano, S. Staderini, and L. Triggiani

Lipid-coated zinc oxide nanocrystals as innovative ROS-generators for photodynamic therapy

Author(s): Ancona A, Engelke H, Garino N, Racca L, Dumontel B, Fazzini W, Cauda V
Published in: Proceeding of the Merck Young Chemists Symposium, 2017, ISBN 978-88-86208-89-5
Publisher: F. Bella, L. Botta, A. Bauchicchio, R. Cucciniello, A. D’Urso, A. Erba, P. Franco, E. Lenci, G. Mazzone, A. Soldà, S. Staderini, L. Triggiani, and D. Spinelli

Intellectual Property Rights

Patent (2)

BIOMIMETIC NON-IMMUNOGENIC NANOASSEMBLY FOR THE ANTITUMOR THERAPY

Application/Publication number: 18 807126
Date: 2018-10-30
Applicant(s): POLITECNICO DI TORINO

METHOD OF ACTIVATION OF A SONOSENSITIZING AGENT

Application/Publication number: 20 20052014
Date: 2020-03-09
Applicant(s): POLITECNICO DI TORINO