Periodic Reporting for period 4 - OCLD (Tracking the Dynamics of Human Metabolism using Spectroscopy-Integrated Liver-on-Chip Microdevices)
Período documentado: 2021-04-01 hasta 2021-09-30
Our model successfully captured metabolic oscillations in a 3D model of the human liver, as well as the onset of circadian rhythms in a 3D model of a developing embryo. This proprietary technology was patented at the Hebrew University of Jerusalem and licensed to Tissue Dynamics, a groundbreaking Organ-on-Chip company developing the first physiological bioanalyzer. The last 18 months of the project included major breakthroughs identifying novel metabolic mechanisms of drug induced kidney and cardiac injury as well as identified virus-induced lipotoxicity as a cause of lung damage in COVID-19.