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Targeting replication stress recovery pathways in oncology

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Genomic instability, inflammatory signaling and response to cancer immunotherapy.

Author(s): Mengting Chen; Renske Linstra; Marcel A. T. M. van Vugt
Published in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Issue 1, 2021, ISSN 0304-419X
Publisher: Elsevier BV
DOI: 10.1016/j.bbcan.2021.188661

Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies

Author(s): Colin Stok, Yannick P Kok, Nathalie van den Tempel, Marcel A T M van Vugt
Published in: Nucleic Acids Research, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab151

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

Author(s): Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S. N. Fehrmann, Nathalie van den Tempel, Marcel A. T. M. van Vugt
Published in: Oncogenesis, Issue 9/10, 2020, ISSN 2157-9024
Publisher: Nature Publishing Group
DOI: 10.1038/s41389-020-00270-2

Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions

Author(s): Martijn R. H. Zwinderman; Thamar Jessurun Lobo; Petra E van der Wouden; Diana C.J. Spierings; Marcel A. T. M. van Vugt; Peter M. Lansdorp; Peter M. Lansdorp; Peter M. Lansdorp; Victor Guryev; Frank J. Dekker
Published in: ACS chemical biology, 16(11), 2193 - 2201. AMER CHEMICAL SOC, Issue 1, 2021, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.1c00321

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells

Author(s): Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga, Bjorn Bakker, Floris Foijer, Diana C. J. Spierings, Marcel A. T. M. Vugt
Published in: Molecular Oncology, Issue 13/11, 2019, Page(s) 2422-2440, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12573

The RECQL helicase prevents replication fork collapse during replication stress

Author(s): Bente Benedict, Marit AE van Bueren, Frank PA van Gemert, Cor Lieftink, Sergi Guerrero Llobet, Marcel ATM van Vugt, Roderick L Beijersbergen, Hein te Riele
Published in: Life Science Alliance, Issue 3/10, 2020, Page(s) e202000668, ISSN 2575-1077
Publisher: [Woodbury, NY] : Life Science Alliance, LLC, [2018]-
DOI: 10.26508/lsa.202000668

Transcriptional effects of copy number alterations in a large set of human cancers

Author(s): Arkajyoti Bhattacharya, Rico D. Bense, Carlos G. Urzúa-Traslaviña, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14605-5

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

Author(s): Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Published in: Nature Communications, Issue 8, 2017, Page(s) 15981, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15981

Shutting down the power supply for DNA repair in cancer cells

Author(s): Marcel A.T.M. van Vugt
Published in: The Journal of Cell Biology, Issue 216/2, 2017, Page(s) 295-297, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201701026

Therapeutic targeting and patient selection for cancers with homologous recombination defects

Author(s): Francien Talens, Mathilde Jalving, Jourik A. Gietema, Marcel A. Van Vugt
Published in: Expert Opinion on Drug Discovery, Issue 12/6, 2017, Page(s) 565-581, ISSN 1746-0441
Publisher: Informa Healthcare
DOI: 10.1080/17460441.2017.1322061

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach

Author(s): Mathilde R. W. de Jong, Lydia Visser, Gerwin Huls, Arjan Diepstra, Marcel van Vugt, Emanuele Ammatuna, Rozemarijn S. van Rijn, Edo Vellenga, Anke van den Berg, Rudolf S. N. Fehrmann, Tom van Meerten
Published in: PLOS ONE, Issue 13/2, 2018, Page(s) e0193098, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0193098

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells

Author(s): Stephanie E. van Gijn, Elles Wierenga, Nathalie van den Tempel, Yannick P. Kok, Anne Margriet Heijink, Diana C. J. Spierings, Floris Foijer, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Published in: Oncogene, Issue 38/6, 2019, Page(s) 852-867, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-018-0470-2

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

Author(s): Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07927-y

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

Author(s): Walderik W. Zomerman, Sabine L.A. Plasschaert, Siobhan Conroy, Frank J. Scherpen, Tiny G.J. Meeuwsen-de Boer, Harm J. Lourens, Sergi Guerrero Llobet, Marlinde J. Smit, Lorian Slagter-Menkema, Annika Seitz, Corrie E.M. Gidding, Esther Hulleman, Pieter Wesseling, Lisethe Meijer, Leon C. van Kempen, Anke van den Berg, Daniël O. Warmerdam, Frank A.E. Kruyt, Floris Foijer, Marcel A.T.M. van Vugt, Wilf
Published in: Cell Reports, Issue 22/12, 2018, Page(s) 3206-3216, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.02.089

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Author(s): Ewa Gogola, Alexandra A. Duarte, Julian R. de Ruiter, Wouter W. Wiegant, Jonas A. Schmid, Roebi de Bruijn, Dominic I. James, Sergi Guerrero Llobet, Daniel J. Vis, Stefano Annunziato, Bram van den Broek, Marco Barazas, Ariena Kersbergen, Marieke van de Ven, Madalena Tarsounas, Donald J. Ogilvie, Marcel van Vugt, Lodewyk F.A. Wessels, Jirina Bartkova, Irina Gromova, Miguel Andújar-Sánchez, Jiri Ba
Published in: Cancer Cell, Issue 33/6, 2018, Page(s) 1078-1093.e12, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2018.05.008

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

Author(s): Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt, Arnab Ray Chaudhuri
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11246-1

Inflammatory signaling in genomically instable cancers

Author(s): Francien Talens, Marcel A.T.M. Van Vugt
Published in: Cell Cycle, Issue 18/16, 2019, Page(s) 1830-1848, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2019.1638192

Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

Author(s): Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G.E. de Vries, Michael J. Lee, Marcel A.T.M. van Vugt
Published in: Cell Reports, Issue 28/9, 2019, Page(s) 2345-2357.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.07.070

Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

Author(s): Sergi Guerrero Llobet, Bert van der Vegt, Evelien Jongeneel, Rico D. Bense, Mieke C. Zwager, Carolien P. Schröder, Marieke Everts, Rudolf S. N. Fehrmann, Geertruida H. de Bock, Marcel A. T. M. van Vugt
Published in: npj Breast Cancer, Issue 6/1, 2020, ISSN 2374-4677
Publisher: New York, NY : Breast Cancer Research Foundation : Nature Publishing Group, [2015]-
DOI: 10.1038/s41523-020-00181-w

Improving gene function predictions using independent transcriptional components

Author(s): Carlos G. Urzúa-Traslaviña, Vincent C. Leeuwenburgh, Arkajyoti Bhattacharya, Stefan Loipfinger, Marcel A. T. M. van Vugt, Elisabeth G. E. de Vries, Rudolf S. N. Fehrmann
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21671-w

Never tear us a-PARP: Dealing with DNA lesions during mitosis

Author(s): Pepijn M. Schoonen, Marcel A.T.M. van Vugt
Published in: Molecular & Cellular Oncology, Issue 5/1, 2017, Page(s) e1382670, ISSN 2372-3556
Publisher: Taylor & Francis
DOI: 10.1080/23723556.2017.1382670

Replication stress: Driver and therapeutic target in genomically instable cancers

Author(s): Pepijn M. Schoonen, Sergi Guerrero Llobet, Marcel A.T.M. van Vugt
Published in: DNA Repair, Issue 115, 2019, Page(s) 157-201, ISBN 9780-128155592
Publisher: Elsevier
DOI: 10.1016/bs.apcsb.2018.10.006

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