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Targeting replication stress recovery pathways in oncology

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Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

Author(s): Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Published in: Nature Communications, Issue 8, 2017, Page(s) 15981, ISSN 2041-1723
DOI: 10.1038/ncomms15981

Shutting down the power supply for DNA repair in cancer cells

Author(s): Marcel A.T.M. van Vugt
Published in: The Journal of Cell Biology, Issue 216/2, 2017, Page(s) 295-297, ISSN 0021-9525
DOI: 10.1083/jcb.201701026

Therapeutic targeting and patient selection for cancers with homologous recombination defects

Author(s): Francien Talens, Mathilde Jalving, Jourik A. Gietema, Marcel A. Van Vugt
Published in: Expert Opinion on Drug Discovery, Issue 12/6, 2017, Page(s) 565-581, ISSN 1746-0441
DOI: 10.1080/17460441.2017.1322061

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach

Author(s): Mathilde R. W. de Jong, Lydia Visser, Gerwin Huls, Arjan Diepstra, Marcel van Vugt, Emanuele Ammatuna, Rozemarijn S. van Rijn, Edo Vellenga, Anke van den Berg, Rudolf S. N. Fehrmann, Tom van Meerten
Published in: PLOS ONE, Issue 13/2, 2018, Page(s) e0193098, ISSN 1932-6203
DOI: 10.1371/journal.pone.0193098

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells

Author(s): Stephanie E. van Gijn, Elles Wierenga, Nathalie van den Tempel, Yannick P. Kok, Anne Margriet Heijink, Diana C. J. Spierings, Floris Foijer, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Published in: Oncogene, Issue 38/6, 2019, Page(s) 852-867, ISSN 0950-9232
DOI: 10.1038/s41388-018-0470-2

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

Author(s): Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-018-07927-y

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

Author(s): Walderik W. Zomerman, Sabine L.A. Plasschaert, Siobhan Conroy, Frank J. Scherpen, Tiny G.J. Meeuwsen-de Boer, Harm J. Lourens, Sergi Guerrero Llobet, Marlinde J. Smit, Lorian Slagter-Menkema, Annika Seitz, Corrie E.M. Gidding, Esther Hulleman, Pieter Wesseling, Lisethe Meijer, Leon C. van Kempen, Anke van den Berg, Daniël O. Warmerdam, Frank A.E. Kruyt, Floris Foijer, Marcel A.T.M. van Vugt, Wilf
Published in: Cell Reports, Issue 22/12, 2018, Page(s) 3206-3216, ISSN 2211-1247
DOI: 10.1016/j.celrep.2018.02.089

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Author(s): Ewa Gogola, Alexandra A. Duarte, Julian R. de Ruiter, Wouter W. Wiegant, Jonas A. Schmid, Roebi de Bruijn, Dominic I. James, Sergi Guerrero Llobet, Daniel J. Vis, Stefano Annunziato, Bram van den Broek, Marco Barazas, Ariena Kersbergen, Marieke van de Ven, Madalena Tarsounas, Donald J. Ogilvie, Marcel van Vugt, Lodewyk F.A. Wessels, Jirina Bartkova, Irina Gromova, Miguel Andújar-Sánchez, Jiri Ba
Published in: Cancer Cell, Issue 33/6, 2018, Page(s) 1078-1093.e12, ISSN 1535-6108
DOI: 10.1016/j.ccell.2018.05.008

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

Author(s): Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt, Arnab Ray Chaudhuri
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-11246-1

Inflammatory signaling in genomically instable cancers

Author(s): Francien Talens, Marcel A.T.M. Van Vugt
Published in: Cell Cycle, Issue 18/16, 2019, Page(s) 1830-1848, ISSN 1538-4101
DOI: 10.1080/15384101.2019.1638192

Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

Author(s): Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G.E. de Vries, Michael J. Lee, Marcel A.T.M. van Vugt
Published in: Cell Reports, Issue 28/9, 2019, Page(s) 2345-2357.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.07.070

Never tear us a-PARP: Dealing with DNA lesions during mitosis

Author(s): Pepijn M. Schoonen, Marcel A.T.M. van Vugt
Published in: Molecular & Cellular Oncology, Issue 5/1, 2017, Page(s) e1382670, ISSN 2372-3556
DOI: 10.1080/23723556.2017.1382670

Replication stress: Driver and therapeutic target in genomically instable cancers

Author(s): Pepijn M. Schoonen, Sergi Guerrero Llobet, Marcel A.T.M. van Vugt
Published in: DNA Repair, Issue 115, 2019, Page(s) 157-201
DOI: 10.1016/bs.apcsb.2018.10.006