Origins of Alzheimer's disease across the life-course

Project Information

ORACLE

Grant agreement ID: 678543

DOI 10.3030/678543

Project closed

EC signature date 7 June 2016

Start date 1 September 2016

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 495 715,00

EU contribution € 1 495 715,00

Coordinated by

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

Publications

Peer reviewed articles (18)

Cortical gyrification in relation to age and cognition in older adults.

Author(s): Sander Lamballais; Elisabeth J Vinke; Meike W. Vernooij; M. Arfan Ikram; Ryan L. Muetzel
Published in: Neuroimage, Issue 1, 2020, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.116637

Sociodemographic, Lifestyle, Physical, and Psychosocial Determinants of Cognitive Reserve

Author(s): Jendé L Zijlmans, Sander Lamballais, Meike W Vernooij, M Arfan Ikram, Annemarie I Luik
Published in: Journal of Alzheimer's disease, 2022, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-215122

Life Expectancy With and Without Dementia: A Population-Based Study of Dementia Burden and Preventive Potential.

Author(s): Frank J. Wolters; Liselotte M Tinga; Klodian Dhana; Klodian Dhana; Klodian Dhana; Peter J. Koudstaal; Albert Hofman; Daniel Bos; Oscar H. Franco; M. Arfan Ikram
Published in: American Journal of Epidemiology, Issue 1, 2019, ISSN 1476-6256
Publisher: Oxford University Press
DOI: 10.1093/aje/kwy234

Genetic scores for adult subcortical volumes associate with subcortical volumes during infancy and childhood.

Author(s): Sander Lamballais; Philip R. Jansen; Jeremy A. Labrecque; M. Arfan Ikram; Tonya White
Published in: Human Brain Mapping, 42(6), 1583 - 1593. Wiley-Liss Inc., Issue 1, 2021, ISSN 1097-0193
Publisher: Wiley Periodicals
DOI: 10.1002/hbm.25292

Implementation and validation of ASL perfusion measurements for population imaging

Author(s): Esther A. H. Warnert; Rebecca M. E. Steketee; Meike W. Vernooij; M. Arfan Ikram; Mika W. Vogel; Juan‐Antonio Hernandez Tamames; Gyula Kotek
Published in: Magnetic Resonance in Medicine, Issue 1, 2020, ISSN 1522-2594
Publisher: Wiley
DOI: 10.1002/mrm.28271

Heritability of the shape of subcortical brain structures in the general population

Author(s): Gennady V. Roshchupkin, Boris A. Gutman, Meike W. Vernooij, Neda Jahanshad, Nicholas G. Martin, Albert Hofman, Katie L. McMahon, Sven J. van der Lee, Cornelia M. van Duijn, Greig I. de Zubicaray, André G. Uitterlinden, Margaret J. Wright, Wiro J. Niessen, Paul M. Thompson, M. Arfan Ikram, Hieab H. H. Adams
Published in: Nature Communications, Issue 7, 2016, Page(s) 13738, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13738

Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

Author(s): Lori B. Chibnik, Frank J. Wolters, Kristoffer Bäckman, Alexa Beiser, Claudine Berr, Joshua C. Bis, Eric Boerwinkle, Daniel Bos, Carol Brayne, Jean-Francois Dartigues, Sirwan K. L. Darweesh, Stephanie Debette, Kendra L. Davis-Plourde, Carole Dufouil, Myriam Fornage, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M. Arfan Ikram, M. Kamran Ikram, Silke Kern, Lew
Published in: European Journal of Epidemiology, Issue 32/10, 2017, Page(s) 931-938, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-017-0320-5

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author(s): Hieab H H Adams, Derrek P Hibar, Vincent Chouraki, Jason L Stein, Paul A Nyquist, Miguel E Rentería, Stella Trompet, Alejandro Arias-Vasquez, Sudha Seshadri, Sylvane Desrivières, Ashley H Beecham, Neda Jahanshad, Katharina Wittfeld, Sven J Van der Lee, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S Aribisala, Nicola J Armstrong, Lavinia Athanas
Published in: Nature Neuroscience, Issue 19/12, 2016, Page(s) 1569-1582, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/nn.4398

HASE: Framework for efficient high-dimensional association analyses

Author(s): G. V. Roshchupkin, H. H. H. Adams, M. W. Vernooij, A. Hofman, C. M. Van Duijn, M. A. Ikram, W. J. Niessen
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep36076

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

Author(s): Dina Vojinovic, Hieab H. Adams, Xueqiu Jian, Qiong Yang, Albert Vernon Smith, Joshua C. Bis, Alexander Teumer, Markus Scholz, Nicola J. Armstrong, Edith Hofer, Yasaman Saba, Michelle Luciano, Manon Bernard, Stella Trompet, Jingyun Yang, Nathan A. Gillespie, Sven J. van der Lee, Alexander Neumann, Shahzad Ahmad, Ole A. Andreassen, David Ames, Najaf Amin, Konstantinos Arfanakis, Mark E. Bastin, Dian
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06234-w

Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging

Author(s): Maria J. Knol, Alis Heshmatollah, Lotte G.M. Cremers, M. Kamran Ikram, André G. Uitterlinden, Cornelia M. van Duijn, Wiro J. Niessen, Meike W. Vernooij, M. Arfan Ikram, Hieab H.H. Adams
Published in: Aging, Issue 11/5, 2019, Page(s) 1440-1456, ISSN 1945-4589
Publisher: Impact Journals LLC
DOI: 10.18632/aging.101844

Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer’s Association Reserve, Resilience and Protective Factors Professional Interest Area working groups

Author(s): Robert Perneczky, Gerd Kempermann, Amos D. Korczyn, Fiona E. Matthews, M. Arfan Ikram, Nikolaos Scarmeas, Gael Chetelat, Yaakov Stern, Michael Ewers
Published in: BMC Medicine, Issue 17/1, 2019, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-019-1283-z

Association of Blood Pressure and Arterial Stiffness With Cognition in 2 Population‐Based Child and Adult Cohorts

Author(s): Sander Lamballais, Ayesha Sajjad, Maarten J. G. Leening, Romy Gaillard, Oscar H. Franco, Francesco U. S. Mattace‐Raso, Vincent W. V. Jaddoe, Sabine J. Roza, Henning Tiemeier, M. Arfan Ikram
Published in: Journal of the American Heart Association, Issue 7/21, 2018, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.118.009847

Trajectories of imaging markers in brain aging: the Rotterdam Study

Author(s): Elisabeth J. Vinke, Marius de Groot, Vikram Venkatraghavan, Stefan Klein, Wiro J. Niessen, M. Arfan Ikram, Meike W. Vernooij
Published in: Neurobiology of Aging, Issue 71, 2018, Page(s) 32-40, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.07.001

Design and overview of the Origins of Alzheimer's Disease Across the Life course (ORACLE) study

Author(s): Sander Lamballais; Maria C. Adank; Rowina F. Hussainali; Sarah Schalekamp-Timmermans; Meike W. Vernooij; Annemarie I. Luik; Eric A.P. Steegers; Mohammad Arfan Ikram
Published in: European Journal of Epidemiology, Issue 1, 2021, ISSN 1573-7284
Publisher: Springer
DOI: 10.1007/s10654-020-00696-3

Child mental health problems as a risk factor for academic underachievement: A multi‐informant, population‐based study

Author(s): Isabel K. Schuurmans; Nathalie Tamayo Martinez; Elisabet Blok; Manon H. J. Hillegers; M. Arfan Ikram; Annemarie I. Luik; Charlotte A. M. Cecil
Published in: Acta Psychiatrica Scandinavica, Issue 146(6), 2022, Page(s) 578-590, ISSN 1600-0447
Publisher: Wiley
DOI: 10.1111/acps.13426

Genetic determinants of cortical structure (thickness, surface area and volumes) among disease free adults in the CHARGE Consortium

Author(s): Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H. H.; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Bernard, Manon; Bis, Joshua C.; Gillespie, Nathan A.; Luciano, Michelle; Mishra, Aniket; Scholz, Markus; Teumer, Alexander; Xia, Rui; Jian, Xueqiu; Mosley, Thomas H.; Saba, Yasaman; Pirpamer, Lukas; Seiler, Stephan; Becker, J
Published in: Nature Communications, Issue 1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18367-y

Genetic Burden for Late-Life Neurodegenerative Disease and Its Association With Early-Life Lipids, Brain, Behavior, and Cognition

Author(s): Sander Lamballais; Ryan L. Muetzel; Ryan L. Muetzel; Mohammad Arfan Ikram; Henning Tiemeier; Henning Tiemeier; Meike W. Vernooij; Meike W. Vernooij; Tonya White; Tonya White; Hieab H. H. Adams; Hieab H. H. Adams; Hieab H. H. Adams
Published in: Frontiers in Psychiatry, 11, Issue 1, 2020, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.00033