Title of Proposal: Restoring the immune system homeostasis and organ function in severe community acquired pneumonia- induced sepsis through adipose derived allogeneic stem cells (SEPCELL Proje

Informations projet

SEPCELL

N° de convention de subvention: 681031

DOI 10.3030/681031

Projet clôturé

Date de signature de la CE 1 Octobre 2015

Date de début 1 Novembre 2015

Date de fin 30 Avril 2022

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total € 12 000 695,00

Contribution de l’UE € 5 369 886,00

Coordonné par

TIGENIX SA
Spain

Publications

Peer reviewed articles (4)

Human Adipose-Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae.

Auteurs: Perlee D, de Vos AF, Scicluna BP, Mancheño P, de la Rosa O, Dalemans W, Nürnberg P, Lombardo E, van der Poll T.
Publié dans: Stem Cells Transl Med., 2019, ISSN 2157-6564
Éditeur: AlphaMed Press

Role of tissue factor in the procoagulant and antibacterial effects of human adipose-derived mesenchymal stem cells during pneumosepsis in mice.

Auteurs: Perlee, Desirée; de Vos, Alex F.; Scicluna, Brendon P.; Maag, Anja; Mancheño, Pablo; de la Rosa, Olga; Dalemans, Wilfried; Florquin, Sandrine; van’t Veer, Cornelis; Lombardo, Eleuterio; van der Poll, Tom
Publié dans: VOLUME=10;ISSUE=1;ISSN=1757-6512;TITLE=STEM CELL RESEARCH & THERAPY, Numéro 1, 2019, Page(s) 10(1):286, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-019-1391-x

A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit.

Auteurs: Laterre PF, Sánchez-García M, van der Poll T, de la Rosa O, Cadogan KA, Lombardo E, François B
Publié dans: BMC Pulm Med, 2020, Page(s) 20(1):309, ISSN 1471-2466
Éditeur: BioMed Central
DOI: 10.1186/s12890-020-01324-2

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2

Auteurs: Ortiz-Virumbrales M, Menta R, Pérez LM, Lucchesi O, Mancheño-Corvo P, Avivar-Valderas Á, Palacios I, Herrero-Mendez A, Dalemans W, de la Rosa O, Lombardo
Publié dans: Stem Cell Res Ther., 2020, Page(s) 11(1):462, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-020-01975-2