Evolution of antibiotic tolerance in the 'wild': A quantitative approach

Project Information

Tolerome

Grant agreement ID: 681819

DOI 10.3030/681819

Project closed

EC signature date 20 April 2016

Start date 1 May 2016

End date 31 October 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 978 750,00

EU contribution € 1 978 750,00

Coordinated by

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

Publications

Peer reviewed articles (10)

Epistasis between antibiotic tolerance, persistence, and resistance mutations

Author(s): Irit Levin-Reisman, Asher Brauner, Irine Ronin, Nathalie Q. Balaban
Published in: Proceedings of the National Academy of Sciences, Issue 116/29, 2019, Page(s) 14734-14739, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1906169116

Effect of tolerance on the evolution of antibiotic resistance under drug combinations

Author(s): Liu, J., Gefen, O., Ronin, I., Bar-Meir, M., and Balaban
Published in: Science, Issue 10 Jan 2020, 2020, Page(s) Vol. 367, Issue 6474, pp. 200-204, ISSN 1095-9203
Publisher: AAAS
DOI: 10.1126/science.aay3041

A long-term epigenetic memory switch controls bacterial virulence bimodality

Author(s): Irine Ronin, Naama Katsowich, Ilan Rosenshine, Nathalie Q Balaban
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.19599

Antibiotic tolerance facilitates the evolution of resistance

Author(s): Irit Levin-Reisman, Irine Ronin, Orit Gefen, Ilan Braniss, Noam Shoresh, Nathalie Q. Balaban
Published in: Science, Issue 355/6327, 2017, Page(s) 826-830, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaj2191

TDtest: easy detection of bacterial tolerance and persistence in clinical isolates by a modified disk-diffusion assay

Author(s): Orit Gefen, Betty Chekol, Jacob Strahilevitz, Nathalie Q. Balaban
Published in: Scientific Reports, Issue 7, 2017, Page(s) 41284, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep41284

An Experimental Framework for Quantifying Bacterial Tolerance

Author(s): Asher Brauner, Noam Shoresh, Ofer Fridman, Nathalie Q. Balaban
Published in: Biophysical Journal, Issue 112/12, 2017, Page(s) 2664-2671, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2017.05.014

Definitions and guidelines for research on antibiotic persistence

Author(s): Nathalie Q. Balaban, Sophie Helaine, Kim Lewis, Martin Ackermann, Bree Aldridge, Dan I. Andersson, Mark P. Brynildsen, Dirk Bumann, Andrew Camilli, James J. Collins, Christoph Dehio, Sarah Fortune, Jean-Marc Ghigo, Wolf-Dietrich Hardt, Alexander Harms, Matthias Heinemann, Deborah T. Hung, Urs Jenal, Bruce R. Levin, Jan Michiels, Gisela Storz, Man-Wah Tan, Tanel Tenson, Laurence Van Melderen, Annel
Published in: Nature Reviews Microbiology, Issue 17/7, 2019, Page(s) 441-448, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/s41579-019-0196-3

Inheritance of Cell-Cycle Duration in the Presence of Periodic Forcing

Author(s): Noga Mosheiff, Bruno M. C. Martins, Sivan Pearl-Mizrahi, Alexander Grünberger, Stefan Helfrich, Irina Mihalcescu, Dietrich Kohlheyer, James C. W. Locke, Leon Glass, Nathalie Q. Balaban
Published in: Physical Review X, Issue 8/2, 2018, ISSN 2160-3308
Publisher: American Physical Society
DOI: 10.1103/physrevx.8.021035

Observation of universal ageing dynamics in antibiotic persistence

Author(s): Yoav Kaplan, Shaked Reich, Elyaqim Oster, Shani Maoz, Irit Levin-Reisman, Irine Ronin, Orit Gefen, Oded Agam & Nathalie Q. Balaban
Published in: Nature, Issue 600, 2021, Page(s) 290-294, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-021-04114-w

Persistence to anti-cancer treatments in the stationary to proliferating transition

Author(s): Sivan Pearl Mizrahi, Orit Gefen, Itamar Simon, Nathalie Q. Balaban
Published in: Cell Cycle, Issue 15/24, 2016, Page(s) 3442-3453, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2016.1248006