Optimized drug combinations for effective cancer treatment: a personalised approach.

Project Information

OPTIM

Grant agreement ID: 680209

DOI 10.3030/680209

Project closed

EC signature date 6 April 2016

Start date 1 May 2016

End date 30 April 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 199 436,00

EU contribution € 1 199 436,00

Coordinated by

UNIVERSITE DE GENEVE
Switzerland

Publications

Peer reviewed articles (12)

A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7)

Author(s): Judy R. van Beijnum, Patrycja Nowak-Sliwinska, Maaike van Berkel, Tse J. Wong, Arjan W. Griffioen
Published in: Angiogenesis, Issue 20/4, 2017, Page(s) 641-654, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-017-9576-3

Current Trends in Multidrug Optimization: An Alley of Future Successful Treatment of Complex Disorders

Author(s): Andrea Weiss, Patrycja Nowak-Sliwinska
Published in: SLAS TECHNOLOGY: Translating Life Sciences Innovation, Issue 22/3, 2017, Page(s) 254-275, ISSN 2472-6303
Publisher: SAGE journals
DOI: 10.1177/2472630316682338

Angiogenesis inhibitors in combinatorial approaches

Author(s): Patrycja Nowak-Sliwinska, Arjan W. Griffioen
Published in: Angiogenesis, Issue 20/2, 2017, Page(s) 183-184, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-017-9544-y

Consensus guidelines for the use and interpretation of angiogenesis assays

Author(s): Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C. Aplin, Robert Auerbach, Hellmut G. Augustin, David O. Bates, Judy R. van Beijnum, R. Hugh F. Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C. Böck, Peter C. Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M. Cimpean, Ondine Cleaver, George Coukos, George E.
Published in: Angiogenesis, 2018, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-018-9613-x

Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

Author(s): Patrycja Nowak-Sliwinska, Leonardo Scapozza, Ariel Ruiz i Altaba
Published in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Issue 1871/2, 2019, Page(s) 434-454, ISSN 0304-419X
Publisher: Elsevier BV
DOI: 10.1016/j.bbcan.2019.04.005

Short-term 3D culture systems of various complexity for treatment optimization of colorectal carcinoma

Author(s): Marloes Zoetemelk, Magdalena Rausch, Didier J. Colin, Olivier Dormond, Patrycja Nowak-Sliwinska
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-42836-0

Optimization for multidrug combinations: Challenges and perspectives in complex disorders

Author(s): Patrycja Nowak-Sliwinska
Published in: Pharmacological Research, 2019, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2019.02.004

Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity

Author(s): Robert H. Berndsen, Andrea Weiss, U. Kulsoom Abdul, Tse J. Wong, Patrick Meraldi, Arjan W. Griffioen, Paul J. Dyson, Patrycja Nowak-Sliwinska
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep43005

Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment

Author(s): Patrycja Nowak-Sliwinska, Judy R. van Beijnum, Elisabeth J. M. Huijbers, Paula C. Gasull, Laurie Mans, Axel Bex, Arjan W. Griffioen
Published in: British Journal of Cancer, Issue 120/2, 2019, Page(s) 218-228, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-018-0347-8

Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

Author(s): George M. Ramzy, Thibaud Koessler, Eloise Ducrey, Thomas McKee, Frédéric Ris, Nicolas Buchs, Laura Rubbia-Brandt, Pierre-Yves Dietrich, Patrycja Nowak-Sliwinska
Published in: Cancers, Issue 12/6, 2020, Page(s) 1423, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061423

Colorectal Cancer Growth Retardation through Induction of Apoptosis, Using an Optimized Synergistic Cocktail of Axitinib, Erlotinib, and Dasatinib

Author(s): Robert H. Berndsen, Nathalie Swier, Judy R. van Beijnum, Patrycja Nowak-Sliwinska
Published in: Cancers, Issue 11/12, 2019, Page(s) 1878, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11121878

Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment

Author(s): Marloes Zoetemelk, George M. Ramzy, Magdalena Rausch, Patrycja Nowak-Sliwinska
Published in: Molecules, Issue 25/11, 2020, Page(s) 2614, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25112614