Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity

Informacje na temat projektu

PLEIO-RANK

Identyfikator umowy o grant: 682935

DOI 10.3030/682935

Projekt został zamknięty

Data podpisania przez KE 26 Lipca 2016

Data rozpoczęcia 1 Października 2016

Data zakończenia 31 Marca 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity € 1 999 960,00

Wkład UE € 1 999 960,00

Koordynowany przez

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain

Publikacje

Peer reviewed articles (10)

RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer

Autorzy: Marina Ciscar, Eva M Trinidad, Gema Perez-Chacon, Maria Jimenez, Maria J Jimenez-Santos, Hector Perez-Montoyo, Adrian Sanz-Moreno, Andrea Vethencourt, Michael Toss, Anna Petit, Maria T Soler-Monso, Victor Lopez, Jorge Gomez-Miragaya, Clara Gomez-Aleza, Lacey E Dobrolecki, Michael T Lewis, Alejandra Bruna, Silvana Mouron, Miguel Quintela-Fandino, Fatima Al-Shahrour, Antonio Martinez-Aranda, Angels
Opublikowane w: EMBO Molecular Medicine, 2023, ISSN 1757-4684
Wydawca: EMBO Press
DOI: 10.15252/emmm.202216715

Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Autorzy: Alex Cordero, Patricia G. Santamaría, Eva Gonzalez-Suarez
Opublikowane w: JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2023, ISSN 1083-3021
Wydawca: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10911-023-09530-4

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

Autorzy: Sandra Benítez, Alex Cordero, Patricia G. Santamaría, Jaime Redondo-Pedraza, Ana S. Rocha, Alejandro Collado-Solé, Maria Jimenez, Adrian Sanz-Moreno, Guillermo Yoldi, Juliana C. Santos, Ilaria De Benedictis, Clara Gómez-Aleza, Sabela Da Silva-Álvarez, Kevin Troulé, Gonzalo Gómez-López, Noelia Alcazar, Ignacio Palmero, Manuel Collado, Manuel Serrano, Eva Gonzalez-Suarez,
Opublikowane w: Developmental Cell, 2021, Strona(/y) 1727-1741.e7, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2021.04.022.

RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation

Autorzy: Guillermo Yoldi, Pasquale Pellegrini, Eva M. Trinidad, Alex Cordero, Jorge Gomez-Miragaya, Jordi Serra-Musach, William C. Dougall, Purificación Muñoz, Miguel-Angel Pujana, Lourdes Planelles, Eva González-Suárez
Opublikowane w: Cancer Research, Numer 76/19, 2016, Strona(/y) 5857-5869, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-15-2745

RANKL inhibitors for osteosarcoma treatment: hope and caution

Autorzy: Eva M. Trinidad, Eva González-Suárez
Opublikowane w: Annals of Translational Medicine, Numer 4/24, 2016, Strona(/y) 534-534, ISSN 2305-5839
Wydawca: Science Translational Medicine
DOI: 10.21037/atm.2016.12.10

Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody

Autorzy: Roger von Moos, Luis Costa, Eva Gonzalez-Suarez, Evangelos Terpos, Daniela Niepel, Jean–Jacques Body
Opublikowane w: Cancer Treatment Reviews, 2019, ISSN 0305-7372
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2019.05.003

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Autorzy: Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A. Jarzabek, Steven de Jong, Jos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunh
Opublikowane w: Nature Reviews Cancer, Numer 17/4, 2017, Strona(/y) 254-268, ISSN 1474-175X
Wydawca: Nature Publishing Group
DOI: 10.1038/nrc.2016.140

European Network of Breast Development and Cancer turned 10 years: a growing family of mammary gland researchers

Autorzy: Zuzana Koledova, Beatrice A. Howard, Johanna Englund, Karsten Bach, Mohammed Bentires-Alj, Eva Gonzalez-Suarez
Opublikowane w: Breast Cancer Research, Numer 20/1, 2018, ISSN 1465-542X
Wydawca: Breast Cancer Research
DOI: 10.1186/s13058-018-1032-9

RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer

Autorzy: Adrián Sanz-Moreno, Sonia Palomeras, Kim Pedersen, Beatriz Morancho, Tomas Pascual, Patricia Galván, Sandra Benítez, Jorge Gomez-Miragaya, Marina Ciscar, Maria Jimenez, Sonia Pernas, Anna Petit, María Teresa Soler-Monsó, Gemma Viñas, Mansour Alsaleem, Emad A. Rakha, Andrew R. Green, Patricia G. Santamaria, Celine Mulder, Simone Lemeer, Joaquin Arribas, Aleix Prat, Teresa Puig, Eva Gonzalez-S
Opublikowane w: Breast Cancer Research, Numer 23/1, 2021, ISSN 1465-542X
Wydawca: Springer Nature
DOI: 10.1186/s13058-021-01390-2

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

Autorzy: Clara Gómez-Aleza, Bastien Nguyen, Guillermo Yoldi, Marina Ciscar, Alexandra Barranco, Enrique Hernández-Jiménez, Marion Maetens, Roberto Salgado, Maria Zafeiroglou, Pasquale Pellegrini, David Venet, Soizic Garaud, Eva M. Trinidad, Sandra Benítez, Peter Vuylsteke, Laura Polastro, Hans Wildiers, Philippe Simon, Geoffrey Lindeman, Denis Larsimont, Gert Van den Eynden, Chloé Velghe, Françoise R
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-20138-8