Targeting replication stress recovery pathways in oncology

Informazioni relative al progetto

TENSION

ID dell’accordo di sovvenzione: 682421

DOI

10.3030/682421

Progetto chiuso

Data della firma CE 1 Luglio 2016

Data di avvio 1 Agosto 2016

Data di completamento 31 Luglio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 972 500,00

Contributo UE

€ 1 972 500,00

Coordinato da

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (20)

Genomic instability, inflammatory signaling and response to cancer immunotherapy.

Autori: Mengting Chen; Renske Linstra; Marcel A. T. M. van Vugt
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Numero 1, 2021, ISSN 0304-419X
Editore: Elsevier BV
DOI: 10.1016/j.bbcan.2021.188661

Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies

Autori: Colin Stok, Yannick P Kok, Nathalie van den Tempel, Marcel A T M van Vugt
Pubblicato in: Nucleic Acids Research, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab151

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

Autori: Yannick P. Kok, Sergi Guerrero Llobet, Pepijn M. Schoonen, Marieke Everts, Arkajyoti Bhattacharya, Rudolf S. N. Fehrmann, Nathalie van den Tempel, Marcel A. T. M. van Vugt
Pubblicato in: Oncogenesis, Numero 9/10, 2020, ISSN 2157-9024
Editore: Nature Publishing Group
DOI: 10.1038/s41389-020-00270-2

Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions

Autori: Martijn R. H. Zwinderman; Thamar Jessurun Lobo; Petra E van der Wouden; Diana C.J. Spierings; Marcel A. T. M. van Vugt; Peter M. Lansdorp; Peter M. Lansdorp; Peter M. Lansdorp; Victor Guryev; Frank J. Dekker
Pubblicato in: ACS chemical biology, 16(11), 2193 - 2201. AMER CHEMICAL SOC, Numero 1, 2021, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.1c00321

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells

Autori: Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga, Bjorn Bakker, Floris Foijer, Diana C. J. Spierings, Marcel A. T. M. Vugt
Pubblicato in: Molecular Oncology, Numero 13/11, 2019, Pagina/e 2422-2440, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.12573

The RECQL helicase prevents replication fork collapse during replication stress

Autori: Bente Benedict, Marit AE van Bueren, Frank PA van Gemert, Cor Lieftink, Sergi Guerrero Llobet, Marcel ATM van Vugt, Roderick L Beijersbergen, Hein te Riele
Pubblicato in: Life Science Alliance, Numero 3/10, 2020, Pagina/e e202000668, ISSN 2575-1077
Editore: [Woodbury, NY] : Life Science Alliance, LLC, [2018]-
DOI: 10.26508/lsa.202000668

Transcriptional effects of copy number alterations in a large set of human cancers

Autori: Arkajyoti Bhattacharya, Rico D. Bense, Carlos G. Urzúa-Traslaviña, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14605-5

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

Autori: Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 15981, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15981

Shutting down the power supply for DNA repair in cancer cells

Autori: Marcel A.T.M. van Vugt
Pubblicato in: The Journal of Cell Biology, Numero 216/2, 2017, Pagina/e 295-297, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201701026

Therapeutic targeting and patient selection for cancers with homologous recombination defects

Autori: Francien Talens, Mathilde Jalving, Jourik A. Gietema, Marcel A. Van Vugt
Pubblicato in: Expert Opinion on Drug Discovery, Numero 12/6, 2017, Pagina/e 565-581, ISSN 1746-0441
Editore: Informa Healthcare
DOI: 10.1080/17460441.2017.1322061

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach

Autori: Mathilde R. W. de Jong, Lydia Visser, Gerwin Huls, Arjan Diepstra, Marcel van Vugt, Emanuele Ammatuna, Rozemarijn S. van Rijn, Edo Vellenga, Anke van den Berg, Rudolf S. N. Fehrmann, Tom van Meerten
Pubblicato in: PLOS ONE, Numero 13/2, 2018, Pagina/e e0193098, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0193098

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells

Autori: Stephanie E. van Gijn, Elles Wierenga, Nathalie van den Tempel, Yannick P. Kok, Anne Margriet Heijink, Diana C. J. Spierings, Floris Foijer, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Pubblicato in: Oncogene, Numero 38/6, 2019, Pagina/e 852-867, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-018-0470-2

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

Autori: Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-07927-y

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

Autori: Walderik W. Zomerman, Sabine L.A. Plasschaert, Siobhan Conroy, Frank J. Scherpen, Tiny G.J. Meeuwsen-de Boer, Harm J. Lourens, Sergi Guerrero Llobet, Marlinde J. Smit, Lorian Slagter-Menkema, Annika Seitz, Corrie E.M. Gidding, Esther Hulleman, Pieter Wesseling, Lisethe Meijer, Leon C. van Kempen, Anke van den Berg, Daniël O. Warmerdam, Frank A.E. Kruyt, Floris Foijer, Marcel A.T.M. van Vugt, Wilf
Pubblicato in: Cell Reports, Numero 22/12, 2018, Pagina/e 3206-3216, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.02.089

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Autori: Ewa Gogola, Alexandra A. Duarte, Julian R. de Ruiter, Wouter W. Wiegant, Jonas A. Schmid, Roebi de Bruijn, Dominic I. James, Sergi Guerrero Llobet, Daniel J. Vis, Stefano Annunziato, Bram van den Broek, Marco Barazas, Ariena Kersbergen, Marieke van de Ven, Madalena Tarsounas, Donald J. Ogilvie, Marcel van Vugt, Lodewyk F.A. Wessels, Jirina Bartkova, Irina Gromova, Miguel Andújar-Sánchez, Jiri Ba
Pubblicato in: Cancer Cell, Numero 33/6, 2018, Pagina/e 1078-1093.e12, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2018.05.008

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

Autori: Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt, Arnab Ray Chaudhuri
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11246-1

Inflammatory signaling in genomically instable cancers

Autori: Francien Talens, Marcel A.T.M. Van Vugt
Pubblicato in: Cell Cycle, Numero 18/16, 2019, Pagina/e 1830-1848, ISSN 1538-4101
Editore: Landes Bioscience
DOI: 10.1080/15384101.2019.1638192

Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

Autori: Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G.E. de Vries, Michael J. Lee, Marcel A.T.M. van Vugt
Pubblicato in: Cell Reports, Numero 28/9, 2019, Pagina/e 2345-2357.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.07.070

Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

Autori: Sergi Guerrero Llobet, Bert van der Vegt, Evelien Jongeneel, Rico D. Bense, Mieke C. Zwager, Carolien P. Schröder, Marieke Everts, Rudolf S. N. Fehrmann, Geertruida H. de Bock, Marcel A. T. M. van Vugt
Pubblicato in: npj Breast Cancer, Numero 6/1, 2020, ISSN 2374-4677
Editore: New York, NY : Breast Cancer Research Foundation : Nature Publishing Group, [2015]-
DOI: 10.1038/s41523-020-00181-w

Improving gene function predictions using independent transcriptional components

Autori: Carlos G. Urzúa-Traslaviña, Vincent C. Leeuwenburgh, Arkajyoti Bhattacharya, Stefan Loipfinger, Marcel A. T. M. van Vugt, Elisabeth G. E. de Vries, Rudolf S. N. Fehrmann
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21671-w

Non-peer reviewed articles (1)

Never tear us a-PARP: Dealing with DNA lesions during mitosis

Autori: Pepijn M. Schoonen, Marcel A.T.M. van Vugt
Pubblicato in: Molecular & Cellular Oncology, Numero 5/1, 2017, Pagina/e e1382670, ISSN 2372-3556
Editore: Taylor & Francis
DOI: 10.1080/23723556.2017.1382670

Book chapters (1)

Replication stress: Driver and therapeutic target in genomically instable cancers

Autori: Pepijn M. Schoonen, Sergi Guerrero Llobet, Marcel A.T.M. van Vugt
Pubblicato in: DNA Repair, Numero 115, 2019, Pagina/e 157-201, ISBN 9780-128155592
Editore: Elsevier
DOI: 10.1016/bs.apcsb.2018.10.006