Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers

Project Information

inHForm

Grant agreement ID: 679242

DOI 10.3030/679242

Project closed

EC signature date 17 March 2016

Start date 1 April 2016

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 496 625,00

EU contribution € 1 496 625,00

Coordinated by

LUNDS UNIVERSITET
Sweden

Publications

Peer reviewed articles (28)

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Author(s): Ioanna Ntalla, Lu-Chen Weng, James H. Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, Carolina Roselli, Michael R. Barnes, Borbala Mifsud, Helen R. Warren, Caroline Hayward, Jonathan Marten, James J. Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M. Araujo, Maria Fernanda Lima-
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15706-x

Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk

Author(s): Debby Ngo, Mark D. Benson, Jonathan Z. Long, Zsu-Zsu Chen, Ruiqi Wang, Anjali K. Nath, Michelle J. Keyes, Dongxiao Shen, Sumita Sinha, Eric Kuhn, Jordan E. Morningstar, Xu Shi, Bennet D. Peterson, Christopher Chan, Daniel H. Katz, Usman A. Tahir, Laurie A. Farrell, Olle Melander, Jonathan D. Mosley, Steven A. Carr, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Qiong Yan
Published in: JCI Insight, Issue 6/5, 2021, ISSN 2379-3708
Publisher: American Society for Clinical Investigations
DOI: 10.1172/jci.insight.144392

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Author(s): Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G. Aragam, Johan Ärnlöv, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Jeffrey Brandimarto, Michael R. Brown, Leonard Buckbinder,
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13690-5

Methods for isolation and transcriptional profiling of individual cells from the human heart

Author(s): Neha Pimpalwar, Tomasz Czuba, Maya Landenhed Smith, Johan Nilsson, Olof Gidlöf, J. Gustav Smith
Published in: Heliyon, Issue 6/12, 2020, Page(s) e05810, ISSN 2405-8440
Publisher: Elsevier / Cell Press
DOI: 10.1016/j.heliyon.2020.e05810

Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease

Author(s): J. Gustav Smith, Robert E. Gerszten
Published in: Circulation, Issue 135/17, 2017, Page(s) 1651-1664, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.025446

Molecular Epidemiology of Heart Failure

Author(s): J. Gustav Smith
Published in: JACC: Basic to Translational Science, Issue 2/6, 2017, Page(s) 757-769, ISSN 2452-302X
Publisher: Elsevier
DOI: 10.1016/j.jacbts.2017.07.010

A Swedish Nationwide Adoption Study of the Heritability of Heart Failure

Author(s): Magnus P. Lindgren, MirNabi PirouziFard, J. Gustav Smith, Jan Sundquist, Kristina Sundquist, Bengt Zöller
Published in: JAMA Cardiology, Issue 3/8, 2018, Page(s) 703, ISSN 2380-6583
Publisher: American Medical Association
DOI: 10.1001/jamacardio.2018.1919

Longitudinal evaluation of ventricular ejection fraction and NT-proBNP across heart failure subgroups

Author(s): Andreas Martinsson, Petter Oest, Maj-Britt Wiborg, Öyvind Reitan, J. Gustav Smith
Published in: Scandinavian Cardiovascular Journal, Issue 52/4, 2018, Page(s) 205-210, ISSN 1401-7431
Publisher: Taylor & Francis
DOI: 10.1080/14017431.2018.1461920

Vascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure

Author(s): Yan Borné, Klas Gränsbo, Jan Nilsson, Olle Melander, Marju Orho-Melander, J. Gustav Smith, Gunnar Engström
Published in: Journal of the American College of Cardiology, Issue 71/5, 2018, Page(s) 580-582, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.058

Age-Specific Trends in Incidence, Mortality, and Comorbidities of Heart Failure in Denmark, 1995 to 2012

Author(s): Mia N. Christiansen, Lars Køber, Peter Weeke, Ramachandran S. Vasan, Jørgen L. Jeppesen, J. Gustav Smith, Gunnar H. Gislason, Christian Torp-Pedersen, Charlotte Andersson
Published in: Circulation, Issue 135/13, 2017, Page(s) 1214-1223, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.025941

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

Author(s): J. Gustav Smith, Janine F. Felix, Alanna C. Morrison, Andreas Kalogeropoulos, Stella Trompet, Jemma B. Wilk, Olof Gidlöf, Xinchen Wang, Michael Morley, Michael Mendelson, Roby Joehanes, Symen Ligthart, Xiaoyin Shan, Joshua C. Bis, Ying A. Wang, Marketa Sjögren, Julius Ngwa, Jeffrey Brandimarto, David J. Stott, David Aguilar, Kenneth M. Rice, Howard D. Sesso, Serkalem Demissie, Brendan M. Buckley
Published in: PLOS Genetics, Issue 12/5, 2016, Page(s) e1006034, ISSN 1553-7404
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pgen.1006034

Blood lactate is a predictor of short-term mortality in patients with myocardial infarction complicated by heart failure but without cardiogenic shock

Author(s): Grunde Gjesdal, Oscar Ö. Braun, J. Gustav Smith, Fredrik Scherstén, Patrik Tydén
Published in: BMC Cardiovascular Disorders, Issue 18/1, 2018, ISSN 1471-2261
Publisher: BioMed Central
DOI: 10.1186/s12872-018-0744-1

Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study

Author(s): Pontus Andell, Xinjun Li, Andreas Martinsson, Charlotte Andersson, Martin Stagmo, Bengt Zöller, Kristina Sundquist, J Gustav Smith
Published in: Heart, Issue 103/21, 2017, Page(s) 1696-1703, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2016-310894

Heritability of Atrial Fibrillation

Author(s): Lu-Chen Weng, Seung Hoan Choi, Derek Klarin, J. Gustav Smith, Po-Ru Loh, Mark Chaffin, Carolina Roselli, Olivia L. Hulme, Kathryn L. Lunetta, Josée Dupuis, Emelia J. Benjamin, Christopher Newton-Cheh, Sekar Kathiresan, Patrick T. Ellinor, Steven A. Lubitz
Published in: Circulation: Cardiovascular Genetics, Issue 10/6, 2017, ISSN 1942-3268
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001838

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Author(s): Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huf
Published in: Nature Genetics, Issue 49/6, 2017, Page(s) 946-952, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3843

Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production

Author(s): Connie Wu, Pankaj Arora, Obiajulu Agha, Liam A. Hurst, Kaitlin Allen, Daniel I. Nathan, Dongjian Hu, Pawina Jiramongkolchai, J. Gustav Smith, Olle Melander, Sander Trenson, Stefan P. Janssens, Ibrahim Domian, Thomas J. Wang, Kenneth D. Bloch, Emmanuel S. Buys, Donald B. Bloch, Christopher Newton-Cheh
Published in: Molecular and Cellular Biology, Issue 36/14, 2016, Page(s) 1977-1987, ISSN 0270-7306
Publisher: American Society for Microbiology
DOI: 10.1128/MCB.01114-15

Predictive Value of High-Sensitivity Troponin T for Systolic Dysfunction and Infarct Size (Six Months) After ST-Elevation Myocardial Infarction

Author(s): Moman A. Mohammad, Sasha Koul, J. Gustav Smith, Marco Noc, Irene Lang, Michael Holzer, Peter Clemmensen, Ulf Jensen, Thomas Engstrøm, Håkan Arheden, Stefan James, Bertil Lindahl, Bernhard Metzler, David Erlinge
Published in: The American Journal of Cardiology, Issue 122/5, 2018, Page(s) 735-743, ISSN 0002-9149
Publisher: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2018.05.005

Multi-ethnic genome-wide association study for atrial fibrillation

Author(s): Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Ca
Published in: Nature Genetics, Issue 50/9, 2018, Page(s) 1225-1233, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0133-9

Genome-wide analysis yields new loci associating with aortic valve stenosis

Author(s): Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir, Olafur A. Stefansson, Vinicius Tragante, Rosa B. Thorolfsdottir, Ingileif Jonsdottir, Thorsteinn Bjornsson, Valgerdur Steinthorsdottir, Niek Verweij, Jonas B. Nielsen, Wei Zhou, Lasse Folkersen, Andreas Martinsson, Mahyar Heydarpour, Siddharth Prakash, Gylfi Oskarsson, Tomas Gudbjartsson, Arnar Geirsson, Isleifur Olafsson, Emil L. Sigur
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03252-6

Genetic Architecture of the Cardiovascular Risk Proteome

Author(s): Mark D. Benson, Qiong Yang, Debby Ngo, Yineng Zhu, Dongxiao Shen, Laurie A. Farrell, Sumita Sinha, Michelle J. Keyes, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Robert E. Gerszten
Published in: Circulation, Issue 137/11, 2018, Page(s) 1158-1172, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.117.029536

Familial Aggregation of Aortic Valvular Stenosis

Author(s): Andreas Martinsson, Xinjun Li, Bengt Zöller, Pontus Andell, Charlotte Andersson, Kristina Sundquist, J. Gustav Smith
Published in: Circulation: Cardiovascular Genetics, Issue 10/6, 2017, ISSN 1942-3268
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001742

Immunological Serum Protein Profiles for Noninvasive Detection of Acute Cellular Rejection After Heart Transplantation

Author(s): Ihdina Sukma Dewi, Olof Gidlöf, Zsuzsanna Hollander, Karen K. Lam, Mark D. Benson, Oscar O. Braun, Johan Nilsson, Scott J. Tebbutt, Raymond T. Ng, Jenny Öhman, Bruce M. McManus, J. Gustav Smith
Published in: Journal of the American College of Cardiology, Issue 70/23, 2017, Page(s) 2946-2947, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2017.10.012

Orthogonal P-wave morphology is affected by intra-atrial pressures

Author(s): Richard Petersson, J. Gustav Smith, David A. Larsson, Öyvind Reitan, Jonas Carlson, Pyotr Platonov, Fredrik Holmqvist
Published in: BMC Cardiovascular Disorders, Issue 17/1, 2017, ISSN 1471-2261
Publisher: BioMed Central
DOI: 10.1186/s12872-017-0724-x

Heritability of Mitral Regurgitation

Author(s): Francesca N. Delling, Xinjun Li, Shuo Li, Qiong Yang, Vanessa Xanthakis, Andreas Martinsson, Pontus Andell, Birgitta T. Lehman, Ewa W. Osypiuk, Plamen Stantchev, Bengt Zöller, Emelia J. Benjamin, Kristina Sundquist, Ramachandran S. Vasan, J. Gustav Smith
Published in: Circulation: Cardiovascular Genetics, Issue 10/5, 2017, ISSN 1942-3268
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001736

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study

Author(s): Stephen Zewinger, Marcus E Kleber, Vinicius Tragante, Raymond O McCubrey, Amand F Schmidt, Kenan Direk, Ulrich Laufs, Christian Werner, Wolfgang Koenig, Dietrich Rothenbacher, Ute Mons, Lutz P Breitling, Herrmann Brenner, Richard T Jennings, Ioannis Petrakis, Sarah Triem, Mira Klug, Alexandra Filips, Stefan Blankenberg, Christoph Waldeyer, Christoph Sinning, Renate B Schnabel, Karl J Lackner, Efth
Published in: The Lancet Diabetes & Endocrinology, Issue 5/7, 2017, Page(s) 534-543, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/S2213-8587(17)30096-7

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

Author(s): Philipp S. Wild, Janine F. Felix, Arne Schillert, Alexander Teumer, Ming-Huei Chen, Maarten J.G. Leening, Uwe Völker, Vera Großmann, Jennifer A. Brody, Marguerite R. Irvin, Sanjiv J. Shah, Setia Pramana, Wolfgang Lieb, Reinhold Schmidt, Alice V. Stanton, Dörthe Malzahn, Albert Vernon Smith, Johan Sundström, Cosetta Minelli, Daniela Ruggiero, Leo-Pekka Lyytikäinen, Daniel Tiller, J. Gustav Smi
Published in: Journal of Clinical Investigation, Issue 127/5, 2017, Page(s) 1798-1812, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI84840

Genetic Risk Prediction of Atrial Fibrillation

Author(s): Steven A. Lubitz, Xiaoyan Yin, Henry J. Lin, Matthew Kolek, J. Gustav Smith, Stella Trompet, Michiel Rienstra, Natalia S. Rost, Pedro L. Teixeira, Peter Almgren, Christopher D. Anderson, Lin Y. Chen, Gunnar Engström, Ian Ford, Karen L. Furie, Xiuqing Guo, Martin G. Larson, Kathryn L. Lunetta, Peter W. Macfarlane, Bruce M. Psaty, Elsayed Z. Soliman, Nona Sotoodehnia, David J. Stott, Kent D. Taylor
Published in: Circulation, Issue 135/14, 2017, Page(s) 1311-1320, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.024143

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Author(s): Lasse Folkersen, Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Åsa K. Hedman, Andrew Schork, Karen Page, Daria V. Zhernakova, Yang Wu, James Peters, Niclas Eriksson, Sarah E. Bergen, Thibaud S. Boutin, Andrew D. Bretherick, Stefan Enroth, Anette Kalnapenkis, Jesper R. Gådin, Bianca E. Suur, Yan Chen, Ljubica Matic, Jeremy D. Gale, Julie Lee, Weidong Zhang, Amira Quazi, Mika Ala-Korpela, S
Published in: Nature Metabolism, Issue 2/10, 2020, Page(s) 1135-1148, ISSN 2522-5812
Publisher: Nature Springer
DOI: 10.1038/s42255-020-00287-2