Targeting iNKT cell and adipocyte crosstalk for control of metabolism and body weight

Información del proyecto

FAT NKT

Identificador del acuerdo de subvención: 679173

DOI 10.3030/679173

Proyecto cerrado

Fecha de la firma de la CE 24 Agosto 2016

Fecha de inicio 1 Septiembre 2016

Fecha de finalización 31 Agosto 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 804 052,00

Aportación de la UE € 1 804 052,00

Coordinado por

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Publicaciones

Peer reviewed articles (10)

Immune and non-immune functions of adipose tissue leukocytes

Autores: William Trim, Lydia Lynch
Publicado en: Nature Reviews in Immunology, 2021, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41577-021-00635-7

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

Autores: Nelson M. LaMarche, Harry Kane, Ayano C. Kohlgruber, Han Dong, Lydia Lynch, Michael B. Brenner
Publicado en: Cell Metabolism, Edición 32/2, 2020, Página(s) 243-258.e6, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.05.017

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

Autores: Lydia Lynch, Andrew E. Hogan, Danielle Duquette, Chantel Lester, Alexander Banks, Katherine LeClair, David E. Cohen, Abhisek Ghosh, Bing Lu, Michelle Corrigan, Darko Stevanovic, Eleftheria Maratos-Flier, Daniel J. Drucker, Donal O’Shea, Michael Brenner
Publicado en: Cell Metabolism, Edición 24/3, 2016, Página(s) 510-519, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2016.08.003

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

Autores: Selma Boulenouar, Xavier Michelet, Danielle Duquette, David Alvarez, Andrew E. Hogan, Christina Dold, Donal O’Connor, Suzanne Stutte, Ali Tavakkoli, Desmond Winters, Mark A. Exley, Donal O’Shea, Michael B. Brenner, Ulrich von Andrian, Lydia Lynch
Publicado en: Immunity, Edición 46/2, 2017, Página(s) 273-286, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2017.01.008

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Autores: Ayano C. Kohlgruber, Shani T. Gal-Oz, Nelson M. LaMarche, Moto Shimazaki, Danielle Duquette, Hung N. Nguyen, Amir I. Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Alexander S. Banks, Tal Shay, Michael B. Brenner, Lydia Lynch
Publicado en: Nature Immunology, Edición 19/5, 2018, Página(s) 464-474, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-018-0094-2

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Autores: Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay, Lydia Lynch
Publicado en: Nature Immunology, Edición 19/12, 2018, Página(s) 1330-1340, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-018-0251-7

Innate Immune Control of Adipose Tissue Homeostasis

Autores: Harry Kane, Lydia Lynch
Publicado en: Trends in Immunology, Edición 40/9, 2019, Página(s) 857-872, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2019.07.006

Adipose Dendritic Cells Come Out of Hiding

Autores: Nelson M. LaMarche, Lydia Lynch
Publicado en: Cell Metabolism, Edición 27/3, 2018, Página(s) 485-486, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2018.02.014

New Job for NK Cells: Architects of the Tumor Microenvironment

Autores: Lydia Dyck, Lydia Lynch
Publicado en: Immunity, Edición 48/1, 2018, Página(s) 9-11, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2018.01.001

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Autores: Noella Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau, Nital Sumaria, Ayano C. Kohlgruber, Gina J. Fiala, Leandro Z. Agudelo, Lydia Dyck, Harry Kane, Aaron Douglas, Stephen Cunningham, Hannah Prendeville, Roisin Loftus, Colleen Carmody, Philippe Pierre, Manolis Kellis, Michael Brenner, Rafael J. Argüello, Bruno Silva-Santos, Daniel J. Pennington, Lydia Lynch
Publicado en: Nature Immunology, Edición 22/2, 2021, Página(s) 179-192, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-00848-3