Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers

Publikacje

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Autorzy: Ioanna Ntalla, Lu-Chen Weng, James H. Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, Carolina Roselli, Michael R. Barnes, Borbala Mifsud, Helen R. Warren, Caroline Hayward, Jonathan Marten, James J. Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M. Araujo, Maria Fernanda Lima-
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-15706-x

Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk

Autorzy: Debby Ngo, Mark D. Benson, Jonathan Z. Long, Zsu-Zsu Chen, Ruiqi Wang, Anjali K. Nath, Michelle J. Keyes, Dongxiao Shen, Sumita Sinha, Eric Kuhn, Jordan E. Morningstar, Xu Shi, Bennet D. Peterson, Christopher Chan, Daniel H. Katz, Usman A. Tahir, Laurie A. Farrell, Olle Melander, Jonathan D. Mosley, Steven A. Carr, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Qiong Yan
Opublikowane w: JCI Insight, Numer 6/5, 2021, ISSN 2379-3708
Wydawca: American Society for Clinical Investigations
DOI: 10.1172/jci.insight.144392

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Autorzy: Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G. Aragam, Johan Ärnlöv, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Jeffrey Brandimarto, Michael R. Brown, Leonard Buckbinder,
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-13690-5

Methods for isolation and transcriptional profiling of individual cells from the human heart

Autorzy: Neha Pimpalwar, Tomasz Czuba, Maya Landenhed Smith, Johan Nilsson, Olof Gidlöf, J. Gustav Smith
Opublikowane w: Heliyon, Numer 6/12, 2020, Strona(/y) e05810, ISSN 2405-8440
Wydawca: Elsevier / Cell Press
DOI: 10.1016/j.heliyon.2020.e05810

Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease

Autorzy: J. Gustav Smith, Robert E. Gerszten
Opublikowane w: Circulation, Numer 135/17, 2017, Strona(/y) 1651-1664, ISSN 0009-7322
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.025446

Molecular Epidemiology of Heart Failure

Autorzy: J. Gustav Smith
Opublikowane w: JACC: Basic to Translational Science, Numer 2/6, 2017, Strona(/y) 757-769, ISSN 2452-302X
Wydawca: Elsevier
DOI: 10.1016/j.jacbts.2017.07.010

A Swedish Nationwide Adoption Study of the Heritability of Heart Failure

Autorzy: Magnus P. Lindgren, MirNabi PirouziFard, J. Gustav Smith, Jan Sundquist, Kristina Sundquist, Bengt Zöller
Opublikowane w: JAMA Cardiology, Numer 3/8, 2018, Strona(/y) 703, ISSN 2380-6583
Wydawca: American Medical Association
DOI: 10.1001/jamacardio.2018.1919

Longitudinal evaluation of ventricular ejection fraction and NT-proBNP across heart failure subgroups

Autorzy: Andreas Martinsson, Petter Oest, Maj-Britt Wiborg, Öyvind Reitan, J. Gustav Smith
Opublikowane w: Scandinavian Cardiovascular Journal, Numer 52/4, 2018, Strona(/y) 205-210, ISSN 1401-7431
Wydawca: Taylor & Francis
DOI: 10.1080/14017431.2018.1461920

Vascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure

Autorzy: Yan Borné, Klas Gränsbo, Jan Nilsson, Olle Melander, Marju Orho-Melander, J. Gustav Smith, Gunnar Engström
Opublikowane w: Journal of the American College of Cardiology, Numer 71/5, 2018, Strona(/y) 580-582, ISSN 0735-1097
Wydawca: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.058

Age-Specific Trends in Incidence, Mortality, and Comorbidities of Heart Failure in Denmark, 1995 to 2012

Autorzy: Mia N. Christiansen, Lars Køber, Peter Weeke, Ramachandran S. Vasan, Jørgen L. Jeppesen, J. Gustav Smith, Gunnar H. Gislason, Christian Torp-Pedersen, Charlotte Andersson
Opublikowane w: Circulation, Numer 135/13, 2017, Strona(/y) 1214-1223, ISSN 0009-7322
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.025941

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

Autorzy: J. Gustav Smith, Janine F. Felix, Alanna C. Morrison, Andreas Kalogeropoulos, Stella Trompet, Jemma B. Wilk, Olof Gidlöf, Xinchen Wang, Michael Morley, Michael Mendelson, Roby Joehanes, Symen Ligthart, Xiaoyin Shan, Joshua C. Bis, Ying A. Wang, Marketa Sjögren, Julius Ngwa, Jeffrey Brandimarto, David J. Stott, David Aguilar, Kenneth M. Rice, Howard D. Sesso, Serkalem Demissie, Brendan M. Buckley
Opublikowane w: PLOS Genetics, Numer 12/5, 2016, Strona(/y) e1006034, ISSN 1553-7404
Wydawca: Public Library of Science (PLoS)
DOI: 10.1371/journal.pgen.1006034

Blood lactate is a predictor of short-term mortality in patients with myocardial infarction complicated by heart failure but without cardiogenic shock

Autorzy: Grunde Gjesdal, Oscar Ö. Braun, J. Gustav Smith, Fredrik Scherstén, Patrik Tydén
Opublikowane w: BMC Cardiovascular Disorders, Numer 18/1, 2018, ISSN 1471-2261
Wydawca: BioMed Central
DOI: 10.1186/s12872-018-0744-1

Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study

Autorzy: Pontus Andell, Xinjun Li, Andreas Martinsson, Charlotte Andersson, Martin Stagmo, Bengt Zöller, Kristina Sundquist, J Gustav Smith
Opublikowane w: Heart, Numer 103/21, 2017, Strona(/y) 1696-1703, ISSN 1355-6037
Wydawca: BMJ Publishing Group
DOI: 10.1136/heartjnl-2016-310894

Heritability of Atrial Fibrillation

Autorzy: Lu-Chen Weng, Seung Hoan Choi, Derek Klarin, J. Gustav Smith, Po-Ru Loh, Mark Chaffin, Carolina Roselli, Olivia L. Hulme, Kathryn L. Lunetta, Josée Dupuis, Emelia J. Benjamin, Christopher Newton-Cheh, Sekar Kathiresan, Patrick T. Ellinor, Steven A. Lubitz
Opublikowane w: Circulation: Cardiovascular Genetics, Numer 10/6, 2017, ISSN 1942-3268
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001838

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Autorzy: Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huf
Opublikowane w: Nature Genetics, Numer 49/6, 2017, Strona(/y) 946-952, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/ng.3843

Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production

Autorzy: Connie Wu, Pankaj Arora, Obiajulu Agha, Liam A. Hurst, Kaitlin Allen, Daniel I. Nathan, Dongjian Hu, Pawina Jiramongkolchai, J. Gustav Smith, Olle Melander, Sander Trenson, Stefan P. Janssens, Ibrahim Domian, Thomas J. Wang, Kenneth D. Bloch, Emmanuel S. Buys, Donald B. Bloch, Christopher Newton-Cheh
Opublikowane w: Molecular and Cellular Biology, Numer 36/14, 2016, Strona(/y) 1977-1987, ISSN 0270-7306
Wydawca: American Society for Microbiology
DOI: 10.1128/MCB.01114-15

Predictive Value of High-Sensitivity Troponin T for Systolic Dysfunction and Infarct Size (Six Months) After ST-Elevation Myocardial Infarction

Autorzy: Moman A. Mohammad, Sasha Koul, J. Gustav Smith, Marco Noc, Irene Lang, Michael Holzer, Peter Clemmensen, Ulf Jensen, Thomas Engstrøm, Håkan Arheden, Stefan James, Bertil Lindahl, Bernhard Metzler, David Erlinge
Opublikowane w: The American Journal of Cardiology, Numer 122/5, 2018, Strona(/y) 735-743, ISSN 0002-9149
Wydawca: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2018.05.005

Multi-ethnic genome-wide association study for atrial fibrillation

Autorzy: Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Ca
Opublikowane w: Nature Genetics, Numer 50/9, 2018, Strona(/y) 1225-1233, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-018-0133-9

Genome-wide analysis yields new loci associating with aortic valve stenosis

Autorzy: Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir, Olafur A. Stefansson, Vinicius Tragante, Rosa B. Thorolfsdottir, Ingileif Jonsdottir, Thorsteinn Bjornsson, Valgerdur Steinthorsdottir, Niek Verweij, Jonas B. Nielsen, Wei Zhou, Lasse Folkersen, Andreas Martinsson, Mahyar Heydarpour, Siddharth Prakash, Gylfi Oskarsson, Tomas Gudbjartsson, Arnar Geirsson, Isleifur Olafsson, Emil L. Sigur
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-03252-6

Genetic Architecture of the Cardiovascular Risk Proteome

Autorzy: Mark D. Benson, Qiong Yang, Debby Ngo, Yineng Zhu, Dongxiao Shen, Laurie A. Farrell, Sumita Sinha, Michelle J. Keyes, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Robert E. Gerszten
Opublikowane w: Circulation, Numer 137/11, 2018, Strona(/y) 1158-1172, ISSN 0009-7322
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.117.029536

Familial Aggregation of Aortic Valvular Stenosis

Autorzy: Andreas Martinsson, Xinjun Li, Bengt Zöller, Pontus Andell, Charlotte Andersson, Kristina Sundquist, J. Gustav Smith
Opublikowane w: Circulation: Cardiovascular Genetics, Numer 10/6, 2017, ISSN 1942-3268
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001742

Immunological Serum Protein Profiles for Noninvasive Detection of Acute Cellular Rejection After Heart Transplantation

Autorzy: Ihdina Sukma Dewi, Olof Gidlöf, Zsuzsanna Hollander, Karen K. Lam, Mark D. Benson, Oscar O. Braun, Johan Nilsson, Scott J. Tebbutt, Raymond T. Ng, Jenny Öhman, Bruce M. McManus, J. Gustav Smith
Opublikowane w: Journal of the American College of Cardiology, Numer 70/23, 2017, Strona(/y) 2946-2947, ISSN 0735-1097
Wydawca: Elsevier BV
DOI: 10.1016/j.jacc.2017.10.012

Orthogonal P-wave morphology is affected by intra-atrial pressures

Autorzy: Richard Petersson, J. Gustav Smith, David A. Larsson, Öyvind Reitan, Jonas Carlson, Pyotr Platonov, Fredrik Holmqvist
Opublikowane w: BMC Cardiovascular Disorders, Numer 17/1, 2017, ISSN 1471-2261
Wydawca: BioMed Central
DOI: 10.1186/s12872-017-0724-x

Heritability of Mitral Regurgitation

Autorzy: Francesca N. Delling, Xinjun Li, Shuo Li, Qiong Yang, Vanessa Xanthakis, Andreas Martinsson, Pontus Andell, Birgitta T. Lehman, Ewa W. Osypiuk, Plamen Stantchev, Bengt Zöller, Emelia J. Benjamin, Kristina Sundquist, Ramachandran S. Vasan, J. Gustav Smith
Opublikowane w: Circulation: Cardiovascular Genetics, Numer 10/5, 2017, ISSN 1942-3268
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001736

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study

Autorzy: Stephen Zewinger, Marcus E Kleber, Vinicius Tragante, Raymond O McCubrey, Amand F Schmidt, Kenan Direk, Ulrich Laufs, Christian Werner, Wolfgang Koenig, Dietrich Rothenbacher, Ute Mons, Lutz P Breitling, Herrmann Brenner, Richard T Jennings, Ioannis Petrakis, Sarah Triem, Mira Klug, Alexandra Filips, Stefan Blankenberg, Christoph Waldeyer, Christoph Sinning, Renate B Schnabel, Karl J Lackner, Efth
Opublikowane w: The Lancet Diabetes & Endocrinology, Numer 5/7, 2017, Strona(/y) 534-543, ISSN 2213-8587
Wydawca: Elsevier BV
DOI: 10.1016/S2213-8587(17)30096-7

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

Autorzy: Philipp S. Wild, Janine F. Felix, Arne Schillert, Alexander Teumer, Ming-Huei Chen, Maarten J.G. Leening, Uwe Völker, Vera Großmann, Jennifer A. Brody, Marguerite R. Irvin, Sanjiv J. Shah, Setia Pramana, Wolfgang Lieb, Reinhold Schmidt, Alice V. Stanton, Dörthe Malzahn, Albert Vernon Smith, Johan Sundström, Cosetta Minelli, Daniela Ruggiero, Leo-Pekka Lyytikäinen, Daniel Tiller, J. Gustav Smi
Opublikowane w: Journal of Clinical Investigation, Numer 127/5, 2017, Strona(/y) 1798-1812, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/JCI84840

Genetic Risk Prediction of Atrial Fibrillation

Autorzy: Steven A. Lubitz, Xiaoyan Yin, Henry J. Lin, Matthew Kolek, J. Gustav Smith, Stella Trompet, Michiel Rienstra, Natalia S. Rost, Pedro L. Teixeira, Peter Almgren, Christopher D. Anderson, Lin Y. Chen, Gunnar Engström, Ian Ford, Karen L. Furie, Xiuqing Guo, Martin G. Larson, Kathryn L. Lunetta, Peter W. Macfarlane, Bruce M. Psaty, Elsayed Z. Soliman, Nona Sotoodehnia, David J. Stott, Kent D. Taylor
Opublikowane w: Circulation, Numer 135/14, 2017, Strona(/y) 1311-1320, ISSN 0009-7322
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.024143

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Autorzy: Lasse Folkersen, Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Åsa K. Hedman, Andrew Schork, Karen Page, Daria V. Zhernakova, Yang Wu, James Peters, Niclas Eriksson, Sarah E. Bergen, Thibaud S. Boutin, Andrew D. Bretherick, Stefan Enroth, Anette Kalnapenkis, Jesper R. Gådin, Bianca E. Suur, Yan Chen, Ljubica Matic, Jeremy D. Gale, Julie Lee, Weidong Zhang, Amira Quazi, Mika Ala-Korpela, S
Opublikowane w: Nature Metabolism, Numer 2/10, 2020, Strona(/y) 1135-1148, ISSN 2522-5812
Wydawca: Nature Springer
DOI: 10.1038/s42255-020-00287-2

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