Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity

Project Information

PLEIO-RANK

Grant agreement ID: 682935

DOI 10.3030/682935

Project closed

EC signature date 26 July 2016

Start date 1 October 2016

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 960,00

EU contribution € 1 999 960,00

Coordinated by

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain

Publications

Peer reviewed articles (10)

RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer

Author(s): Marina Ciscar, Eva M Trinidad, Gema Perez-Chacon, Maria Jimenez, Maria J Jimenez-Santos, Hector Perez-Montoyo, Adrian Sanz-Moreno, Andrea Vethencourt, Michael Toss, Anna Petit, Maria T Soler-Monso, Victor Lopez, Jorge Gomez-Miragaya, Clara Gomez-Aleza, Lacey E Dobrolecki, Michael T Lewis, Alejandra Bruna, Silvana Mouron, Miguel Quintela-Fandino, Fatima Al-Shahrour, Antonio Martinez-Aranda, Angels
Published in: EMBO Molecular Medicine, 2023, ISSN 1757-4684
Publisher: EMBO Press
DOI: 10.15252/emmm.202216715

Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Author(s): Alex Cordero, Patricia G. Santamaría, Eva Gonzalez-Suarez
Published in: JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2023, ISSN 1083-3021
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10911-023-09530-4

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

Author(s): Sandra Benítez, Alex Cordero, Patricia G. Santamaría, Jaime Redondo-Pedraza, Ana S. Rocha, Alejandro Collado-Solé, Maria Jimenez, Adrian Sanz-Moreno, Guillermo Yoldi, Juliana C. Santos, Ilaria De Benedictis, Clara Gómez-Aleza, Sabela Da Silva-Álvarez, Kevin Troulé, Gonzalo Gómez-López, Noelia Alcazar, Ignacio Palmero, Manuel Collado, Manuel Serrano, Eva Gonzalez-Suarez,
Published in: Developmental Cell, 2021, Page(s) 1727-1741.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.04.022.

RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation

Author(s): Guillermo Yoldi, Pasquale Pellegrini, Eva M. Trinidad, Alex Cordero, Jorge Gomez-Miragaya, Jordi Serra-Musach, William C. Dougall, Purificación Muñoz, Miguel-Angel Pujana, Lourdes Planelles, Eva González-Suárez
Published in: Cancer Research, Issue 76/19, 2016, Page(s) 5857-5869, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-15-2745

RANKL inhibitors for osteosarcoma treatment: hope and caution

Author(s): Eva M. Trinidad, Eva González-Suárez
Published in: Annals of Translational Medicine, Issue 4/24, 2016, Page(s) 534-534, ISSN 2305-5839
Publisher: Science Translational Medicine
DOI: 10.21037/atm.2016.12.10

Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody

Author(s): Roger von Moos, Luis Costa, Eva Gonzalez-Suarez, Evangelos Terpos, Daniela Niepel, Jean–Jacques Body
Published in: Cancer Treatment Reviews, 2019, ISSN 0305-7372
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2019.05.003

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Author(s): Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A. Jarzabek, Steven de Jong, Jos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunh
Published in: Nature Reviews Cancer, Issue 17/4, 2017, Page(s) 254-268, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/nrc.2016.140

European Network of Breast Development and Cancer turned 10 years: a growing family of mammary gland researchers

Author(s): Zuzana Koledova, Beatrice A. Howard, Johanna Englund, Karsten Bach, Mohammed Bentires-Alj, Eva Gonzalez-Suarez
Published in: Breast Cancer Research, Issue 20/1, 2018, ISSN 1465-542X
Publisher: Breast Cancer Research
DOI: 10.1186/s13058-018-1032-9

RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer

Author(s): Adrián Sanz-Moreno, Sonia Palomeras, Kim Pedersen, Beatriz Morancho, Tomas Pascual, Patricia Galván, Sandra Benítez, Jorge Gomez-Miragaya, Marina Ciscar, Maria Jimenez, Sonia Pernas, Anna Petit, María Teresa Soler-Monsó, Gemma Viñas, Mansour Alsaleem, Emad A. Rakha, Andrew R. Green, Patricia G. Santamaria, Celine Mulder, Simone Lemeer, Joaquin Arribas, Aleix Prat, Teresa Puig, Eva Gonzalez-S
Published in: Breast Cancer Research, Issue 23/1, 2021, ISSN 1465-542X
Publisher: Springer Nature
DOI: 10.1186/s13058-021-01390-2

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

Author(s): Clara Gómez-Aleza, Bastien Nguyen, Guillermo Yoldi, Marina Ciscar, Alexandra Barranco, Enrique Hernández-Jiménez, Marion Maetens, Roberto Salgado, Maria Zafeiroglou, Pasquale Pellegrini, David Venet, Soizic Garaud, Eva M. Trinidad, Sandra Benítez, Peter Vuylsteke, Laura Polastro, Hans Wildiers, Philippe Simon, Geoffrey Lindeman, Denis Larsimont, Gert Van den Eynden, Chloé Velghe, Françoise R
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20138-8