Targeting iNKT cell and adipocyte crosstalk for control of metabolism and body weight

Informazioni relative al progetto

FAT NKT

ID dell’accordo di sovvenzione: 679173

DOI 10.3030/679173

Progetto chiuso

Data della firma CE 24 Agosto 2016

Data di avvio 1 Settembre 2016

Data di completamento 31 Agosto 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 804 052,00

Contributo UE € 1 804 052,00

Coordinato da

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Pubblicazioni

Peer reviewed articles (10)

Immune and non-immune functions of adipose tissue leukocytes

Autori: William Trim, Lydia Lynch
Pubblicato in: Nature Reviews in Immunology, 2021, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41577-021-00635-7

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis

Autori: Nelson M. LaMarche, Harry Kane, Ayano C. Kohlgruber, Han Dong, Lydia Lynch, Michael B. Brenner
Pubblicato in: Cell Metabolism, Numero 32/2, 2020, Pagina/e 243-258.e6, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.05.017

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

Autori: Lydia Lynch, Andrew E. Hogan, Danielle Duquette, Chantel Lester, Alexander Banks, Katherine LeClair, David E. Cohen, Abhisek Ghosh, Bing Lu, Michelle Corrigan, Darko Stevanovic, Eleftheria Maratos-Flier, Daniel J. Drucker, Donal O’Shea, Michael Brenner
Pubblicato in: Cell Metabolism, Numero 24/3, 2016, Pagina/e 510-519, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2016.08.003

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

Autori: Selma Boulenouar, Xavier Michelet, Danielle Duquette, David Alvarez, Andrew E. Hogan, Christina Dold, Donal O’Connor, Suzanne Stutte, Ali Tavakkoli, Desmond Winters, Mark A. Exley, Donal O’Shea, Michael B. Brenner, Ulrich von Andrian, Lydia Lynch
Pubblicato in: Immunity, Numero 46/2, 2017, Pagina/e 273-286, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2017.01.008

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Autori: Ayano C. Kohlgruber, Shani T. Gal-Oz, Nelson M. LaMarche, Moto Shimazaki, Danielle Duquette, Hung N. Nguyen, Amir I. Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Alexander S. Banks, Tal Shay, Michael B. Brenner, Lydia Lynch
Pubblicato in: Nature Immunology, Numero 19/5, 2018, Pagina/e 464-474, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0094-2

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Autori: Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay, Lydia Lynch
Pubblicato in: Nature Immunology, Numero 19/12, 2018, Pagina/e 1330-1340, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0251-7

Innate Immune Control of Adipose Tissue Homeostasis

Autori: Harry Kane, Lydia Lynch
Pubblicato in: Trends in Immunology, Numero 40/9, 2019, Pagina/e 857-872, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2019.07.006

Adipose Dendritic Cells Come Out of Hiding

Autori: Nelson M. LaMarche, Lydia Lynch
Pubblicato in: Cell Metabolism, Numero 27/3, 2018, Pagina/e 485-486, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2018.02.014

New Job for NK Cells: Architects of the Tumor Microenvironment

Autori: Lydia Dyck, Lydia Lynch
Pubblicato in: Immunity, Numero 48/1, 2018, Pagina/e 9-11, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2018.01.001

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Autori: Noella Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau, Nital Sumaria, Ayano C. Kohlgruber, Gina J. Fiala, Leandro Z. Agudelo, Lydia Dyck, Harry Kane, Aaron Douglas, Stephen Cunningham, Hannah Prendeville, Roisin Loftus, Colleen Carmody, Philippe Pierre, Manolis Kellis, Michael Brenner, Rafael J. Argüello, Bruno Silva-Santos, Daniel J. Pennington, Lydia Lynch
Pubblicato in: Nature Immunology, Numero 22/2, 2021, Pagina/e 179-192, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-020-00848-3