Unfolding the Mechanism of Chromosome Cohesion and Condensation using Single-Molecule Biophysical Approaches

Project Information

Mechan-of-Chromo

Grant agreement ID: 681299

DOI

10.3030/681299

Project closed

EC signature date 20 April 2016

Start date 1 June 2016

End date 30 November 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 894 999,00

EU contribution

€ 1 894 999,00

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

Double-stranded RNA bending by AU-tract sequences

Author(s): Alberto Marin-Gonzalez, Clara Aicart-Ramos, Mikel Marin-Baquero, Alejandro Martín-González, Maarit Suomalainen, Abhilash Kannan, J G Vilhena, Urs F Greber, Fernando Moreno-Herrero, Rubén Pérez
Published in: Nucleic Acids Research, Issue 48(22), 2020, Page(s) 12917–12928, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1128

Functional characterization of the different oligomeric forms of human surfactant protein SP-D

Author(s): Raquel Arroyo, Mercedes Echaide, Fernando Moreno-Herrero, Jesus Perez-Gil, Paul S. Kingma
Published in: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Issue 1868/8, 2020, Page(s) 140436, ISSN 1570-9639
Publisher: Elsevier BV
DOI: 10.1016/j.bbapap.2020.140436

Characterizing microfluidic approaches for a fast and efficient reagent exchange in single-molecule studies

Author(s): Julene Madariaga-Marcos, Roberta Corti, Silvia Hormeño, Fernando Moreno-Herrero
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-74523-w

Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction

Author(s): Pilar Gutierrez-Escribano, Silvia Hormeño, Julene Madariaga-Marcos, Roger Solé-Soler, Francis J. O’Reilly, Kyle Morris, Clara Aicart-Ramos, Ricardo Aramayo, Alex Montoya, Holger Kramer, Juri Rappsilber, Jordi Torres-Rosell, Fernando Moreno-Herrero, Luis Aragon
Published in: Molecular Cell, Issue 80, 2020, Page(s) 1-16, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.11.012

A molecular view of DNA flexibility

Author(s): Alberto Marin-Gonzalez, J. G. Vilhena; Ruben Perez, Fernando Moreno-Herrero
Published in: Quarterly Reviews of Biophysics, Issue 54, e8, 2021, Page(s) 1-20, ISSN 0033-5835
Publisher: Cambridge University Press
DOI: 10.1017/s0033583521000068

CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

Author(s): Francisco de Asis Balaguer, Clara Aicart-Ramos, Gemma LM Fisher, Sara de Bragança, Eva M Martin-Cuevas, Cesar L Pastrana, Mark Simon Dillingham, Fernando Moreno-Herrero
Published in: eLife, Issue 1, 2021, Page(s) 1-28, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.67554

Dynamics of DNA nicking and unwinding by the RepC–PcrA complex

Author(s): Carolina Carrasco, Cesar L Pastrana, Clara Aicart-Ramos, Sanford H Leuba, Saleem A Khan, Fernando Moreno-Herrero
Published in: Nucleic Acids Research, Issue 48/4, 2020, Page(s) 2013-2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz1200

Understanding the mechanical response of double-stranded DNA and RNA under constant stretching forces using all-atom molecular dynamics

Author(s): Alberto Marin-Gonzalez, J. G. Vilhena, Ruben Perez, Fernando Moreno-Herrero
Published in: Proceedings of the National Academy of Sciences, Issue 114/27, 2017, Page(s) 7049-7054, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1705642114

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

Author(s): Gemma LM Fisher, César L Pastrana, Victoria A Higman, Alan Koh, James A Taylor, Annika Butterer, Timothy Craggs, Frank Sobott, Heath Murray, Matthew P Crump, Fernando Moreno-Herrero, Mark S Dillingham
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.28086

Force determination in lateral magnetic tweezers combined with TIRF microscopy

Author(s): J. Madariaga-Marcos, S. Hormeño, C. L. Pastrana, G. L. M. Fisher, M. S. Dillingham, F. Moreno-Herrero
Published in: Nanoscale, Issue 10/9, 2018, Page(s) 4579-4590, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7nr07344e

Supramolecular Assembly of Human Pulmonary Surfactant Protein SP-D

Author(s): R. Arroyo, A. Martín-González, M. Echaide, A. Jain, W.H. Brondyk, J. Rosenbaum, F. Moreno-Herrero, J. Pérez-Gil
Published in: Journal of Molecular Biology, Issue 430/10, 2018, Page(s) 1495-1509, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2018.03.027

The TubR–centromere complex adopts a double-ring segrosome structure in Type III partition systems

Author(s): Bárbara Martín-García, Alejandro Martín-González, Carolina Carrasco, Ana M Hernández-Arriaga, Rubén Ruíz-Quero, Ramón Díaz-Orejas, Clara Aicart-Ramos, Fernando Moreno-Herrero, María A Oliva
Published in: Nucleic Acids Research, Issue 46/11, 2018, Page(s) 5704-5716, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky370

CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

Author(s): Oliver J Wilkinson, Alejandro Martín-González, Haejoo Kang, Sarah J Northall, Dale B Wigley, Fernando Moreno-Herrero, Mark Simon Dillingham
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.42129

ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements

Author(s): Julene Madariaga-Marcos, Cesar L Pastrana, Gemma LM Fisher, Mark Simon Dillingham, Fernando Moreno-Herrero
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.43812

DNA Crookedness Regulates DNA Mechanical Properties at Short Length Scales

Author(s): Alberto Marin-Gonzalez, J. G. Vilhena, Fernando Moreno-Herrero, Ruben Perez
Published in: Physical Review Letters, Issue 122/4, 2019, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.122.048102

Bulk and single-molecule analysis of a bacterial DNA2-like helicase–nuclease reveals a single-stranded DNA looping motor

Author(s): Oliver J Wilkinson, Carolina Carrasco, Clara Aicart-Ramos, Fernando Moreno-Herrero, Mark S Dillingham
Published in: Nucleic Acids Research, Issue 48/14, 2020, Page(s) 7991-8005, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa562

Understanding the paradoxical mechanical response of in-phase A-tracts at different force regimes

Author(s): Alberto Marin-Gonzalez, Cesar L Pastrana, Rebeca Bocanegra, Alejandro Martín-González, J G Vilhena, Rubén Pérez, Borja Ibarra, Clara Aicart-Ramos, Fernando Moreno-Herrero
Published in: Nucleic Acids Research, Issue 48/9, 2020, Page(s) 5024-5036, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa225

Human HELB is a processive motor protein which catalyses RPA clearance from single-stranded DNA

Author(s): S Hormeno, OJ Wilkinson, C Aicart-Ramos, S Kuppa, E Antony, MS Dillingham, F Moreno-Herrero
Published in: bioRxiv, 2021, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.05.27.445972

Long Noncoding RNA NIHCOLE Promotes Ligation Efficiency of DNA Double-Strand Breaks in Hepatocellular Carcinoma

Author(s): Juan P. Unfried, Mikel Marín-Baquero, Ángel Rivera-Calzada, Nerea Razquin, Eva M. Martín-Cuevas, Sara de Bragança, Clara Aicart-Ramos, Christopher McCoy, Laura Prats-Mari, Raquel Arribas-Bosacoma, Linda Lee, Stefano Caruso, Jessica Zucman-Rossi, Bruno Sangro, Gareth Williams, Fernando Moreno-Herrero, Oscar Llorca, Susan P. Lees-Miller and Puri Fortes
Published in: Cancer Research, Issue 81(19), 2021, Page(s) 4910-4925, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-0463

Sequence-dependent mechanical properties of double-stranded RNA

Author(s): Alberto Marin-Gonzalez, J. G. Vilhena, Fernando Moreno-Herrero, Ruben Perez
Published in: Nanoscale, Issue 11/44, 2019, Page(s) 21471-21478, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr07516j

Book chapters (1)

High-Resolution Atomic Force Microscopy Imaging of Nucleic Acids

Author(s): Pablo Ares, Julio Gomez-Herrero, Fernando Moreno-Herrero
Published in: Nanoscale Imaging, Issue 1814, 2018, Page(s) 3-17, ISBN 978-1-4939-8590-6
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8591-3_1