Optimized drug combinations for effective cancer treatment: a personalised approach.

Informazioni relative al progetto

OPTIM

ID dell’accordo di sovvenzione: 680209

DOI 10.3030/680209

Progetto chiuso

Data della firma CE 6 Aprile 2016

Data di avvio 1 Maggio 2016

Data di completamento 30 Aprile 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 199 436,00

Contributo UE € 1 199 436,00

Coordinato da

UNIVERSITE DE GENEVE
Switzerland

Pubblicazioni

Peer reviewed articles (12)

A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7)

Autori: Judy R. van Beijnum, Patrycja Nowak-Sliwinska, Maaike van Berkel, Tse J. Wong, Arjan W. Griffioen
Pubblicato in: Angiogenesis, Numero 20/4, 2017, Pagina/e 641-654, ISSN 0969-6970
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10456-017-9576-3

Current Trends in Multidrug Optimization: An Alley of Future Successful Treatment of Complex Disorders

Autori: Andrea Weiss, Patrycja Nowak-Sliwinska
Pubblicato in: SLAS TECHNOLOGY: Translating Life Sciences Innovation, Numero 22/3, 2017, Pagina/e 254-275, ISSN 2472-6303
Editore: SAGE journals
DOI: 10.1177/2472630316682338

Angiogenesis inhibitors in combinatorial approaches

Autori: Patrycja Nowak-Sliwinska, Arjan W. Griffioen
Pubblicato in: Angiogenesis, Numero 20/2, 2017, Pagina/e 183-184, ISSN 0969-6970
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10456-017-9544-y

Consensus guidelines for the use and interpretation of angiogenesis assays

Autori: Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C. Aplin, Robert Auerbach, Hellmut G. Augustin, David O. Bates, Judy R. van Beijnum, R. Hugh F. Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C. Böck, Peter C. Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M. Cimpean, Ondine Cleaver, George Coukos, George E.
Pubblicato in: Angiogenesis, 2018, ISSN 0969-6970
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10456-018-9613-x

Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer

Autori: Patrycja Nowak-Sliwinska, Leonardo Scapozza, Ariel Ruiz i Altaba
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Numero 1871/2, 2019, Pagina/e 434-454, ISSN 0304-419X
Editore: Elsevier BV
DOI: 10.1016/j.bbcan.2019.04.005

Short-term 3D culture systems of various complexity for treatment optimization of colorectal carcinoma

Autori: Marloes Zoetemelk, Magdalena Rausch, Didier J. Colin, Olivier Dormond, Patrycja Nowak-Sliwinska
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-42836-0

Optimization for multidrug combinations: Challenges and perspectives in complex disorders

Autori: Patrycja Nowak-Sliwinska
Pubblicato in: Pharmacological Research, 2019, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2019.02.004

Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity

Autori: Robert H. Berndsen, Andrea Weiss, U. Kulsoom Abdul, Tse J. Wong, Patrick Meraldi, Arjan W. Griffioen, Paul J. Dyson, Patrycja Nowak-Sliwinska
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep43005

Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment

Autori: Patrycja Nowak-Sliwinska, Judy R. van Beijnum, Elisabeth J. M. Huijbers, Paula C. Gasull, Laurie Mans, Axel Bex, Arjan W. Griffioen
Pubblicato in: British Journal of Cancer, Numero 120/2, 2019, Pagina/e 218-228, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-018-0347-8

Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

Autori: George M. Ramzy, Thibaud Koessler, Eloise Ducrey, Thomas McKee, Frédéric Ris, Nicolas Buchs, Laura Rubbia-Brandt, Pierre-Yves Dietrich, Patrycja Nowak-Sliwinska
Pubblicato in: Cancers, Numero 12/6, 2020, Pagina/e 1423, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061423

Colorectal Cancer Growth Retardation through Induction of Apoptosis, Using an Optimized Synergistic Cocktail of Axitinib, Erlotinib, and Dasatinib

Autori: Robert H. Berndsen, Nathalie Swier, Judy R. van Beijnum, Patrycja Nowak-Sliwinska
Pubblicato in: Cancers, Numero 11/12, 2019, Pagina/e 1878, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11121878

Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment

Autori: Marloes Zoetemelk, George M. Ramzy, Magdalena Rausch, Patrycja Nowak-Sliwinska
Pubblicato in: Molecules, Numero 25/11, 2020, Pagina/e 2614, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25112614